LOCUS AF207601 2530 bp mRNA linear HUM 27-DEC-1999
DEFINITION Homo sapiens cell-line GM11201 hypoxia-inducible factor 1 alpha
(HIF1A) mRNA, complete cds.
ACCESSION AF207601
VERSION AF207601.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2530)
AUTHORS Rupert,J.L. and Hochachka,P.W.
TITLE HIF1a sequence in the Quechua, a high altitude population
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2530)
AUTHORS Rupert,J.L. and Hochachka,P.W.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-1999) Zoology, University of British Columbia,
6270 University Blvd., Vancouver, BC V6T 1Z4, Canada
FEATURES Location/Qualifiers
source 1..2530
/db_xref="H-InvDB:HIT000073892"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q21-q24"
/cell_line="GM11201 (Coriell)"
/cell_type="lymphoblast"
/note="derived from a high altitude native (Quechua)"
gene 1..2530
/gene="HIF1A"
/note="HIF1-alpha"
CDS 11..2491
/gene="HIF1A"
/note="transcription factor; hypoxia-inducible factor 1a"
/codon_start=1
/product="hypoxia-inducible factor 1 alpha"
/protein_id="AAF20139.1"
/translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
DCEVNAPIQGSRNLLQGEELLRALDQVN"
BASE COUNT 836 a 524 c 508 g 662 t
ORIGIN
1 ccgattcacc atggagggcg ccggcggcgc gaacgacaag aaaaagataa gttctgaacg
61 tcgaaaagaa aagtctcgag atgcagccag atctcggcga agtaaagaat ctgaagtttt
121 ttatgagctt gctcatcagt tgccacttcc acataatgtg agttcgcatc ttgataaggc
181 ctctgtgatg aggcttacca tcagctattt gcgtgtgagg aaacttctgg atgctggtga
241 tttggatatt gaagatgaca tgaaagcaca gatgaattgc ttttatttga aagccttgga
301 tggttttgtt atggttctca cagatgatgg tgacatgatt tacatttctg ataatgtgaa
361 caaatacatg ggattaactc agtttgaact aactggacac agtgtgtttg attttactca
421 tccatgtgac catgaggaaa tgagagaaat gcttacacac agaaatggcc ttgtgaaaaa
481 gggtaaagaa caaaacacac agcgaagctt ttttctcaga atgaagtgta ccctaactag
541 ccgaggaaga actatgaaca taaagtctgc aacatggaag gtattgcact gcacaggcca
601 cattcacgta tatgatacca acagtaacca acctcagtgt gggtataaga aaccacctat
661 gacctgcttg gtgctgattt gtgaacccat tcctcaccca tcaaatattg aaattccttt
721 agatagcaag actttcctca gtcgacacag cctggatatg aaattttctt attgtgatga
781 aagaattacc gaattgatgg gatatgagcc agaagaactt ttaggccgct caatttatga
841 atattatcat gctttggact ctgatcatct gaccaaaact catcatgata tgtttactaa
901 aggacaagtc accacaggac agtacaggat gcttgccaaa agaggtggat atgtctgggt
961 tgaaactcaa gcaactgtca tatataacac caagaattct caaccacagt gcattgtatg
1021 tgtgaattac gttgtgagtg gtattattca gcacgacttg attttctccc ttcaacaaac
1081 agaatgtgtc cttaaaccgg ttgaatcttc agatatgaaa atgactcagc tattcaccaa
1141 agttgaatca gaagatacaa gtagcctctt tgacaaactt aagaaggaac ctgatgcttt
1201 aactttgctg gccccagccg ctggagacac aatcatatct ttagattttg gcagcaacga
1261 cacagaaact gatgaccagc aacttgagga agtaccatta tataatgatg taatgctccc
1321 ctcacccaac gaaaaattac agaatataaa tttggcaatg tctccattac ccaccgctga
1381 aacgccaaag ccacttcgaa gtagtgctga ccctgcactc aatcaagaag ttgcattaaa
1441 attagaacca aatccagagt cactggaact ttcttttacc atgccccaga ttcaggatca
1501 gacacctagt ccttccgatg gaagcactag acaaagttca cctgagccta atagtcccag
1561 tgaatattgt ttttatgtgg atagtgatat ggtcaatgaa ttcaagttgg aattggtaga
1621 aaaacttttt gctgaagaca cagaagcaaa gaacccattt tctactcagg acacagattt
1681 agacttggag atgttagctc cctatatccc aatggatgat gacttccagt tacgttcctt
1741 cgatcagttg tcaccattag aaagcagttc cgcaagccct gaaagcgcaa gtcctcaaag
1801 cacagttaca gtattccagc agactcaaat acaagaacct actgctaatg ccaccactac
1861 cactgccacc actgatgaat taaaaacagt gacaaaagac cgtatggaag acattaaaat
1921 attgattgca tctccatctc ctacccacat acataaagaa actactagtg ccacatcatc
1981 accatataga gatactcaaa gtcggacagc ctcaccaaac agagcaggaa aaggagtcat
2041 agaacagaca gaaaaatctc atccaagaag ccctaacgtg ttatctgtcg ctttgagtca
2101 aagaactaca gttcctgagg aagaactaaa tccaaagata ctagctttgc agaatgctca
2161 gagaaagcga aaaatggaac atgatggttc actttttcaa gcagtaggaa ttggaacatt
2221 attacagcag ccagacgatc atgcagctac tacatcactt tcttggaaac gtgtaaaagg
2281 atgcaaatct agtgaacaga atggaatgga gcaaaagaca attattttaa taccctctga
2341 tttagcatgt agactgctgg ggcaatcaat ggatgaaagt ggattaccac agctgaccag
2401 ttatgattgt gaagttaatg ctcctataca aggcagcaga aacctactgc agggtgaaga
2461 attactcaga gctttggatc aagttaactg agctttttct taatttcatt cctttttttg
2521 gacactgggg
//