LOCUS AF218085 2216 bp mRNA linear HUM 23-OCT-2001
DEFINITION Homo sapiens SH3-SAM adaptor protein (HACS1) mRNA, complete cds.
ACCESSION AF218085
VERSION AF218085.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2216)
AUTHORS Claudio,J.O., Zhu,Y.X., Benn,S.J., Shukla,A.H., McGlade,C.J.,
Falcioni,N. and Stewart,A.K.
TITLE HACS1 encodes a novel SH3-SAM adaptor protein differentially
expressed in normal and malignant hematopoietic cells
JOURNAL Oncogene 20 (38), 5373-5377 (2001)
PUBMED 11536050
REFERENCE 2 (bases 1 to 2216)
AUTHORS Claudio,J.O., Zhu,Y.X., Benn,S.J., Shukla,A.H., McGlade,C.J.,
Falcioni,N. and Stewart,A.K.
TITLE Direct Submission
JOURNAL Submitted (21-DEC-1999) Division of Hematology-Oncology, The Arthur
and Sonia Labatt Brain Tumour Research Center, Toronto General
Hospital Research Institute, Hospital for Sick Children and
Canadian Blood Services, Toronto Center, Toronto, Ontario M5G 2M1,
Canada
REFERENCE 3 (bases 1 to 2216)
AUTHORS Claudio,J.O., Zhu,Y.X., Benn,S.J., Shukla,A.H., McGlade,C.J.,
Falcioni,N. and Stewart,A.K.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-2001) Division of Hematology-Oncology, The Arthur
and Sonia Labatt Brain Tumour Research Center, Toronto General
Hospital Research Institute, Hospital for Sick Children and
Canadian Blood Services, Toronto Center, Toronto, Ontario M5G 2M1,
Canada
REMARK Sequence update by submitter
COMMENT On May 25, 2001 this sequence version replaced AF218085.1.
FEATURES Location/Qualifiers
source 1..2216
/db_xref="H-InvDB:HIT000074282"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="21"
gene 1..2216
/gene="HACS1"
CDS 176..1501
/gene="HACS1"
/codon_start=1
/product="SH3-SAM adaptor protein"
/protein_id="AAK07746.1"
/translation="MEIRLDTLSASLGRSSTLNDCNLEDKLAWYEGEAYMWHHWKPFP
ENPLWTCLDFQIAQVGPWDYCSSCIRHTRLKSSCSDMDLLHSWRSSSFGNFDRFRNNS
LSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEE
KDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRD
SFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLN
NKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNG
YETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDI
SLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD"
misc_feature 581..631
/gene="HACS1"
/note="Region: nuclear localization signal"
misc_feature 875..1048
/gene="HACS1"
/note="Region: SH3 domain"
misc_feature 1064..1084
/gene="HACS1"
/note="Region: nuclear localization signal"
misc_feature 1091..1294
/gene="HACS1"
/note="Region: SAM domain"
misc_feature 1244..1264
/gene="HACS1"
/note="Region: nuclear localization signal"
BASE COUNT 781 a 373 c 437 g 625 t
ORIGIN
1 ggaagctcag cagtgtccac tgtcgccatt ccttggccat agaaaacaat gtatttgaat
61 tttgatgtaa gcatagcaaa ttgaagatga agatgacacg ttgatttctt gtttgaaatt
121 aaccaagtcc cgagaaaaga aagtgaatag tgttagcacg aggaggaagg aagaaatgga
181 gattagattg gatactcttt ctgcatcact gggtagatcc agcactttaa atgactgcaa
241 cttggaagat aaattagctt ggtatgaagg tgaagcttac atgtggcatc actggaagcc
301 ttttcctgaa aaccctctct ggacatgtct tgatttccaa atagcacaag ttggaccctg
361 ggactactgc tcctcttgta ttcgccacac acgtctcaag tcttcctgct cagatatgga
421 tctcctacat tcatggcgaa gcagcagttt tgggaatttc gatcgttttc ggaataattc
481 tttatcaaaa ccagatgatt caactgaggc acatgaagga gatcccacaa atggaagtgg
541 agaacaaagt aaaacttcaa ataatggagg cggtttgggt aaaaaaatga gagctatttc
601 atggacaatg aagaaaaaag tgggtaaaaa gtacatcaaa gccctttctg aggaaaagga
661 tgaggaagat ggagagaatg cccacccata tagaaacagt gaccctgtga ttgggaccca
721 cacagagaag gtgtccctca aagccagtga ctccatggat agtctctaca gtggacagag
781 ctcatcaagt ggcataacaa gctgttcaga tggtacaagt aaccgggaca gctttcgact
841 ggatgacgat ggcccctatt caggaccatt ctgtggccgt gccagagtgc atacggattt
901 cacgccaagt ccctatgaca ctgactccct caaaatcaag aaaggagaca tcatagacat
961 tatttgcaaa acaccaatgg ggatgtggac aggaatgttg aacaataaag tgggaaactt
1021 caaattcatt tatgtggatg tcatctcaga agaggaagca gcccccaaga aaataaaggc
1081 aaaccgaagg agtaacagca aaaaatccaa gactctgcag gagttcctag agaggattca
1141 tctgcaggaa tacacctcaa cacttttgct caatggttat gagactctag aagatttaaa
1201 agatataaaa gagagtcacc tcattgaatt aaatattgaa aacccagatg acagaagaag
1261 gttactatca gctgctgaaa acttccttga agaagaaatt attcaagagc aagaaaatga
1321 acctgagccc ctatccttga gctcagacat ctccttaaat aagtcacagt tagatgactg
1381 cccaagggac tctggttgct atatctcatc aggaaattca gataatggca aagaggatct
1441 ggagtctgaa aatctgtctg acatggtaca taagattatt atcacagagc caagtgactg
1501 aacacgcatt cccaactata tatctacaga tgcattccat tttaactctt cttgagctaa
1561 aacgtcaaat aggagaggaa gataagataa atatttgtaa ataaaaccta aagtttaaat
1621 gttttaatct gaataattgt acataaaatt ttgtatctct aacattccaa attactgtca
1681 ataaaatata tatttattat tttaaatgct atgtgttaat atttcacttg cttgtattag
1741 aaaggcaaaa tgtaagactt tggtatgtgt gacatatgct ttatttggct ttattttaca
1801 agtacagtat ctgcaaaaaa caaagtaacc ttttttcata cctgccagtt ttgaatttat
1861 atatgttatt gaacaaatag taatagagga ttcgctgttg aaacaagttg tccaagcaat
1921 gttatattca tttttatact tattgggaaa gtgtgagtta atattggaca cattttatcc
1981 tgatccacag tggagtttta gtaattatat tttgttgatt tcttcatttt gttttctggt
2041 ataaaagtag agataatgtg tagtcacttc tgatttagtg aaaccaattg taataattgt
2101 ggaaatgttt tgtctttaag tgtaaatatt ttaaaatttg acatacccta atgttaataa
2161 taaaaagaac tatttgcata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//