LOCUS AF223574 2790 bp mRNA linear HUM 06-APR-2000
DEFINITION Homo sapiens serum-inducible kinase (SNK) mRNA, complete cds.
ACCESSION AF223574
VERSION AF223574.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2790)
AUTHORS Anderson,K.M., Nerurkar,S.S., Hansbury,M.J., Fornwald,J., Scott,G.,
Bouzyk,M., Mui,P., Imbrugia,C.S., Carlson,K., Marshall,L.A. and
Roshak,A.K.
TITLE Identification and Characterization of Human Serum-Inducible Kinase
(SNK), A Novel Member of the Polo-Kinase Family of Cell Cycle
Regulators: Potential Implication for Regulation of Vascular Smooth
Muscle Proliferation
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2790)
AUTHORS Nerurkar,S.S., Anderson,K.M., Roshak,A.K., Fornwald,J. and
Hansbury,M.J.
TITLE Direct Submission
JOURNAL Submitted (11-JAN-2000) Cardiovascular Pharmacology, SmithKline
Beecham, 709 Swedeland Road, King Of Prussia, PA 19406, USA
FEATURES Location/Qualifiers
source 1..2790
/db_xref="H-InvDB:HIT000074411"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q12.1-q13.2; between D5S491 and D5S427"
/cell_type="carcinoma"
/tissue_type="colon"
gene 1..2790
/gene="SNK"
CDS 124..2181
/gene="SNK"
/note="serine/threonine kinase"
/codon_start=1
/product="serum-inducible kinase"
/protein_id="AAF62897.1"
/translation="MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQP
PQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDL
TNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLE
YCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAME
LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLG
RPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF
LQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKED
EDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVR
GTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWV
DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFI
SQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVN
FYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQ
RCN"
BASE COUNT 837 a 611 c 657 g 685 t
ORIGIN
1 gaattcggca cgaggttggg tgctattcgg caccagaggc aagggtgcga ggaccacggc
61 cggctcggac gtgtgaccgc gcctaggggg tggcagcggg cagtgcgggg cggcaaggcg
121 accatggagc ttttgcggac tatcacctac cagccagccg ccagcaccaa aatgtgcgag
181 caggcgctgg gcaagggttg cggagcagac tcgaagaaga agcggccgcc gcagcccccc
241 gaggaatcgc agccacctca gtcccaggcg caagtgcccc cggcggcccc tcaccaccat
301 caccaccatt cgcactcggg gccggagatc tcgcggatta tcgtcgaccc cacgactggg
361 aagcgctact gccggggcaa agtgctggga aagggtggct ttgcaaaatg ttacgagatg
421 acagatttga caaataacaa agtctacgcc gcaaaaatta ttcctcacag cagagtagct
481 aaacctcatc aaagggaaaa gattgacaaa gaaatagagc ttcacagaat tcttcatcat
541 aagcatgtag tgcagtttta ccactacttc gaggacaaag aaaacattta cattctcttg
601 gaatactgca gtagaaggtc aatggctcat attttgaaag caagaaaggt gttgacagag
661 ccagaagttc gatactacct caggcagatt gtgtctggac tgaaatacct tcatgaacaa
721 gaaatcttgc acagagatct caaactaggg aactttttta ttaatgaagc catggaacta
781 aaagttgggg acttcggtct ggcagccagg ctagaaccct tggaacacag aaggagaacg
841 atatgtggta ccccaaatta tctctctcct gaagtcctca acaaacaagg acatggctgt
901 gaatcagaca tttgggccct gggctgtgta atgtatacaa tgttactagg gaggccccca
961 tttgaaacta caaatctcaa agaaacttat aggtgcataa gggaagcaag gtatacaatg
1021 ccgtcctcat tgctggctcc tgccaagcac ttaattgcta gtatgttgtc caaaaaccca
1081 gaggataggc ctagtttgga tgacatcatt cgacatgact tttttttgca gggcttcact
1141 ccggacagac tgtcttctag ctgttgtcat acagttccag atttccactt atcaagccca
1201 gctaagaatt tctttaagaa agcagctgct gctctttttg gtggcaaaaa agacaaagca
1261 agatatattg acacacataa tagagtgtct aaagaagatg aagacatcta caagcttagg
1321 catgatttga aaaagacttc aataactcag caacccagca aacacaggac agatgaggag
1381 ctccagccac ctaccaccac agttgccagg tctggaacac ccgcagtaga aaacaagcag
1441 cagattgggg atgctattcg gatgatagtc agagggactc ttggcagctg tagcagcagc
1501 agtgaatgcc ttgaagacag taccatggga agtgttgcag acacagtggc aagggttctt
1561 cggggatgtc tggaaaacat gccggaagct gattgcattc ccaaagagca gctgagcaca
1621 tcatttcagt gggtcaccaa atgggttgat tactctaaca aatatggctt tgggtaccag
1681 ctctcagacc acaccgtcgg tgtccttttc aacaatggtg ctcacatgag cctccttcca
1741 gacaaaaaaa cagttcacta ttacgcagag cttggccaat gctcagtttt cccagcaaca
1801 gatgctcctg agcaatttat tagtcaagtg acggtgctga aatacttttc tcattacatg
1861 gaggagaacc tcatggatgg tggagatctg cctagtgtta ctgatattcg aagacctcgg
1921 ctctacctcc ttcagtggct aaaatctgat aaggccctaa tgatgctctt taatgatggc
1981 acctttcagg tgaatttcta ccatgatcat acaaaaatca tcatctgtag ccaaaatgaa
2041 gaataccttc tcacctacat caatgaggat aggatatcta caactttcag gctgacaact
2101 ctgctgatgt ctggctgttc atcagaatta aaaaatcgaa tggaatatgc cctgaacatg
2161 ctcttacaaa gatgtaactg aaagactttt cgaatggacc ctatgggact cctcttttcc
2221 actgtgagat ctacagggaa cccaaaagaa tgatctagag tatgttgaag aagatggaca
2281 tgtggtggta cgaaaacaat tcccctgtgg cctgctggac tgggtggaac cagaacaggc
2341 taaggcatac agttcttgac tttggacaat ccaagagtga accagaatgc agttttcctt
2401 gagatacctg ttttaaaagg tttttcagac aattttgcag aaaggtgcat tgattcttaa
2461 attctctctg ttgagagcat ttcagccaga ggactttgga actgtgaata tacttcctga
2521 aggggaggga gaagggagga agctcccatg ttgtttaaag gctgtaattg gagcagcttt
2581 tggctgcgta actgtgaact atggccatat ataatttttt ttcattaatt tttgaagata
2641 cttgtggctg gaaaagtgca ttccttgtta ataaactttt tatttattac agcccaaaga
2701 gcagtattta ttatcaaaat gtctttttct ttgaccattt taaaccgttg gcaataaaga
2761 gtatgaaaac gcaaaaaaaa aaaaaaaaaa
//