LOCUS AF191838 2827 bp mRNA linear HUM 08-DEC-1999
DEFINITION Homo sapiens TANK binding kinase TBK1 (TBK1) mRNA, complete cds.
ACCESSION AF191838
VERSION AF191838.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2827)
AUTHORS Pomerantz,J.L. and Baltimore,D.
TITLE NF-kappaB activation by a signaling complex containing TRAF2, TANK
and TBK1, a novel IKK-related kinase
JOURNAL EMBO J. 18 (23), 6694-6704 (1999)
PUBMED 10581243
REFERENCE 2 (bases 1 to 2827)
AUTHORS Pomerantz,J.L. and Baltimore,D.
TITLE Direct Submission
JOURNAL Submitted (04-OCT-1999) Biology, California Institute of
Technology, 1200 East California Boulvard, MC 147-75, Pasadena, CA
91125, USA
FEATURES Location/Qualifiers
source 1..2827
/db_xref="H-InvDB:HIT000073281"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="spleen"
gene 1..2827
/gene="TBK1"
CDS 63..2252
/gene="TBK1"
/note="protein kinase"
/codon_start=1
/product="TANK binding kinase TBK1"
/protein_id="AAF05989.1"
/translation="MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNIS
FLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS
NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA
ARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS
LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVL
LTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATI
FHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGL
IYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELI
KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRL
SSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQF
KKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKML
HLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNT
LVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL"
BASE COUNT 959 a 465 c 593 g 810 t
ORIGIN
1 gccggcggtg gcgcggcgga gacccggctg gtataacaag aggattgcct gatccagcca
61 agatgcagag cacttctaat catctgtggc ttttatctga tattttaggc caaggagcta
121 ctgcaaatgt ctttcgtgga agacataaga aaactggtga tttatttgct atcaaagtat
181 ttaataacat aagcttcctt cgtccagtgg atgttcaaat gagagaattt gaagtgttga
241 aaaaactcaa tcacaaaaat attgtcaaat tatttgctat tgaagaggag acaacaacaa
301 gacataaagt acttattatg gaattttgtc catgtgggag tttatacact gttttagaag
361 aaccttctaa tgcctatgga ctaccagaat ctgaattctt aattgttttg cgagatgtgg
421 tgggtggaat gaatcatcta cgagagaatg gtatagtgca ccgtgatatc aagccaggaa
481 atatcatgcg tgttataggg gaagatggac agtctgtgta caaactcaca gattttggtg
541 cagctagaga attagaagat gatgagcagt ttgtttctct gtatggcaca gaagaatatt
601 tgcaccctga tatgtatgag agagcagtgc taagaaaaga tcatcagaag aaatatggag
661 caacagttga tctttggagc attggggtaa cattttacca tgcagctact ggatcactgc
721 catttagacc ctttgaaggg cctcgtagga ataaagaagt gatgtataaa ataattacag
781 gaaagccttc tggtgcaata tctggagtac agaaagcaga aaatggacca attgactgga
841 gtggagacat gcctgtttct tgcagtcttt ctcggggtct tcaggttcta cttacccctg
901 ttcttgcaaa catccttgaa gcagatcagg aaaagtgttg gggttttgac cagttttttg
961 cagaaactag tgatatactt caccgaatgg taattcatgt tttttcgcta caacaaatga
1021 cagctcataa gatttatatt catagctata atactgctac tatatttcat gaactggtat
1081 ataaacaaac caaaattatt tcttcaaatc aagaacttat ctacgaaggg cgacgcttag
1141 tcttagaacc tggaaggctg gcacaacatt tccctaaaac tactgaggaa aaccctatat
1201 ttgtagtaag ccgggaacct ctgaatacca taggattaat atatgaaaaa atttccctcc
1261 ctaaagtaca tccacgttat gatttagacg gggatgctag catggctaag gcaataacag
1321 gggttgtgtg ttatgcctgc agaattgcca gtaccttact gctttatcag gaattaatgc
1381 gaaaggggat acgatggctg attgaattaa ttaaagatga ttacaatgaa actgttcaca
1441 aaaagacaga agttgtgatc acattggatt tctgtatcag aaacattgaa aaaactgtga
1501 aagtatatga aaagttgatg aagatcaacc tggaagcggc agagttaggt gaaatttcag
1561 acatacacac caaattgttg agactttcca gttctcaggg aacaatagaa accagtcttc
1621 aggatatcga cagcagatta tctccaggtg gatcactggc agacgcatgg gcacatcaag
1681 aaggcactca tccgaaagac agaaatgtag aaaaactaca agtcctgtta aattgcatga
1741 cagagattta ctatcagttc aaaaaagaca aagcagaacg tagattagct tataatgaag
1801 aacaaatcca caaatttgat aagcaaaaac tgtattacca tgccacaaaa gctatgacgc
1861 actttacaga tgaatgtgtt aaaaagtatg aggcattttt gaataagtca gaagaatgga
1921 taagaaagat gcttcatctt aggaaacagt tattatcgct gactaatcag tgttttgata
1981 ttgaagaaga agtatcaaaa tatcaagaat atactaatga gttacaagaa actctgcctc
2041 agaaaatgtt tacagcttcc agtggaatca aacataccat gaccccaatt tatccaagtt
2101 ctaacacatt agtagaaatg actcttggta tgaagaaatt aaaggaagag atggaagggg
2161 tggttaaaga acttgctgaa aataaccaca ttttagaaag gtttggctct ttaaccatgg
2221 atggtggcct tcgcaacgtt gactgtcttt agctttctaa tagaagttta agaaaagttt
2281 ccgtttgcac aagaaaataa cgcttgggca ttaaatgaat gcctttatag atagtcactt
2341 gtttctacaa ttcagtattt gatgtggtcg tgtaaatatg tacaatattg taaatacata
2401 aaaaatatac aaatttttgg ctgctgtgaa gatgtaattt tatcttttaa catttataat
2461 tatatgagga aatttgacct cagtgatcac gagaagaaag ccatgaccga ccaatatgtt
2521 gacatactga tcctctactc tgagtggggc taaataagtt attttctctg accgcctact
2581 ggaaatattt ttaagtggaa ccaaaatagg catccttaca aatcaggaag actgacttga
2641 cacgtttgta aatggtagaa cggtggctac tgtgagtggg gagcagaacc gcaccactgt
2701 tatactggga taacaatttt tttgagaagg ataaagtggc attattttat tttacaaggt
2761 gcccagatcc cagttatcct tgtatccatg taatttcaga tgaattatta agcaaacatt
2821 ttaaagt
//