LOCUS AF219624 1817 bp mRNA linear HUM 12-FEB-2004
DEFINITION Homo sapiens matrix metalloproteinase-28 precursor, mRNA, complete
cds.
ACCESSION AF219624
VERSION AF219624.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1817)
AUTHORS Lohi,J., Wilson,C.L., Roby,J.D. and Parks,W.C.
TITLE Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed
in testis and keratinocytes and in response to injury
JOURNAL J. Biol. Chem. 276 (13), 10134-10144 (2001)
PUBMED 11121398
REFERENCE 2 (bases 1 to 1817)
AUTHORS Lohi,J.L., Wilson,C.L., Roby,J.D. and Parks,W.C.
TITLE Direct Submission
JOURNAL Submitted (28-DEC-1999) Pathology, Univ. Helsinki, P.O. Box 21
(Haartmaninkatu 3), Helsinki FIN-00014, Finland
FEATURES Location/Qualifiers
source 1..1817
/db_xref="H-InvDB:HIT000074308"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/cell_type="keratinocyte"
/tissue_type="testis"
5'UTR 1..169
CDS 170..1732
/note="neutral metalloproteinase; MMP-28; member of the
neutral endopeptidase group of matrix metalloproteinases
or matrixins; similar to interstitial collagenase (MMP-1)"
/codon_start=1
/product="matrix metalloproteinase-28 precursor"
/protein_id="AAK01480.1"
/translation="MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYG
YLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAW
AERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQ
LWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHF
DQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDV
LAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVD
RQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGR
CWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEP
YYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWM
GCWHANSGSALF"
sig_peptide 170..235
misc_feature 236..1729
/note="encodes matrix metalloproteinase-28 proprotein;
proenzyme form"
misc_feature 434..454
/note="Region: pro-sequence"
misc_feature 521..535
/note="Region: furin recognition sequence"
mat_peptide 536..1729
/product="matrix metalloproteinase-28"
/note="active form"
misc_feature 659..670
/note="putative N-glycosylation site"
misc_feature 887..919
/note="Region: catalytic center"
misc_feature 1232..1243
/note="putative N-glycosylation site"
3'UTR 1733..1817
BASE COUNT 325 a 613 c 568 g 311 t
ORIGIN
1 accggcccag agcgcgcagc tagggcactg gcgaaacccc gggacagtcc ctctccgtgc
61 gggggcggcg cagagcagtc ccatccccgg ggttccgggc gcggctgact gccggctggt
121 tccctgcgcg cagtagctcc ccgagccggg ctgcaccgga ggcggcgaga tggtcgcgcg
181 cgtcggcctc ctgctgcgcg ccctgcagct gctactgtgg ggccacctgg acgcccagcc
241 cgcggagcgc ggaggccagg agctgcgcaa ggaggcggag gcattcctag agaagtacgg
301 atacctcaat gaacaggtcc ccaaagctcc cacctccact cgattcagcg atgccatcag
361 agcgtttcag tgggtgtccc agctacctgt cagcggcgtg ttggaccgcg ccaccctgcg
421 ccagatgact cgtccccgct gcggggttac agataccaac agttatgcgg cctgggctga
481 gaggatcagt gacttgtttg ctagacaccg gaccaaaatg aggcgtaaga aacgctttgc
541 aaagcaaggt aacaaatggt acaagcagca cctctcctac cgcctggtga actggcctga
601 gcatctgccg gagccggcag ttcggggcgc cgtgcgcgcc gccttccagt tgtggagcaa
661 cgtctcagcg ctggagttct gggaggcccc agccacaggc cccgctgaca tccggctcac
721 cttcttccaa ggggaccaca acgatgggct gggcaatgcc tttgatggcc cagggggcgc
781 cctggcgcac gccttcctgc cccgccgcgg cgaagcgcac ttcgaccaag atgagcgctg
841 gtccctgagc cgccgccgcg ggcgcaacct gttcgtggtg ctggcgcacg agatcggtca
901 cacgcttggc ctcacccact cgcccgcgcc gcgcgcgctc atggcgccct actacaagag
961 gctgggccgc gacgcgctgc tcagctggga cgacgtgctg gccgtgcaga gcctgtatgg
1021 gaagccccta gggggctcag tggccgtcca gctcccagga aagctgttca ctgactttga
1081 gacctgggac tcctacagcc cccaaggaag gcgccctgaa acgcagggcc ctaaatactg
1141 ccactcttcc ttcgatgcca tcactgtaga caggcaacag caactgtaca tttttaaagg
1201 gagccatttc tgggaggtgg cagctgatgg caacgtctca gagccccgtc cactgcagga
1261 aagatgggtc gggctgcccc ccaacattga ggctgcggca gtgtcattga atgatggaga
1321 tttctacttc ttcaaagggg gtcgatgctg gaggttccgg ggccccaagc cagtgtgggg
1381 tctcccacag ctgtgccggg cagggggcct gccccgccat cctgacgccg ccctcttctt
1441 ccctcctctg cgccgcctca tcctcttcaa gggtgcccgc tactacgtgc tggcccgagg
1501 gggactgcaa gtggagccct actacccccg aagtctgcag gactggggag gcatccctga
1561 ggaggtcagc ggcgccctgc cgaggcccga tggctccatc atcttcttcc gagatgaccg
1621 ctactggcgc ctcgaccagg ccaaactgca ggcaaccacc tcgggccgct gggccaccga
1681 gctgccctgg atgggctgct ggcatgccaa ctcggggagc gccctgttct gaaggcacct
1741 cctcacctca gaaactggtg gtgctctcag ggcaaaatca tgttccccac ccccggggca
1801 gaacccctct tagaagc
//