LOCUS AF211943 2264 bp mRNA linear HUM 05-MAY-2000
DEFINITION Homo sapiens WW domain-containing protein WWOX mRNA, complete cds.
ACCESSION AF211943
VERSION AF211943.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2264)
AUTHORS Bednarek,A.K., Laflin,K.J., Daniel,R.L., Liao,Q., Hawkins,K.A. and
Aldaz,C.M.
TITLE WWOX, a novel WW domain-containing protein mapping to human
chromosome 16q23.3-24.1, a region frequently affected in breast
cancer
JOURNAL Cancer Res. 60 (8), 2140-2145 (2000)
PUBMED 10786676
REFERENCE 2 (bases 1 to 2264)
AUTHORS Bednarek,A.K. and Aldaz,C.M.
TITLE Direct Submission
JOURNAL Submitted (06-DEC-1999) Carcinogenesis, University of Texas M.D.
Anderson Cancer Center, Science Park-Research Division, Park Road
1C POB389, Smithville, TX 78957, USA
FEATURES Location/Qualifiers
source 1..2264
/db_xref="H-InvDB:HIT000074040"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q23.3-q24.1"
5'UTR 1..125
CDS 126..1370
/note="putative hydroxysteroid dehydrogenase"
/codon_start=1
/product="WW domain-containing protein WWOX"
/protein_id="AAF27049.1"
/translation="MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQW
EHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
TRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMAR
ASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPW
SLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLD
FSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRS
WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEE
TARTLWALSERLIQERLGSQSG"
3'UTR 1371..2264
regulatory 2217..2222
/regulatory_class="polyA_signal_sequence"
BASE COUNT 594 a 580 c 586 g 504 t
ORIGIN
1 gcagtgcgca ggcgtgagcg gtcgggcccc gacgcgcgcg ggtctcgttt ggagcgggag
61 tgagttcctg agcgagtgga cccggcagcg ggcgataggg gggccaggtg cctccacagt
121 cagccatggc agcgctgcgc tacgcggggc tggacgacac ggacagtgag gacgagctgc
181 ctccgggctg ggaggagaga accaccaagg acggctgggt ttactacgcc aatcacaccg
241 aggagaagac tcagtgggaa catccaaaaa ctggaaaaag aaaacgagtg gcaggagatt
301 tgccatacgg atgggaacaa gaaactgatg agaacggaca agtgtttttt gttgaccata
361 taaataaaag aaccacctac ttggacccaa gactggcgtt tactgtggat gataatccga
421 ccaagccaac cacccggcaa agatacgacg gcagcaccac tgccatggaa attctccagg
481 gccgggattt cactggcaaa gtggttgtgg tcactggagc taattcagga atagggttcg
541 aaaccgccaa gtcttttgcc ctccatggtg cacatgtgat cttggcctgc aggaacatgg
601 caagggcgag tgaagcagtg tcacgcattt tagaagaatg gcataaagcc aaggtagaag
661 caatgaccct ggacctcgct ctgctccgta gcgtgcagca ttttgctgaa gcattcaagg
721 ccaagaatgt gcctcttcat gtgcttgtgt gcaacgcagc aacttttgct ctaccctgga
781 gtctcaccaa agatggcctg gagaccacct ttcaagtgaa tcatctgggg cacttctacc
841 ttgtccagct cctccaggat gttttgtgcc gctcagctcc tgcccgtgtc attgtggtct
901 cctcagagtc ccatcgattt acagatatta acgactcctt gggaaaactg gacttcagtc
961 gcctctctcc aacaaaaaac gactattggg cgatgctggc ttataacagg tccaagctct
1021 gcaacatcct cttctccaac gagctgcacc gtcgcctctc cccacgcggg gtcacgtcga
1081 acgcagtgca tcctggaaat atgatgtact ccaacattca tcgcagctgg tgggtgtaca
1141 cactgctgtt taccttggcg aggcctttca ccaagtccat gcaacaggga gctgccacca
1201 ccgtgtactg tgctgctgtc ccagaactgg agggtctggg agggatgtac ttcaacaact
1261 gctgccgctg catgccctca ccagaagctc agagcgaaga gacggcccgg accctgtggg
1321 cgctcagcga gaggctgatc caagaacggc ttggcagcca gtccggctaa gtggagctca
1381 gagcggatgg gcacacacac ccgccctgtg tgtgtcccct cacgcaagtg ccagggctgg
1441 gccccttcca aatgtccctc caacacagat ccgcaagagt aaaggaaata agagcagtca
1501 caacagagtg aaaaatctta agtaccaatg ggaagcaggg aattcctggg gtaaagtatc
1561 acttttctgg ggctgggcta ggcataggtc tctttgcttt ctggtggtgg cctgtttgaa
1621 agtaaaaacc tgcttggtgt gtaggttccg tatctccctg gagaagcacc agcaattctc
1681 tttcttttac tgttatagaa tagcctgagg tcccctcgtc ccatccagct accaccacgg
1741 ccaccactgc agccgggggc tggccttctc ctacttaggg aagaaaaagc aagtgttcac
1801 tgctccttgc tgcattgatc caggagataa ttgtttcatt catcctgacc aagactgagc
1861 cagcttagca actgctgggg agacaaatct cagaaccttg tcccagccag tgaggatgac
1921 agtgacaccc agagggagta gaatacgcag aactaccagg tggcaaagta cttgtcatag
1981 actcctttgc taatgctatg caaaaaattc tttagagatt ataacaaatt tttcaaatca
2041 ttccttagat accttgaaag gcaggaaggg aagcgtatat acttaagaat acacaggata
2101 ttttgggggg cagagaataa aacgttagtt aatccctttg tctgtcaatc acagtctcag
2161 ttctcttgct ttcacattgt acttaaacct cctgctgtgc ctcgcatcct atgcttaata
2221 aaagaacatg cttgaatatc aaaaaaaaaa aaaaaaaaaa aaaa
//