LOCUS AF200815 3948 bp mRNA linear HUM 03-AUG-2000
DEFINITION Homo sapiens FUSED serine/threonine kinase mRNA, complete cds.
ACCESSION AF200815
VERSION AF200815.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3948)
AUTHORS Murone,M., Luoh,S.M., Stone,D., Li,W., Gurney,A., Armanini,M.,
Grey,C., Rosenthal,A. and de Sauvage,F.J.
TITLE Gli regulation by the opposing activities of fused and suppressor
of fused
JOURNAL Nat. Cell Biol. 2 (5), 310-312 (2000)
PUBMED 10806483
REFERENCE 2 (bases 1 to 3948)
AUTHORS Murone,M., Luoh,S.-L., Stone,D., Li,W., Gurney,A., Armanini. M.,
Grey,C., Rosenthal,A. and de Sauvage,F.J.
TITLE Direct Submission
JOURNAL Submitted (01-NOV-1999) Molecular Oncology, Genentech Inc., 1 DNA
Way, South San Francisco, CA 94080, USA
FEATURES Location/Qualifiers
source 1..3948
/db_xref="H-InvDB:HIT000073757"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q35"
CDS 1..3948
/function="modulator of Gli activity"
/note="Hedgehog signal transduction"
/codon_start=1
/product="FUSED serine/threonine kinase"
/protein_id="AAF97028.1"
/translation="MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKE
LRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQV
QAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSI
KGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVR
WPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKV
APGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFP
EERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRI
QSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSL
LRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLD
LLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLL
HGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQV
CWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALE
SLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVS
LVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILL
LQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDW
TLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPH
GSEFLPVVVLSVCQLLCFPFALDMDADLLIVVLADLRDSEVAAHLLQVCCYHLPLMQV
ELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHT
ARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGA
LQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDP
QAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQ
EPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM"
BASE COUNT 827 a 1159 c 1044 g 918 t
ORIGIN
1 atggaaaagt accacgtgtt ggagatgatt ggagaaggct cttttgggag ggtgtacaag
61 ggtcgaagaa aatacagtgc tcaggtcgtg gccctgaagt tcatcccaaa attggggcgc
121 tcagagaagg agctgaggaa tttgcaacga gagattgaaa taatgcgggg tctgcggcat
181 cccaacattg tgcatatgct tgacagcttt gaaactgata aagaggtggt ggtggtgaca
241 gactatgctg agggagagct ctttcagatc ctagaagatg acggaaaact tcctgaagac
301 caggttcagg ccattgctgc ccagttggtg tcagccctgt actatctgca ttcccaccgc
361 atcctacacc gagatatgaa gcctcagaac atcctcctcg ccaagggtgg tggcatcaag
421 ctctgtgact ttggatttgc ccgggctatg agcaccaata caatggtgct gacatccatc
481 aaaggcacac cactctatat gtctccagag ctggtggagg agcgaccata cgaccacaca
541 gcggacctct ggtctgttgg ctgcatacta tatgaactgg cagtaggcac ccctcccttc
601 tatgctacaa gcatctttca gctggtcagc ctcattctca aggaccctgt gcgctggccc
661 tcaaccatca gtccctgctt taagaacttc ctgcagggac tgctcaccaa agacccacgg
721 cagcgactgt cctggccaga cctcttatat caccccttta ttgctggtca tgtcaccata
781 ataactgagc cagcaggccc agatttgggg accccattca ccagccgcct acccccagaa
841 cttcaggtcc taaaggacga acaggcccat cggttggccc ccaagggtaa tcagtctcgc
901 atcttgactc aggcctataa acgcatggct gaggaggcca tgcagaagaa acatcagaac
961 acaggacctg cccttgagca agaggacaag accagcaagg tggctcctgg cacagcccct
1021 ctgcccagac tcggggccac tcctcaggaa tcaagcctcc tggccgggat cttagcctca
1081 gaattgaaga gcagctgggc taaatcaggg actggagagg tgccctctgc acctcgggaa
1141 aaccggacca ccccagattg tgaacgagca ttcccagagg agaggccaga ggtgctgggc
1201 cagcggagca ctgatgtagt ggacctggaa aatgaggagc cagacagtga caatgagtgg
1261 cagcacctgc tagagaccac tgagcctgtg cctattcaac tgaaggctcc tctcaccttg
1321 ctgtgtaatc ctgacttctg ccagcgcatc cagagtcagc tgcatgaagc tggagggcag
1381 atcctgaaag gcatcttgga gggtgcttcc cacatcctgc ctgcattccg ggtcctgagc
1441 agtcttctct ccagctgcag tgattctgtt gccttgtatt ccttctgccg ggaggcaggg
1501 cttcctgggc tgctgctgag tctactcagg cacagtcagg agagcaacag cctccagcag
1561 caatcttggt atgggacctt cttacaggac ctgatggctg tgattcaggc ctactttgcc
1621 tgtaccttca atctggagag gagccagaca agtgacagcc tgcaggtgtt tcaggaggct
1681 gccaaccttt ttctggacct gttggggaaa ctgctggccc aaccagatga ctctgagcag
1741 actttgcgga gggacagcct tatgtgcttt actgtcctgt gcgaagccat ggatgggaac
1801 agccgggcca tctccaaagc cttttactcc agcttgctga cgacacagca ggttgtcttg
1861 gatgggctcc ttcatggctt gacagttcca cagctccctg tccacactcc ccaaggagcc
1921 ccgcaagtga gccagccact gcgagagcag agtgaggata tacctggagc catttcctct
1981 gccctggcag ccatatgcac tgctcctgtg ggactgcccg actgctggga tgccaaggag
2041 caggtctgtt ggcatttggc aaatcagcta actgaagaca gcagccagct caggccatcc
2101 ctcatctctg gcctgcagca tcccatcctg tgcctgcacc ttctcaaggt tctatactcc
2161 tgctgccttg tcagtgaggg cctgtgccgt cttctggggc aggagcccct ggccttggaa
2221 tccctgttta tgttgattca gggcaaggta aaagtagtag attgggaaga gtctactgaa
2281 gtgacactct acttcctctc ccttcttgtc tttcggctcc aaaacctgcc ttgtggaatg
2341 gagaagctag gcagtgacgt tgctactctc tttacccatt cgcatgtcgt ctctcttgtg
2401 agtgcagcag cctgtctatt gggacagctt ggtcagcaag gggtgacctt tgacctccag
2461 cccatggaat ggatggctgc agccacacat gccttgtctg cccctgcaga ggttcggttg
2521 actccaccag gtagttgtgg attctatgat ggcctcctta tccttctgtt gcagctcctc
2581 actgagcagg ggaaggctag cctaatcagg gatatgtcca gttcagaaat gtggaccgtt
2641 ttgtggcacc gcttctccat ggtcctgagg ctccccgagg aggcatctgc acaggaaggg
2701 gagctttcgc tatccagtcc accaagccct gagccagact ggacactgat ttctccccag
2761 ggcatggcag ccctgctgag cctggccatg gccaccttta cccaggagcc ccagttatgc
2821 ctgagctgcc tgtcccagca tggaagtatc ctcatgtcca tcctgaagca tctgctttgc
2881 cccagcttcc tgaatcaact gcgccaggcg cctcatgggt ctgagtttct ccctgtcgtg
2941 gtgctctctg tctgccagct cctttgcttc ccctttgcgc tggacatgga tgctgacctc
3001 cttatagttg tcttggccga cctcagggac tcagaagttg cagcccatct gctgcaggtc
3061 tgctgctacc atcttccgtt gatgcaagtg gagctgccca tcagccttct cacacgcctg
3121 gccctcatgg atcccacctc tctcaaccag tttgtgaaca cagtgtctgc ctcccctaga
3181 accatcgtct cgtttctctc agttgccctc ctgagtgacc agccactgtt gacctccgac
3241 cttctctctc tgctggccca tactgccagg gtcctgtctc ccagccactt gtcctttatc
3301 caagagcttc tggctggctc tgatgaatcc tatcggcccc tgcgcagcct cctgggccac
3361 ccagagaatt ctgtgcgggc acacacttat aggctcctgg gacacttgct ccaacacagc
3421 atggccctgc gtggggcact gcagagccag tctggactgc tcagccttct gctgcttggg
3481 cttggagaca aggatcctgt tgtgcggtgc agtgccagct ttgctgtggg caatgcagcc
3541 taccaggctg gtcctctggg acctgccctg gcagctgcag tgcccagtat gacccagctg
3601 cttggagatc ctcaggctgg tatccggcgc aatgttgcat cagctctggg caacttggga
3661 cctgaaggtt tgggagagga gctgttacag tgcgaagtac cccagcggct cctagaaatg
3721 gcatgtggag acccccagcc aaatgtgaag gaggctgccc tcattgccct ccggagcctg
3781 caacaggagc ctggcatcca tcaggtactg gtgtccctgg gtgccagtga gaaactatcc
3841 ttgctctctc tggggaatca gtcactgcca cacagcagtc ctaggcctgc ctctgccaaa
3901 cactgcagga aactcattca cctcctgagg ccagcccata gcatgtga
//