LOCUS AF184965 2640 bp mRNA linear HUM 14-FEB-2000
DEFINITION Homo sapiens ribosomal S6 kinase (RPS6KA6) mRNA, complete cds.
ACCESSION AF184965
VERSION AF184965.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2640)
AUTHORS Yntema,H.G., van den Helm,B., Kissing,J., van Duijnhoven,G.,
Poppelaars,F., Chelly,J., Moraine,C., Fryns,J.-P., Hamel,B.C.J.,
Heilbronner,H., Pander,H.-J., Brunner,H.G., Ropers,H.-H.,
Cremers,F.P.M. and van Bokhoven,H.
TITLE A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in
patients with complex X-linked mental retardation
JOURNAL Genomics 62 (3), 332-343 (1999)
PUBMED 10644430
REFERENCE 2 (bases 1 to 2640)
AUTHORS Yntema,H.G.
TITLE Direct Submission
JOURNAL Submitted (09-SEP-1999) Human Genetics (417), University Hospital
Nijmegen, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands
FEATURES Location/Qualifiers
source 1..2640
/db_xref="H-InvDB:HIT000072887"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq21.1"
gene 1..2640
/gene="RPS6KA6"
/note="RSK4"
CDS 81..2318
/gene="RPS6KA6"
/note="90 kDa; polypeptide 4"
/codon_start=1
/product="ribosomal S6 kinase"
/protein_id="AAF13190.1"
/translation="MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEAD
SCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLY
AMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV
FTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG
LSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK
DRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANID
WDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVA
TSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNM
EFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDR
ILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDF
GFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFAN
GPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSW
ITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKR
TSTGL"
BASE COUNT 830 a 448 c 566 g 796 t
ORIGIN
1 acggtttttt tttttttttt tttttttttt tttttttttt tttttttttt ttttataaaa
61 ttattagtat aaaaggggaa atgctaccat tcgctcctca ggacgagccc tgggaccgag
121 aaatggaagt gttcagcggc ggcggcgcga gcagcggcga ggtaaatggt cttaaaatgg
181 ttgatgagcc aatggaagag ggagaagcag attcttgtca tgatgaagga gttgttaaag
241 aaatccctat tactcatcat gttaaggaag gctatgagaa agcagatcct gcacagtttg
301 agttgctcaa ggttcttggt caggggtcat ttggaaaggt ttttcttgtt agaaagaaga
361 ccggtcctga tgctgggcag ctctatgcaa tgaaggtgtt aaaaaaagcc tctttaaaag
421 ttcgagacag agttcggaca aagatggaga gggatatact ggtggaagta aatcatccat
481 ttattgtcaa attgcactat gcctttcaga ctgaagggaa actgtactta atactggatt
541 ttctcagggg aggagatgtt ttcacaagat tatccaaaga ggttctgttt acagaggaag
601 atgtgaaatt ctacctcgca gaactggccc ttgctttgga tcatctgcac caattaggaa
661 ttgtttatag agacctgaag ccagaaaaca ttttgcttga tgaaatagga catatcaaat
721 taacagattt tggactcagc aaggagtcag tagatcaaga aaagaaggct tactcatttt
781 gtggtacagt agagtatatg gctcctgaag tagtaaatag gagaggccat tcccagagtg
841 ctgattggtg gtcatatggt gttcttatgt ttgaaatgct tactggtact ctgccatttc
901 aaggtaaaga cagaaatgag accatgaata tgatattaaa agcaaaactt ggaatgcctc
961 aatttcttag tgctgaagca caaagtcttc taaggatgtt attcaaaagg aatccagcaa
1021 atagattggg atcagaagga gttgaagaaa tcaaaagaca tctgtttttt gcaaatattg
1081 actgggataa attatataaa agagaagttc aacctccttt caaacctgct tctggaaaac
1141 cagatgatac tttttgtttt gatcctgaat ttactgcaaa aacacctaaa gattctcccg
1201 gtttgccagc cagtgcaaat gctcatcagc tcttcaaagg attcagcttt gttgcaactt
1261 ctattgcaga agaatataaa atcactccta tcacaagtgc aaatgtatta ccaattgttc
1321 agataaatgg aaatgctgca caatttggtg aagtatatga attgaaggag gatattggtg
1381 ttggctccta ctctgtttgc aagcgatgca tacatgcaac taccaacatg gaatttgcag
1441 tgaagatcat tgacaaaagt aagcgagacc cttcagaaga gattgaaata ttgatgcgct
1501 atggacaaca tcccaacatt attactttga aggatgtctt tgatgatggt agatatgttt
1561 accttgttac ggatttaatg aaaggaggag agttacttga ccgtattctc aaacaaaaat
1621 gtttctcgga acgggaggct agtgatatac tatatgtaat aagtaagaca gttgactatc
1681 ttcattgtca aggagttgtt catcgtgatc ttaaacctag taatatttta tacatggatg
1741 aatcagccag tgcagattca atcaggatat gtgattttgg gtttgcaaaa caacttcgag
1801 gagaaaatgg acttctctta actccatgct acactgcaaa ctttgttgca cctgaggttc
1861 ttatgcaaca gggatatgat gctgcttgtg atatctggag tttaggagtc cttttttaca
1921 caatgttggc tggctacact ccatttgcta atggccccaa tgatactcct gaagagatac
1981 tgctgcgtat aggcaatgga aaattctctt tgagtggtgg aaactgggac aatatttcag
2041 acggagcaaa ggatttgctt tcccatatgc ttcatatgga cccacatcag cggtatactg
2101 ctgaacaaat attaaagcac tcatggataa ctcacagaga ccagttgcca aatgatcagc
2161 caaagagaaa tgatgtgtca catgttgtta agggagcaat ggttgcaaca tactctgccc
2221 tgactcacaa gacctttcaa ccagtcctag agcctgtagc tgcttcaagc ttagcccagc
2281 gacggagcat gaaaaagcga acatcaactg gcctgtaaga tttgtggtgt tcctaggcca
2341 aactggatga agatgaaatt aaatgtgtgg cttttttcct attcttatca aaggcatcgt
2401 tgtctgctaa attacttgaa tattaagtaa tattaaatcc ccatttttag gggaagtgag
2461 atttaaaaaa ccattcacag gtccacaata ttcatactat gtgtttgcag tagtgttcaa
2521 gtgtttattt aagcatataa ttggtgtcca ccaggtcctc acaacttctc tgcacacaag
2581 cttctaaaat tcctttcaaa taaagttact ttaatattta aaaaaaaaaa aaaaaaaaaa
//