LOCUS AF195092 2930 bp mRNA linear HUM 25-JAN-2000
DEFINITION Homo sapiens sialic acid-binding immunoglobulin-like lectin-8
(SIGLEC8) mRNA, complete cds.
ACCESSION AF195092
VERSION AF195092.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2930)
AUTHORS Floyd,H., Ni,J., Cornish,A.L., Zeng,Z., Liu,D., Carter,K.C.,
Steel,J. and Crocker,P.R.
TITLE Siglec-8. A novel eosinophil-specific member of the immunoglobulin
superfamily
JOURNAL J. Biol. Chem. 275 (2), 861-866 (2000)
PUBMED 10625619
REFERENCE 2 (bases 1 to 2930)
AUTHORS Floyd,H., Ni,J., Cornish,A.L., Zeng,Z., Liu,D., Carter,K.C.,
Steel,J. and Crocker,P.R.
TITLE Direct Submission
JOURNAL Submitted (14-OCT-1999) Biochemistry, Dundee University, Dow
Street, Dundee DD15EH, United Kingdom
FEATURES Location/Qualifiers
source 1..2930
/db_xref="H-InvDB:HIT000073636"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.33-q13.41"
/cell_type="eosinophil"
gene 1..2930
/gene="SIGLEC8"
CDS 58..1353
/gene="SIGLEC8"
/note="Siglec-8; implicated in eosinophil cell-cell
interactions and signalling functions"
/codon_start=1
/product="sialic acid-binding immunoglobulin-like
lectin-8"
/protein_id="AAF27622.1"
/translation="MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVH
VPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDI
WSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDIL
ILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDH
GTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEG
QSLRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQ
GSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGAGATALAFLSFCIIFIIVRSCRKKSA
RPAAGVGDTGMEDAKAIRGSASQVSDVGFSTPSIQPGHL"
BASE COUNT 654 a 836 c 721 g 719 t
ORIGIN
1 acgcgtccgc tgaggaacag acgttccctg gcggccctgg cgccttcaaa cccagacatg
61 ctgctgctgc tgctgctgct gcccctgctc tgggggacaa aggggatgga gggagacaga
121 caatatgggg atggttactt gctgcaagtg caggagctgg tgacggtgca ggagggcctg
181 tgtgtccatg tgccctgctc cttctcctac ccccaggatg gctggactga ctctgaccca
241 gttcatggct actggttccg ggcaggagac agaccatacc aagacgctcc agtggccaca
301 aacaacccag acagagaagt gcaggcagag acccagggcc gattccaact ccttggggac
361 atttggagca acgactgctc cctgagcatc agagacgcca ggaagaggga taaggggtca
421 tatttctttc ggctagagag aggaagcatg aaatggagtt acaaatcaca gttgaattac
481 aaaactaagc agctgtctgt gtttgtgaca gccctgaccc ataggcctga catcctcatc
541 ctagggaccc tagagtctgg ccactccagg aacctgacct gctctgtgcc ctgggcctgt
601 aagcagggga caccccccat gatctcctgg attggggcct ccgtgtcctc cccgggcccc
661 actactgccc gctcctcagt gctcaccctt accccaaagc cccaggacca cggcaccagc
721 ctcacctgtc aggtgacctt gcctgggaca ggtgtgacca cgaccagtac cgtccgcctc
781 gatgtgtcct accctccttg gaacttgacc atgactgtct tccaaggaga tgccacagca
841 tccacagccc tgggaaatgg ctcatctctt tcagtccttg agggccagtc tctgcgcctg
901 gtctgtgctg tcaacagcaa tccccctgcc aggctgagct ggacccgggg gagcctgacc
961 ctgtgcccct cacggtcctc aaaccctggg ctgctggagc tgcctcgagt gcacgtgagg
1021 gatgaagggg aattcacctg ccgagctcag aacgctcagg gctcccagca catttccctg
1081 agcctctccc tgcagaatga gggcacaggc acctcaagac ctgtatcaca agtgacactg
1141 gcagcagtcg ggggagctgg agccacagcc ctggccttcc tgtccttctg catcatcttc
1201 atcatagtga ggtcctgcag gaagaaatcg gcaaggccag cagcgggcgt gggggataca
1261 ggcatggaag atgcaaaggc catcaggggc tcggcctctc aggtgagtga tgtgggcttc
1321 tccacaccga gcatccagcc tggacacctc tgacaggatg gcccccagga tcgctctctt
1381 tggtatggcc aaagtcactt cctcgtctcc tcctccttcc cacaggccgg cttctacagg
1441 actcccccat cttgctgaca gcatggcagt ccctaccccc aatttttccc aggccaggca
1501 ctgagtagga gttatctcct ctctgtcctc cttttcttct ctatagcccc gattcaccat
1561 ctctcctcca tttttcctcc ccaagaatag ctggcatctc ttctccctgg ccccagccat
1621 cctgacccct ctcattattt ttcctattgg cgggacctga tttctttgac cggcttgtca
1681 tccttacgcc actaacctgt gagcttcccc aggtcaggta tcatgtctca attaaggccc
1741 tgtaattctc tctcatttac tctcgttttg cccgttgtat cataatttac atgtagatac
1801 tcatttctta tttttatttt tttctcgagg cagaatcttg ctctgtcacc taggctggag
1861 tgcagtgggg caatctcggc tcactgcaac ctctgcctcc caggttcaag caattctcct
1921 gcctcagcct cccaagtagc cgggattgca ggcgcgcgcc accaggccag gctaattttt
1981 gtatttttag tagagacggg gtttcaccgt gtcggccagc tggtctcgaa ctcctgacct
2041 cgtgatccgc ccgcctcagc ctcccaaagt gttaggatta ggggcatgag ccaccgcacc
2101 cagcttgcat tgaatatttt caaggagcta aaagaagatt ttaaatggtc tcacaaaaac
2161 agataaatat ttgcacagat gggtgtgcta atcattgtgc cttgatggtt ccacgatgta
2221 tccgggtgtg gaaatctcac tgggtctctc tcaaggccac tcggctactc aggacagggc
2281 tggaatttaa agcctgtccg attctgaggt ctcttctctc atctagcact gagtcaagca
2341 atcagcaggc tgggcacccc ttagccataa gttttcagga aataaattcc ttgagggcat
2401 tgacttttac aaaagaggga gcagcaatgg cctagagtct caggaacaag acaggtgcac
2461 tgaggagatg aaggccggga ccccctgccc aacctgtatg gcgggtctgt acttattttg
2521 tttaccccca atttaaaacg ttttttttta ttgcaggttg tttgtttgat atggtttggc
2581 tgtgtcccca cccaaatctt atctagaatt gtaatcagaa ttataatccc catgtgttgg
2641 gggagggacc tggtgggagg tgataggatc atgggggtgg ttcccccatg ctgttctgat
2701 agtgagtgag ttatcacgag atctgatggt tttgtaagtg gtggtttccc ctgctcttct
2761 ctcttgcctg ccaccatgta agatgtgcct ggttcccctt ccgccatgat tgtaagtttc
2821 ctgaggcctc ccccgccatg tggaactgtg agtcaattac acctctttca tttataaaaa
2881 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//