LOCUS AF217197 1799 bp mRNA linear HUM 29-NOV-2001
DEFINITION Homo sapiens FBP-interacting repressor (FIR) mRNA, complete cds.
ACCESSION AF217197
VERSION AF217197.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1799)
AUTHORS Liu,J., He,L., Collins,I., Ge,H., Libutti,D., Li,J., Egly,J.M. and
Levens,D.
TITLE The FBP interacting repressor targets TFIIH to inhibit activated
transcription
JOURNAL Mol. Cell 5 (2), 331-341 (2000)
PUBMED 10882074
REFERENCE 2 (bases 1 to 1799)
AUTHORS Liu,J. and Levens,D.L.
TITLE Direct Submission
JOURNAL Submitted (16-DEC-1999) Laboratory of Pathology, National Cancer
Institute, 10 Center Drive, Bethesda, MD 20892, USA
REFERENCE 3 (bases 1 to 1799)
AUTHORS Liu,J. and Levens,D.L.
TITLE Direct Submission
JOURNAL Submitted (29-NOV-2001) Laboratory of Pathology, National Cancer
Institute, 10 Center Drive, Bethesda, MD 20892, USA
REMARK Sequence update by submitter
COMMENT On Nov 29, 2001 this sequence version replaced AF217197.1.
FEATURES Location/Qualifiers
source 1..1799
/db_xref="H-InvDB:HIT000074164"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1799
/gene="FIR"
CDS 11..1639
/gene="FIR"
/note="transcription repressor; targets the p89 subunit of
TFIIH and represses activated but not basal transcription"
/codon_start=1
/product="FBP-interacting repressor"
/protein_id="AAF27522.2"
/translation="MATATIALQVNGQQGGGSEPAAAAAVVAAGDKWKPPQGTDSIKM
ENGQSTAAKLGLPPLTPEQQEALQKAKKYAMEQSIKSVLVKQTIAHQQQQLTNLQMAA
QRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEY
EVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQ
DLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLG
GQYLRVGKAVTPPMPLLTPATPGGLPPAAAVAAAAATAKITAQEAVAGAAVLGTLGTP
GLVSPALTLAQPLGTLPQAVMAAQAPGVITGVTPARPPIPVTIPSVGVVNPILASPPT
LGLLEPKKEKEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLR
NMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDAEIIVKIFVEFSIASET
HKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA"
BASE COUNT 401 a 531 c 556 g 311 t
ORIGIN
1 cggacgcaag atggcgacgg cgaccatagc tctccaggtc aatggccagc aaggaggggg
61 gtccgagccg gcggcggcgg cggcagtggt ggcagcggga gacaaatgga aacctccaca
121 gggcacagac tccatcaaga tggagaacgg gcagagcaca gccgccaagc tggggctgcc
181 tcccctgacg cccgagcagc aggaggccct tcagaaggcc aagaagtacg ccatggagca
241 gagcatcaag agtgtgctgg tgaagcagac catcgcgcac cagcagcagc agctcaccaa
301 cctgcagatg gcggctcagc ggcagcgggc gctggccatc atgtgccgcg tctacgtggg
361 ctctatctac tatgagctgg gggaggacac catccgccag gcctttgccc cctttggccc
421 catcaagagc atcgacatgt cctgggactc cgtcaccatg aagcacaagg gctttgcctt
481 cgtggagtat gaggtccccg aagctgcaca gctggccttg gagcagatga actcggtgat
541 gctggggggc aggaacatca aggtgggcag acccagcaac atagggcagg cccagcccat
601 catagaccag ttggctgagg aggcacgggc cttcaaccgc atctacgtgg cctctgtgca
661 ccaggacctc tcagacgatg acatcaagag cgtgtttgag gcctttggca agatcaagtc
721 ctgcacactg gcccgggacc ccacaactgg caagcacaag ggctacggct tcattgagta
781 cgagaaggcc cagtcgtccc aagatgctgt gtcttccatg aacctctttg acctgggtgg
841 ccagtacttg cgggtgggca aggctgtcac accgcccatg cccctactca caccagccac
901 gcctggaggc ctcccacctg ccgctgctgt ggcagctgct gcagccactg ccaagatcac
961 agctcaggaa gcagtggccg gagcagcggt gctgggtacc ctgggcacac ctggactggt
1021 gtccccagca ctgaccctgg cccagcccct gggcactttg ccccaggctg tcatggctgc
1081 ccaggcacct ggagtcatca caggtgtgac cccagcccgt cctcctatcc cggtcaccat
1141 cccctcggtg ggagtggtga accccatcct ggccagccct ccaacgctgg gtctcctgga
1201 gcccaagaag gagaaggaag aagaggagct gtttcccgag tcagagcggc cagagatgct
1261 gagcgagcag gagcacatga gcatctcggg cagtagcgcc cgacacatgg tgatgcagaa
1321 gctgctccgc aagcaggagt ctacagtgat ggttctgcgc aacatggtgg accccaagga
1381 catcgatgat gacctggaag gggaggtgac agaggagtgt ggcaagttcg gggccgtgaa
1441 ccgcgtcatc atctaccaag agaaacaagg cgaggaggag gatgcagaaa tcattgtcaa
1501 gatctttgtg gagttttcca tagcctctga gactcataag gccatccagg ccctcaatgg
1561 ccgctggttt gctggccgca aggtggtggc tgaagtgtac gaccaggagc gttttgataa
1621 cagtgacctc tctgcgtgac agtggtccct ctccccggac ttgcacttgt tccttgtttc
1681 ctctgggttt tatagtgata cagtggtgtc cccggggcca ggcgcgctct gcccagccca
1741 gcctacagtg cggataaagg tgcggatgct gctggccctg aaaaaaaaaa aaaaaaaaa
//