LOCUS AF213459 5799 bp mRNA linear HUM 23-MAR-2001
DEFINITION Homo sapiens ephrin receptor EPHA3 complete form (EPHA3) mRNA,
complete cds.
ACCESSION AF213459
VERSION AF213459.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5799)
AUTHORS Chiari,R., Hames,G., Stroobant,V., Texier,C., Maillere,B., Boon,T.
and Coulie,P.G.
TITLE Identification of a tumor-specific shared antigen derived from an
Eph receptor and presented to CD4 T cells on HLA class II molecules
JOURNAL Cancer Res. 60 (17), 4855-4863 (2000)
PUBMED 10987298
REFERENCE 2 (bases 1 to 5799)
AUTHORS Chiari,R., Hames,G. and Coulie,P.G.
TITLE Direct Submission
JOURNAL Submitted (08-DEC-1999) Cellular Genetics Unit, Universite
Catholique de Louvain, 74 avenue Hippocrate, Brussels B-1200,
Belgium
FEATURES Location/Qualifiers
source 1..5799
/db_xref="H-InvDB:HIT000074098"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolate="patient LB33"
/db_xref="taxon:9606"
/cell_line="MEL.A-1"
/tissue_type="melanoma"
gene 1..5799
/gene="EPHA3"
CDS 226..3177
/gene="EPHA3"
/codon_start=1
/product="ephrin receptor EPHA3 complete form"
/protein_id="AAG43576.1"
/translation="MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGW
ISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFT
LRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDR
ILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPM
DSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPG
FYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVIS
NINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNT
TVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSR
NSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQ
IRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGR
FCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISID
KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNI
IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM
GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAY
RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQL
MLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFR
TTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKAL
ETQSKNGPVPV"
BASE COUNT 1753 a 1148 c 1199 g 1699 t
ORIGIN
1 cccgctctgc ttcagcgcac gctgaagacg gcactaggac ccagggaagt ccccgagcgg
61 ggttcgcgga aaggcagcca gactcctcct tatctccagt gtcaaacttg acatcagcct
121 gcgagcggag catggtaact tctccagcaa tcagagcgct ccccctcaca tcagtggcat
181 gcttcatgga gatatgctcc tctcactgcc ctctgcacca gcaacatgga ttgtcagctc
241 tccatcctcc tccttctcag ctgctctgtt ctcgacagct tcggggaact gattccgcag
301 ccttccaatg aagtcaatct actggattca aaaacaattc aaggggagct gggctggatc
361 tcttatccat cacatgggtg ggaagagatc agtggtgtgg atgaacatta cacacccatc
421 aggacttacc aggtgtgcaa tgtcatggac cacagtcaaa acaattggct gagaacaaac
481 tgggtcccca ggaactcagc tcagaagatt tatgtggagc tcaagttcac tctacgagac
541 tgcaatagca ttccattggt tttaggaact tgcaaggaga cattcaacct gtactacatg
601 gagtctgatg atgatcatgg ggtgaaattt cgagagcatc agtttacaaa gattgacacc
661 attgcagctg atgaaagttt cactcaaatg gatcttgggg accgtattct gaagctcaac
721 actgagatta gagaagtagg tcctgtcaac aagaagggat tttatttggc atttcaagat
781 gttggtgctt gtgttgcctt ggtgtctgtg agagtatact tcaaaaagtg cccatttaca
841 gtgaagaatc tggctatgtt tccagacacg gtacccatgg actcccagtc cctggtggag
901 gttagagggt cttgtgtcaa caattctaag gaggaagatc ctccaaggat gtactgcagt
961 acagaaggcg aatggcttgt acccattggc aagtgttcct gcaatgctgg ctatgaagaa
1021 agaggtttta tgtgccaagc ttgtcgacca ggtttctaca aggcattgga tggtaatatg
1081 aagtgtgcta agtgcccgcc tcacagttct actcaggaag atggttcaat gaactgcagg
1141 tgtgagaata attacttccg ggcagacaaa gaccctccat ccatggcttg tacccgacct
1201 ccatcttcac caagaaatgt tatctctaat ataaacgaga cctcagttat cctggactgg
1261 agttggcccc tggacacagg aggccggaaa gatgttacct tcaacatcat atgtaaaaaa
1321 tgtgggtgga atataaaaca gtgtgagcca tgcagcccaa atgtccgctt cctccctcga
1381 cagtttggac tcaccaacac cacggtgaca gtgacagacc ttctggcaca tactaactac
1441 acctttgaga ttgatgccgt taatggggtg tcagagctga gctccccacc aagacagttt
1501 gctgcggtca gcatcacaac taatcaggct gctccatcac ctgtcctgac gattaagaaa
1561 gatcggacct ccagaaatag catctctttg tcctggcaag aacctgaaca tcctaatggg
1621 atcatattgg actacgaggt caaatactat gaaaagcagg aacaagaaac aagttatacc
1681 attctgaggg caagaggcac aaatgttacc atcagtagcc tcaagcctga cactatatac
1741 gtattccaaa tccgagcccg aacagccgct ggatatggga cgaacagccg caagtttgag
1801 tttgaaacta gtccagactc tttctccatc tctggtgaaa gtagccaagt ggtcatgatc
1861 gccatttcag cggcagtagc aattattctc ctcactgttg tcatctatgt tttgattggg
1921 aggttctgtg gctataagtc aaaacatggg gcagatgaaa aaagacttca ttttggcaat
1981 gggcatttaa aacttccagg tctcaggact tatgttgacc cacatacata tgaagaccct
2041 acccaagctg ttcatgagtt tgccaaggaa ttggatgcca ccaacatatc cattgataaa
2101 gttgttggag caggtgaatt tggagaggtg tgcagtggtc gcttaaaact tccttcaaaa
2161 aaagagattt cagtggccat taagaccctg aaagttggct acacagaaaa gcagaggaga
2221 gacttcctgg gagaagcaag cattatggga cagtttgacc accccaatat cattcgactg
2281 gaaggagttg ttaccaaaag taagccagtt atgattgtca cagaatacat ggagaatggt
2341 tccttggata gtttcctacg taaacacgat gcccagttta ctgtcattca gctagtgggg
2401 atgcttcgag ggatagcatc tggcatgaag tacctgtcag acatgggcta tgttcaccga
2461 gacctcgctg ctcggaacat cttgatcaac agtaacttgg tgtgtaaggt ttctgatttc
2521 ggactttcgc gtgtcctgga ggatgaccca gaagctgctt atacaacaag aggagggaag
2581 atcccaatca ggtggacatc accagaagct atagcctacc gcaagttcac gtcagccagc
2641 gatgtatgga gttatgggat tgttctctgg gaggtgatgt cttatggaga gagaccatac
2701 tgggagatgt ccaatcagga tgtaattaaa gctgtagatg agggctatcg actgccaccc
2761 cccatggact gcccagctgc cttgtatcag ctgatgctgg actgctggca gaaagacagg
2821 aacaacagac ccaagtttga gcagattgtt agtattctgg acaagcttat ccggaatccc
2881 ggcagcctga agatcatcac cagtgcagcc gcaaggccat caaaccttct tctggaccaa
2941 agcaatgtgg atatcactac cttccgcaca acaggtgact ggcttaatgg tgtctggaca
3001 gcacactgca aggaaatctt cacgggtgtg gagtacagtt cttgtgacac aatagccaag
3061 atttccacag atgacatgaa aaaggttggt gtcaccgtgg ttgggccaca gaagaagatc
3121 atcagtagca ttaaagctct agaaacgcaa tcaaagaatg gcccagttcc cgtgtaaagc
3181 acgggacgga agtgcttctg gacggaagtg gtggctgtgg aaggcgtagc atcatcctgc
3241 agacagacaa taattctgga gatactggtg gaagttccaa gtccaataag acactcaaat
3301 atgagtacaa atgccttaaa atggaattga aaaactcttt attttcccct atcatttatt
3361 ggatgggtgg gtggggtatt tttttgtaat tgctttttta aatattagtt aatggattaa
3421 atttaattct tcagcgtaaa atggtgaaga actagcatat agccattgat cataaactga
3481 ctatcataaa atcaaaacaa gtgaaataac aaaatggaca tggtggcttt gtttaggtag
3541 agccacaaaa gaaaagactt gtaatatttt tatatacaga ggaaatctgt aacaggtatt
3601 ttgtttcttt taaagcaagc aacacagagg aatttatacc tcaaactatc tggccatatt
3661 tactacctta tcactgcatt attctctttt atctgtttaa agcatataga gatgaagttt
3721 gtagttgttt taagtactac acatttttaa attgttagct tccttaagta tatcatgtaa
3781 agaaatgtct taatttttga aaaaagtaca tatttatttt cttttgaatt gtttttattg
3841 ttttctattt atgccttgat gatttaatat ggatttgtta cagccaagtg ccaaatgctc
3901 tctcaaattg tcagcaattt aactagacac agataataat gggtttcttt cagatttttt
3961 gaaccatcca cttacatata tttttaaaaa atgaaatcct tttcctgttc atacactaac
4021 caaatctctc aaatctgtta tcccaatcat tgttgcctct ccgtttatta taaactgtat
4081 gctcacaact tagtgtaata taccagcttg tatgcaatgg attttcaacc agataacata
4141 cctttcctgc tctggtgctt agagactatc aactccctcc tttagtgaag gagccgtgtt
4201 agagcttccg agaatagctc cactggagag aagtggaatc ctatatagaa tgctgcacta
4261 attgacaaca cagcctatag gccaatgcat gagtaaaaaa aaaaacaatt actggctcac
4321 tggctttgaa aagtcactta ctattgttgc tgaaacttgc tgagctgttt atagagaatg
4381 atgataacag aacttttcct ctgtatcact ggtgtttagg tgaattaatt aaacattgtg
4441 atcattagta ccaggtatta ttatctttaa gagtcttcca cttcaatgca catggtgcag
4501 ttttggtgtg taacttagaa ggattgaact tctttgaatt tactggacat aacattttca
4561 gaatagttgg tcatctagca accgcctcaa aatgtgtaag caggagagaa atttctcatc
4621 acagggattt agacttacta ttacataaag gctaactatg agcttgctca ttaattttga
4681 aaagatgtac ctggtggata tctagctagt aatatattct gaagcaacat tttagctcta
4741 ttgatactct ttctaatgct gatatgatct tgagtataag aaatgcatat gtcactagaa
4801 tggataaaat aatgctgcaa acttaatgtt cttatgcaaa atggaacgct aatgaaacac
4861 agcttacaat cgcaaatcaa aactcacaag tgctcatctg ttgtagattt agtgtaataa
4921 gacttagatt gtgctccttc ggatatgatt gtttctcaaa tcttggcaat attccttagt
4981 caaatcaggc tactagaatt ctgtattgga tatataagag catgaaattt ttaaaaatac
5041 acttgtgatt ataaaattaa tcacaaattt cacttatacc tgctatcagc agctagaaaa
5101 catttttttt ttaaatcaag tattttgtgt ttggaatgtt agaatgagat ctgaatgtgg
5161 tttcaatcta attttttccc agactactat ttctttttag gtattattct gagcatactc
5221 aacaaaaccc atgcatttca taaactaata gaagttgagg attgttgaat ctatttcact
5281 tattttggct gtggtttcca tctgaaagta gaggttgtat acaccatata ctgttcttca
5341 ttttattaat atttttctcc ttgacctctc ataaatttac tttacacaat tcttaccctg
5401 tacatatgta aacataagtg tacgattctt aaccatggag tagaggtact agaatgctta
5461 cggccatctc tttgtacagg aactgcattg actttcagta aacataaagc cacaactcct
5521 acatgatgtt atgtaccata tgatctgttt tgtatcttaa atttgattta catatattat
5581 ttatttctgg taactcactc agtttatgct gtgctaaata tcaatcaagc catgtataaa
5641 tgtgatatga ttggcaatat gtgtttatgt tgtacaatgt aaatggcctc ttactaatgt
5701 aaaatgattt gtagtggaaa catttatatt tttataataa acataatgaa aatatttttt
5761 acagattgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//