LOCUS AF187043 3031 bp mRNA linear HUM 26-OCT-1999
DEFINITION Homo sapiens protein tyrosine phosphatase receptor-type O truncated
PTPROt mRNA, alternatively spliced, complete cds.
ACCESSION AF187043
VERSION AF187043.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3031)
AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.
and Shipp,M.A.
TITLE PTPROt: an alternatively spliced and developmentally regulated
B-lymphoid phosphatase that promotes G0/G1 arrest
JOURNAL Blood 94 (7), 2403-2413 (1999)
PUBMED 10498613
REFERENCE 2 (bases 1 to 3031)
AUTHORS Aguiar,R.C.T. and Shipp,M.A.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-1999) Adult Oncology, Dana Farber Cancer
Institute, 44 Binney St., Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..3031
/db_xref="H-InvDB:HIT000072930"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p12-p13"
/clone="YAC 931h4"
/note="anti-Ig activated normal B-lymphocytes"
CDS 487..1704
/note="alternatively spliced; truncated; 47 kDa isoform;
mouse PTP-phi homolog; tissue-specific; related to Homo
sapiens GLEPP1 and PTP-U2; similar to the sequence
presented in GenBank Accession Number AF152378"
/codon_start=1
/product="protein tyrosine phosphatase receptor-type O
truncated PTPROt"
/protein_id="AAF04086.1"
/translation="MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMAREC
GAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRK
LTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNI
LPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQK
SQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYAD
EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGT
FIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQF
CISDVIYENVSKS"
BASE COUNT 841 a 603 c 670 g 917 t
ORIGIN
1 aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat
61 ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct
121 atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag
181 taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc
241 ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct
301 gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa
361 ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac
421 aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc
481 tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt
541 agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg
601 cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat
661 ggaaagcttc catacaactg gcgtaggagt atatttgctt tcttaaccct gctaccctca
721 tgtctttgga ctgattatct tttggcattt tatattaatc cttggagtaa aaatggttta
781 aagaagagga aactgacaaa cccggttcaa ctggatgact ttgatgccta tattaaggat
841 atggccaaag actctgacta taaattttct cttcagtttg aggagttgaa attgattgga
901 ctggatatcc cacactttgc tgcagatctt ccactgaatc gatgtaaaaa ccgttacaca
961 aacatcctac catatgactt cagccgtgtg agattagtct ccatgaatga agaggaaggt
1021 gcagactaca tcaatgccaa ctatattcct ggatacaact caccccagga gtatattgcc
1081 acccaggggc cactgcctga aaccagaaat gacttctgga agatggtcct gcaacaaaag
1141 tctcagatta ttgtcatgct cactcagtgt aatgagaaaa ggagggtgaa atgtgaccat
1201 tactggccat tcacggaaga acctatagcc tatggagaca tcactgtgga gatgatttca
1261 gaggaagagc aggacgactg ggcctgtaga cacttccgga tcaactatgc tgacgagatg
1321 caggatgtga tgcattttaa ctacactgca tggcctgatc atggtgtgcc cacagcaaat
1381 gctgcagaaa gtatcctgca gtttgtacac atggtccgac agcaagctac caagagcaaa
1441 ggtcccatga tcattcactg cagtgctggc gtgggacgga caggaacatt cattgccctg
1501 gacaggctct tgcagcacat tcgggatcat gagtttgttg acatcttagg gctggtgtca
1561 gaaatgaggt cataccggat gtctatggta cagacagagg agcagtacat ttttatccat
1621 cagtgtgtgc aactgatgtg gatgaagaag aagcagcagt tctgcatcag tgatgtcata
1681 tacgagaatg ttagcaagtc ctagttcaga atccggagca gagaggacat gatgtgcgcc
1741 catcctccct tgcttccaga ttgttttagt gggccctgat ggtcattttt ctaaacagag
1801 gccctgcttt gtaatatgtg gccaaggaga taatttatct cacagaagca ccgggaagac
1861 ttagccttaa agagcctaca gtgtcctttt ggactctttc acttcgggac atttaataat
1921 ggaccaaatt caacagaaca ccaggaaggt caagacgctc tccaaagggc aggaagtaca
1981 gcacttccga agagtttagt tggccctttg ctggttgggc tgagtttttt atttttaagt
2041 gtttgttttt cagtgcaata atttttgtgt gtgtgtgatt cttatcagaa agttgaattg
2101 ttttctgcct acaccgttca tcagccccat aacccaggaa ggaacaggca ttgttagcat
2161 cagattatac ctcattatta aaaggaggca tggccacaca tgaagaaatg gtcattctac
2221 ttcaaagaaa ttgagccagc actatctgta ctccaacatt accggatctg gattggggga
2281 ggttggtcag ggaagagagg ggttctaccc acagatcaac tgtgtaatct tttactattc
2341 aagctataat tcagcttcaa agtagagtag aaaaaaaatt gtcttaactg ttctagttct
2401 tgatggtttt cttccttatt aacagttggt gtttcttcct tggccctttt ggactaatgt
2461 tactgtccaa gttctttctc aagaaaccac atctggttca gaagagtgtc aagttggact
2521 ctttgaactc tgttgctgtc tgagcaatcg tggtgcctag actttgcatt ccttgttctg
2581 ttgacctgca tacatgtgag agctatttct ttaagaacta tataggctgt gaaaacgcac
2641 tttctttccc ccaaagagct gggaatttat gaagttatgg caatgaactg cagcatgctg
2701 ggacaattat ttgactactt ttttttgtaa tattgtcaaa tgtctctatg gattctgaca
2761 gagatttctt tttgttttgt tattcttttg gttgtcagtt tcattttaac gagtgtaact
2821 agtaacattt tattctttgg attttgtata attacagtac atgattgtgt attgtgacat
2881 gaatgctgtc aaaatgacat tgatggcatt gtgaagcctg ttactttgtg tcacttcctg
2941 ataaataaga ggtgatgaca tggatataca acagaaaaca ctttgagttg aaagtaaaca
3001 caagctggct gcttccctgt ggcaactgtg g
//