LOCUS AF183810 10011 bp mRNA linear HUM 10-JAN-2000
DEFINITION Homo sapiens zinc finger transcription factor TRPS1 mRNA, complete
cds.
ACCESSION AF183810
VERSION AF183810.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10011)
AUTHORS Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
TITLE Mutations in a new gene, encoding a zinc-finger protein, cause
tricho-rhino-phalangeal syndrome type I
JOURNAL Nat. Genet. 24 (1), 71-74 (2000)
PUBMED 10615131
REFERENCE 2 (bases 1 to 10011)
AUTHORS Momeni,P., Gloeckner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
Rosenthal,A., Horsthemke,B. and Luedecke,H.-J.
TITLE Direct Submission
JOURNAL Submitted (06-SEP-1999) Institut fuer Humangenetik,
Universitaetsklinikum, Hufelandstr. 55, D-45122 Essen, Germany
FEATURES Location/Qualifiers
source 1..10011
/db_xref="H-InvDB:HIT000072874"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.1"
CDS 639..4484
/note="tricho-rhino-phalangeal syndrome type I protein"
/codon_start=1
/product="zinc finger transcription factor TRPS1"
/protein_id="AAF23614.1"
/translation="MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSE
NTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPH
DEVTDRNMLAFSFPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKA
TEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPE
LQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHS
KDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFR
CKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSG
DLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLK
LLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKK
DFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPF
CPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTP
DVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEIS
RHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEP
KIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGAD
ILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGA
PAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGG
YVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNE
EQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHK
RMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIE
KYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPT
FNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEK
VDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHI
QRGLHRNNAQVEKNGKPKE"
BASE COUNT 3067 a 1963 c 2056 g 2925 t
ORIGIN
1 ttcctccgcg aaggctcctt tgatattaat agtgttggtg tcttgaaact gacgtaatgc
61 gcggagactg aggtcctgac aagcgataac atttctgata aagacccgat cttactgcaa
121 tctctagcgt cctctttttt ggtgctgctg gtttctccag acctcgcgtc ctctcgattg
181 ctctctcgcc ttcctatttc tttttttttt ttttaaacaa aaaacaacac cccctcccct
241 ctcccacccg gcaccgggca catccttgct ctatttcctt tctctttctc tctctctctc
301 tctctttttt aataagggtg ggggagggaa agggggggga ggcaggaaag acctttttct
361 ctcccccccg caataatcca agatcaactc tgcaaacaac agaagacggt tcatggcttt
421 ggccgccgcg ccaccatctt tcgggctgcc gagggtgttc ttgacgatta atcaacagat
481 gtacagatca gctctcaaaa tgtcttctgt gtcttctgag cgtcttctaa gacaattgca
541 ttagcctcct gctagttgac taatagaatt aataattgta aaaagcactc taaagccaca
601 tgccttatga agtcaatgct gggtatgatt ttacaaatat ggtccggaaa aagaaccccc
661 ctctgagaaa cgttgcaagt gaaggcgagg gccagatcct ggagcctata ggtacagaaa
721 gcaaggtatc tggaaagaac aaagaattct ctgcagatca gatgtcagaa aatacggatc
781 agagtgatgc tgcagaacta aatcataagg aggaacatag cttgcatgtt caagatccat
841 cttctagcag taagaaggac ttgaaaagcg cagttctgag tgagaaggct ggcttcaatt
901 atgaaagccc cagtaaggga ggaaactttc cctcctttcc gcatgatgag gtgacagaca
961 gaaatatgtt ggctttctca tttccagctg ctgggggagt ctgtgagccc ttgaagtctc
1021 cgcaaagagc agaggcagat gaccctcaag atatggcctg caccccctca ggggactcac
1081 tggagacaaa ggaagatcag aagatgtcac caaaggctac agaggaaaca gggcaagcac
1141 agagtggtca agccaattgt caaggtttga gcccagtttc agtggcctca aaaaacccac
1201 aagtgccttc agatgggggt gtaagactga ataaatccaa aactgactta ctggtgaatg
1261 acaacccaga cccggcacct ctgtctccag agcttcagga ctttaaatgc aatatctgtg
1321 gatatggtta ctacggcaac gaccccacag atctgattaa gcacttccga aagtatcact
1381 taggactgca taaccgcacc aggcaagatg ctgagctgga cagcaaaatc ttggcccttc
1441 ataacatggt gcagttcagc cattccaaag acttccagaa ggtcaaccgt tctgtgtttt
1501 ctggtgtgct gcaggacatc aattcttcaa ggcctgtttt actaaatggg acctatgatg
1561 tgcaggtgac ttcaggtgga acattcattg gcattggacg gaaaacacca gattgccaag
1621 ggaacaccaa gtatttccgc tgtaaattct gcaatttcac ttatatgggc aactcatcca
1681 ccgaattaga acaacatttt cttcagactc acccaaacaa aataaaagct tctctcccct
1741 cctctgaggt tgcaaaacct tcagagaaaa actctaacaa gtccatccct gcacttcaat
1801 ccagtgattc tggagacttg ggaaaatggc aggacaagat aacagtcaaa gcaggagatg
1861 acactcctgt tgggtactca gtgcccataa agcccctcga ttcctctaga caaaatggta
1921 cagaggccac cagttactac tggtgtaaat tttgtagttt cagctgtgag tcatctagct
1981 cacttaaact gctagaacat tatggcaagc agcacggagc agtgcagtca ggcggcctta
2041 atccagagtt aaatgataag ctttccaggg gctctgtcat taatcagaat gatctagcca
2101 aaagttcaga aggagagaca atgaccaaga cagacaagag ctcgagtggg gctaaaaaga
2161 aggacttctc cagcaaggga gccgaggata atatggtaac gagctataat tgtcagttct
2221 gtgacttccg atattccaaa agccatggcc ctgatgtaat tgtagtgggg ccacttctcc
2281 gtcattatca acagctccat aacattcaca agtgtaccat taaacactgt ccattctgtc
2341 ccagaggact ttgcagccca gaaaagcacc ttggagaaat tacttatccg tttgcttgta
2401 gaaaaagtaa ttgttcccac tgtgcactct tgcttctgca cttgtctcct ggggcggctg
2461 gaagctcgcg agtcaaacat cagtgccatc agtgttcatt caccacccct gacgtagatg
2521 tactcctctt tcactatgaa agtgtgcatg agtcccaagc atcggatgtc aaacaagaag
2581 caaatcacct gcaaggatcg gatgggcagc agtctgtcaa ggaaagcaaa gaacactcat
2641 gtaccaaatg tgattttatt acccaagtgg aagaagagat ttcccgacac tacaggagag
2701 cacacagctg ctacaaatgc cgtcagtgca gttttacagc tgccgatact cagtcactac
2761 tggagcactt caacactgtt cactgccagg aacaggacat cactacagcc aacggcgaag
2821 aggacggtca tgccatatcc accatcaaag aggagcccaa aattgacttc agggtctaca
2881 atctgctaac tccagactct aaaatgggag agccagtttc tgagagtgtg gtgaagagag
2941 agaagctgga agagaaggac gggctcaaag agaaagtttg gaccgagagt tccagtgatg
3001 accttcgcaa tgtgacttgg agaggggcag acatcctgcg ggggagtccg tcatacaccc
3061 aagcaagcct ggggctgctg acgcctgtgt ctggcaccca agagcagaca aagactctaa
3121 gggatagtcc caatgtggag gccgcccatc tggcgcgacc tatttatggc ttggctgtgg
3181 aaaccaaggg attcctgcag ggggcgccag ctggcggaga gaagtctggg gccctccccc
3241 agcagtatcc tgcatcggga gaaaacaagt ccaaggatga atcccagtcc ctgttacgga
3301 ggcgtagagg ctccggtgtt ttttgtgcca attgcctgac cacaaagacc tctctctggc
3361 gaaagaatgc aaatggcgga tatgtatgca acgcgtgtgg cctctaccag aagcttcact
3421 cgactcccag gcctttaaac atcattaaac aaaacaacgg tgagcagatt attaggagga
3481 gaacaagaaa gcgccttaac ccagaggcac ttcaggctga gcagctcaac aaacagcaga
3541 ggggcagcaa tgaggagcaa gtcaatggaa gcccgttaga gaggaggtca gaagatcatc
3601 taactgaaag tcaccagaga gaaattccac tccccagcct aagtaaatac gaagcccagg
3661 gttcattgac taaaagccat tctgctcagc agccagtcct ggtcagccaa actctggata
3721 ttcacaaaag gatgcaacct ttgcacattc agataaaaag tcctcaggaa agtactggag
3781 atccaggaaa tagttcatcc gtatctgaag ggaaaggaag ttctgagaga ggcagtccta
3841 tagaaaagta catgagacct gcgaaacacc caaattattc accaccaggc agccctattg
3901 aaaagtacca gtacccactt tttggacttc cctttgtaca taatgacttc cagagtgaag
3961 ctgattggct gcggttctgg agtaaatata agctctccgt tcctgggaat ccgcactact
4021 tgagtcacgt gcctggccta ccaaatcctt gccaaaacta tgtgccttat cccaccttca
4081 atctgcctcc tcatttttca gctgttggat cagacaatga cattcctcta gatttggcga
4141 tcaagcattc cagacctggg ccaactgcaa acggtgcctc caaggagaaa acgaaggcac
4201 caccaaatgt aaaaaatgaa ggtcccttga atgtagtaaa aacagagaaa gttgatagaa
4261 gtactcaaga tgaactttca acaaaatgtg tgcactgtgg cattgtcttt ctggatgaag
4321 tgatgtatgc tttgcatatg agttgccatg gtgacagtgg acctttccag tgcagcatat
4381 gccagcatct ttgcacggac aaatatgact tcacaacaca tatccagagg ggcctgcata
4441 ggaacaatgc acaagtggaa aaaaatggaa aacctaaaga gtaaaacctt agcacttagc
4501 acaattaaat agaaataggt tttcttgatg ggaattcaat agcttgtaat gtcttatgaa
4561 gacctattaa aaaaatactt catagagcct gccttatcca acatgaaatt cccttctttt
4621 gttattcttt cttttgatga gtaggttacc aagattaaaa agtgagataa atggtcaatg
4681 agaaagaatg gaagatggta aacaatcact ttttaaaacc tgttaagtca aaaccatctt
4741 ggctaatatg tactggggaa ataatccata agagatatca ccagactaga attaatatat
4801 ttataaagaa agagaccaaa actgtctaga atttgaaagg gtttacatat tattatacta
4861 aagcagtact ggactggcca ttggaccatt tgttccaaaa cccataaatt gttgcctaaa
4921 tttataatga tcatgaaacc ctaggcagag gaggagaaat tgaaggtcca gggcaatgaa
4981 agaaaaatgg cgccctctca atttagtctt ctctcattgg ccatgtttca gattttgacc
5041 tagaaatgcg agctgtggtt aggcttggtt agagtgcagc aagcaacatg acagatggtg
5101 gcacgctgtt tttacccagc cctgcctgta catacacatg cacaccctct ctgatatttt
5161 tgtcctttag atgttcaaat actcagtagt ccttttgttt gcggtttaga ttcattttgt
5221 ccacacatgt acccatttta aaaaacaatg tcctcgatgc ttctgtagtg atttcatttt
5281 agccaggtat ttctttcttg tgtgtgatga accagtatgg atttgctttt ctaagcctcc
5341 tgttggttac taatctcact tggcacatta taactaaagg aatcccctca attcaaaagc
5401 atagatggat acaaatgtca gaccgtgggt ttaatttgtt tagaacacat ggcatttctt
5461 cacaaggtaa cctgctgtat ttatttattt tcttttggtt aaatataatt tccaaacttt
5521 gtggtcaggc agcgtctaag gttacgttac cacagactga cagttggtat atgtaccagc
5581 caatcccttc attaaatgta tacagattta gttaagtagc attaaatagg attcttagaa
5641 gtatgtcctc atagaacttt taatacttaa ggctttgtaa aaactatcca tgaagggaaa
5701 gctcctcagc ataactgctc agggaaatag ggctaaataa ctgaacatta aataattggt
5761 taaaggtgct gttagtcgag cctcaatgct tgctacaagg atgtatgtac aaggactgac
5821 tttaataatt tgcattatat tgtcccaacc agtagtttat tttttgccac ggagatgtag
5881 aagatattac aagctactgg atgcactgtc agattaactt atttcattaa agaagttggg
5941 agaacaaata ggaaaaaaaa aacttatttt tctagtaaat attaatgtat tacatttcaa
6001 ataatggtgc ctgacatatt gaataattat tttctacagt gtacgtatgc aacaaagata
6061 ttccatcatg cattagagtc agttctggct ctgcctagct gtttacattt gcaaatgtag
6121 caaacaaggt aatgaagcaa ctatttctat tgcagtagat atccttttgt gtgtgtgtgt
6181 gtgcattaaa gttgtaaacg gtaacatgaa acaaatgaaa gttcttgcta taatggtatg
6241 gaaaacaaga aggaaatgaa aatattttta tgcctactta ggaaaaaaag ggtagcactt
6301 attcattcca agtacttttt tttttttaat ttttaagctc ttaactcaca ttgttatgct
6361 taagatgata aacatatatc ctctttttat tgctttgtct atgtttcata tgaaacattt
6421 cagaaattat tttgataagt gttgctggaa tctgcaacgc tgattttttt ttgcattctg
6481 tagtcgcatt tgcactccat ttttacatta attcgcagtt gctttgtatc attgttttgt
6541 ttgggttttg tttctttttc acagtgccgg gtcttcgttt cttaaagttg gatggcaggt
6601 agagttcaac cagttcgtga ctgttgtagc gaatgaagtt aaaaaaatgt ctttctgatg
6661 ttgtgttgtc attttcattt ttgcattttt ttgtttgcat attaaaaaaa gagaaaagag
6721 aaagcaagag acagaaatca ggactaagtc ctctgcttca gtttcattgt taacgggcct
6781 tattctgatc tcacctgtcg cgtagctcta atattcacat aaactgaaat aaagaagtgg
6841 aatgaggagc tttgacattc aaattatgtg atgtaattta tcttccttag gaattttgat
6901 ggatgcatct caaaatgtat agccagactt gagaggtgac aattaaagat ctaaaaaaga
6961 gaggagattc ccccaaacaa caatatttaa ttttcttagt aaaaagaata acagaatgca
7021 tcgtggcaat ccttaagcaa cattatctat gtggactgct taaatcagca aaacaccaga
7081 agtttggtta acttgggcaa tatgacaagt attacttttt gggcaaaact actcattaag
7141 caatttctct agtgtgtcgg acacaaatag gttctttatt tttggcatgt atgccttttt
7201 attttcattc aatttttttt ttttctcaga cagacatagt agtatcaact agcattggaa
7261 aatacatatc actattcttg gaatatttat ggtcagtcta ctttttagta aaatattttt
7321 ggatagcgtt gacacgatag atcttattcc atacttcttt attattgata attttatttt
7381 cattttttgc tttcattatt atacatattt tggtggagaa gaggttgggc ttttttgaaa
7441 gagacaaaaa tttattataa cactaaacac tccttttttg acatattaaa gcctttattc
7501 catctctcaa gatatattat aaaatttatt tttttaattt aagatttctg aattatttta
7561 tcttaaattg tgattttaaa cgagctatta tggtacggaa ctttttttaa tgaggaattt
7621 catgatgatt taggaatttt ctctcttgga aaaggcttcc cctgtgatga aaatgatgtg
7681 ccagctaaaa ttgtgtgcca tttaaaaact gaaaatattt taaaattatt tgtctatatt
7741 ctaaattgag ctttggatca aactttaggc caggaccagc tcatgcgttc tcattcttcc
7801 ttttctcact ctttctctca tcactcacct ctgtattcat tctgttgttt gggatagaaa
7861 aatcataaag agccaaccca tctcagaacg ttgtggattg agagagacac tacatgactc
7921 caagtatatg agaaaaggac agagctctaa ttgataactc tgtagttcaa aaggaaaaga
7981 gtatgcccaa ttctctctac atgacatatt gagatttttt ttaatcaact tttaagatag
8041 tgatgttctg ttctaaactg ttctgtttta gtgaaggtag atttttataa aacaagcatg
8101 gggattcttt tctaaggtaa tattaatgag aagggaaaaa agtatcttta acagctcttt
8161 gttgaagcct gtggtagcac attatgttta taattgcaca tgtgcacata atctattatg
8221 atccaatgca aatacagctc caaaaatatt aaatgtatat atattttaaa atgcctgagg
8281 aaatacattt ttcttaataa actgaagagt ctcagtatgg ctattaaaat aattattagc
8341 ctcctgttgt gtggctgcaa aacatcacaa agtgaccggt cttgagacct gtgaactgct
8401 gccctgttta gtaaataaaa ttaatgcatt tctagagggg gaatatctgc catccagtgg
8461 tggaaatgtg gagtaaagaa gctggtggtc tgcttctgtg ctgtatgcca gccttttgcc
8521 ttaagttgag aggaggtcaa ctttagctac tgtctttggt ttgagagcca tggcaaaaaa
8581 aaaaaaagaa aaaaagatca agtcgtcttt ggtgagccag taaggtgaaa gcttgctgac
8641 tgtccaaggc acaagagaaa attgaggaat tgaaatgcaa cctgagtatc aaactaaata
8701 ttctaatcaa aggtaggtac tgttaggtgg aattctatca gcaggcaact gcaaatgaga
8761 agaagataga aggacgcccg tcgggacttt ggagggcatt gttattttcc caaagaaaga
8821 cggccaaggg cagaggcatg gattctttgc agagcacttc cttttggttt ttcagtactg
8881 tttcatagac agtgggctca catgttcctg atagtgctgc agttgcttag aaagcatccc
8941 agttaattgc agtaattaga acttctggaa tatgctaggg cagaagtatg tcaagtatgt
9001 cacatgaaga aaatgtgaaa ttcaagagta atccacacgt gagaaactag acaatgtaca
9061 ttcatgtgtt ctcttgaaag gaaagggaga gctgtaagct tcactctgtc ctacaccgga
9121 gaaaagcagg aataacttta ccgtggaaat aatgtttagc ttttatcaga gaaaattgtc
9181 cttctagagc atagagtccc aaaactcaat tctggttttc ccctgttttt tttttttttt
9241 tttttcccaa catatgaact gcagcatatc actttttctt tttgtgcctc aggttcctca
9301 cctgtaaaat tgaaaaatat atgtattaat aatattatta ataataataa tggtaatgta
9361 gtacttgttt gtaaagcact ttgagatcct tggttgaaag gcaccatagg agtgccaagt
9421 attattatgt ggccaagggg gttatttaaa ctgtcagttc ccaaaggcca ggaaaggttg
9481 gggtcatttt tcttaaagac gagctgtaaa tatcaactag gcagccaata gtgttgacta
9541 tgaagatgca aaactattac taggctgata aaatcatagt ttcttaatgg ctaccaataa
9601 ggcaaatatc acaataataa acgccaaatt ccttagggcg gactatttga caaccacatg
9661 gaaaactttg ggggaggcat gaggggggaa catctcaaaa tgccaatgta aaatttaact
9721 tacagcaata ttcaccagca gaaaatgtct ttcatatgga atgatttcat gttgctaaga
9781 aaaagaattc aatttgtagt cctgatttga atactagaat gttggctata atagttctgt
9841 tcttacaaca catgaaattt tttcgtttta ttttattttg ttttcatagt gcatgttcat
9901 ttctactcac aaacatgttc ttggtgtatt tcttatgcaa acaatcttca ggcagcaaag
9961 atgtctgtta catctaaact tgaataataa agttttacca ccagttacac a
//