LOCUS AF181490 1749 bp mRNA linear HUM 18-FEB-2000
DEFINITION Homo sapiens prenylcysteine lyase (PCL1) mRNA, complete cds.
ACCESSION AF181490
VERSION AF181490.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1749)
AUTHORS Tschantz,W.R., Zhang,L. and Casey,P.J.
TITLE Cloning, expression, and cellular localization of a human
prenylcysteine lyase
JOURNAL J. Biol. Chem. 274 (50), 35802-35808 (1999)
PUBMED 10585463
REFERENCE 2 (bases 1 to 1749)
AUTHORS Tschantz,W.R., Zhang,L. and Casey,P.J.
TITLE Direct Submission
JOURNAL Submitted (27-AUG-1999) Dept of Pharacology and Cancer Biology,
Duke University Medical Center, Box 3686, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..1749
/db_xref="H-InvDB:HIT000072819"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
gene 1..1749
/gene="PCL1"
CDS 56..1573
/gene="PCL1"
/function="catalyzes degradation of prenylated cysteines"
/note="carbon-sulfur cleavage enzyme"
/codon_start=1
/product="prenylcysteine lyase"
/protein_id="AAF16937.1"
/translation="MGRVVAELVSSLLGLWLLLCSCGCPEGAELRAPPDKIAIIGAGI
GGTSAAYYLRQKFGKDVKIDLFEREEVGGRLATMMVQGQEYEAGGSVIHPLNLHMKRF
VKDLGLSAVQASGGLLGIYNGETLVFEESNWFIINVIKLVWRYGFQSLRMHMWVEDVL
DKFMRIYRYQSHDYAFSSVEKLLHALGGDDFLGMLNRTLLETLQKAGFSEKFLNEMIA
PVMRVNYGQSTDINAFVGAVSLSCSDSGLWAVEGGNKLVCSGLLQASKSNLISGSVMY
IEEKTKTKYTGNPTKMYEVVYQIGTETRSDFYDIVLVATPLNRKMSNITFLNFDPPIE
EFHQYYHHIVTTLVKGELNTSIFSSRPIDKFGLNTVLTTDNSDLFINSIGIVPSVREK
EDPEPSTDGTYVWKIFSQETLTKAQILKLFLSYDYAVKKPWLAYPHYKPPEKCPSIIL
HDRLYYLNGIECAASAMEMSAIAAHNAALLAYHRWNGHTDMIDQDGLYEKLKTEL"
BASE COUNT 480 a 369 c 422 g 478 t
ORIGIN
1 gagcggtggg aggactgcgg ggctcttgag gccagctgca gagcttgtgg aggccatggg
61 gcgcgtcgtc gcggagctcg tctcctcgct gctggggttg tggctgttgc tgtgcagctg
121 cggatgcccc gagggtgccg agctgcgtgc tccgccagat aaaatcgcga ttattggagc
181 cggaattggt ggcacttcag cagcctatta cctgcggcag aaatttggga aagatgtgaa
241 gatagacctg tttgaaagag aagaggtcgg gggccgcctg gctaccatga tggtgcaggg
301 gcaagaatac gaggcaggag gttctgtcat ccatccttta aatctgcaca tgaaacgttt
361 tgtcaaagac ctgggtctct ctgctgttca ggcctctggt ggcctactgg ggatatataa
421 tggagagact ctggtatttg aggagagcaa ctggttcata attaacgtga ttaaattagt
481 ttggcgctat ggatttcaat ccctccgtat gcacatgtgg gtagaggacg tgttagacaa
541 gttcatgagg atctaccgct accagtctca tgactatgcc ttcagtagtg tcgaaaaatt
601 acttcatgct ctaggaggag atgacttcct tggaatgctt aatcgaacac ttcttgaaac
661 cttgcaaaag gccggctttt ctgagaagtt cctcaatgaa atgattgctc ctgttatgag
721 ggtcaattat ggccaaagca cggacatcaa tgcctttgtg ggggcggtgt cactgtcctg
781 ttctgattct ggcctttggg cagtagaagg tggcaataaa cttgtttgct cagggcttct
841 gcaggcatcc aaaagcaatc ttatatctgg ctcagtaatg tacatcgagg agaaaacaaa
901 gaccaagtac acaggaaatc caacaaagat gtatgaagtg gtctaccaaa ttggaactga
961 gactcgttca gacttctatg acatcgtctt ggtggccact ccgttgaatc gaaaaatgtc
1021 gaatattact tttctcaact ttgatcctcc aattgaggaa ttccatcaat attatcacca
1081 tatagtgaca actttagtta agggggaatt gaatacatct atctttagct ctagacccat
1141 agataaattt ggccttaata cagttttaac cactgataat tcagatttgt tcattaacag
1201 tattgggatt gtgccctctg tgagagaaaa ggaagatcct gagccatcaa cagatggaac
1261 atatgtttgg aagatctttt cccaagaaac tcttactaaa gcacaaattt taaagctctt
1321 tctgtcctat gattatgctg tgaagaagcc atggcttgca tatcctcact ataagccccc
1381 ggagaaatgc ccctctatca ttctccatga tcgactttat tacctcaatg gcatagagtg
1441 tgcagcaagt gccatggaga tgagtgccat tgcagcccac aacgctgcac tccttgccta
1501 tcaccgctgg aacgggcaca cagacatgat tgatcaggat ggcttatatg agaaacttaa
1561 aactgaacta tgaagtgaca cactcctttt tcccctccta gttccaaatg actatcagtg
1621 gcaaaaaaga acaaaatctg agcagagatg attttgaacc agatattttg ccattatcat
1681 tgtttaataa aagtaatccc tgctggtcat aggaaaacac acggttctaa ttaagtgtga
1741 aggtataac
//