LOCUS AF187042 3979 bp mRNA linear HUM 26-OCT-1999
DEFINITION Homo sapiens protein tyrosine phosphatase receptor-type O truncated
PTPROt mRNA, alternatively spliced, complete cds.
ACCESSION AF187042
VERSION AF187042.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3979)
AUTHORS Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Tiwari,S., Freeman,G.J.
and Shipp,M.A.
TITLE PTPROt: an alternatively spliced and developmentally regulated
B-lymphoid phosphatase that promotes G0/G1 arrest
JOURNAL Blood 94 (7), 2403-2413 (1999)
PUBMED 10498613
REFERENCE 2 (bases 1 to 3979)
AUTHORS Aguiar,R.C.T. and Shipp,M.A.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-1999) Adult Oncology, Dana Farber Cancer
Institute, 44 Binney St., Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..3979
/db_xref="H-InvDB:HIT000072929"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p12-p13"
/clone="YAC 931h4"
/note="anti-Ig activated normal B-lymphocytes"
CDS 487..1620
/note="alternatively spliced; truncated; 43 kDa isoform;
mouse PTP-phi homolog; tissue-specific; related to Homo
sapiens GLEPP1 and PTP-U2; similar to the sequence
presented in GenBank Accession Number AF152378"
/codon_start=1
/product="protein tyrosine phosphatase receptor-type O
truncated PTPROt"
/protein_id="AAF04085.1"
/translation="MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMAREC
GAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQ
FEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP
GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEP
IAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESIL
QFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRS
YRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS"
BASE COUNT 1147 a 785 c 912 g 1135 t
ORIGIN
1 aagtaaaaaa atggaagggg gaaaaggcaa agtattctgc cttccaagtt agatagctat
61 ctttatgaaa ggacatattt caaaggcaat ataaagtctt tatggtgctc ttacctacct
121 atatttgaat tgggggatgc ttcacctgct tattagtgaa agaagaaaga atacacttag
181 taaattaaat tttttttaaa actttgtctt tgctcagaac cagctccacc caaatcactc
241 ttcgcagtga acaaaaccca gacttcagtg actttgctgt gggtggaaga gggagtagct
301 gatttctttg aagttttctg tcaacaagtt ggctccagtc agaaaaccaa acttcaggaa
361 ccagttgctg tttcttccca tgtcgtgacc atctccagcc ttcttcctgc cactgcctac
421 aattgtagtg tcaccagctt tagccatgac agccccagtg tccctacgtt catagccgtc
481 tcaacaatgg ttacagagat gaatcccaat gtggtagtga tctccgtgct ggccatcctt
541 agcacacttt taattggact gttgcttgtt accctcatta ttcttaggaa aaagcatctg
601 cagatggcta gggagtgtgg agctggtaca tttgtcaatt ttgcatcctt agagagggat
661 ggaaagcttc catacaactg gagtaaaaat ggtttaaaga agaggaaact gacaaacccg
721 gttcaactgg atgactttga tgcctatatt aaggatatgg ccaaagactc tgactataaa
781 ttttctcttc agtttgagga gttgaaattg attggactgg atatcccaca ctttgctgca
841 gatcttccac tgaatcgatg taaaaaccgt tacacaaaca tcctaccata tgacttcagc
901 cgtgtgagat tagtctccat gaatgaagag gaaggtgcag actacatcaa tgccaactat
961 attcctggat acaactcacc ccaggagtat attgccaccc aggggccact gcctgaaacc
1021 agaaatgact tctggaagat ggtcctgcaa caaaagtctc agattattgt catgctcact
1081 cagtgtaatg agaaaaggag ggtgaaatgt gaccattact ggccattcac ggaagaacct
1141 atagcctatg gagacatcac tgtggagatg atttcagagg aagagcagga cgactgggcc
1201 tgtagacact tccggatcaa ctatgctgac gagatgcagg atgtgatgca ttttaactac
1261 actgcatggc ctgatcatgg tgtgcccaca gcaaatgctg cagaaagtat cctgcagttt
1321 gtacacatgg tccgacagca agctaccaag agcaaaggtc ccatgatcat tcactgcagt
1381 gctggcgtgg gacggacagg aacattcatt gccctggaca ggctcttgca gcacattcgg
1441 gatcatgagt ttgttgacat cttagggctg gtgtcagaaa tgaggtcata ccggatgtct
1501 atggtacaga cagaggagca gtacattttt atccatcagt gtgtgcaact gatgtggatg
1561 aagaagaagc agcagttctg catcagtgat gtcatatacg agaatgttag caagtcctag
1621 ttcagaatcc ggagcagtaa gtggagaaga gctctccacg agtgttcagt cttagaacta
1681 ttagaggggg atgtgatgga tgggacaaaa gacagcagta gccatttgta ttgactctga
1741 cttcacatga gtatttcttc ccagctcctg gcctcacatg ggtggtcaca gggagaaaca
1801 agtactgtag cagatctttg agtttcaatg caccttggtt ggtgttggca acaaacagga
1861 gcttctgcac atcatgatga ctttacctcc attccctcta cccagaaccc taaattattc
1921 tgttattgga tctgtgcctg taatatcagg atactaccat ccaaatctat ctagatatct
1981 tgtgcaaata ttttattgat tacaagggct gtatacgggg ttacaaaaag acatgagctg
2041 gattggacac tcctaaaacc aaaaacaaca gtgacaatag agtctcagga tagcagagtc
2101 tgaaaatacc ttggtctccc ccattatgtg agcccttatt tgagagcttc atgaagacac
2161 ttgtaacata ttcaacgtcc tgtactccag ttttgactac gagatcagat tttggaggtg
2221 taagtaatct tggctgaggt aacagtaatc tgcccattta gttcagtaaa cagactgtag
2281 agtgtctgac tatactgggg gaagaggagc caatgacagg gtagggagat gacagtggtg
2341 catgatggga gaatcatgaa agtctgggaa gcatatggac cagtgggaag gataggatta
2401 gcactgcacc tctacatcca tcaagagaga cagagcgcac aatggagcag gaaggataaa
2461 aaataaagaa agacagagac aaacaaattt gctgggagag ggaaagacat tcagacccac
2521 agaaaggagg cagcacacag agaaagatgc acagatcaac ccacatctgc atgggttgtg
2581 agactgagca tagtgagagc agtggtggag caatagaaga ttgctgtgac accaggctgc
2641 ttactgtctt tctttgtctc attcacagga gaggacatga tgtgcgccca tcctcccttg
2701 cttccagatt gttttagtgg gccctgatgg tcatttttct aaacagaggc cctgctttgt
2761 aatatgtggc caaggagata atttatctca cagaagcacc gggaagactt agccttaaag
2821 agcctacagt gtccttttgg actctttcac ttcgggacat ttaataatgg accaaattca
2881 acagaacacc aggaaggtca agacgctctc caaagggcag gaagtacagc acttccgaag
2941 agtttagttg gccctttgct ggttgggctg agttttttat ttttaagtgt ttgtttttca
3001 gtgcaataat ttttgtgtgt gtgtgattct tatcagaaag ttgaattgtt ttctgcctac
3061 accgttcatc agccccataa cccaggaagg aacaggcatt gttagcatca gattatacct
3121 cattattaaa aggaggcatg gccacacatg aagaaatggt cattctactt caaagaaatt
3181 gagccagcac tatctgtact ccaacattac cggatctgga ttgggggagg ttggtcaggg
3241 aagagagggg ttctacccac agatcaactg tgtaatcttt tactattcaa gctataattc
3301 agcttcaaag tagagtagaa aaaaaattgt cttaactgtt ctagttcttg atggttttct
3361 tccttattaa cagttggtgt ttcttccttg gcccttttgg actaatgtta ctgtccaagt
3421 tctttctcaa gaaaccacat ctggttcaga agagtgtcaa gttggactct ttgaactctg
3481 ttgctgtctg agcaatcgtg gtgcctagac tttgcattcc ttgttctgtt gacctgcata
3541 catgtgagag ctatttcttt aagaactata taggctgtga aaacgcactt tctttccccc
3601 aaagagctgg gaatttatga agttatggca atgaactgca gcatgctggg acaattattt
3661 gactactttt ttttgtaata ttgtcaaatg tctctatgga ttctgacaga gatttctttt
3721 tgttttgtta ttcttttggt tgtcagtttc attttaacga gtgtaactag taacatttta
3781 ttctttggat tttgtataat tacagtacat gattgtgtat tgtgacatga atgctgtcaa
3841 aatgacattg atggcattgt gaagcctgtt actttgtgtc acttcctgat aaataagagg
3901 tgatgacatg gatatacaac agaaaacact ttgagttgaa agtaaacaca agctggctgc
3961 ttccctgtgg caactgtgg
//