LOCUS       AF195657                4895 bp    mRNA    linear   HUM 11-JAN-2000
DEFINITION  Homo sapiens DNA mismatch repair protein (MLH3) mRNA, complete cds.
ACCESSION   AF195657
VERSION     AF195657.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Lipkin,S.M., Wang,V., Jacoby,R., Banerjee-Basu,S., Baxevanis,A.D.,
            Lynch,H.T., Elliott,R.M. and Collins,F.S.
  TITLE     MLH3: a DNA mismatch repair gene associated with mammalian
            microsatellite instability
  JOURNAL   Nat. Genet. 24 (1), 27-35 (2000)
   PUBMED   10615123
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   Lipkin,S.M., Wang,V., Jacoby,R., Banerjee-Basu,S., Baxevanis,A.D.,
            Elliott,R.M., Lynch,H.T. and Collins,F.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-1999) GMBB, NHGRI, 49 Convent Drive, Bethesda, MD
            20892, USA
FEATURES             Location/Qualifiers
     source          1..4895
                     /db_xref="H-InvDB:HIT000073653"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4895
                     /gene="MLH3"
     CDS             115..4404
                     /gene="MLH3"
                     /codon_start=1
                     /product="DNA mismatch repair protein"
                     /protein_id="AAF23904.1"
                     /translation="MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVR
                     VNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIAD
                     MASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRK
                     CMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLG
                     KSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES
                     IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWD
                     TLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQE
                     ACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGH
                     SKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLERSSLENPCGTSLEMF
                     LSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLP
                     FATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETE
                     HSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYG
                     LENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPI
                     VRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRL
                     ENSDVCKITTMEHSDSDSSCQPASHILDSEKFPFSKDEDCLEQQMPSLRESPMTLKEL
                     SLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSV
                     LTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVL
                     PYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARA
                     CSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVD
                     VVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWD
                     NPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLM
                     STKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLG
                     LEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGG
                     IQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLP
                     LADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP"
BASE COUNT         1561 a          932 c         1084 g         1318 t
ORIGIN      
        1 gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt
       61 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc taccatgatc
      121 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg gtttggccat aagctccttg
      181 ggccaatgtg ttgaggaact tgccctcaac agtattgatg ctgaagcaaa atgtgtggct
      241 gtcagggtga atatggaaac cttccaagtt caagtgatag acaatggatt tgggatgggg
      301 agtgatgatg tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag
      361 gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac
      421 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac ttttgtgaaa
      481 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg atgtgactag agcaagcgct
      541 gggactactg taacagtgta taacctattt taccagcttc ctgtaaggag gaaatgcatg
      601 gaccctagac tggagtttga gaaggttagg cagagaatag aagctctctc actcatgcac
      661 ccttccattt ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct
      721 aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag
      781 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat cagctctgaa
      841 gcacattaca acaagaatat gcagtttttg tttgtgaaca aaagactagt tttaaggaca
      901 aagctacata aactcattga ctttttatta aggaaagaaa gtattatatg caagccaaag
      961 aatggtccca ccagtaggca aatgaattca agtcttcggc accggtctac cccagaactc
     1021 tatggcatat atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag
     1081 ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa
     1141 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg tgaggatatt
     1201 aaggaattta gtgaagataa tggttttagt ttatttgatg ctactcttca gaagcgtgtg
     1261 acttccgatg agaggagcaa tttccaggaa gcatgtaata atattttaga ttcctatgag
     1321 atgtttaatt tgcagtcaaa agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca
     1381 cagagttcta gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt
     1441 tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac
     1501 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc agaagctggt
     1561 gaaaatgaga aacataaaaa atctttcctg gaacgtagct ctttagaaaa tccgtgtgga
     1621 accagtttag aaatgttttt aagccctttt cagacaccat gtcactttga ggagagtggg
     1681 caggatctag aaatatggaa agaaagtact actgttaatg gcatggctgc caacatcttg
     1741 aaaaataata gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc
     1801 cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag
     1861 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg gcgagttaaa
     1921 ttatgttcca ctggctttat aactcatgta gtacaaaatg aaaaaactaa atcaactgaa
     1981 acagaacatt catttaaaaa ttatgttaga cctggtccca cacgtgccca agaaacattt
     2041 ggaaatagaa cacgtcattc agttgaaact ccagacatca aagatttagc cagcacttta
     2101 agtaaagaat ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg
     2161 ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa
     2221 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg gtatagacac
     2281 gtttccaatg atagtaggaa aacagataaa ttaattggtt tctccaaacc aatcgtccgt
     2341 aagaagctaa gcttgagttc acagctagga tctttagaga agtttaagag gcaatatggg
     2401 aaggttgaaa atcctctgga tacagaagta gaggaaagta atggagtcac taccaatctc
     2461 agtcttcaag ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat
     2521 gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc
     2581 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt agaacaacag
     2641 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt tatctctctt taatagaaaa
     2701 cctttggacc ttgagaagtc atctgaatca ctagcctcta aattatccag actgaagggt
     2761 tccgaaagag aaactcaaac aatggggatg atgagtcgtt ttaatgaact tccaaattca
     2821 gattccagta ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta
     2881 tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca
     2941 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac aacagagaac
     3001 tgtgtgatat cagaaactcc tttggtattg ccctataata attctaaagt taccggtaaa
     3061 gattcagatg ttcttatcag agcctcagaa caacagatag gaagtcttga ctctcccagt
     3121 ggaatgttaa tgaatccggt agaagatgcc acaggtgacc aaaatggaat ttgttttcag
     3181 agtgaggaat ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca
     3241 gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact
     3301 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac taaagacctg
     3361 acaactgtgg ctgtggatgt tgtacttgag aatgggtctc agtacaggtg tcaacctttt
     3421 agaagcgacc ttgttcttcc tttccttccg agagctcgag cagagaggac tgtgatgaga
     3481 caggataaca gagatactgt ggatgatact gttagtagcg aatcgcttca gtctttgttc
     3541 tcagaatggg acaatccagt atttgcccgt tatccagagg ttgctgttga tgtaagcagt
     3601 ggccaggctg agagcttagc agttaaaatt cacaacatct tgtatcccta tcgtttcacc
     3661 aaaggaatga ttcattcaat gcaggttctc cagcaagtag ataacaagtt tattgcctgt
     3721 ttgatgagca ctaagactga agagaatggc gaggcagatt cctacgagaa gcaacaggca
     3781 caaggctctg gtcggaaaaa attactgtct tctactctaa ttcctccgct agagataaca
     3841 gtgacagagg aacaaaggag actcttatgg tgttaccaca aaaatctgga agatctgggc
     3901 cttgaatttg tatttccaga cactagtgat tctctggtcc ttgtgggaaa agtaccacta
     3961 tgttttgtgg aaagagaagc caatgaactt cggagaggaa gatctactgt gaccaagagt
     4021 attgtggagg aatttatccg agaacaactg gagctactcc agaccaccgg aggcatccaa
     4081 gggacattgc cactgactgt ccagaaggtg ttggcatccc aagcctgcca tggggccatt
     4141 aagtttaatg atggcctgag cttacaggaa agttgccgcc ttattgaagc tctgtcctca
     4201 tgccagctgc cattccagtg tgctcacggg agaccttcta tgctgccgtt agctgacata
     4261 gaccacttgg aacaggaaaa acagattaaa cccaacctca ctaaacttcg caaaatggcc
     4321 caggcctggc gtctctttgg aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc
     4381 atgcctccct gtgagccacc atgagaacag aatcactggt ctaaaaggaa caaagggatg
     4441 ttcactgtat gcctctgagc agagagcagc agcagcaggt accagcacgg ccctgactga
     4501 atcagcccag tgtccctgag cagcttagac agcagggctc tctgtatcag tctttcttga
     4561 gcagatgatt cccctagttg agtagccaga tgaaattcaa gcctaaagac aattcattca
     4621 tttgcatcca tgggcacaga aggttgctat atagtatcta ccttttgcta cttatttaat
     4681 gataaaattt aatgacagtt taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg
     4741 atttttgttt ttgtacagtt ttttttcaag cttcacattt gcgtgtatct aattcagctg
     4801 atgctcaagt ccaaggggta gtctgccttc ccaggctgcc cccagggttt ctgcactggt
     4861 cccctctttt cccttcagtc ttcttcactt ccctt
//