LOCUS AF211189 5952 bp mRNA linear HUM 30-MAY-2000
DEFINITION Homo sapiens T-type calcium channel alpha1 subunit Alpha1I-a
isoform (CACNA1I) mRNA, complete cds.
ACCESSION AF211189
VERSION AF211189.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5952)
AUTHORS Monteil,A., Chemin,J., Leuranguer,V., Altier,C., Mennessier,G.,
Bourinet,E., Lory,P. and Nargeot,J.
TITLE Specific properties of T-type calcium channels generated by the
human alpha 1I subunit
JOURNAL J. Biol. Chem. 275 (22), 16530-16535 (2000)
PUBMED 10749850
REFERENCE 2 (bases 1 to 5952)
AUTHORS Monteil,A., Chemin,J., Mennessier,G., Bourinet,E., Lautier,C.,
Nargeot,J. and Lory,P.
TITLE Direct Submission
JOURNAL Submitted (03-DEC-1999) Human Genetics Institute - U.P.R. 1142,
C.N.R.S., 141 rue de la Cardonille, Montpellier 34396, France
FEATURES Location/Qualifiers
source 1..5952
/db_xref="H-InvDB:HIT000074025"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5952
/gene="CACNA1I"
CDS 1..5946
/gene="CACNA1I"
/codon_start=1
/product="T-type calcium channel alpha1 subunit Alpha1I-a
isoform"
/protein_id="AAF44626.1"
/translation="MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDG
ADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPC
DDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMA
GMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFF
VFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNG
IMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPH
KGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINL
CLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAK
RRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP
ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGA
SSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI
EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIW
EIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFI
FSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS
TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKL
QEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGS
RKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLL
SAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSV
DLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEID
YTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIF
LNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS
WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
TLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYR
WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFIS
FLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYA
TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTV
FVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIM
RVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV
CNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ
FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG
PRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELT
IIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDP
TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRS
WLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGS
WASLRSPRVNCTLLRQVPTPPRP"
BASE COUNT 1095 a 1947 c 1733 g 1177 t
ORIGIN
1 atggctgaga gcgcctcccc gccctcctca tctgcagcag ccccagccgc tgagccagga
61 gtcaccacgg agcagcccgg accccggagc cccccatcct ccccgccagg cctggaggag
121 cctctggatg gagctgatcc tcatgtccca cacccagacc tggcgcctat tgccttcttc
181 tgcctgcgac agaccaccag cccccggaac tggtgcatca agatggtgtg caacccgtgg
241 tttgaatgtg tcagcatgct ggtgatcctg ctgaactgcg tgacacttgg catgtaccag
301 ccgtgcgacg acatggactg cctgtccgac cgctgcaaga tcctgcaggt ctttgatgac
361 ttcatcttta tcttctttgc catggagatg gtgctcaaga tggtggccct ggggattttt
421 ggcaagaagt gctacctcgg ggacacatgg aaccgcctgg atttcttcat cgtcatggca
481 gggatggtcg agtactccct ggaccttcag aacatcaacc tgtcagccat ccgcaccgtg
541 cgcgtcctga ggcccctcaa agccatcaac cgcgtgccca gtatgcggat cctggtgaac
601 ctgctcctgg acacactgcc catgctgggg aatgtcctgc tgctctgctt ctttgtcttc
661 ttcatctttg gcatcatagg tgtgcagctc tgggcgggcc tgctgcgtaa ccgctgcttc
721 ctggaggaga acttcaccat acaaggggat gtggccttgc ccccatacta ccagccggag
781 gaggatgatg agatgccctt catctgctcc ctgtcgggcg acaatgggat aatgggctgc
841 catgagatcc ccccgctcaa ggagcagggc cgtgagtgct gcctgtccaa ggacgacgtc
901 tacgactttg gggcggggcg ccaggacctc aatgccagcg gcctctgtgt caactggaac
961 cgttactaca atgtgtgccg cacgggcagc gccaaccccc acaagggtgc catcaacttt
1021 gacaacatcg gttatgcttg gattgtcatc ttccaggtga tcactctgga aggctgggtg
1081 gagatcatgt actacgtgat ggatgctcac tccttctaca acttcatcta cttcatcctg
1141 cttatcatag tgggctcctt cttcatgatc aacctgtgcc tcgttgtcat agcgacccag
1201 ttctcggaga ccaagcaacg ggagcaccgg ctgatgctgg agcagcggca gcgctacctg
1261 tcctccagca cggtggccag ctacgccgag cctggcgact gctacgagga gatcttccag
1321 tatgtctgcc acatcctgcg caaggccaag cgccgcgccc tgggcctcta ccaggccctg
1381 cagagccggc gccaggccct gggcccggag gccccggccc ccgccaaacc tgggccccac
1441 gccaaggagc cccggcacta ccagctgtgc ccgcaacata gccccctgga tgcgacgccc
1501 cacaccctgg tgcagcccat ccccgccacg ctggcttccg atcccgccag ctgcccttgc
1561 tgccagcatg aggacggccg gcggccctcg ggcctgggca gcaccgactc gggccaggag
1621 ggctcgggct ccgggagctc cgctggtggc gaggacgagg cggatgggga cggggcccgg
1681 agcagcgagg acggagcctc ctcagaactg gggaaggagg aggaggagga ggagcaggcg
1741 gatggggcgg tctggctgtg cggggatgtg tggcgggaga cgcgagccaa gctgcgcggc
1801 atcgtggaca gcaagtactt caaccggggc atcatgatgg ccatcctggt caacaccgtc
1861 agcatgggca tcgagcacca cgagcagccg gaggagctga ccaacatcct ggagatctgc
1921 aatgtggtct tcaccagcat gtttgccctg gagatgatcc tgaagctggc tgcatttggg
1981 ctcttcgact acctgcgtaa cccctacaac atcttcgaca gcatcattgt catcatcagc
2041 atctgggaga ttgtggggca ggcggacggt gggctgtcgg tgctgcggac cttccggctg
2101 ctgcgcgtgc tgaaactggt gcgcttcatg cctgccctgc ggcgccagct cgtggtgctc
2161 atgaagacca tggacaacgt ggccaccttc tgcatgctgc tcatgctctt catcttcatc
2221 ttcagcatcc ttgggatgca tatttttggc tgcaagttca gcctccgcac ggacactgga
2281 gacacggtgc ccgacaggaa gaacttcgac tccctgctgt gggccatcgt cactgtgttc
2341 cagatcctca cccaggagga ctggaacgtc gttctctaca atggcatggc ctccacttct
2401 ccctgggcct ccctctactt tgtcgccctc atgaccttcg gcaactatgt gctcttcaac
2461 ctgctggtgg ccatcctggt ggagggcttc caggcggagg gtgacgccaa tcgctcctac
2521 tcggacgagg accagagctc atccaacata gaagagtttg ataagctcca ggaaggcctg
2581 gacagcagcg gagatcccaa gctctgccca atccccatga cccccaatgg gcacctggac
2641 cccagtctcc cactgggtgg gcacctaggt cctgctgggg ctgcgggacc tgccccccga
2701 ctctcactgc agccggaccc catgctggtg gccctgggct cccgaaagag cagtgtcatg
2761 tctctaggga ggatgagcta tgaccagcgc tccctgtcca gctcccggag ctcctactac
2821 gggccatggg gccgcagcgc ggcctgggcc agccgtcgct ccagctggaa cagcctcaag
2881 cacaagccgc cgtcggcgga gcatgagtcc ctgctctctg cggagcgcgg cggcggcgcc
2941 cgggtctgcg aggttgccgc ggacgagggg ccgccgcggg ccgcacccct gcacacccca
3001 cacgcccacc acattcatca cgggccccat ctggcgcacc gccaccgcca ccaccgccgg
3061 acgctgtccc tcgacaacag ggactcggtg gacctggccg agctggtgcc cgcggtgggc
3121 gcccaccccc gggccgcctg gagggcggca ggcccggccc ccgggcatga ggactgcaat
3181 ggcaggatgc ccagcatcgc caaagacgtc ttcaccaaga tgggcgaccg cggggatcgc
3241 ggggaggatg aggaggaaat cgactacacc ctgtgcttcc gcgtccgcaa gatgatcgac
3301 gtctataagc ccgactggtg cgaggtccgc gaagactggt ctgtctacct cttctctccc
3361 gagaacaggt tccgggtcct gtgtcagacc attattgccc acaaactctt cgactacgtc
3421 gtcctggcct tcatctttct caactgcatc accatcgccc tggagcggcc tcagatcgag
3481 gccggcagca ccgaacgcat ctttctcacc gtgtccaact acatcttcac ggccatcttc
3541 gtgggcgaga tgacattgaa ggtagtctcg ctgggcctgt acttcggcga gcaggcgtac
3601 ctacgcagca gctggaacgt gctggatggc tttcttgtct tcgtgtccat catcgacatc
3661 gtggtgtccc tggcctcagc cgggggagcc aagatcttgg gggtcctccg agtcttgcgg
3721 ctcctgcgca ccctacgccc cctgcgtgtc atcagccggg cgccgggcct gaagctggtg
3781 gtggagacac tcatctcctc cctcaagccc atcggcaaca tcgtgctcat ctgctgtgcc
3841 ttcttcatca tctttggcat cctgggagtg cagctcttca agggcaagtt ctaccactgt
3901 ctgggcgtgg acacccgcaa catcaccaac cgctcggact gcatggccgc caactaccgc
3961 tgggtccatc acaaatacaa cttcgacaac ctgggccagg ctctgatgtc cctctttgtc
4021 ctggcatcca aggatggttg ggtgaacatc atgtacaatg gactggatgc tgttgctgtg
4081 gaccagcagc ctgtgaccaa ccacaacccc tggatgctgc tgtacttcat ctccttcctg
4141 ctcatcgtca gcttctttgt gctcaacatg tttgtgggtg tcgtggtgga gaacttccac
4201 aagtgccggc agcaccagga ggctgaagag gcacggcggc gtgaggagaa gcggctgcgg
4261 cgcctggaga agaagcgccg gaaggcccag cggctgccct actatgccac ctattgtcac
4321 acccggctgc tcatccactc catgtgcacc agccactacc tggacatctt catcaccttc
4381 atcatctgcc tcaacgtggt caccatgtcc ctggagcact acaatcagcc cacgtccctg
4441 gagacagccc tcaagtactg caactatatg ttcaccactg tctttgtgct ggaggctgtg
4501 ctgaagctgg tggcatttgg tctgaggcgc ttcttcaagg accgatggaa ccagctggac
4561 ctggccattg tgctactgtc agtcatgggc atcaccctgg aggagatcga gatcaatgcg
4621 gccctgccca tcaatcccac catcatccgc atcatgaggg ttctgcgcat tgcccgagtg
4681 ctgaagctgt tgaagatggc cacaggaatg cgggccctgc tggacacggt ggtgcaagct
4741 ttgccccagg tgggcaacct gggcctcctc ttcatgctgc tcttcttcat ctatgctgct
4801 ctcggggtgg agctctttgg gaagctggtc tgcaacgacg agaacccgtg cgagggcatg
4861 agccggcatg ccaccttcga gaacttcggc atggccttcc tcacactctt ccaggtctcc
4921 acgggtgaca actggaacgg gatcatgaag gacacgctgc gggactgcac ccacgacgag
4981 cgcagctgcc tgagcagcct gcagtttgtg tcgccgctgt acttcgtgag cttcgtgctc
5041 accgcgcagt tcgtgctcat caacgtggtg gtggctgtgc tcatgaagca cctggacgac
5101 agcaacaagg aggcgcagga ggacgccgag atggatgccg agctcgagct ggagatggcc
5161 catggcctgg gccctggccc gaggctgcct accggctccc cgggcgcccc tggccgaggg
5221 ccgggagggg cgggcggcgg gggcgacacc gagggcggct tgtgccggcg ctgctactcg
5281 cctgcccagg agaacctgtg gctggacagc gtctctttaa tcatcaagga ctccttggag
5341 ggggagctga ccatcatcga caacctgtcg ggctccatct tccaccacta ctcctcgcct
5401 gccggctgca agaagtgtca ccacgacaag caagaggtgc agctggctga gacggaggcc
5461 ttctccctga actcagacag gtcctcgtcc atcctgctgg gtgacgacct gagtctcgag
5521 gaccccacag cctgcccacc tggccgcaaa gacagcaagg gtgagctgga cccacctgag
5581 cccatgcgtg tgggagacct gggcgaatgc ttcttcccct tgtcctctac ggccgtctcg
5641 ccggatccag agaacttcct gtgtgagatg gaggagatcc cattcaaccc tgtccggtcc
5701 tggctgaaac atgacagcag tcaagcaccc ccaagtccct tctccccgga tgcctccagc
5761 cctctcctgc ccatgccagc cgagttcttc caccctgcag tgtctgccag ccagaaaggc
5821 ccagaaaagg gcactggcac tggaaccctc cccaagattg cgctgcaggg ctcctgggca
5881 tctctgcggt caccaagggt caactgtacc ctcctccggc aggtaccgac acctcccagg
5941 ccctagagca ct
//