LOCUS AF197927 4235 bp mRNA linear HUM 19-DEC-1999
DEFINITION Homo sapiens AF5q31 protein (AF5q31) mRNA, complete cds.
ACCESSION AF197927
VERSION AF197927.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4235)
AUTHORS Taki,T., Kano,H., Taniwaki,M., Sako,M., Yanagisawa,M. and
Hayashi,Y.
TITLE AF5q31, a newly identified AF4-related gene, is fused to MLL in
infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (25), 14535-14540 (1999)
PUBMED 10588740
REFERENCE 2 (bases 1 to 4235)
AUTHORS Taki,T., Kano,H., Taniwaki,M., Sako,M., Yanagisawa,M. and
Hayashi,Y.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-1999) Department of Pediatrics, Faculty of
Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo
113-8655, Japan
FEATURES Location/Qualifiers
source 1..4235
/db_xref="H-InvDB:HIT000073689"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q31"
/note="acute lymphoblastic leukemia patient"
gene 1..4235
/gene="AF5q31"
CDS 338..3829
/gene="AF5q31"
/note="AF4-related protein; MLL fusion partner"
/codon_start=1
/product="AF5q31 protein"
/protein_id="AAF18981.1"
/translation="MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSK
EDKLSSRIQSMLGNYDEMKDFIGDRSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGGS
HQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSG
SSSRKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDA
NWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYS
SQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAI
HTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDS
DGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSD
SEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGRE
QGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ
PKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPT
AEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVE
EEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGE
KKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNR
ESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSK
NSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKLVFDDRNYS
ADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSE
TVDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTE
HLKNSYNNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGNYSSGASSASASGSSVTIPQK
IHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVR
YTRQGLHWLRQDAKLIS"
BASE COUNT 1310 a 1044 c 955 g 926 t
ORIGIN
1 cgccagcgga cggggcgggg atcctggtgc caggtcttcg ttaacccgcc cccgcctgcc
61 tcagtcagct gtcccagccc gggcccgacc gtcatggagc ggtgcggggc ctacgcctgt
121 tccgtgtgag gcgcatcgct gccgccgccg ccgacgccgc cttcgtttgt cgaggcctcc
181 ggaacccccg ccgcctcccg gagcccctcg cccttggcag cctgtcaccg ccccctgggc
241 gggctcgaat gcgcgtccgg tgaaggtgca ggcccggcgc cgccactgcc gcagccagga
301 gatggttcgg gcctagcgga gccgggactg gagcaacatg aaccgtgaag accggaatgt
361 gctgcgtatg aaagaacggg aaaggcggaa tcaggaaatt cagcagggcg aagacgcctt
421 cccacctagc tctcctctct ttgcagagcc atacaaagtt actagcaaag aagataagtt
481 atcaagtcgt attcagagta tgcttggaaa ctacgatgaa atgaaggatt tcataggaga
541 cagatctata ccaaagcttg ttgcaattcc caagcctaca gtaccaccat cagcagatga
601 aaaatctaac ccaaatttct ttgaacagag acatggaggc tctcatcaga gtagcaaatg
661 gactccagta ggacccgcac ccagcacttc tcagtctcag aaacggtcct caggcttaca
721 gagtggacat agtagccagc ggaccagcgc aggtagcagt agtggcacta acagtagtgg
781 tcagaggcac gaccgtgagt catataacaa tagtgggagc agtagccgga aaaaaggcca
841 gcatggatca gaacactcca aatcacgttc ttccagccct ggaaaacccc aggctgtttc
901 ttcattaaac tctagtcatt ccaggtctca tgggaatgat caccatagca aggaacatca
961 acgctccaaa tcacctcggg accctgatgc aaactgggat tctccttccc gtgtaccttt
1021 ttcaagtggg cagcactcaa ctcaatcttt cccaccctca ttgatgtcaa agtccaattc
1081 aatgttacag aaacccactg cctatgtgcg gcccatggac ggacaggagt ccatggaacc
1141 aaagctgtcc tctgagcact acagcagcca atcccatggc aacagcatga ctgagctgaa
1201 gcccagcagc aaagcacatc tcaccaagct gaaaatacct tcccaaccac tggatgcatc
1261 agcttctggt gatgtgagct gtgtggatga aatcctaaaa gagatgacgc attcatggcc
1321 tccccctcta acggctattc atacaccatg caaaacagaa ccttccaaat ttccttttcc
1381 aactaaggag tctcagcagt ccaattttgg cactggagaa caaaaaagat ataatccttc
1441 taaaacttca aatgggcacc agtctaaatc tatgttaaaa gatgacttaa aactaagcag
1501 cagtgaagac agtgatgggg aacaggattg tgataagaca atgccgagga gtacaccagg
1561 aagtaactct gaaccttcac accataatag tgaaggagca gataactcca gggatgattc
1621 tagtagccac agtggatctg aaagcagctc tggatctgac tcagagagtg aaagtagttc
1681 cagtgacagt gaggcaaatg agccatccca gagtgcatct cccgagcctg aacccccgcc
1741 aacaaacaaa tggcaacttg ataattggct gaataaagtg aacccacata aagtgtcacc
1801 cgcctcttca gtggacagta acatcccatc atctcaaggc tacaaaaagg aaggccgaga
1861 gcagggcact gggaatagct acactgatac aagtggacct aaagaaacga gttccgctac
1921 tccgggacga gactccaaaa ccatccaaaa gggatcagaa agtgggcgtg ggaggcagaa
1981 atctcctgca cagagtgaca gcacaacaca gagaagaact gtaggcaaaa aacaacccaa
2041 aaaggctgag aaggcagctg ctgaagagcc tcgtggaggc ctgaagatag aaagtgaaac
2101 ccctgtagac ttggctagca gcatgccctc cagcagacac aaagcagcca ccaaaggctc
2161 aaggaaaccc aatataaaga aggagtctaa gtcttcccct cgacctacag cagagaaaaa
2221 gaaatataag tcaacaagta aatcttccca gaaatcaagg gaaatcatag aaacagatac
2281 ctcatcctca gattcagatg aaagtgagag ccttcctcct tcctcacaaa ctcctaagta
2341 ccccgagagc aataggactc ctgttaaacc ctcctcagtg gaggaagaag atagcttttt
2401 tcggcaacga atgttctctc ctatggaaga gaaggaactt ctttcacccc tcagtgagcc
2461 tgatgacagg tacccactta ttgtgaagat tgacctgaat cttttgacta gaataccagg
2521 aaagccttac aaagaaacag agccgcccaa gggggaaaag aaaaatgtgc cagaaaagca
2581 cacgagagag gctcagaaac aagcctcaga aaaagtttcc aacaaaggca agaggaagca
2641 taagaatgaa gatgataacc gagccagtga gagcaagaaa cccaaaacgg aggacaagaa
2701 ttcagcaggc cataagccat ccagcaacag agagtcatct aagcagagtg ctgcaaaaga
2761 aaaggatttg ttgccttctc ccgctgggcc tgttccttca aaagatccaa aaacagagca
2821 tggctctcgg aagaggacta ttagtcagtc ttcttcctta aagtcaagca gtaacagcaa
2881 caaggagacg agtggcagca gcaaaaacag ttcctccaca tcaaagcaga agaagaccga
2941 agggaagact tccagtagct ccaaggaggt taaggaaaag gctccaagta gctcctctaa
3001 ctgtcctcca tctgcaccaa ctcttgattc ttctaagcct cggagaacaa agcttgtctt
3061 tgatgacaga aattattcag cagaccatta tttacaagaa gcaaaaaagc taaagcacaa
3121 tgcagatgca ttgtctgata ggtttgagaa agctgtatac tatcttgatg ctgtggtatc
3181 tttcattgaa tgtgggaatg cattagagaa gaatgctcag gaatccaaat ccccattccc
3241 tatgtattca gagacggtgg atctcatcaa atacactatg aagctaaaga attacttggc
3301 accagatgct acagctgcag ataaacgact cacagtactt tgcctgcgat gcgagtcttt
3361 gctgtacctg aggctgttca aactgaagaa ggaaaatgct ctgaagtact caaagacact
3421 gacagagcac ctgaagaatt cttataataa ttctcaagca ccatcgcctg gcttgggaag
3481 caaagctgtg gggatgcctt cccctgtttc tccaaagctg tcaccaggca attcaggaaa
3541 ttattcatct ggggccagta gtgcttctgc aagtggttct tcagtgacca ttccacagaa
3601 gatccaccag atggcagcca gctatgttca ggtcacatcc aacttcctct atgccaccga
3661 aatttgggac caagctgaac agctttccaa agagcaaaaa gaattctttg ctgaactgga
3721 taaagtaatg ggccctctca tctttaatgc aagcatcatg acagatctag ttcgttatac
3781 ccggcaggga ctgcactggc ttcgccagga tgccaagttg atatcttgaa ctgaacacat
3841 tctcgttgcc tctgattttc tccacaacac tgtgtcacat cacgaaggaa aactgccata
3901 acataccacc tagtcgacac taagaatgag gaatagtttt ctcctcgttg gttcatgtgt
3961 tgttgttttt gataatccaa agcgatcatg tcagttggcc ctttaatatt tccaatgtga
4021 aagattattt aaatgctttt aaatctgcag cacattgata agatggtttc cgtgagctat
4081 gataagattg aaattccagt tgcaattcat aactaatgaa ttgaaatttt atttatttta
4141 atttttttaa gttcccagat tggggctagt ttaagactta gttatttctg cctataaatt
4201 tactctgttg aatatttagc ataaatttaa tgtag
//