LOCUS AF208045 5393 bp mRNA linear HUM 17-AUG-2004
DEFINITION Homo sapiens breast cancer-associated antigen BRCAA1 (BRCAA1) mRNA,
complete cds.
ACCESSION AF208045
VERSION AF208045.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5393)
AUTHORS Cui,D.X., Gao,T.W., Jin,G.Q., Sun,T.B. and Sarai,A.
TITLE Cloning, chromosomal location and characterization analysis of
BRCAA1
JOURNAL Zi Ran Za Zhi 25 (6), 365-368 (2003)
REFERENCE 2 (bases 1 to 5393)
AUTHORS Cui,D., Jin,G., Gao,T., Sun,T., Tian,F., Estrada,G.G., Gao,H. and
Sarai,A.
TITLE Characterization of BRCAA1 and its novel antigen epitope
identification
JOURNAL Cancer Epidemiol. Biomarkers Prev. 13 (7), 1136-1145 (2004)
PUBMED 15247124
REFERENCE 3 (bases 1 to 5393)
AUTHORS Gao,T.W., Cao,J.N., Stanbridge,E.J., Cui,D. and Irie,R.F.
TITLE Direct Submission
JOURNAL Submitted (24-NOV-1999) Department of Dermatology, Xijing Hospital,
Fourth Military Medical University, Xi'an 710032, P.R. China
REFERENCE 4 (bases 1 to 5393)
AUTHORS Cui,D., Gao,T.W., Sun,T. and Gao,H.
TITLE Direct Submission
JOURNAL Submitted (18-APR-2002) Bio-Nano-Engineering Center, Max Planck
Institute, Heisenbergstr.3, Stuttgart 70569, Germany
REMARK Sequence update by submitter
COMMENT On May 15, 2002 this sequence version replaced AF208045.1.
FEATURES Location/Qualifiers
source 1..5393
/db_xref="H-InvDB:HIT000073910"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q42.1-q43"
/cell_line="MCF-7"
/note="one of three clones isolated using an IgG antibody
from a breast cancer patient"
gene 1..5393
/gene="BRCAA1"
CDS 45..3686
/gene="BRCAA1"
/note="similar to RB-binding protein"
/codon_start=1
/product="breast cancer-associated antigen BRCAA1"
/protein_id="AAF23433.3"
/translation="MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRH
DSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLR
RSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSD
EDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFK
DGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSS
EAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKQPVLG
YRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYG
FEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIEFCGRKEIKMEEER
NIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDK
DDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDK
EKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILN
GLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEEN
KVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIK
RGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKY
NGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDELPNSRAKDRKDVWSSIQGQWPKK
TRKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKP
IEEKQVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPN
QEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKA
CTGQKRVKDAQGGGSSSKKQKRSHKATVVNNTKKGKGTNSSDSEELSAGESITKSQPV
KSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMT
SAERITILQEKLQENQKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI
NSCCYVNFS"
BASE COUNT 1969 a 856 c 1131 g 1437 t
ORIGIN
1 gagatggggg gtgttttaaa ggataccttg gtcccaaagt catcatgaag gcccttgatg
61 agcctcccta tttgacagtg ggcactgatg tgagtgctaa atacagagga gccttttgtg
121 aagccaagat caagacagca aaaagacttg tcaaagtcaa ggtgacattt agacatgatt
181 cttcaacagt ggaagttcag gatgaccaca taaagggccc actaaaggta ggagctattg
241 tggaagtgaa gaatcttgat ggtgcatatc aggaagctgt tatcaataaa ctaacagatg
301 cgagttggta cactgtagtt tttgatgacg gagatgagaa gacactgaga cgatcttcac
361 tgtgcctgaa aggagagagg cattttgccg aaagtgaaac attagaccag ctcccactca
421 ccaaccctga gcattttggc actccagtca taggaaagaa aacaaataga ggaagaagat
481 ctaatcatat accagaggaa gagtcttcat catcctccag tgatgaagat gaggatgata
541 ggaaacagat tgatgagcta ctaggcaaag ttgtatgtgt agattacatt agtttggata
601 aaaagaaagc actgtggttt cctgcattgg tggtttgtcc tgattgtagt gatgagattg
661 ctgtaaaaaa ggacaatatt cttgttcgat ctttcaaaga tggaaaattt acttcagttc
721 caagaaaaga tgtccatgaa attactagtg acactgcacc aaagcctgat gctgttttaa
781 agcaagcctt tgaacaggca cttgaatttc acaaaagtag aactattcct gctaactgga
841 agactgaatt gaaagaagat agctctagca gtgaagcaga ggaagaagag gaggaggaag
901 atgatgaaaa agaaaaggag gataatagca gtgaagaaga agaagaaata gaaccatttc
961 cagaagaaag ggagaacttt cttcagcaat tgtacaaatt tatggaagat agaggtacac
1021 ctattaacaa acaacctgta cttggatatc gaaatttgaa tctctttaag ttattcagac
1081 ttgtacacaa acttggagga tttgataata ttgaaagtgg agctgtttgg aaacaagtct
1141 accaagatct tggaatccct gtcttaaatt cagctgcagg atacaatgtt aaatgtgctt
1201 ataaaaaata cttatatggt tttgaggagt actgtagatc agccaacatt gaatttcaga
1261 tggcattgcc agagaaagtt gttaacaagc aatgtaagga gtgtgaaaat gtaaaagaaa
1321 taaaagttaa ggaggaaaat gaaacagaga tcgaattctg cggccgcaaa gaaataaaga
1381 tggaggagga gaggaatata ataccaagag aagaaaagcc tattgaggat gaaattgaaa
1441 gaaaagaaaa tattaagccc tctctgggaa gtaaaaagaa tttattagaa tctataccta
1501 cacattctga tcaggaaaaa gaagttaaca ttaaaaaacc agaagacaat gaaaatctgg
1561 atgacaaaga tgatgacaca actagggtag atgaatccct caacataaag gtagaagctg
1621 aggaagaaaa agcaaaatct ggatacgatg aatggattaa agcagataaa atagtaagac
1681 ctgctgataa aaatgtgcca aagataaaac atcggaagaa aataaagaat aaattagaca
1741 aagaaaaaga caaagatgaa aaatactctc caaaaaactg taaacttcgg cgcttgtcca
1801 aaccaccatt tcagacaaat ccatctcctg aaatggtatc caaactggat ctcactgatg
1861 ccaaaaactc tgatactgct catattaagt ccatagaaat tacttcgatc cttaatggac
1921 ttcaagcttc tgaaagttct gctgaagaca gtgagcagga agatgagaga ggtgctcaag
1981 acatggataa taatggcaaa gaagaatcta agattgatca tttgaccaac aacagaaatg
2041 atcttatttc aaaggaggaa cagaacagtt catctttgct agaagaaaac aaagttcatg
2101 cagatttggt aatatccaaa ccagtgtcaa aatctccaga aagattaagg aaagatatag
2161 aagtattatc cgaagatact gattatgaag aagatgaagt cacaaaaaag agaaaggatg
2221 tcaagaagga cacaacagat aaatcttcaa aaccacaaat aaaacgtggt aaaagaaggt
2281 attgcaatac agaagagtgt ctaaaaactg gatcacctgg caaaaaggaa gagaaggcca
2341 agaacaaaga atcactttgc atggaaaaca gtagcaacag ctcttcagat gaagatgaag
2401 aagaaacaaa agcaaagatg acaccaacta agaaatacaa tggtttggag gaaaaaagaa
2461 aatctctacg gacaactggt ttctattcag gattttcaga agtggcagaa aaaaggatta
2521 aacttttaaa taactctgat gaacttccaa acagcagggc caaagatcga aaagatgtct
2581 ggtcaagtat tcagggacag tggcctaaaa aaacgcgtaa agagcttttt tcagactctg
2641 atactgaggc tgcagcttcc ccaccgcatc ctgccccaga ggagggggtg gcagaggagt
2701 cactgcagac tgtggctgaa gaggagagtt gttcacccag tgtagaacta gaaaaaccac
2761 ctccagtcaa tgtcgatagt aaacccattg aagaaaaaca agtagaggtc aatgacagaa
2821 aagcagaatt tccaagtagt ggcagtaatt cagtgctaaa tacccctcct actacacctg
2881 aatcgccttc atcagtcact gtaacagaag gcagccggca gcagtcttct gtaacagtat
2941 cagaaccact ggctccaaac caagaagagg ttcgaagtat caagagtgaa actgatagca
3001 caattgaggt ggatagtgtt gctggggagc tccaagacct ccagtctgaa gggaatagct
3061 cgccagcagg ttttgatgcc agtgtgagct caagcagtag taatcagcca gaaccagaac
3121 atcctgaaaa agcctgtaca ggtcagaaaa gagtgaaaga tgctcaggga ggaggaagtt
3181 catcaaaaaa gcagaaaaga agccataaag caacagtggt aaacaacaca aagaagggaa
3241 aaggcacaaa tagtagtgat agtgaagaac tttcagctgg tgaaagtata actaagagtc
3301 agccagtcaa atcagtttcc actggaatga agtctcatag taccaaatct cccgcaagga
3361 cgcagtctcc aggaaaatgt ggaaagaatg gtgataagga tcctgatctc aaggaaccca
3421 gtaatcgatt acccaaagtt tacaaatgga gttttcagat gtcggacctg gaaaatatga
3481 caagtgccga acgcatcaca attcttcaag aaaaacttca agaaaatcag aaacattatc
3541 tgtcattaaa atctgaagta gcttccattg atcggaggag aaagcgttta aagaagaaag
3601 agagagaaag tgctgctaca tcctcatcct cctcttcacc ttcatccagt tccataaaca
3661 gctgctgtta tgttaacttt agctgaaccg tcaatgtcca gcgcatcaca aaatggaatg
3721 tcagttgagt gacaggtgac agcaggactt gctaaagcac tttggcactt aatggctgtt
3781 gagggccact ttttttttat actgcacagt ggcacaaaaa aatatcagac aagcactatt
3841 ttaatattta aaaattgttt cttgacaagc tgacttggca cttaagtgca cttttttatg
3901 aagaaaaagt acaatgaact gcttttcctc aagcaataat tgtttccaac ttgtctggga
3961 attgtgtgtc tggtaactgg aaggccttcc actgtggcaa atggaggctt ttcactgcct
4021 gtagagacaa tacagtaagc atagttaagg ggtgggtcag aacatgttaa gataacttac
4081 tgtatatgta ttcccttgta ttttgttaaa gctggaacat ttgatatttt tccatttatt
4141 tatgaaaaaa tatgaaccta ttttcatttg tacaaggtaa ttgtttttta aagcaagtca
4201 ccttagggtg gctttaattg tataagtcaa gcacatgtaa taaattcaaa acctgcagtt
4261 aacaggatat tagacatcaa tcctggtaac caaatattaa agattctctt taaaaaagac
4321 tgaacatgtt tacaggtttg aattaggcta aaaggtcttg cagtggcttt tcatggccct
4381 tcaaattgga atggaactac tgtactttgc catttttcta taaatcagta ttttttttta
4441 attttgatat acattgtgtg aaaaaagaaa atggcctaat aaactgtatt aaatcttaaa
4501 caatgtataa agattgtact tagccagttc aaagtgtata tttattcata atgaattata
4561 tttttgtgtt ttcttgtaaa tgtttctttt cccttaaata cagataattc atttgtattg
4621 cttattttat tatgagctac aacaaaagga cttcaggaac aagtaatgta ttagtatggt
4681 tcaagattgt tgataggact gtctcaaaag gatggtggtt attttaaata taaatagcta
4741 atgggggtgg taggcctata aaattaaatg ccttgtataa gatccaaaat gaatgcaaaa
4801 ttgttttcac ttgtattgac tttatgttgt atggattcca atctctgttc tgtttggcac
4861 ttgtatttaa ttcttcacct ttgtaagaca tttgtatatt gtggatgtgt tcattcaagc
4921 tatttaatat ctggcactgt taatacacag tactttattg tacagactgt tttactgttt
4981 taattgtagt tctgtgtact ttttttggat ggggctggca tgttttcttt gtttcctggc
5041 aatacgacgt gggaatttca atgcgttttg ttgtagatgc taacgtgtca gaatccttta
5101 cattcaactt ttctaagaaa agcattttca gtcttgtagt gtgtgcttac agtaactaat
5161 tttgttgaaa atggtttcaa gttattcaaa tttgtacagg actgtaaaga tttgttgaca
5221 gcaaaatgtt gaagaaaaaa gcttatagaa taaaagctat aaagtatata ttaggatctg
5281 caaacaatga agaattatgt aatatattgt acaaatgtaa gcaaaggctc tgaaataaaa
5341 tgccatagtt tgtgaatcct taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//