LOCUS       AF186377                9138 bp    mRNA    linear   HUM 05-JUN-2001
DEFINITION  Homo sapiens LIP isoform of BLIP (BLIP) mRNA, complete cds.
ACCESSION   AF186377
VERSION     AF186377.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9138)
  AUTHORS   Sanchez,P., Pastor,J., Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of BLIP, a novel isoform of LIP with a
            FRAP/ATM-like kinase domain
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9138)
  AUTHORS   Sanchez,P., Pastor,J., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-SEP-1999) CBMSO, CSIC-UAM, Universidad Autonoma-Canto
            Blanco, Madrid 28049, Spain
FEATURES             Location/Qualifiers
     source          1..9138
                     /db_xref="H-InvDB:HIT000072915"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..9138
                     /gene="BLIP"
     CDS             152..7330
                     /gene="BLIP"
                     /function="regulates NF-kappaB"
                     /note="contains FRAP/ATM-like kinase domain"
                     /codon_start=1
                     /product="LIP isoform of BLIP"
                     /protein_id="AAK58892.1"
                     /translation="MKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKW
                     QSITENVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTE
                     DCLIPLFSEALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAA
                     KFARKRGNVSLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEK
                     TKLLYTAGQSTHAMEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQ
                     VYRAQHQQNFTGLSTLSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQ
                     LYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTI
                     TEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLS
                     ELDESATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRV
                     EQSTDDMIVMATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEV
                     YVRQSICNLLCRVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEE
                     LLVSECEGGSPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQML
                     VAELRRVTVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREK
                     HTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYGDAIENALEKLKTPLNPAKPGSS
                     WIPFKEIMLNLQQRAQKRASYILRLEEISPWLAAMTNTEIALPGEVSARDTVTIHSVG
                     GTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQ
                     ETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQ
                     NPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKE
                     LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNV
                     CFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLE
                     AFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVN
                     WFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHT
                     LQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQ
                     MDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATV
                     ALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITA
                     TEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLS
                     LASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQL
                     LKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYT
                     LESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQY
                     GELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKID
                     IIREARSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQN
                     TVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFIS
                     ALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTA
                     WKKHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILT
                     SMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAER
                     RNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQF
                     NSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVC
                     ETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEY
                     KSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPL
                     VTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPP
                     STVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSV
                     AEQVDYVIKEATNLDNLAQLYEGWTAWV"
BASE COUNT         2738 a         1903 c         2150 g         2347 t
ORIGIN      
        1 agaaaaaata gagtttcact ctgttgccca ggctggagtg cagtgacgca atctcggctc
       61 actgcagcct ctgccctctg agttcaagtg attctcctgc ctcagcctcc tgagtagctg
      121 ggattacagg tgtctgccac cgtgcccaga catgaaaaaa ctgcttccta acatgttaag
      181 tccggatccg agggaacttc agaaatccat tgaagttcaa ttgttaagaa gttctgtttg
      241 tttggcaact gctttaaacc cgatagaaca agatcagaag tggcagtcta taactgaaaa
      301 tgtggtaaag tacttgaagc aaacatcccg catcgctatt ggacctctga gactttctac
      361 tttaacagtt tcacagtctt tgccagttct aagtaccttg cagctgtatt gctcatctgc
      421 tttggagaac acagtttcta acagactttc aacagaggac tgtcttattc cactcttcag
      481 tgaagcttta cgttcatgta aacagcatga cgtgaggcca tggatgcagg cattaaggta
      541 tactatgtac cagaatcagt tgttggagaa aattaaagaa caaacagtcc caattagaag
      601 ccatctcatg gaattaggtc taacagcagc aaaatttgct agaaaacgag ggaatgtgtc
      661 ccttgcaaca agactgctgg cacagtgcag tgaagttcag ctgggaaaga ccaccactgc
      721 acaggattta gtccaacatt ttaaaaaact atcaacccaa ggtcaagtgg atgaaaaatg
      781 ggggcccgaa cttgatattg aaaaaaccaa attgctttat acagcaggcc agtcaacaca
      841 tgcaatggaa atgttgagtt cttgtgccat atctttctgc aagtctgtga aagctgaata
      901 tgcagttgct aaatcaattc tgacactggc taaatggatc caggcagaat ggaaagagat
      961 ttcaggacag ctgaaacagg tttacagagc tcagcaccaa cagaacttca caggtctttc
     1021 tactttgtct aaaaacatac tcactctaat agaactgcca tctgttaata cgatggaaga
     1081 agagtatcct cggatcgaga gtgaatctac agtgcatatt ggagttggag aacctgactt
     1141 cattttggga cagttgtatc acctgtcttc agtacaggca cctgaagtag ccaaatcttg
     1201 ggcagcgttg gccagctggg cttataggtg gggcagaaag gtggttgaca atgccagtca
     1261 gggagaaggt gttcgtctgc tgcctagaga aaaatctgaa gttcagaatc tacttccaga
     1321 cactataact gaggaagaga aagagagaat atatggtatt cttggacagg ctgtgtgtcg
     1381 gccggcgggg attcaggatg aagatataac acttcagata actgagagtg aagacaacga
     1441 agaagatgac atggttgatg ttatctggcg tcagttgata tcaagctgcc catggctttc
     1501 agaacttgat gaaagtgcaa ctgaaggagt tattaaagtg tggaggaaag ttgtagatag
     1561 aatattcagc ctgtacaaac tctcttgcag tgcatacttt actttcctta aactcaacgc
     1621 tggtcaaatt cctttagatg aggatgaccc taggctgcat ttaagtcaca gagtggaaca
     1681 gagcactgat gacatgattg tgatggccac attgcgcctg ctgcggttgc tcgtgaagca
     1741 cgctggtgag cttcggcagt atctggagca cggcttggag acaacaccca ctgcaccatg
     1801 gagaggaatt attccgcaac ttttctcacg cttaaaccac cctgaagtgt atgtgcgcca
     1861 aagtatttgt aaccttctct gccgtgtggc tcaagattcc ccacatctca tattgtatcc
     1921 tgcaatagtg ggtaccatat cgcttagtag tgaatcccag gcttcaggaa ataaattttc
     1981 cactgcaatt ccaactttac ttggcaatat tcaaggagaa gaattgctgg tttctgaatg
     2041 tgagggagga agtcctcctg catctcagga tagcaataag gatgaaccta aaagtggatt
     2101 aaatgaagac caagccatga tgcaggattg ttacagcaaa attgtagata agctgtcctc
     2161 tgcaaacccc accatggtat tacaggttca gatgctcgtg gctgaactgc gcagggtcac
     2221 tgtgctctgg gatgagctct ggctgggagt tttgctgcaa caacacatgt atgtcctgag
     2281 acgaattcag cagcttgaag atgaggtgaa gagagtccag aacaacaaca ccttacgcaa
     2341 agaagagaaa attgcaatca tgagggagaa gcacacagct ttgatgaagc ccatcgtatt
     2401 tgctttggag catgtgagga gtatcacagc ggctcctgca gaaacacctc atgaaaaatg
     2461 gtttcaggat aactatggtg atgccattga aaatgcccta gaaaaactga agactccatt
     2521 gaaccctgca aagcctggga gcagctggat tccatttaaa gagataatgc taaatttgca
     2581 acagagagca cagaaacgtg caagttacat cttgcgtctt gaagaaatca gtccatggtt
     2641 ggctgccatg actaacactg aaattgctct tcctggggaa gtctcagcca gagacactgt
     2701 cacaatccat agtgtgggcg gaaccatcac aatcttaccg actaaaacca agccaaagaa
     2761 acttctcttt cttggatcag atgggaagag ctatccttat cttttcaaag gactggagga
     2821 tttacatctg gatgagagaa taatgcagtt cctatctatt gtgaatacca tgtttgctac
     2881 aattaatcgc caagaaacac cccggttcca tgctcgacac tattctgtaa caccactagg
     2941 aacaagatca ggactaatcc agtgggtaga tggagccaca cccttatttg gtctttacaa
     3001 acgatggcaa caacgggaag ctgccttaca agcacaaaag gcccaagatt cctaccaaac
     3061 tcctcagaat cctggaattg taccccgtcc tagtgaactt tattacagta aaattggccc
     3121 tgctttgaaa acagttgggc ttagcctgga tgtgtcccgt cgggattggc ctcttcatgt
     3181 aatgaaggca gtattggaag agttaatgga ggccacaccc ccgaatctcc ttgccaaaga
     3241 gctctggtca tcttgcacaa cacctgatga atggtggaga gttacgcagt cttatgcaag
     3301 atctactgca gtcatgtcta tggttggata cataattggc cttggagaca gacatctgga
     3361 taatgttctt atagatatga cgactggaga agttgttcac atagattaca atgtttgctt
     3421 tgaaaaaggt aaaagcctta gagttcctga gaaagtacct tttcgaatga cacaaaacat
     3481 tgaaacagca ctgggtgtaa ctggagtaga aggtgtattt aggctttcat gtgagcaggt
     3541 tttacacatt atgcggcgtg gcagagagac cctgctgacg ctgctggagg cctttgtgta
     3601 cgaccctctg gtggactgga cagcaggagg cgaggctggg tttgctggtg ctgtctatgg
     3661 tggaggtggc cagcaggccg agagcaagca gagcaagaga gagatggagc gagagatcac
     3721 ccgcagcctg ttttcttcta gagtagctga gattaaggtg aactggttta agaatagaga
     3781 tgagatgctg gttgtgcttc ccaagttgga cggtagctta gatgaatacc taagcttgca
     3841 agagcaactg acagatgtgg aaaaactgca gggcaaacta ctggaggaaa tagagtttct
     3901 agaaggagct gaaggggtgg atcatccttc tcatactctg caacacaggt attctgagca
     3961 cacccaacta cagactcagc aaagagctgt tcaggaagca atccaggtga agctgaatga
     4021 atttgaacaa tggataacac attatcaggc tgcattcaat aatttagaag caacacagct
     4081 tgcaagcttg cttcaagaga taagcacaca aatggacctt ggtcctccaa gttacgtgcc
     4141 agcaacagcc tttctgcaga atgctggtca ggcccacttg attagccagt gcgagcagct
     4201 ggagggggag gttggtgctc tcctgcagca gaggcgctcc gtgctccgtg gctgtctgga
     4261 gcaactgcat cactatgcaa ccgtggccct gcagtatccg aaggccatat ttcagaaaca
     4321 tcgaattgaa cagtggaaga cctggatgga agagctcatc tgtaacacca cagtagagcg
     4381 ttgtcaagag ctctatagga aatatgaaat gcaatatgct ccccagccac ccccaacagt
     4441 gtgtcagttc atcactgcca ctgaaatgac cctgcagcga tacgcagcag acatcaacag
     4501 cagacttatt agacaagtgg aacgcttgaa acaggaagct gtcactgtgc cagtttgtga
     4561 agatcagttg aaagaaattg aacgttgcat taaagttttc cttcatgaga atggagaaga
     4621 aggatctttg agtctagcaa gtgttattat ttctgccctt tgtaccctta caaggcgtaa
     4681 cctgatgatg gaaggtgcag cgtcaagtgc tggagaacag ctggttgatc tgacttctcg
     4741 ggatggagcc tggttcttgg aggaactctg cagtatgagc ggaaacgtca cctgcttggt
     4801 tcagttactg aagcagtgcc acctggtgcc acaggactta gatatcccga accccatgga
     4861 agcgtctgag acagttcact tagccaatgg agtgtatacc tcacttcagg aattgaattc
     4921 gaatttccgg caaatcatat ttccagaagc acttcgatgt ttaatgaaag gggaatacac
     4981 gttagaaagt atgctgcatg aactggacgg tcttattgag cagaccaccg atggcgttcc
     5041 cctgcagact ctagtggaat ctcttcaggc ctacttaaga aacgcagcta tgggactgga
     5101 agaagaaaca catgctcatt acatcgatgt tgccagacta ctacatgctc agtacggtga
     5161 attaatccaa ccgagaaatg gttcagttga tgaaacaccc aaaatgtcag ctggccagat
     5221 gcttttggta gcattcgatg gcatgtttgc tcaagttgaa actgctttca gcttattagt
     5281 tgaaaagttg aacaagatgg aaattcccat agcttggcga aagattgaca tcataaggga
     5341 agccaggagt actcaagtta atttttttga tgatgataat caccggcagg tgctagaaga
     5401 gattttcttt ctaaaaagac tacagactat taaggagttc ttcaggctct gtggtacctt
     5461 ttctaaaaca ttgtcaggat caagttcact tgaagatcag aatactgtga atgggcctgt
     5521 acagattgtc aatgtgaaaa ccctttttag aaactcttgt ttcagtgaag accaaatggc
     5581 caaacctatc aaggcattca cagctgactt tgtgaggcag ctcttgatag ggctacccaa
     5641 ccaagccctc ggactcacac tgtgcagttt tatcagtgct ctgggtgtag acatcattgc
     5701 tcaagtagag gcaaaggact ttggtgccga aagcaaagtt tctgttgatg atctctgtaa
     5761 gaaagcggtg gaacataaca tccagatagg gaagttctct cagctggtta tgaacagggc
     5821 aactgtgtta gcaagttctt acgacactgc ctggaagaag catgacttgg tgcgaaggct
     5881 agaaaccagt atttcttctt gtaagacaag cctgcagcgg gttcagctgc atattgccat
     5941 gtttcagtgg caacatgaag atctacttat caatagacca caagccatgt cagtcacacc
     6001 tcccccacgg tctgctatcc taaccagcat gaaaaagaag ctgcataccc tgagccagat
     6061 tgaaacttct attgcgacag ttcaggagaa gctagctgca cttgaatcaa gtattgaaca
     6121 gcgactcaag tgggcaggtg gtgccaaccc tgcattggcc cctgtactac aagattttga
     6181 agcaacgata gctgaaagaa gaaatcttgt ccttaaagag agccaaagag caagtcaggt
     6241 cacatttctc tgcagcaata tcattcattt tgaaagttta cgaacaagaa ctgcagaagc
     6301 cttaaacctg gatgcggcgt tatttgaact aatcaagcga tgtcagcaga tgtgttcgtt
     6361 tgcatcacag tttaacagtt cagtgtctga gttagagctt cgtttattac agagagtgga
     6421 cactggtctt gaacatccta ttggcagctc tgaatggctt ttgtcagcac acaaacagtt
     6481 gacccaggat atgtctactc agagggcaat tcagacagag aaagagcagc agatagaaac
     6541 ggtctgtgaa acaattcaga atctggttga taatataaag actgtgctca ctggtcataa
     6601 ccgacagctt ggagatgtca aacatctctt gaaagctatg gctaaggatg aagaagctgc
     6661 tctggcagat ggtgaagatg ttccctatga gaacagtgtt aggcagtttt tgggtgaata
     6721 taaatcatgg caagacaaca ttcaaacagt tctatttaca ttagtccagg ctatgggtca
     6781 ggttcgaagt caagaacacg ttgaaatgct ccaggaaatc actcccacct tgaaagaact
     6841 gaaaacacaa agtcagagta tctataataa tttagtgagt tttgcatcac ccttagtcac
     6901 cgatgcaaca aatgaatgtt cgagtccaac gtcatctgct acttatcagc catccttcgc
     6961 tgcagcagtc cggagtaaca ctggccagaa gactcagcct gatgtcatgt cacagaatgc
     7021 tagaaagctg atccagaaaa atcttgctac atcagctgat actccaccaa gcaccgttcc
     7081 aggaactggc aagagtgttg cttgtagtcc taaaaaggca gtcagagacc ctaaaactgg
     7141 gaaagcggtg caagagagaa actcctatgc agtgagtgtg tggaagagag tgaaagccaa
     7201 gttagagggc cgagatgttg atccgaatag gaggatgtca gttgctgaac aggttgacta
     7261 tgtcattaag gaagcaacta atctagataa cttggctcag ctgtatgaag gttggacagc
     7321 ctgggtgtga atggcaagac agtagatgag tctggttaag cgaggtcaga catccaccag
     7381 aatcaactca gcctcaggca tccaaagcca caccacagtc ggtggtgatg caactggggg
     7441 cttactctga ggaaacctag gaaatctcgg tgcactagga agtgaatccc gcaggacagc
     7501 tgcactcagg gatacgccca acaccatggc ctgcaacccc agggtcaagg gtgaaggaaa
     7561 gcaagctcac cgcctgaaca cggagattgt ctttctgcca cagaacagca gcagacgtgt
     7621 cgggaggtta gctgcggaaa gaaatcggga tgccgcggag cacagagtga tttggaactc
     7681 cattccacct gaccctgtgt gtacaatcca ggaaaaaaac aaaccccact cagaaacaga
     7741 gaaaactggg gtcgcgaaga aatcacagcc aaggaagatt tgatgcattc agattctcgt
     7801 gtaacacttg ttgcttggca acagtactgg ttgggttgac cagtaagtag aaaaaggcta
     7861 aaggctatgc gatatgaatt tcagaaatgg actgaaaatg gagagctatg taacagatac
     7921 actacagtag aagaacttac ttctgaaatg aagggaaaaa aaccacccca tcgttcccta
     7981 ctcctcccca ccacttaccc gttccccctt tacctaatct agtagattag ccatctttca
     8041 aattcacttt tatttcagtc cttatatttc atatacttcc gtctcgatgc tgttaacaac
     8101 ttctgataac atggaaaatt caaggattgt ttaaaggtct gatgatcaca cacaaaatgt
     8161 aattccggtt atttaagtca tttctgtgat tctatcatgt acagtttcca gaattgtcac
     8221 tgtgcattca aaagtaatga atctaacaga catttgattt aatgtacact cccttttgct
     8281 tatagtgtgc attttttttg gaggtcattc aaattttccc tcttctgtga tagctgtagt
     8341 ttctttcata gaaagtagct aatccagtgt aatcttttac ctttttaaaa accaagatag
     8401 agtatctatt agagttttac attgttgatg atagattaac aataaagtga tgttctggtg
     8461 gaggtagact gaaatttttt taattcatgt ttttcatttg atacttttaa tttacactta
     8521 gtaaattaaa agttgtttaa tttacttggc attttaggac atgtacatga aacagtgaaa
     8581 atgagatcca ccaacatctt ttattaagtt cagttattag tctgtgaagt gctttacttt
     8641 ttgcacaatt ttaatagctt gctattcagt aatacattat agtgaattca tgatcaaggt
     8701 ttccttaaat ttagcattgc atttcagtac tgactgtgta agctaaattg ctgatccaaa
     8761 ataaaaaccc agactagaat agggttctta aaatcaagta tcaatacaaa atagaacaca
     8821 attaaaatct taattgttgg ctgggcacag tggctcacgc ctgtaatccc agcactttgg
     8881 gaggccgagg cgggcggatc atgaggttag gagagcgaga ccatcctggc taacacggtg
     8941 aaaccccgtc tttactaaaa tacaaaaaaa attagccggg tgtggtggcg ggcgcctgta
     9001 gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg aacccaggag gcggagcttg
     9061 cagtgagccg agattgtgcc actgcactcc agcctgggca acagagctag actctgtgtc
     9121 aaaaataaat gactagat
//