LOCUS AF214454 3404 bp mRNA linear HUM 11-JUL-2001 DEFINITION Homo sapiens alkaline phytoceramidase (APHC) mRNA, complete cds. ACCESSION AF214454 VERSION AF214454.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3404) AUTHORS Mao,C., Xu,R., Szulc,Z.M., Bielawska,A., Galadari,S.H. and Obeid,L.M. TITLE Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide JOURNAL J. Biol. Chem. 276 (28), 26577-26588 (2001) PUBMED 11356846 REFERENCE 2 (bases 1 to 3404) AUTHORS Mao,C., Xu,R. and Obeid,L.M. TITLE Direct Submission JOURNAL Submitted (09-DEC-1999) Medicine, Medical University of SC, 114 Doughty Street, Charleston, SC 29425, USA FEATURES Location/Qualifiers source 1..3404 /db_xref="H-InvDB:HIT000074114" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /tissue_type="kidney" gene 1..3404 /gene="APHC" /note="hAPHC" CDS 59..862 /gene="APHC" /function="hydrolyzes phytoceramide into phytosphingosine and fatty acid" /note="aPHC; similar to Saccharomyces cerevisiae alkaline ceramidase YPC1p but lacks reverse activity of synthesizing phytoceramide from phytosphingosine and a fatty acid" /codon_start=1 /product="alkaline phytoceramidase" /protein_id="AAK71923.1" /translation="MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMI IPPMFGAIQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCI FVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRS IYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHA WWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH" BASE COUNT 980 a 690 c 667 g 1065 t ORIGIN 1 tcgccagcct aacccggcac agtgagcgga gcgcctgggc ggcggcggcg gcggcgtgat 61 ggctccggcc gcggaccgag agggctactg gggccccacg acctccacgc tggactggtg 121 cgaggagaac tactccgtga cctggtacat cgccgagttc tggaatacag tgagtaacct 181 gatcatgatt atacctccaa tgttcggtgc aattcagagt gttagagacg gtctggaaaa 241 acggtacatt gcttcttatt tagcactcac agtggtagga atgggatcct ggtgcttcca 301 catgactctg aaatatgaaa tgcagctatt ggatgaactc ccaatgatat acagctgttg 361 catatttgtg tactgcatgt ttgaatgttt caagatcaag aactcagtaa actaccatct 421 gctttttacc ttagttctat tcagtttaat agtaaccaca gtttacctta aggtaaaaga 481 gccaatattc catcaggtca tgtatggaat gttggtcttt acattagtac ttcgatctat 541 ttatattgtt acatgggttt atccatggct tagaggactg ggttatacat cattgggtat 601 atttttattg ggatttttat tttggaatat agataacata ttttgtgagt cactgaggaa 661 ctttcgaaag aaggtaccac ctatcatagg tattaccaca caatttcatg catggtggca 721 tattttaact ggccttggtt cctatcttca catccttttc agtttgtata caagaacact 781 ttacctgaga tataggccaa aagtgaagtt tctctttgga atctggccag tgatcctgtt 841 tgagcctctc aggaagcatt gatgaatcat tccaccaaga aaacaaacaa gcacctacca 901 tagacctggc agaataaata aggaaatcct taaagatcta caagttcaaa tatgtcatga 961 ccatcacagc agaggagtga ctttctgact aatgctgcca cccacacaga gaataaggag 1021 tagggcctgc tgggtgttta gctcatggct ttatcttatt tgtccccctc ctcctttcac 1081 gctccagttt ataaagaaac agagatgatg tgtgtgtatg cctcaaatgc agaaacagtt 1141 gggcttttct taacaggtta acagtttgtg ctggttataa gaaattaacc ttcttttctt 1201 tttgccaagg gttgcatgtg aattatacct ttcttaatat ttgattaaat aatgcagtca 1261 gctaagagcc aacaaaaccc catatccaga tagttagctg tgagccagca ctcagctgtg 1321 tcagatttga ttaatattgt attaatctca tggatggttc tcaaaggtaa aaaaagagag 1381 agaaagagag agagctagct gtgggattct gtgtagttct tcactatctg ttccagggct 1441 agtcggagga tcataagcaa gctcagacct gcccccagtt cagtacttga ccacatccca 1501 ggatttatgg tgtctgtcta tggccacagc caaccagaat gagtgggtca tcttataacc 1561 tttctgaagc tccatgagga catgtataga atgctgcacc ttcagccagc tctgctctga 1621 tctttgcaga tctttaagtt gtcactgttt ctacggctag acaaatatga ctggtggtct 1681 agactaccca tagttcatcc tcctcacata acttatttga agttgtcagg gaatgtcatt 1741 acactctgat ttttaaaatt atgcagtatt ttccagttct cagagaggtc atggttgtgc 1801 ccagggaagt gtgttgcatt aactaaagct aaaattatca gaatcctatt tacataaagc 1861 atattaaaat atctgctcct taattttctg aaggaaatag atgtaagttt ctgctacttg 1921 aaacctacag aaccgacaaa aattagggtg ctaaaaaaat gacagtgaaa tctcatcgta 1981 aggcagctag ttctaatttg catttgaatg tataacaaat tgcatcactt ttcacaaact 2041 taacacctgc ctggagtaaa aatctgattt gacccctctg ctcatgtttc atcatatttg 2101 tagctctgca tcatttagca tttttatgac tttttttgct ttatataaat tattgtaaaa 2161 tccagattgt ttttaccaca tgatgacgtg actcaggatt aaatcctgag ctacagtttc 2221 aaaaggaaaa tcattttttt cttatgcaaa gatggtaaaa cactgttgtc attttttcca 2281 gtattcaata agtagccttt gtacaaattt aaaaccaaaa actattctgt tgtttttctt 2341 cacctactag ccttagtttt taaccaagta tccaaggatg tcaacttgac atccttccct 2401 tagcatgcca acaagccatt agactgattc ttccaccnac ttttatgaac ctccaggaag 2461 aaaaacactt gccaaaacat taagagaact ttgattctgc cttaagaggg tataaaacta 2521 aaccatttga aggcacagcc catnaagact atacttgatt ttgccccaag attctgactt 2581 ctggctacat ttcacctgca gttacctggg ctatcggccg tgatacattt tttaattcat 2641 ttgttttcca ccattatatt tttatacttt tcagttagat atacttctgc ataaagagta 2701 tatatacagt gtaggataaa ggcatatcgt acatggcaat gctgttaaac atggtaagac 2761 tgaggttctg caggattaaa gtcagattaa gggtacagaa agcacacctt gatactgagg 2821 ccatttagag caatttgttt aatgagtggt tcagccatca ccaccagtgg ccacctgttc 2881 aataaaattg cctagcacca cagtggagag tcatctacac cccaaggtga gctgtaagac 2941 tggccaattc tttgaagacc tttttttctg ttgggagaat ggaaagcaga aagggaagcc 3001 aggctcttta atgttccaag tcagctgtgc ctcacacaag gctctctttt tagctactaa 3061 gtaacatact caagactttg tatctgtgca gcattttatg gaaatcactg gtgacctata 3121 ggatattact aaattatttc aatagcttta tttttttcct acttggattc taggtggaca 3181 ttacagagtt gaattcctca ctaccccctc ccgctgtcat ttgttttatt ggaaaacttc 3241 atgttaacta gagtgtacaa aaagtctgtt tcctgctgag ccaatagtga tttgtttgca 3301 tatcacctaa tgtgaaaagt gctcatctgt gaactctaca gcaaattata ttttagaaaa 3361 tactttgtga ggccgggcat ggtggcagag cgagactccg tccc //