LOCUS AF213465 5494 bp mRNA linear HUM 22-AUG-2003
DEFINITION Homo sapiens dual oxidase mRNA, complete cds.
ACCESSION AF213465
VERSION AF213465.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5494)
AUTHORS Edens,W.A., Sharling,L., Cheng,G., Shapira,R., Kinkade,J.M.,
Lee,T., Edens,H.A., Tang,X., Sullards,C., Flaherty,D.B.,
Benian,G.M. and Lambeth,J.D.
TITLE Tyrosine cross-linking of extracellular matrix is catalyzed by
Duox, a multidomain oxidase/peroxidase with homology to the
phagocyte oxidase subunit gp91phox
JOURNAL J. Cell Biol. 154 (4), 879-891 (2001)
PUBMED 11514595
REFERENCE 2 (bases 1 to 5494)
AUTHORS Cheng,G.J., Lee,T. and Lambeth,J.D.
TITLE A Bifunctional Oxidase (Duox-1) With Homology to the
Superoxide-Generating gp91phox and to Peroxidases
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 5494)
AUTHORS Cheng,G.J., Lee,T. and Lambeth,J.D.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-1999) Biochemistry, Emory University, 1510
Clifton Road, Atlanta, GA 30322, USA
FEATURES Location/Qualifiers
source 1..5494
/db_xref="H-InvDB:HIT000074100"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 155..4810
/note="Duox-1; similar to gp91phox and peroxidases;
presumed dual peroxidatic and pyridine
nucleotide-dependent superoxide generating functions"
/codon_start=1
/product="dual oxidase"
/protein_id="AAF71295.1"
/translation="MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRW
GSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFF
GYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPS
NPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAA
PDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELF
QHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMV
PPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQI
AEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRW
QDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRL
RDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCP
QPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNF
KRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQ
LQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSI
QEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREAL
TCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKS
RLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEE
LTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARC
SRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQT
VQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRG
TAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSV
GHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLILAI
MYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGG
DKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWH
KFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADII
REVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFG
RPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF"
variation 3382
/replace="a"
variation 3686
/note="results in phenylalanine to leucine amino acid
substitution"
/replace="c"
variation 4838
/replace="c"
BASE COUNT 1090 a 1690 c 1548 g 1166 t
ORIGIN
1 gcagagctgc agaggcaccg gacgagagag ggctccgcgg gcccagctgg cagccaggcc
61 ggagacaagt tgcagtcccg ggctctggtg acgccgtggc cgcagggtct ccattttggg
121 acattctaat ccctgagccc ctattatttt catcatgggc ttctgcctgg ctctagcatg
181 gacacttctg gttggggcat ggacccctct gggagctcag aaccccattt cgtgggaggt
241 gcagcgattt gatgggtggt acaacaacct catggagcac agatggggca gcaaaggctc
301 ccggctgcag cgcctggtcc cagccagcta tgcagatggc gtgtaccagc ccttgggaga
361 accccacctg cccaaccccc gagaccttag caacaccatc tcaaggggcc ctgcagggct
421 ggcctccctg agaaaccgca cagtgttggg ggtcttcttt ggctatcacg tgctttcaga
481 cctggtgagc gtggaaactc ccggctgccc cgccgagttc ctcaacattc gcatcccgcc
541 cggagacccc atgttcgacc ccgaccagcg cggggacgtg gtgctgccct tccagagaag
601 ccgctgggac cccgagaccg gacggagtcc cagcaatccc cgggacccgg ccaaccaggt
661 gacgggctgg ctggacggca gcgccatcta tggttcctcg cattcctgga gcgacgcgct
721 gcggagcttc tccaggggac agctggcgtc ggggcccgac cccgcttttc cccgagactc
781 gcagaacccc ctgctcatgt gggcggcgcc cgaccccgcc accgggcaga acgggccccg
841 ggggctgtac gccttcgggg cagagagagg gaaccgggaa cccttcctgc aggcgctggg
901 cctgctctgg ttccgctacc acaacctgtg ggcgcagagg ctggcccgcc agcacccaga
961 ctgggaggac gaggagctgt tccagcacgc acgcaagagg gtcatcgcca cctaccagaa
1021 catcgctgtg tatgagtggc tgcccagctt cctgcagaaa acactcccgg agtatacagg
1081 ataccggcca tttctggacc ccagcatctc ctcagagttc gtggcggcct ctgagcagtt
1141 cctgtccacc atggtgcccc ctggcgtcta catgagaaat gccagctgcc acttccaggg
1201 ggtcatcaat cggaactcaa gtgtctccag agctctccgg gtctgcaaca gctactggag
1261 ccgtgagcac ccaagcctac aaagtgctga agatgtggat gcactgctgc tgggcatggc
1321 ctcccagatc gcagagcgag aggaccatgt gttggttgaa gatgtgcggg atttctggcc
1381 tgggccactg aagttttccc gcacagacca cctggccagc tgcctgcagc ggggccggga
1441 tctgggcctg ccctcttaca ccaaggccag ggcagcactg ggcttgtctc ccattacccg
1501 ctggcaggac atcaaccctg cactctcccg gagcaatgac actgtactgg aggccacagc
1561 tgccctgtac aaccaggact tatcctggct agagctgctc cctgggggac tcctggagag
1621 ccaccgggac cctggacctc tgttcagcac catcgtcctt gaacaatttg tgcggctacg
1681 ggatggtgac cgctactggt ttgagaacac caggaatggg ctgttctcca agaaggagat
1741 tgaagaaatc cgaaatacca ccctgcagga cgtgctggtc gctgttatca acattgaccc
1801 cagtgctctg cagcccaatg tctttgtctg gcataaagga gacccctgtc cgcagccgag
1861 acagctcagc actgaaggcc tgccagcgtg tgctccctct gttgttcgtg actattttga
1921 gggcagtgga tttggcttcg gggtcaccat cgggaccctc tgttgcttcc ctttggtgag
1981 cctgctcagt gcctggattg ttgcccggct ccggatgaga aatttcaaga ggctccaggg
2041 ccaggaccgc cagagcatcg tgtctgagaa gctcgtggga ggcatggaag ctttggaatg
2101 gcaaggccac aaggagccct gccggcccgt gcttgtgtac ctgcagcccg ggcagatccg
2161 tgtggtagat ggcaggctca ccgtgctccg caccatccag ctgcagcctc cacagaaggt
2221 caacttcgtc ctgtccagca accgtggacg ccgcactctg ctgctcaaga tccccaagga
2281 gtatgacctg gtgctgctgt ttaacttgga ggaagagcgg caggcgctgg tggaaaatct
2341 ccggggagct ctgaaggaga gcgggttgag catccaggag tgggagctgc gggagcagga
2401 gctgatgaga gcagctgtga cacgggagca gcggaggcac ctcctggaga cctttttcag
2461 gcaccttttc tcccaggtgc tggacatcaa ccaggccgac gcagggaccc tgcccctgga
2521 ctcctcccag aaggtgcggg aggccctgac ctgtgagctg agcagggccg agtttgccga
2581 gtccctgggc ctcaagcccc aggacatgtt tgtggagtcc atgttctctc tggctgacaa
2641 ggatggcaat ggctacctgt ccttccgaga gttcctggac atcctggtgg tcttcatgaa
2701 aggctctcct gaggaaaagt ctcgccttat gttccgcatg tacgactttg atgggaatgg
2761 cctcatttcc aaggatgagt tcatcaggat gctgagatcc ttcatcgaga tctccaacaa
2821 ctgcctgtcc aaggcccagc tggctgaggt ggtggagtcc atgttccggg agtcgggatt
2881 ccaggacaag gaggaactga catgggaaga ttttcacttc atgctgcggg accacaatag
2941 cgagctccgc ttcacgcagc tctgtgtcaa aggggtggag gtgcctgaag tcatcaagga
3001 cctctgccgg cgagcctcct acatcagcca ggatatgatc tgtccctctc ccagagtgag
3061 tgcccgctgt tcccgcagcg acattgagac tgagttgaca cctcagagac tgcagtgccc
3121 catggacaca gaccctcccc aggagattcg gcggaggttt ggcaagaagg taacgtcatt
3181 ccagcccttg ctgttcactg aggcgcaccg agagaagttc caacgcagct gtctccacca
3241 gacggtgcaa cagttcaagc gcttcattga gaactaccgg cgccacatcg gctgcgtggc
3301 cgtgttctac gccatcgctg gggggctttt cctggagagg gcctactact acgcctttgc
3361 cgcacatcac acgggcatca cggacaccac ccgcgtggga atcatcctgt cgcggggcac
3421 agcagccagc atctctttca tgttctccta catcttgctc accatgtgcc gcaacctcat
3481 caccttcctg cgagaaacct tcctcaaccg ctacgtgccc ttcgacgccg ccgtggactt
3541 ccatcgcctc attgcctcca ccgccatcgt cctcacagtc ttacacagtg tgggccatgt
3601 ggtgaatgtg tacctgttct ccatcagccc cctcagcgtc ctctcttgcc tctttcctgg
3661 cctcttccat gatgatgggt ctgagttccc ccagaagtat tactggtggt tcttccagac
3721 cgtaccaggc ctcacggggg ttgtgctgct cctgatcctg gccatcatgt atgtctttgc
3781 ctcccaccac ttccgccgcc gcagtttccg gggcttctgg ctgacccacc acctctacat
3841 cctgctctat gtcctgctca tcatccatgg tagctttgcc ctgatccagc tgccccgttt
3901 ccacatcttc ttcctggtcc cagcaatcat ctatgggggc gacaagctgg tgagcctgag
3961 ccggaagaag gtggagatca gcgtggtgaa ggcggagctg ctgccctcag gagtgaccca
4021 cctgcggttc cagcggcccc agggctttga gtacaagtca gggcagtggg tgcggatcgc
4081 ttgcctggct ctggggacca ccgagtacca ccccttcaca ctgacctctg cgccccatga
4141 ggacacgctt agcctgcaca tccgggcagc agggccctgg accactcgcc tcagggagat
4201 ctactcagcc ccgacgggtg acagatgtgc cagataccca aagctgtacc ttgatggacc
4261 atttggagag ggccaccagg agtggcataa gtttgaggtg tcagtgttag tgggaggggg
4321 cattggggtc accccttttg cctccatcct caaagacctg gtcttcaagt catccgtcag
4381 ctgccaagtg ttctgtaaga agatctactt catctgggtg acgcggaccc agcgtcagtt
4441 tgagtggctg gctgacatca tccgagaggt ggaggagaat gaccaccagg acctggtgtc
4501 tgtgcacatc tacatcaccc agctggctga gaagttcgac ctcaggacca ctatgctgta
4561 catctgtgag cggcacttcc agaaggttct gaaccggagt ctattcacag gcctgcgctc
4621 catcacccac tttggccgtc ccccctttga gcccttcttc aactccctgc aggaggtcca
4681 cccccaggtc cggaagatcg gggtgtttag ctgtggcccc cctggcatga ccaagaatgt
4741 ggaaaaggcc tgtcagctca tcaacaggca ggaccggact cacttctccc accattatga
4801 gaacttctag gcccctgccc gggggttctg cccactgtcc agttgagcag aggtttgagc
4861 ccacacctca cctctgttct tcctatttct ggctgcctca gccttctctg atttcccacc
4921 tcccaacctt gttccaggtg gccatagtca gtcaccatgt gtgggctcag ggacccccag
4981 gaccaggatg tgtctcagcc tggagaaatg gtgggggggc agtgtctagg gactagagtg
5041 agaagtaggg gagctactga tttggggcaa agtgaaacct ctgcttcaga cttcagaaac
5101 aaatctcaga agacaagctg acctgacaag tactatgtgt gtgcatgtct gtatgtgtgt
5161 tggggcggtg agtgtaagga tgcagtggga gcatggatgc tggcatctta gaaccctccc
5221 tactcccata cctcctcctc ttctgggctc cccactgtca gacgggctgg caaatgcctt
5281 gcaggaggta gaggctggac ccatggcaag ccatttacag aaacccactc ggcaccccag
5341 tctaacacca caactaattt cacccaaggt tttaagcacg ttctttcatc agaccctggc
5401 ccaataccta tgtatgcaat gctcctcagc cctcttctcc ctgctccagt agtctccctt
5461 ccaaataaat cacttttctg ccaaaaaaaa aaaa
//