LOCUS AF230097 1617 bp mRNA linear HUM 29-DEC-2016
DEFINITION Homo sapiens class I histone deacetylase (HDAC8) mRNA, complete
cds.
ACCESSION AF230097
VERSION AF230097.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1617)
AUTHORS Hu,E., Chen,Z., Fredrickson,T., Zhu,Y., Kirkpatrick,R., Zhang,G.F.,
Johanson,K., Sung,C.M., Liu,R. and Winkler,J.
TITLE Cloning and characterization of a novel human class I histone
deacetylase that functions as a transcription repressor
JOURNAL J. Biol. Chem. 275 (20), 15254-15264 (2000)
PUBMED 10748112
REFERENCE 2 (bases 1 to 1617)
AUTHORS Hu,E., Chen,Z., Frederickson,T., Zhu,Y., Kirkpatrick,R.,
Zhang,G.-F., Johanson,K., Sung,C.-M., Liu,R. and Winkler,J.
TITLE Direct Submission
JOURNAL Submitted (19-MAY-2000) Renal Pharmacology, SmithKline Beecham, 709
Swedeland Road, King of Prussia, PA 19406, USA
REFERENCE 3 (bases 1 to 1617)
AUTHORS Hu,E., Chen,Z., Frederickson,T., Zhu,Y., Kirkpatrick,R.,
Zhang,G.-F., Johanson,K., Sung,C.-M., Liu,R. and Winkler,J.
TITLE Direct Submission
JOURNAL Submitted (29-DEC-2016) Renal Pharmacology, SmithKline Beecham, 709
Swedeland Road, King of Prussia, PA 19406, USA
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Dec 29, 2016 this sequence version replaced AF230097.1.
FEATURES Location/Qualifiers
source 1..1617
/db_xref="H-InvDB:HIT000074544"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1617
/gene="HDAC8"
CDS 19..1152
/gene="HDAC8"
/codon_start=1
/product="class I histone deacetylase"
/protein_id="AAF73076.1"
/translation="MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSL
IEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDC
PATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVL
GILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVG
LGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCS
FNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDH
EFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV"
BASE COUNT 459 a 336 c 431 g 384 t
ORIGIN
1 aacggtttta agcggaagat ggaggagccg gaggaaccgg cggacagtgg gcagtcgctg
61 gtcccggttt atatctatag tcccgagtat gtcagtatgt gtgactccct ggccaagatc
121 cccaaacggg ccagtatggt gcattctttg attgaagcat atgcactgca taagcaaatg
181 aggatagtta agcctaaagt ggcctccatg gaggagatgg ccaccttcca cactgatgct
241 tatctgcagc atctccagaa ggtcagccaa gagggcgatg atgatcatcc ggactccata
301 gaatatgggc taggttatga ctgcccagcc actgaaggga tatttgacta tgcagcagct
361 ataggagggg ctacgatcac agctgcccaa tgcctgattg acggaatgtg caaagtagca
421 attaactggt ctggagggtg gcatcatgca aagaaagatg aagcatctgg tttttgttat
481 ctcaatgatg ctgtcctggg aatattacga ttgcgacgga aatttgagcg tattctctac
541 gtggatttgg atctgcacca tggagatggt gtagaagacg cattcagttt cacctccaaa
601 gtcatgaccg tgtccctgca caaattctcc ccaggatttt tcccaggaac aggtgacgtg
661 tctgatgttg gcctagggaa gggacggtac tacagtgtaa atgtgcccat tcaggatggc
721 atacaagatg aaaaatatta ccagatctgt gaaagtgtac taaaggaagt ataccaagcc
781 tttaatccca aagcagtggt cttacagctg ggagctgaca caatagctgg ggatcccatg
841 tgctccttta acatgactcc agtgggaatt ggcaagtgtc ttaagtacat ccttcaatgg
901 cagttggcaa cactcatttt gggaggagga ggctataacc ttgccaacac ggctcgatgc
961 tggacatact tgaccggggt catcctaggg aaaacactat cctctgagat cccagatcat
1021 gagtttttca cagcatatgg tcctgattat gtgctggaaa tcacgccaag ctgccggcca
1081 gaccgcaatg agccccaccg aatccaacaa atcctcaact acatcaaagg gaatctgaag
1141 catgtggtct agttgacaga aagagatcag gtttccagag ctgaggagtg gtgcctataa
1201 tgaagacagc gtgtttatgc aagcagtttg tggaatttgt gactgcaggg aaaatttgaa
1261 agaaattact tcctgaaaat ttccaagggg catcaagtgg cagctggctt cctggggtga
1321 agaggcaggc accccagagt cctcaactgg acctagggga agaaggagat atcccacatt
1381 taaagttctt atttaaaaaa acacacacac acaaatgaaa tttttaatct ttgaaaatta
1441 tttttaagcg aattggggag gggagtattt taatcatctt aaatgaaaca gatcagaagc
1501 tggatgagag cagtcaccag tttgtagggc aggaggcagc tgacaggcag ggntngggcc
1561 tcnggaccan ccangtggag ccctgggaga ganggtactg atcngcagac tgggagg
//