LOCUS AF207602 2537 bp mRNA linear HUM 27-DEC-1999
DEFINITION Homo sapiens cell-line GM11197 hypoxia-inducible factor 1 alpha
(HIF1A) mRNA, complete cds.
ACCESSION AF207602
VERSION AF207602.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2537)
AUTHORS Rupert,J.L. and Hochachka,P.W.
TITLE HIF1a sequence in the Quechua, a high altitude population
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2537)
AUTHORS Rupert,J.L. and Hochachka,P.W.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-1999) Zoology, University of British Columbia,
6270 University Blvd., Vancouver, BC V6T 1Z4, Canada
FEATURES Location/Qualifiers
source 1..2537
/db_xref="H-InvDB:HIT000073893"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q21-q24"
/cell_line="GM11197 (Coriell)"
/cell_type="lymphoblast"
/note="derived from a high altitude native (Quechua)"
gene 1..2537
/gene="HIF1A"
/note="HIF1-alpha"
CDS 8..2488
/gene="HIF1A"
/note="transcription factor; hypoxia-inducible factor 1a"
/codon_start=1
/product="hypoxia-inducible factor 1 alpha"
/protein_id="AAF20140.1"
/translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
DCEVNAPIQGSRNLLQGEELLRALDQVN"
BASE COUNT 838 a 526 c 507 g 666 t
ORIGIN
1 attcaccatg gagggcgccg gcggcgcgaa cgacaagaaa aagataagtt ctgaacgtcg
61 aaaagaaaag tctcgagatg cagccagatc tcggcgaagt aaagaatctg aagtttttta
121 tgagcttgct catcagttgc cacttccaca taatgtgagt tcgcatcttg ataaggcctc
181 tgtgatgagg cttaccatca gctatttgcg tgtgaggaaa cttctggatg ctggtgattt
241 ggatattgaa gatgacatga aagcacagat gaattgcttt tatttgaaag ccttggatgg
301 ttttgttatg gttctcacag atgatggtga catgatttac atttctgata atgtgaacaa
361 atacatggga ttaactcagt ttgaactaac tggacacagt gtgtttgatt ttactcatcc
421 atgtgaccat gaggaaatga gagaaatgct tacacacaga aatggccttg tgaaaaaggg
481 taaagaacaa aacacacagc gaagcttttt tctcagaatg aagtgtaccc taactagccg
541 aggaagaact atgaacataa agtctgcaac atggaaggta ttgcactgca caggccacat
601 tcacgtatat gataccaaca gtaaccaacc tcagtgtggg tataagaaac cacctatgac
661 ctgcttggtg ctgatttgtg aacccattcc tcacccatca aatattgaaa ttcctttaga
721 tagcaagact ttcctcagtc gacacagcct ggatatgaaa ttttcttatt gtgatgaaag
781 aattaccgaa ttgatgggat atgagccaga agaactttta ggccgctcaa tttatgaata
841 ttatcatgct ttggactctg atcatctgac caaaactcat catgatatgt ttactaaagg
901 acaagtcacc acaggacagt acaggatgct tgccaaaaga ggtggatatg tctgggttga
961 aactcaagca actgtcatat ataacaccaa gaattctcaa ccacagtgca ttgtatgtgt
1021 gaattacgtt gtgagtggta ttattcagca cgacttgatt ttctcccttc aacaaacaga
1081 atgtgtcctt aaaccggttg aatcttcaga tatgaaaatg actcagctat tcaccaaagt
1141 tgaatcagaa gatacaagta gcctctttga caaacttaag aaggaacctg atgctttaac
1201 tttgctggcc ccagccgctg gagacacaat catatcttta gattttggca gcaacgacac
1261 agaaactgat gaccagcaac ttgaggaagt accattatat aatgatgtaa tgctcccctc
1321 acccaacgaa aaattacaga atataaattt ggcaatgtct ccattaccca ccgctgaaac
1381 gccaaagcca cttcgaagta gtgctgaccc tgcactcaat caagaagttg cattaaaatt
1441 agaaccaaat ccagagtcac tggaactttc ttttaccatg ccccagattc aggatcagac
1501 acctagtcct tccgatggaa gcactagaca aagttcacct gagcctaata gtcccagtga
1561 atattgtttt tatgtggata gtgatatggt caatgaattc aagttggaat tggtagaaaa
1621 actttttgct gaagacacag aagcaaagaa cccattttct actcaggaca cagatttaga
1681 cttggagatg ttagctccct atatcccaat ggatgatgac ttccagttac gttccttcga
1741 tcagttgtca ccattagaaa gcagttccgc aagccctgaa agcgcaagtc ctcaaagcac
1801 agttacagta ttccagcaga ctcaaataca agaacctact gctaatgcca ccactaccac
1861 tgccaccact gatgaattaa aaacagtgac aaaagaccgt atggaagaca ttaaaatatt
1921 gattgcatct ccatctccta cccacataca taaagaaact actagtgcca catcatcacc
1981 atatagagat actcaaagtc ggacagcctc accaaacaga gcaggaaaag gagtcataga
2041 acagacagaa aaatctcatc caagaagccc taacgtgtta tctgtcgctt tgagtcaaag
2101 aactacagtt cctgaggaag aactaaatcc aaagatacta gctttgcaga atgctcagag
2161 aaagcgaaaa atggaacatg atggttcact ttttcaagca gtaggaattg gaacattatt
2221 acagcagcca gacgatcatg cagctactac atcactttct tggaaacgtg taaaaggatg
2281 caaatctagt gaacagaatg gaatggagca aaagacaatt attttaatac cctctgattt
2341 agcatgtaga ctgctggggc aatcaatgga tgaaagtgga ttaccacagc tgaccagtta
2401 tgattgtgaa gttaatgctc ctatacaagg cagcagaaac ctactgcagg gtgaagaatt
2461 actcagagct ttggatcaag ttaactgagc tttttcttaa tttcattcct ttttttggac
2521 actggtggct cactact
//