LOCUS       AF231981                 900 bp    mRNA    linear   HUM 10-OCT-2000
DEFINITION  Homo sapiens long chain polyunsaturated fatty acid elongation
            enzyme (HELO1) mRNA, complete cds.
ACCESSION   AF231981
VERSION     AF231981.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Leonard,A.E., Bobik,E.G., Dorado,J., Kroeger,P.E., Chuang,L.T.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y.S. and
            Mukerji,P.
  TITLE     Cloning of a human cDNA encoding a novel enzyme involved in the
            elongation of long-chain polyunsaturated fatty acids
  JOURNAL   Biochem. J. 350 (Pt 3), 765-770 (2000)
   PUBMED   10970790
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Leonard,A.E., Bobik,E.G. Jr., Dorado,J., Kroeger,P.E., Chuang,L.,
            Thurmond,J.M., Parker-Barnes,J.M., Das,T., Huang,Y. and Mukerji,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-FEB-2000) Strategic Discovery Research, Ross Products
            Division of Abbott Laboratories, 3300 Stelzer Rd., Columbus, OH
            43219, USA
FEATURES             Location/Qualifiers
     source          1..900
                     /db_xref="H-InvDB:HIT000074635"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12"
     gene            1..900
                     /gene="HELO1"
     CDS             1..900
                     /gene="HELO1"
                     /function="involved in conversion of GLA to DGLA, AA to
                     adrenic acid, alpha-linolenic acid to 20:3n-3, stearidonic
                     acid to 20:4n-3, and EPA to 22:5n-3"
                     /codon_start=1
                     /product="long chain polyunsaturated fatty acid elongation
                     enzyme"
                     /protein_id="AAF70631.1"
                     /translation="MEHFDASLSTYFKALLGPRDTRVKGWFLLDNYIPTFICSVIYLL
                     IVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTRTA
                     GESDMKIIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHASMLNIWWFVMNW
                     VPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLLQFVLTIIQTS
                     CGVIWPCTFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKDHLKDHQNGSMAA
                     VNGHTNSFSPLENNVKPRKLRKD"
BASE COUNT          230 a          222 c          196 g          252 t
ORIGIN      
        1 atggaacatt ttgatgcatc acttagtacc tatttcaagg cattgctagg ccctcgagat
       61 actagagtaa aaggatggtt tcttctggac aattatatac ccacatttat ctgctctgtc
      121 atatatttac taattgtatg gctgggacca aaatacatga ggaataaaca gccattctct
      181 tgccggggga ttttagtggt gtataacctt ggactcacac tgctgtctct gtatatgttc
      241 tgtgagttag taacaggagt atgggaaggc aaatacaact tcttctgtca gggcacacgc
      301 accgcaggag aatcagatat gaagattatc cgtgtcctct ggtggtacta cttctccaaa
      361 ctcatagaat ttatggacac tttcttcttc atcctgcgca agaacaacca ccagatcacg
      421 gtcctgcacg tctaccacca tgcctcgatg ctgaacatct ggtggtttgt gatgaactgg
      481 gtcccctgcg gccactctta ttttggtgcc acacttaata gcttcatcca cgtcctcatg
      541 tactcttact atggtttgtc gtcagtccct tccatgcgtc catacctctg gtggaagaag
      601 tacatcactc aggggcagct gcttcagttt gtgctgacaa tcatccagac cagctgcggg
      661 gtcatctggc cgtgcacatt ccctcttggt tggttgtatt tccagattgg atacatgatt
      721 tccctgattg ctctcttcac aaacttctac attcagacct acaacaagaa aggggcctcc
      781 cgaaggaaag accacctgaa ggaccaccag aatgggtcca tggctgctgt gaatggacac
      841 accaacagct tttcacccct ggaaaacaat gtgaagccaa ggaagctgcg gaaggattga
//