LOCUS AF213987 5858 bp mRNA linear HUM 28-OCT-2005
DEFINITION Homo sapiens MCEF protein (MCEF) mRNA, complete cds.
ACCESSION AF213987
VERSION AF213987.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5858)
AUTHORS Estable,M.C., Naghavi,M.H., Kato,H., Xiao,H., Qin,J., Vahlne,A. and
Roeder,R.G.
TITLE MCEF, the Newest Member of the AF4 Family of Transcription Factors
Involved in Leukemia, Is a Positive Transcription Elongation
Factor-b-Associated Protein
JOURNAL J. Biomed. Sci. 9 (3), 234-245 (2002)
PUBMED 12065898
REFERENCE 2 (bases 1 to 5858)
AUTHORS Estable,M.C. and Roeder,R.G.
TITLE Direct Submission
JOURNAL Submitted (09-DEC-1999) Biochemistry, Rockefeller University, 1230
York Avenue, New York, NY 10021, USA
REFERENCE 3 (bases 1 to 5858)
AUTHORS Estable,M.C., Niedzielski,M., Sydor,C. and Mandelstam,R.
TITLE Direct Submission
JOURNAL Submitted (28-OCT-2005) Department of Chemistry & Biology, Ryerson
University, Toronto, ON M5B2K3, Canada
REMARK Sequence update by submitter
COMMENT On Oct 28, 2005 this sequence version replaced AF213987.1.
FEATURES Location/Qualifiers
source 1..5858
/db_xref="H-InvDB:HIT000074107"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q1"
/tissue_type="brain"
/dev_stage="fetus"
gene 1..5858
/gene="MCEF"
CDS 66..3557
/gene="MCEF"
/note="P-TEFb component; AF4/FMR2 family member;
transcription factor; possibly implicated in cancers
involving 5q1 Interleukin cluster region translocations;
possibly involved in HIV-1 Tat transactivation; differs
from AF5q31 protein encoded by GenBank Accession Number
AF197927 by having a larger 3' UTR and a short 5' UTR, as
well as several SNPs"
/codon_start=1
/product="MCEF protein"
/protein_id="AAM00184.2"
/translation="MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSK
EDKLSSRIQSMLGNYDEMKDFIGDRSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGGS
HQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSG
SSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDA
NWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQGSMEPKLSSEHYS
SQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAI
HTPCKTEPSKFPFPTKESQQSNFGIGEQKRYNPSKTSNGHQSKSMLKDGLKLSSSEDS
DGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESGSSSSD
SEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGRE
QGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ
PKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPT
AEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVE
EEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGE
KKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNR
ESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSK
NSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKLVFDDRNYS
ADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSE
TVDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTE
HLKNSYNNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGNYSSGASSASASGSSVTIPQK
IHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVR
YTRQGLHWLRQDAKLIS"
BASE COUNT 1834 a 1237 c 1222 g 1565 t
ORIGIN
1 cccggcgccg ccactgccgc agccaggaga tggttcgggc ctagcggagc cgggactgga
61 gcaacatgaa ccgtgaagac cggaatgtgc tgcgtatgaa agaacgggaa aggcggaatc
121 aggaaattca gcagggcgaa gacgccttcc cacctagctc tcctctcttt gcagagccat
181 acaaagttac tagcaaagaa gataagttat caagtcgtat tcagagtatg cttggaaact
241 acgatgaaat gaaggatttc ataggagaca gatctatacc aaagcttgtt gcaattccca
301 agcctacagt accaccatca gcagatgaaa aatctaaccc aaatttcttt gaacagagac
361 atggaggctc tcatcagagt agcaaatgga ctccagtagg acccgcaccc agcacttctc
421 agtctcagaa acggtcctca ggcttacaga gtggacatag tagccagcgg accagcgcag
481 gtagcagtag tggcactaac agtagtggtc agaggcacga ccgtgagtca tataacaata
541 gtgggagcag tagccggaaa aaaggccagc atggatcaga acactccaaa tcacgttctt
601 ccagccctgg aaaaccccag gctgtttctt cattaaactc tagtcattcc aggtctcatg
661 ggaatgatca ccatagcaag gaacatcaac gctccaaatc acctcgggac cctgatgcaa
721 actgggattc tccttcccgt gtaccttttt caagtgggca gcactcaact caatctttcc
781 caccctcatt gatgtcaaag tccaattcaa tgttacagaa acccactgcc tatgtgcggc
841 ccatggacgg acaggggtcc atggaaccaa agctgtcctc tgagcactac agcagccaat
901 cccatggcaa cagcatgact gagctgaagc ccagcagcaa agcacatctc accaagctga
961 aaataccttc ccaaccactg gatgcatcag cttctggtga tgtgagctgt gtggatgaaa
1021 tcctaaaaga gatgacgcat tcatggcctc cccctctaac ggctattcat acaccatgca
1081 aaacagaacc ttccaaattt ccttttccaa ctaaggagtc tcagcagtcc aattttggca
1141 ttggagaaca aaaaagatat aatccttcta aaacttcaaa tgggcaccag tctaaatcta
1201 tgttaaaaga tggcttaaaa ctaagcagca gtgaagacag tgatggggaa caggattgtg
1261 ataagacaat gccgaggagt acaccaggaa gtaactctga accttcgcac cataatagtg
1321 aaggagcaga taactccagg gatgattcta gtagccacag tggatctgaa agcagctctg
1381 gatctgactc agagagtgga agtagttcca gtgacagtga ggcaaatgag ccatcccaga
1441 gtgcatctcc cgagcctgaa cccccgccaa caaacaaatg gcaacttgat aattggctga
1501 ataaagtgaa cccacataaa gtgtcacccg cctcttcagt ggacagtaac atcccatcat
1561 ctcaaggcta caaaaaggaa ggccgagagc agggcactgg gaatagctac actgatacaa
1621 gtggacctaa agaaacgagt tccgctactc cgggacgaga ctccaaaacc atccaaaagg
1681 gatcagaaag tgggcgtggg aggcagaaat ctcctgcaca gagtgacagc acaacacaga
1741 gaagaactgt aggcaaaaaa caacccaaaa aggctgagaa ggcagctgct gaagagcctc
1801 gtggaggcct gaagatagaa agtgaaaccc ctgtagactt ggctagcagc atgccctcca
1861 gcagacacaa agcagccacc aaaggctcaa ggaaacccaa tataaagaag gagtctaagt
1921 cttcccctcg acctacagca gagaaaaaga aatataagtc aacaagtaaa tcttcccaga
1981 aatcaaggga aatcatagaa acagatacct catcctcaga ttcagatgaa agtgagagcc
2041 ttcctccttc ctcacaaact cctaagtacc ccgagagcaa taggactcct gttaaaccct
2101 cctcagtgga ggaagaagat agcttttttc ggcaacgaat gttctctcct atggaagaga
2161 aggaacttct ttcacccctc agtgagcctg atgacaggta cccacttatt gtgaagattg
2221 acctgaatct tttgactaga ataccaggaa agccttacaa agaaacagag ccgcccaagg
2281 gggaaaagaa aaatgtgcca gaaaagcaca cgagagaggc tcagaaacaa gcctcagaaa
2341 aagtttccaa caaaggcaag aggaagcata agaatgaaga tgataaccga gccagtgaga
2401 gcaagaaacc caaaacggag gacaagaatt cagcaggcca taagccatcc agcaacagag
2461 agtcatctaa gcagagtgct gcaaaagaaa aggatttgtt gccttctccc gctgggcctg
2521 ttccttcaaa agatccaaaa acagagcatg gctctcggaa gaggactatt agtcagtctt
2581 cttccttaaa gtcaagcagt aacagcaaca aggagacgag tggcagcagc aaaaacagtt
2641 cctccacatc aaagcagaag aagaccgaag ggaagacttc cagtagctcc aaggaggtta
2701 aggaaaaggc tccaagtagc tcctctaact gtcctccatc tgcaccaact cttgattctt
2761 ctaagcctcg gagaacaaag cttgtctttg atgacagaaa ttattcagca gaccattatt
2821 tacaagaagc aaaaaagcta aagcacaatg cagatgcatt gtctgatagg tttgagaaag
2881 ctgtatacta tcttgatgct gtggtatctt tcattgaatg tgggaatgca ttagagaaga
2941 atgctcagga atccaaatcc ccattcccta tgtattcaga gacggtggat ctcatcaaat
3001 acactatgaa gctaaagaat tacttggcac cagatgctac agctgcagat aaacgactca
3061 cagtactttg cctgcgatgc gagtctttgc tgtacctgag gctgttcaaa ctgaagaagg
3121 aaaatgctct gaagtactca aagacactga cagagcacct gaagaattct tataataatt
3181 ctcaagcacc atcgcctggc ttgggaagca aagctgtggg gatgccttcc cctgtttctc
3241 caaagctgtc accaggcaat tcaggaaatt attcatctgg ggccagtagt gcttctgcaa
3301 gtggttcttc agtgaccatt ccacagaaga tccaccagat ggcagccagc tatgttcagg
3361 tcacatccaa cttcctctat gccaccgaaa tttgggacca agctgaacag ctttccaaag
3421 agcaaaaaga attctttgct gaactggata aagtaatggg ccctctcatc tttaatgcaa
3481 gcatcatgac agatctagtt cgttataccc ggcagggact gcactggctt cgccaggatg
3541 ccaagttgat atcttgaact gaacacattc tcgttgcctc tgattttctc cacaacactg
3601 tgtcacatca cgaaggaaaa ctgccataac ataccaccta gtcgacacta agaatgagga
3661 atagttttct cctcgttggt tcatgtgttg ttgtttttga taatccaaag cgatcatgtc
3721 agttggccct ttaatatttc caatgtgaaa gattatttaa atgcttttaa atctgcagca
3781 cattgataag atggtttccg tgagctatga taagattgaa attccagttg caattcataa
3841 ctaatgaatt gaaattttat ttattttaat ttttttaagt tcccagattg gggctagttt
3901 aagacttagt tatttctgcc tataaattta ctctgttgaa tatttagcat aaatttaatg
3961 tagacatttt tatttatata ccttgggagc tttattacct aatatctttt tgtggtagct
4021 gttctaagag taagaattgg ttcatctaaa ataaggacat attctttcta cacctgctac
4081 ctgacctgat atttgaaatc ttaactccaa ttttattatt gtggaattta cagttagtat
4141 taaggatatt cttctacaca tgaaaaaatc actttaaata tgagaaaatg gcattctaca
4201 tgtatgtact atgaaatgtg tctgatttgg tatgcattat ttcaaaaact gtgaatgtgt
4261 gttaataaca ctacagcaat cacacagtga ctatagcttg catttaatgc attacaaaag
4321 agggaggaca aactttctag aagaagcatt tcatgttgaa gggtttcata aaaggacaat
4381 cctgaacgtt acggatttta ttaaaaccat atgttatttt ttgttgctaa tcatttgaca
4441 cttaatcgaa acagaataag ttactgtgga aaaaaggatg atccaactcc tgaggattgc
4501 cgcctgtgtg tctttaattg attatctttg atagttagag ttatttttca gatttttccc
4561 cctcatactg gattgtgatg ctctgatatg agcatgcaat gactgataca gaaataggct
4621 ggagcttcgg tgtgtgcttt tgctatacag cttacagttc taatgcctga tgtagagatg
4681 atgaatttct cccttttaaa cctatcttct gtttactcct tttgcattat gaaggccctc
4741 ttcaatgatg tatgtttctg atggaatcag aaaatttcac actagaaaag tgacctaact
4801 tgattcagtg tgagctcttg ggacagggag gggagccagg ggtagagctt aaagaagctg
4861 gctctgtaag agttgtatat caaagtacct tttgctacaa ggtgcatata gaagtctaag
4921 ataagaaatg taccctctat actttatttt tcatgcccct atcatgtttg gtgtgcctta
4981 aatcttacct ttaaatgaag actctatgga ttgtttacaa atgaagtttt acactaggac
5041 cagatcgtcc atacatgatt ggtcttctac aataataatg ttcaattctt tcattttaaa
5101 tctttcttta gggtcatata aagattagtt ctttcagaaa agctattgct ttggtacatg
5161 acttagtcta accagttggg taatgctgct ttgaaaaata gttgtcccct ctccccattc
5221 caaaaatgaa tccattcagt cagaaaaaaa gattatccta ctatttgtag atgattgcta
5281 aggcttgaaa taggaaaggg gaaagaaggg atagaaaagt ttcaagtcca gtagtgcagt
5341 gaatcctttg tgtttgagac ttttttacac ttatttttga agttagtgaa ctttcattgt
5401 ccctgtggcc tcatatttat agagcttctt aactgttttg tacctcagat tgtttttaga
5461 tgtcattgaa gattgagatg tacaaattat gttgaattta acctgtttct cttggagaaa
5521 ttgcctctga tatctttcta acttaatctt agtgtgttct aggaacagtt ttccataaga
5581 ggacaacttc tcaatgatca tgatagttat ttagtaagaa ataatggttg ttaatcaaat
5641 acatgttatg tcttgtcctt ctctgatttt tctgacttgg attccttaat ttgcagtgat
5701 gtcttagaaa tggaaaaagt atcctctggg ctttcagact ttcagcaaca acagccagtg
5761 ggatacctct gagttcttgt gttctagtct cttgtatgtc ctgaaaggca gcaggagcat
5821 ttttggggtc acactgatat tttgttaaag cagagttt
//