LOCUS AF222980 6930 bp mRNA linear HUM 02-JUN-2000
DEFINITION Homo sapiens disrupted in Schizophrenia 1 protein (DISC1) mRNA,
complete cds.
ACCESSION AF222980
VERSION AF222980.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6930)
AUTHORS Millar,J.K., Wilson-Annan,J.C., Anderson,S., Christie,S.,
Taylor,M.S., Semple,C.A., Devon,R.S., Clair,D.M., Muir,W.J.,
Blackwood,D.H. and Porteous,D.J.
TITLE Disruption of two novel genes by a translocation co-segregating
with schizophrenia
JOURNAL Hum. Mol. Genet. 9 (9), 1415-1423 (2000)
PUBMED 10814723
REFERENCE 2 (bases 1 to 6930)
AUTHORS Millar,K., Anderson,S. and Christie,S.
TITLE Direct Submission
JOURNAL Submitted (11-JAN-2000) Medical Genetics Section, The University of
Edinburgh, Crewe Road, Edinburgh EH4 2XU, Scotland
FEATURES Location/Qualifiers
source 1..6930
/db_xref="H-InvDB:HIT000074403"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q42.1"
gene 1..6930
/gene="DISC1"
CDS 54..2618
/gene="DISC1"
/codon_start=1
/product="disrupted in Schizophrenia 1 protein"
/protein_id="AAF73889.1"
/translation="MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPG
YMRSSTGPGIGFLSPAVGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKS
AAAPTVTSVRGTSAHFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASW
EAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLG
SAGERGEAEGCPPSREAESHCQSPQEMGAKAASLDGPHEDPRCLSQPFSLLATRVSAD
LAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWE
PVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHF
QLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHV
SITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV
GQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCM
SEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGL
LSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSC
KCPLLGKVWEADLEACRLLIQCLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED
KRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGEKCEDIGKKLLYLEDQLHT
AIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA"
BASE COUNT 1901 a 1625 c 1664 g 1740 t
ORIGIN
1 ggaaggagca ggaggcagcc caggcggagc gggaggagct ggcagcgggg cgcatgccag
61 gcgggggtcc tcagggcgcc ccagccgccg ccggcggcgg cggcgtgagc caccgcgcag
121 gcagccggga ttgcttacca cctgcagcgt gctttcggag gcggcggctg gcacggaggc
181 cgggctacat gagaagctcg acagggcctg ggatcgggtt cctttcccca gcagtgggca
241 cactgttccg gttcccagga ggggtgtctg gcgaggagtc ccaccactcg gagtccaggg
301 ccagacagtg tggccttgac tcgagaggcc tcttggtccg gagccctgtt tccaagagtg
361 cagcagcccc tactgtgacc tctgtgagag gaacctcggc gcactttggg attcagctca
421 gaggtggcac cagattgcct gacaggctta gctggccgtg tggccctggg agtgctgggt
481 ggcagcaaga gtttgcagcc atggatagtt ctgagaccct ggacgccagc tgggaggcag
541 cctgcagcga tggagcaagg cgtgtccggg cagcaggctc tctgccatca gcagagttga
601 gtagcaacag ctgcagccct ggctgtggcc ctgaggtccc cccaacccct cctggctctc
661 acagtgcctt tacctcaagc tttagcttta ttcggctctc gcttggctct gccggggaac
721 gtggagaagc agaaggctgc ccaccatcca gagaggctga gtcccattgc cagagccccc
781 aggagatggg agccaaagct gccagcttgg acgggcctca cgaggacccg cgatgtctct
841 ctcagccctt cagtctcttg gctacacggg tctctgcaga cttggcccag gccgcaagga
901 acagctccag gccagagcgt gacatgcatt ctttaccaga catggaccct ggctcctcca
961 gttctctgga tccctcactg gctggctgtg gtggtgatgg gagcagcggc tcaggggatg
1021 cccactcttg ggacaccctg ctcaggaaat gggagccagt gctgcgggac tgcctgctga
1081 gaaaccggag gcagatggag gtaatatcct taagattaaa acttcagaaa cttcaggaag
1141 atgcagttga gaatgatgat tatgataaag ctgagacgtt acaacaaaga ttagaagacc
1201 tggaacaaga gaaaatcagc ctgcactttc aacttccttc aaggcagcca gctcttagca
1261 gtttcctggg tcacctggca gcacaagtcc aggctgcctt gcgccgtggg gccactcagc
1321 aggccagcgg agatgacacc cacaccccac tgagaatgga gccgaggctg ttggaaccca
1381 ctgctcagga cagcttgcac gtgtccatca cgagacgaga ctggcttctt caggaaaagc
1441 agcagctaca gaaagaaatc gaagctctcc aagcaaggat gtttgtgctg gaagccaaag
1501 atcaacagct gagaagggaa atagaggagc aagagcagca actccagtgg cagggctgcg
1561 acctgacccc actggtgggc cagctgtccc tgggtcagct gcaggaggtc agcaaggcct
1621 tgcaggacac cctggcctca gccggtcaga ttcccttcca tgcagagcca ccggaaacca
1681 taaggagcct ccaggaaaga ataaaatccc tcaacttgtc acttaaagaa atcactacta
1741 aggtgtgtat gagtgagaaa ttctgcagca ccctgaggaa gaaagttaac gatattgaaa
1801 cccaactacc agccttgctt gaagccaaaa tgcatgccat atcaggaaac catttctgga
1861 cggctaaaga cctcaccgag gagattagat cattaacatc agagagagaa gggctggagg
1921 gactcctcag caagctgttg gtgttgagtt ccaggaatgt caaaaagctg ggaagtgtta
1981 aagaagatta caacagactg agaagagaag tggagcacca ggagactgcc tatgaaacaa
2041 gtgtgaagga aaatactatg aagtacatgg aaacacttaa gaataaactg tgcagctgca
2101 agtgtccact gcttgggaaa gtgtgggaag ctgacttgga agcttgtcga ttgcttatcc
2161 agtgcctaca gctccaggaa gccaggggaa gcctgtctgt agaagatgag aggcagatgg
2221 atgacttaga gggagctgct cctcctattc cccccaggct ccactccgag gataaaagga
2281 agaccccttt gaaggtattg gaagaatgga agactcacct catcccctct ctgcactgtg
2341 ctggaggtga acagaaagag gaatcttaca tcctttctgc agaacttgga gaaaagtgtg
2401 aagacatagg caagaagcta ttgtacttgg aagatcaact tcacacagca atccacagtc
2461 atgatgaaga tctcattcag tctctcagga gggagctcca gatggtgaag gaaactctgc
2521 aggccatgat cctgcagctc cagccagcaa aggaggcggg agaaagagaa gctgcagctt
2581 cctgcatgac agctggtgtc cacgaagcac aagcctgagg agtgacggga tgggggaggg
2641 aggtgggcca ccatgtttgg acccgggggg ctgctcttcc ctcccccgcc atagctaaga
2701 tgcctgaatc aattacggag atacagagcc ttgaggtctt tcagtggaaa ggtggttcat
2761 gttcattctc atcagtgtga aactgaggag tctgcaattt ggaatatgga gagagagact
2821 gatttgctga atttccttct aaatgtcact caaaaatttc ttttccatgt cattcttggg
2881 aatgtcttcc acaggatttg agaatagttt catctcagcc cccattagag agaagttggg
2941 gtgaattctg gaaaaatgtc tctttttcct gtgccatttg ccttctgctg caacgaaaat
3001 atttcctgat tcaagattct ataaaaagga aaccaagcat aagactctgt catcatacct
3061 gttacacgtt cctacaggtg cacaatctaa gagagctaat taacctcaga gtctggagtt
3121 aacagctttt caccttactt ctcctgtgat ctaatattat cttagaaaaa ttaatatgca
3181 atttccaaaa gatattttgg taagacaaca acctcccagt gatatgccac ctttcaattt
3241 tccttttgtg gcaatgattg catctgaaga aaggatccct gagagtctct gtttcatcag
3301 gacattctga aatttaccca cagtgaggct gtggatggat caggggacct gtataaaatg
3361 tttgagcctg ttccattttc ccgtggaacc tgtttcactc aatgccaggc agtgcagcat
3421 ttaggaaagc agtgcagtac tcagtaaggc agtgcagtac tcagtaacac aatacagtac
3481 tcaggcagtg cagtactcag taagacagtg cagtgctcag taaggcagtg caatactcag
3541 taacagtgta gtactcagta acagtgaagt actcagtaat acagtacagt attcagtaag
3601 gcagtgaagt actcagtaat acaatacagt actcagttag gcagtgcagt actcaggaat
3661 gcagcacagt actcaggcag tgcaatactc agtgcggtac tcagtaacac agtgcagtac
3721 tcagtaacag tgcagtactc agtaacagtg cagtactcag taaggcagtg cagtactcag
3781 taacacagtg cagtactcag taatacagta cagtactcag taaggcagta tggtactcag
3841 taaagcaatg caatgctcag taacacagtg cagtgctcaa taaggcagtg cagtgctcag
3901 taaggcagtg aattgcttag taacacagtg tagtgctcag taggacagca tagtactcag
3961 taacacaggg cagctagtac tcagtactat aagtactgag tacttatata ggcaatgtag
4021 tactcagtaa atcagtgcag tactcagtaa tgcaagggca tttcaggctc ctgctgggct
4081 gcttctttgg cccagctggg actcctattg agacagctgc aaaacaggct gatttcaatt
4141 aggcagcact tcccaaagtg cactgaggaa ggtggcccca agagaagctc tctaaacaaa
4201 ggagtaccct ctctggtcaa gtacctttgg taaatacacc ataccataat atctgcttgg
4261 agaaccacaa tgcacattag catattagtc tgagagagaa cttatagtaa ggaaactcac
4321 ttgattttat ctaacctcaa actttccaag tttaatggat cgtgaatttt tttcatgtaa
4381 ctcctattca tatcccatag atctagtatt gtacagcact gcattctctg aggaagtccc
4441 agtccaaact ctgatttaca tcactttaga aaccacactc acacttttgc agagtgttga
4501 gcttaataac tacctgccac agattggtaa atttaatcca gtggttgttc tgtttgtgct
4561 tctgttctca tttatgtgtt tagggatagt gaggttcctg ccttcactag gatccacgga
4621 tatgagacca tttttgtcat ttcctgaagt cacactggcg tttccagaag gcatctggtg
4681 ctttgctcag ccttccatgc tgtgcagcac ttctgtcctc agtcaaggag atggccatgc
4741 ttaagccagc aattggctgg ggtccaggaa acaaagcaaa agcacaatat gtgaatgtgc
4801 tgattgtgtt ccctatggct ttatctcgag caaaatacac tctacatatt ttaataataa
4861 gtataattag cttgttcctg gacttcattt tcaatgatga accaaattcc tgaattattt
4921 ataattgtgt ctaaagaaaa ttatgaactg gtcacatggc acttggaatc cttgagttaa
4981 ttccagtgaa gcaaaacttg ggaagagtca ggattggcca cattgccaat aacaaattcc
5041 tacttcgaca tatgtctttt caaaaagcct cccagacaca agacatctta accgtcacta
5101 gcccaagtgt tttgtattac tcagacacca tcatgaaata attctgtgag gtcatgatgt
5161 atttgaaaat tctgcaagtt aataactgcc ttgaattgtt tgaacccgaa ataagggttc
5221 tttggtacct ctagtagata gtgtgttcat ttccctgctg caaattttga agtatttggg
5281 caggtgagtc atgttttaac cacaagccat aactcatctg ttgtctttgc ttggtcttag
5341 agtatcattc agaaagtccg ctaagggcca gcgtgcttct tctggctaca caaccttctc
5401 aggacaagcc cactgtctta agccactttg accctgggag acacaggact gtgtatcctc
5461 aatcatacta tacagcagtt tttgtcaggg gaacataaaa atatccaaga gaggttaggg
5521 cttagattta aaagcatcaa aacaacaaca atggaaattt atgttggcga tagccaagac
5581 cacaagcaaa agcacatact ggaaatgatg agttagaatc tgatttgact gggatgtttt
5641 atgagaatgt aagtgtgata ttatactgtc tgccttgctg gaatgctggc tttcaaatgg
5701 tcacccattt ttctttcact ggcctgagtt aggacatgct atcagtaata gtcccagttc
5761 catccaactt tctgaaattt catttttttt tttgagatgg agtctctctc tgtcacccaa
5821 gttggagtgc agtggccccg caatctcggc tcactgcaac ctctacctcc caggttcaag
5881 ctattctact gcctcagcct cccaagtagc tggggttaca ggcatttgcc accgggccct
5941 gatgattttt gtatttttag tagagacagg gcttcaccat gttggctagg agggtctcaa
6001 actcctgacc tcaggcgatc cacccccacc tcggcttccc aaagtgctga gattacaggt
6061 gtgagccacc gcacccggcc aactttctga aatttcaaaa ctgaattgat ccttctccaa
6121 attagtatat actattggaa acttgtcttt ccctgcagta aggctggttt ccccacccca
6181 gaaacatgta acggttggta ccatgctaag cccttgccat gctaagccct ttacagtcat
6241 atcctataat ccccatatca accttataag gaaggtgttt gtagatgatg caactgagcc
6301 ttaagaggac taattccctt tttctaaggc acagagctgg taaaatgtga agtaatagtg
6361 aacctaacag tcagagacag gcagcatgct cttaactagt gctcttccta aagttccttt
6421 aatgtccttt tgagattttg agccatggaa cttacttgtt cacctggcta agaactcatg
6481 gccactgtgg aaatcttggt tagggagtca aagaaactga gcctggggca aacgaggctt
6541 cccacactgc caggggagcc tcactgtgaa gtctaggctc agacaggcat caacaaacct
6601 attcacccca ccatcatcct gatctaacca ttccccagtc atcccaggaa aaccactcac
6661 agcctgacac tgggctgact ttcttgaaga tcctcatcca attggtgttt ttcagaagtg
6721 ttccaatatt atgaattctg tgttgtggag aaaagcaacc atgcatttac tggtcaatgc
6781 cttcttgtat atgtaattca atacttttac ttttaatatc ctcaccttat ctaatctttg
6841 aattttgtca tgtaatttat tgcttcatta aggttacttt ttgttataca aaataaaagc
6901 tgatatccaa ggcaaaaaaa aaaaaaaaaa
//