LOCUS AF196976 3770 bp mRNA linear HUM 07-OCT-2005
DEFINITION Homo sapiens brain tumor associated protein LRRC4 (LRRC4) mRNA,
complete cds.
ACCESSION AF196976 AF300459
VERSION AF196976.4
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3770)
AUTHORS Wang,J.R., Li,X.L., Fan,S.Q., Tan,C., Xiang,J.J., Tang,K., Wang,R.
and Li,G.Y.
TITLE Expression of LRRC4 has the potential to decrease the growth rate
and tumorigenesis of glioblastoma cell line U251
JOURNAL Ai Zheng 22 (9), 897-902 (2003)
PUBMED 12969517
REFERENCE 2 (bases 1 to 3770)
AUTHORS Fan,S.Q., Wang,J.R., Huang,H., Xiong,W., Xiao,B.Y., Ou,Y.J.,
Cao,L., Tan,C. and Li,G.Y.
TITLE [Function of a novel brain-specific gene LRRC4]
JOURNAL Zhonghua Zhong Liu Za Zhi 27 (7), 393-396 (2005)
PUBMED 16188120
REFERENCE 3 (bases 1 to 3770)
AUTHORS Zhang,Q., Wang,J., Fan,S., Wang,L., Cao,L., Tang,K., Peng,C.,
Li,Z., Li,W., Gan,K., Liu,Z., Li,X., Shen,S. and Li,G.
TITLE Expression and functional characterization of LRRC4, a novel
brain-specific member of the LRR superfamily
JOURNAL FEBS Lett. 579 (17), 3674-3682 (2005)
PUBMED 15967442
REFERENCE 4 (bases 1 to 3770)
AUTHORS Zhang,Q.H., Wang,L.L., Cao,L., Peng,C., Li,X.L., Tang,K., Li,W.F.,
Liao,P., Wang,J.R. and Li,G.Y.
TITLE Study of a novel brain relatively specific gene LRRC4 involved in
glioma tumorigenesis suppression using the Tet-on system
JOURNAL Acta Biochim. Biophys. Sin. (Shanghai) 37 (8), 532-540 (2005)
PUBMED 16077900
REFERENCE 5 (bases 1 to 3770)
AUTHORS Wang,J., Bin,L., Jiang,N. and Li,G.
TITLE Direct Submission
JOURNAL Submitted (20-OCT-1999) Cancer Research Institute, Molecular
Cytogenetic Lab, Hunan Medical University, 88 Xiangya Road,
Changsha, Hunan 410078, P.R. China
REFERENCE 6 (bases 1 to 3770)
AUTHORS Wang,J., Bin,L., Jiang,N. and Li,G.
TITLE Direct Submission
JOURNAL Submitted (20-FEB-2001) Cancer Research Institute, Molecular
Cytogenetic Lab, Hunan Medical University, 88 Xiangya Road,
Changsha, Hunan 410078, P.R. China
REMARK Sequence update by submitter
REFERENCE 7 (bases 1 to 3770)
AUTHORS Wang,J., Bin,L., Jiang,N. and Li,G.
TITLE Direct Submission
JOURNAL Submitted (20-JUN-2001) Cancer Research Institute, Molecular
Cytogenetic Lab, Hunan Medical University, 88 Xiangya Road,
Changsha, Hunan 410078, P.R. China
REMARK Sequence update by submitter
REFERENCE 8 (bases 1 to 3770)
AUTHORS Wang,J., Bin,L., Jiang,N. and Li,G.
TITLE Direct Submission
JOURNAL Submitted (25-FEB-2002) Cancer Research Institute, Molecular
Cytogenetic Lab, Hunan Medical University, 88 Xiangya Road,
Changsha, Hunan 410078, P.R. China
REMARK Sequence update by submitter
COMMENT On Apr 15, 2002 this sequence version replaced AF196976.3.
FEATURES Location/Qualifiers
source 1..3770
/db_xref="H-InvDB:HIT000073683"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q31-q32"
gene 1..3770
/gene="LRRC4"
/gene_synonym="NAG14"
CDS 141..2102
/gene="LRRC4"
/gene_synonym="NAG14"
/note="BAG1; similar to the product of GenBank Accession
Number AL137451; down regulated in brain tumors"
/codon_start=1
/product="brain tumor associated protein LRRC4"
/protein_id="AAG28019.2"
/translation="MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQ
NCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLE
VLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIE
SIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV
GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHN
NLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMH
MRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVL
SHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSN
YSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPA
TDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTV
EIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLG
NSLHPTVTTISEPYIIQTHTKDKVQETQI"
BASE COUNT 1017 a 927 c 945 g 876 t
ORIGIN
1 cggggacacc acgccagtgc tttcctgcct tccttccgag atggaaagag gagctcctag
61 ctcacttaag ccggggtagg gctggttctc ctttccgagc caaaatccca ggcgatggtg
121 aattatgaac gtgccacacc atgaagctct tgtggcaggt aactgtgcac caccacacct
181 ggaatgccat cctgctcccg ttcgtctacc tcacggcgca agtgtggatt ctgtgtgcag
241 ccatcgctgc tgccgcctca gccgggcccc agaactgccc ctccgtctgc tcgtgcagta
301 accagttcag caaggtggtg tgcacgcgcc ggggcctctc cgaggtcccg cagggtattc
361 cctcgaacac ccggtacctc aacctcatgg agaacaacat ccagatgatc caggccgaca
421 ccttccgcca cctccaccac ctggaggtcc tgcagttggg caggaactcc atccggcaga
481 ttgaggtggg ggccttcaac ggcctggcca gcctcaacac cctggagctg ttcgacaact
541 ggctgacagt catccctagc ggggcctttg aatacctgtc caagctgcgg gagctctggc
601 ttcgcaacaa ccccatcgaa agcatcccct cttacgcctt caaccgggtg ccctccctca
661 tgcgcctgga cttgggggag ctcaagaagc tggagtatat ctctgaggga gcttttgagg
721 ggctgttcaa cctcaagtat ctgaacttgg gcatgtgcaa cattaaagac atgcccaatc
781 tcacccccct ggtggggctg gaggagctgg agatgtcagg gaaccacttc cctgagatca
841 ggcctggctc cttccatggc ctgagctccc tcaagaagct ctgggtcatg aactcacagg
901 tcagcctgat tgagcggaat gcttttgacg ggctggcttc acttgtggaa ctcaacttgg
961 cccacaataa cctctcttct ttgccccatg acctctttac cccgctgagg tacctggtgg
1021 agttgcatct acaccacaac ccttggaact gtgattgtga cattctgtgg ctagcctggt
1081 ggcttcgaga gtatataccc accaattcca cctgctgtgg ccgctgtcat gctcccatgc
1141 acatgcgagg ccgctacctc gtggaggtgg accaggcctc cttccagtgc tctgccccct
1201 tcatcatgga cgcacctcga gacctcaaca tttctgaggg tcggatggca gaacttaagt
1261 gtcggactcc ccctatgtcc tccgtgaagt ggttgctgcc caatgggaca gtgctcagcc
1321 acgcctcccg ccacccaagg atctctgtcc tcaacgacgg caccttgaac ttttcccacg
1381 tgctgctttc agacactggg gtgtacacat gcatggtgac caatgttgca ggcaactcca
1441 acgcctcggc ctacctcaat gtgagcacgg ctgagcttaa cacctccaac tacagcttct
1501 tcaccacagt aacagtggag accacggaga tctcgcctga ggacacaacg cgaaagtaca
1561 agcctgttcc taccacgtcc actggttacc agccggcata taccacctct accacggtgc
1621 tcattcagac tacccgtgtg cccaagcagg tggcagtacc cgcgacagac accactgaca
1681 agatgcagac cagcctggat gaagtcatga agaccaccaa gatcatcatt ggctgctttg
1741 tggcagtgac tctgctagct gccgccatgt tgattgtctt ctataaactt cgtaagcggc
1801 accagcagcg gagtacagtc acagccgccc ggactgttga gataatccag gtggacgaag
1861 acatcccagc agcaacatcc gcagcagcaa cagcagctcc gtccggtgta tcaggtgagg
1921 gggcagtagt gctgcccaca attcatgacc atattaacta caacacctac aaaccagcac
1981 atggggccca ctggacagaa aacagcctgg ggaactctct gcaccccaca gtcaccacta
2041 tctctgaacc ttatataatt cagacccata ccaaggacaa ggtacaggaa actcaaatat
2101 gactcccctc ccccaaaaaa cttataaaat gcaatagaat gcacacaaag acagcaactt
2161 ttgtacagag tggggagaga ctttttcttg tatatgctta tatattaagt ctatgggctg
2221 gttaaaaaaa acagattata ttaaaattta aagacaaaaa gtcaaaacaa aaatattttc
2281 taacttgtaa gttctattta aagggggtgg gggggaatct tgggaacgtt gtggggtcca
2341 agccacaagt taacttgcta tgctgccaga agggatttct ggtataaggt tgaaattgct
2401 gagataaaat aaactaaaac aacaaacatc cttaaagagg tagggtgtgg gctgctgagg
2461 gggcaagagg gatagactga atctgtcatt ttttagaaga tgcttcatag gacacaggac
2521 tatccatttc tacagacatc tttcttaagc cgagagctgt ctttgcagaa ttatcttatt
2581 aaaaaaaaat acaaaaaaaa agcaccatga atttgtactg tgccaaaatg atagtggcaa
2641 taatattttt cttcagaggc taaggggaag atagacctgt acatgtattt taagcaggaa
2701 aaccaccaaa attcaaacga acccttaaag gggctgagtc tttgtccatg tgcacaagtc
2761 ttgggggtct gtgcactgga cacacatgtg ccttgcctga cagaattgct tagaaaggag
2821 cagagaagga cgggagctgg cgtagctctc agtctaatgc tttcacattg caccagattc
2881 ctgcagttgg gcttaaccca ctctgcaagg catgtgtcta ttcagggttt cccaggagga
2941 ggaggcccct gaaggggtgc ggcagcaggg gggtggtaag ggagggtaaa gcagagagaa
3001 tgtattcaca ggaggccata aattagcatt gtgccatgtc cacctgttgt tcctggactc
3061 tgacacatga ttgtagacaa tgatggcatt ttatgatttt taaaaaagat tttgtttgtt
3121 ttaaggtgga gagggaggag aagcctgaat tggggagctt gggagtggaa gcttttctca
3181 tgcttgtgat ttggtgactc ttctaaatgc tgattcatta gggattatta cagcggatgt
3241 caactggttg tggtgatggg gtgggggcag aacatgaata gcaaagaaaa gggagagacg
3301 aaaagggtac aggctcatgt aaagtaatga agcctttccc aaccaggatg gttcacaaaa
3361 aagctgtgag atccacagtt acaagtgaca cgcatgcaca catggagttc cacatggggt
3421 actgttgaat ggagcacact gatgggaagc ttccctctcc caggccccct caggagaagg
3481 tggaagagaa agggtgggcg tgggtgggga aggcagagat ctctgttatt ctggtccatc
3541 taatgatgta acttctttca gttattattt tagctttaaa aggaaataag gggttcagat
3601 ttgaaagggg gtggtatggg tgggggaggg gaattgccaa caaaanaacn ctgattgtaa
3661 tgtganaaaa gngtattttt gtattttaat aaanattgtt gaatttttaa aaaaaaaaaa
3721 aaaaaaaaaa aaaaaaaaaa aaaagaaaaa aaaaaaaact ctccagcgct
//