LOCUS AF203687 2059 bp mRNA linear HUM 05-AUG-2003
DEFINITION Homo sapiens SEC12 (SEC12) mRNA, complete cds.
ACCESSION AF203687
VERSION AF203687.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2059)
AUTHORS Edgar,A.J. and Polak,J.M.
TITLE The human and mouse homologues of rat prolactin regulatory element
binding protein
JOURNAL J. Anat. 198, 373 (2001)
REFERENCE 2 (bases 1 to 2059)
AUTHORS Edgar,A.J.
TITLE The gene structure and expression of human ABHD1: overlapping
polyadenylation signal sequence with Sec12
JOURNAL BMC Genomics 4 (1), 18 (2003)
PUBMED 12735795
REMARK http://www.biomedcentral.com/1471-2164/4/18
REFERENCE 3 (bases 1 to 2059)
AUTHORS Edgar,A.J.
TITLE Direct Submission
JOURNAL Submitted (10-NOV-1999) Histochemistry, Imperial College School of
Medicine, Du Cane Road, London W12 0NN, UK
FEATURES Location/Qualifiers
source 1..2059
/db_xref="H-InvDB:HIT000073806"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2059
/gene="SEC12"
CDS 132..1385
/gene="SEC12"
/note="WD motif DNA-binding protein; similar to sequences
encoding the PREB DNA-binding proteins of Mus musculus and
Rattus norvegicus, deposited in GenBank Accession Numbers
AF150808 and AF061817, respectively"
/codon_start=1
/product="SEC12"
/protein_id="AAF19192.1"
/translation="MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNG
VHFLQLELINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQG
NKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVV
CFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLK
ASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQ
PPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQC
LYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSVPVW
LLLLLCVGLIIVTILLLQSAFPGFL"
misc_feature 564..677
/gene="SEC12"
/note="putative WD motif; binding site"
misc_feature 687..800
/gene="SEC12"
/note="putative WD motif; binding site"
misc_feature 813..815
/gene="SEC12"
/note="polymorphism to glutamic acid; other site"
misc_feature 1002..1115
/gene="SEC12"
/note="putative WD motif; binding site"
misc_feature 387..602
/gene="SEC12"
/note="glutamine rich region"
misc_feature 798..968
/gene="SEC12"
/note="proline/glutamine (P/Q) rich region"
variation 814
/gene="SEC12"
/note="converts valine codon to glutamic acid codon"
/replace="a"
misc_feature 2006..2010
/gene="SEC12"
/note="putative mRNA destabilizing element"
regulatory 2010..2015
/regulatory_class="polyA_signal_sequence"
/gene="SEC12"
/note="putative"
BASE COUNT 437 a 576 c 605 g 441 t
ORIGIN
1 gtgtgagagg ggtagggagt gctcccggcg gcgacggggc cgagttcacc agccgccggg
61 gcagtagtcg aaggcccggc gcggcatgtc ctgggtgccg cggtgcgggc agtgaacgcg
121 cgccgggcgg gatgggccgg cgccgggcgc cagagctgta ccgggctccg ttcccgttgt
181 acgcgcttca ggtcgacccc agcactgggc tgctcatcgc tgcgggcgga ggaggcgccg
241 ccaagacagg cataaagaat ggcgtgcact ttctgcagct agagctgatt aatgggcgct
301 tgagtgcctc cttgctgcac tcccatgaca cagagacacg ggccaccatg aacttggcac
361 tggctggtga catccttgct gcagggcagg atgcacactg tcagctcctg cgcttccagg
421 cacatcaaca gcagggcaac aaggcagaga aggccggttc caaggagcag gggcctcgac
481 aaaggaaggg agcagcccca gcagagaaga aatgtggagc ggaaacccag cacgaggggc
541 tagaactcag ggtagagaat ttgcaggcgg tgcagacaga ctttagctcc gatccactgc
601 agaaagttgt gtgcttcaac cacgataata ccctgcttgc cactggagga acagatggct
661 acgtccgtgt ctggaaggtg cccagcctgg agaaggttct ggagttcaaa gcccacgaag
721 gggagattga agacctggct ttagggcctg atggcaagtt ggtaaccgtg ggccgggacc
781 ttaaggcctc tgtgtggcag aaggatcagc tggtgacaca gctgcactgg caagaaaatg
841 gacccacctt ttccagcaca ccttaccgct accaggcctg caggtttggg caggttccag
901 accagcctgc tggcctgcga ctcttcacag tgcaaattcc ccacaagcgg ctgcggcagc
961 cccctccctg ctacctcaca gcctgggatg gctccaactt cttgcccctt cggaccaagt
1021 cctgtggcca tgaagtcgtc tcctgcctcg atgtcagtga atccggcacc ttcctaggcc
1081 tgggcacagt cactggctct gttgccatct acatagcttt ctctctccag tgcctctact
1141 acgtgaggga ggcccatggc attgtggtga cggatgtggc ctttctacct gagaagggtc
1201 gtggtccaga gctccttggg tcccatgaaa ctgccctgtt ctctgtggct gtggacagtc
1261 gttgccagct gcatctgttg ccctcacggc ggagtgttcc tgtgtggctc ctgctcctgc
1321 tgtgtgtcgg gcttattatt gtgaccatcc tgctgctcca gagtgccttt ccaggtttcc
1381 tttagcttcc ctgcttcctg ggaatcagga gcctggacac tgccatctct agagcagagt
1441 ggaggcctgg actccctttg ctcactccat tcgggtccac agctgaggtt gcctctgaca
1501 agatgaatgg gcactgcctg cccttctagt gaaaaggctt ggctatggcc ctgtgtgact
1561 ccaggtccca ggaaccttgc cttcgtcatc tgtggatcca tccagaacag cggtatctga
1621 agcccaggcc atactccctg cctcctttct tctgcctacc agaggctcca gagttgagct
1681 tgtccttatc tagaaacatg tgaagatgcc caagagcctg gaggcactgc tgtccttcct
1741 gcagaaacag tttctcctcc tcccctcagc cttgtggcca gttcctcttc acatgaagcc
1801 cctggcattt gctggggaag ggactggcct ggtacttgct gttagggcag gaaggggcaa
1861 aaggaagact tgggtagtaa tctgggggtt cagatgggta gcactaagcc agctggccta
1921 aagatgcaat aagttcctag gtagtctacc cttaccttga ggaatgggaa aatgaacctc
1981 agcccattag gcaggaaaag ttgatattta ataaacaagg aaagagtgaa ctgagacccc
2041 aaaaaaaaaa aaaaaaaaa
//