LOCUS AF195657 4895 bp mRNA linear HUM 11-JAN-2000 DEFINITION Homo sapiens DNA mismatch repair protein (MLH3) mRNA, complete cds. ACCESSION AF195657 VERSION AF195657.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4895) AUTHORS Lipkin,S.M., Wang,V., Jacoby,R., Banerjee-Basu,S., Baxevanis,A.D., Lynch,H.T., Elliott,R.M. and Collins,F.S. TITLE MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability JOURNAL Nat. Genet. 24 (1), 27-35 (2000) PUBMED 10615123 REFERENCE 2 (bases 1 to 4895) AUTHORS Lipkin,S.M., Wang,V., Jacoby,R., Banerjee-Basu,S., Baxevanis,A.D., Elliott,R.M., Lynch,H.T. and Collins,F.S. TITLE Direct Submission JOURNAL Submitted (17-OCT-1999) GMBB, NHGRI, 49 Convent Drive, Bethesda, MD 20892, USA FEATURES Location/Qualifiers source 1..4895 /db_xref="H-InvDB:HIT000073653" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="14" /map="14q24.3" gene 1..4895 /gene="MLH3" CDS 115..4404 /gene="MLH3" /codon_start=1 /product="DNA mismatch repair protein" /protein_id="AAF23904.1" /translation="MIKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVR VNMETFQVQVIDNGFGMGSDDVEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIAD MASAVEISSKKNRTMKTFVKLFQSGKALKACEADVTRASAGTTVTVYNLFYQLPVRRK CMDPRLEFEKVRQRIEALSLMHPSISFSLRNDVSGSMVLQLPKTKDVCSRFCQIYGLG KSQKLREISFKYKEFELSGYISSEAHYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWD TLLFCIQEGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQE ACNNILDSYEMFNLQSKAVKRKTTAENVNTQSSRDSEATRKNTNDAFLYIYESGGPGH SKMTEPSLQNKDSSCSESKMLEQETIVASEAGENEKHKKSFLERSSLENPCGTSLEMF LSPFQTPCHFEESGQDLEIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPLP FATTLWGVHSAQTEKEKKKESSNCGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETE HSFKNYVRPGPTRAQETFGNRTRHSVETPDIKDLASTLSKESGQLPNKKNCRTNISYG LENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPWYRHVSNDSRKTDKLIGFSKPI VRKKLSLSSQLGSLEKFKRQYGKVENPLDTEVEESNGVTTNLSLQVEPDILLKDKNRL ENSDVCKITTMEHSDSDSSCQPASHILDSEKFPFSKDEDCLEQQMPSLRESPMTLKEL SLFNRKPLDLEKSSESLASKLSRLKGSERETQTMGMMSRFNELPNSDSSRKDSKLCSV LTQDFCMLFNNKHEKTENGVIPTSDSATQDNSFNKNSKTHSNSNTTENCVISETPLVL PYNNSKVTGKDSDVLIRASEQQIGSLDSPSGMLMNPVEDATGDQNGICFQSEESKARA CSETEESNTCCSDWQRHFDVALGRMVYVNKMTGLSTFIAPTEDIQAACTKDLTTVAVD VVLENGSQYRCQPFRSDLVLPFLPRARAERTVMRQDNRDTVDDTVSSESLQSLFSEWD NPVFARYPEVAVDVSSGQAESLAVKIHNILYPYRFTKGMIHSMQVLQQVDNKFIACLM STKTEENGEADSYEKQQAQGSGRKKLLSSTLIPPLEITVTEEQRRLLWCYHKNLEDLG LEFVFPDTSDSLVLVGKVPLCFVEREANELRRGRSTVTKSIVEEFIREQLELLQTTGG IQGTLPLTVQKVLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLP LADIDHLEQEKQIKPNLTKLRKMAQAWRLFGKAECDTRQSLQQSMPPCEPP" BASE COUNT 1561 a 932 c 1084 g 1318 t ORIGIN 1 gtcggcgtcc gaggcggttg gtgtcggaga atttgttaag cgggactcca ggcaattatt 61 tccagtcaga gaaggaaacc agtgcctggc attctcacca tctttctacc taccatgatc 121 aagtgcttgt cagttgaagt acaagccaaa ttgcgttctg gtttggccat aagctccttg 181 ggccaatgtg ttgaggaact tgccctcaac agtattgatg ctgaagcaaa atgtgtggct 241 gtcagggtga atatggaaac cttccaagtt caagtgatag acaatggatt tgggatgggg 301 agtgatgatg tagagaaagt gggaaatcgt tatttcacca gtaaatgcca ctcggtacag 361 gacttggaga atccaaggtt ttatggtttc cgaggagagg ccttggcaaa tattgctgac 421 atggccagtg ctgtggaaat ttcgtccaag aaaaacagga caatgaaaac ttttgtgaaa 481 ctgtttcaga gtggaaaagc cctgaaagct tgtgaagctg atgtgactag agcaagcgct 541 gggactactg taacagtgta taacctattt taccagcttc ctgtaaggag gaaatgcatg 601 gaccctagac tggagtttga gaaggttagg cagagaatag aagctctctc actcatgcac 661 ccttccattt ctttctcttt gagaaatgat gtttctggtt ccatggttct tcagctccct 721 aaaaccaaag acgtatgttc ccgattttgt caaatttatg gattgggaaa gtcccaaaag 781 ctaagagaaa taagttttaa atataaagag tttgagctta gtggctatat cagctctgaa 841 gcacattaca acaagaatat gcagtttttg tttgtgaaca aaagactagt tttaaggaca 901 aagctacata aactcattga ctttttatta aggaaagaaa gtattatatg caagccaaag 961 aatggtccca ccagtaggca aatgaattca agtcttcggc accggtctac cccagaactc 1021 tatggcatat atgtaattaa tgtgcagtgc caattctgtg agtatgatgt gtgcatggag 1081 ccagccaaaa ctctgattga atttcagaac tgggacactc tcttgttttg cattcaggaa 1141 ggagtgaaaa tgtttttaaa gcaagaaaaa ttatttgtgg aattatcagg tgaggatatt 1201 aaggaattta gtgaagataa tggttttagt ttatttgatg ctactcttca gaagcgtgtg 1261 acttccgatg agaggagcaa tttccaggaa gcatgtaata atattttaga ttcctatgag 1321 atgtttaatt tgcagtcaaa agctgtgaaa agaaaaacta ctgcagaaaa cgtaaacaca 1381 cagagttcta gggattcaga agctaccaga aaaaatacaa atgatgcatt tttgtacatt 1441 tatgaatcag gtggtccagg ccatagcaaa atgacagagc catctttaca aaacaaagac 1501 agctcttgct cagaatcaaa gatgttagaa caagagacaa ttgtagcatc agaagctggt 1561 gaaaatgaga aacataaaaa atctttcctg gaacgtagct ctttagaaaa tccgtgtgga 1621 accagtttag aaatgttttt aagccctttt cagacaccat gtcactttga ggagagtggg 1681 caggatctag aaatatggaa agaaagtact actgttaatg gcatggctgc caacatcttg 1741 aaaaataata gaattcagaa tcaaccaaag agatttaaag atgctactga agtgggatgc 1801 cagcctctgc cttttgcaac aacattatgg ggagtacata gtgctcagac agagaaagag 1861 aaaaaaaaag aatctagcaa ttgtggaaga agaaatgttt ttagttatgg gcgagttaaa 1921 ttatgttcca ctggctttat aactcatgta gtacaaaatg aaaaaactaa atcaactgaa 1981 acagaacatt catttaaaaa ttatgttaga cctggtccca cacgtgccca agaaacattt 2041 ggaaatagaa cacgtcattc agttgaaact ccagacatca aagatttagc cagcacttta 2101 agtaaagaat ctggtcaatt gcccaacaaa aaaaattgca gaacgaatat aagttatggg 2161 ctagagaatg aacctacagc aacttataca atgttttctg cttttcagga aggtagcaaa 2221 aaatcacaaa cagattgcat attatctgat acatccccct ctttcccctg gtatagacac 2281 gtttccaatg atagtaggaa aacagataaa ttaattggtt tctccaaacc aatcgtccgt 2341 aagaagctaa gcttgagttc acagctagga tctttagaga agtttaagag gcaatatggg 2401 aaggttgaaa atcctctgga tacagaagta gaggaaagta atggagtcac taccaatctc 2461 agtcttcaag ttgaacctga cattctgctg aaggacaaga accgcttaga gaactctgat 2521 gtttgtaaaa tcactactat ggagcatagt gattcagata gtagttgtca accagcaagc 2581 cacatccttg actcagagaa gtttccattc tccaaggatg aagattgttt agaacaacag 2641 atgcctagtt tgagagaaag tcctatgacc ctgaaggagt tatctctctt taatagaaaa 2701 cctttggacc ttgagaagtc atctgaatca ctagcctcta aattatccag actgaagggt 2761 tccgaaagag aaactcaaac aatggggatg atgagtcgtt ttaatgaact tccaaattca 2821 gattccagta ggaaagacag caagttgtgc agtgtgttaa cacaagattt ttgtatgtta 2881 tttaacaaca agcatgaaaa aacagagaat ggtgtcatcc caacatcaga ttctgccaca 2941 caggataatt cctttaataa aaatagtaaa acacattcta acagcaatac aacagagaac 3001 tgtgtgatat cagaaactcc tttggtattg ccctataata attctaaagt taccggtaaa 3061 gattcagatg ttcttatcag agcctcagaa caacagatag gaagtcttga ctctcccagt 3121 ggaatgttaa tgaatccggt agaagatgcc acaggtgacc aaaatggaat ttgttttcag 3181 agtgaggaat ctaaagcaag agcttgttct gaaactgaag agtcaaacac gtgttgttca 3241 gattggcagc ggcatttcga tgtagccctg ggaagaatgg tttatgtcaa caaaatgact 3301 ggactcagca cattcattgc cccaactgag gacattcagg ctgcttgtac taaagacctg 3361 acaactgtgg ctgtggatgt tgtacttgag aatgggtctc agtacaggtg tcaacctttt 3421 agaagcgacc ttgttcttcc tttccttccg agagctcgag cagagaggac tgtgatgaga 3481 caggataaca gagatactgt ggatgatact gttagtagcg aatcgcttca gtctttgttc 3541 tcagaatggg acaatccagt atttgcccgt tatccagagg ttgctgttga tgtaagcagt 3601 ggccaggctg agagcttagc agttaaaatt cacaacatct tgtatcccta tcgtttcacc 3661 aaaggaatga ttcattcaat gcaggttctc cagcaagtag ataacaagtt tattgcctgt 3721 ttgatgagca ctaagactga agagaatggc gaggcagatt cctacgagaa gcaacaggca 3781 caaggctctg gtcggaaaaa attactgtct tctactctaa ttcctccgct agagataaca 3841 gtgacagagg aacaaaggag actcttatgg tgttaccaca aaaatctgga agatctgggc 3901 cttgaatttg tatttccaga cactagtgat tctctggtcc ttgtgggaaa agtaccacta 3961 tgttttgtgg aaagagaagc caatgaactt cggagaggaa gatctactgt gaccaagagt 4021 attgtggagg aatttatccg agaacaactg gagctactcc agaccaccgg aggcatccaa 4081 gggacattgc cactgactgt ccagaaggtg ttggcatccc aagcctgcca tggggccatt 4141 aagtttaatg atggcctgag cttacaggaa agttgccgcc ttattgaagc tctgtcctca 4201 tgccagctgc cattccagtg tgctcacggg agaccttcta tgctgccgtt agctgacata 4261 gaccacttgg aacaggaaaa acagattaaa cccaacctca ctaaacttcg caaaatggcc 4321 caggcctggc gtctctttgg aaaagcagag tgtgatacaa ggcagagcct gcagcagtcc 4381 atgcctccct gtgagccacc atgagaacag aatcactggt ctaaaaggaa caaagggatg 4441 ttcactgtat gcctctgagc agagagcagc agcagcaggt accagcacgg ccctgactga 4501 atcagcccag tgtccctgag cagcttagac agcagggctc tctgtatcag tctttcttga 4561 gcagatgatt cccctagttg agtagccaga tgaaattcaa gcctaaagac aattcattca 4621 tttgcatcca tgggcacaga aggttgctat atagtatcta ccttttgcta cttatttaat 4681 gataaaattt aatgacagtt taaaaaaaaa aaaaaaaaaa attatttgaa ggggtgggtg 4741 atttttgttt ttgtacagtt ttttttcaag cttcacattt gcgtgtatct aattcagctg 4801 atgctcaagt ccaaggggta gtctgccttc ccaggctgcc cccagggttt ctgcactggt 4861 cccctctttt cccttcagtc ttcttcactt ccctt //