LOCUS AF181467 2466 bp mRNA linear HUM 07-SEP-1999
DEFINITION Homo sapiens protein Z-dependent protease inhibitor precursor,
mRNA, complete cds.
ACCESSION AF181467
VERSION AF181467.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2466)
AUTHORS Han,X., Huang,Z.F., Fiehler,R. and Broze,G.J. Jr.
TITLE The protein Z-dependent protease inhibitor is a serpin
JOURNAL Biochemistry 38 (34), 11073-11078 (1999)
PUBMED 10460162
REFERENCE 2 (bases 1 to 2466)
AUTHORS Han,X., Huang,Z.-F., Fiehler,R. and Broze,G.J. Jr.
TITLE Direct Submission
JOURNAL Submitted (27-AUG-1999) Hematology, Barnes-Jewish Hospital of St.
Louis, 216 South Kingshighway, St. Louis, MO 63110, USA
FEATURES Location/Qualifiers
source 1..2466
/db_xref="H-InvDB:HIT000072818"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
CDS 467..1801
/function="inhibits factor Xa activity in the presence of
protein Z, calcium and phospholipid"
/note="ZPI; member of serpins; proteinase inhibitor"
/codon_start=1
/product="protein Z-dependent protease inhibitor
precursor"
/protein_id="AAD53962.1"
/translation="MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQA
PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSP
FGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGL
TQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIP
KLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFA
STFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNME
VFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDE
RGTEAVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPTLL"
sig_peptide 467..529
mat_peptide 530..1798
/product="protein Z-dependent protease inhibitor"
BASE COUNT 703 a 569 c 618 g 576 t
ORIGIN
1 ctggagtggg gtaagaggcg aattatagac acaaggggct cctctgcagg aaggaggcca
61 agggaaagag gcttgaaagg cttgatattt cacccaccac cactcactgc cggagtaagc
121 aggtctcccc ttcccagggc tgaggggagg cagggatgtg tgctgtccca gggctgagaa
181 gtggcaggtg agctggtgat tccttactgc ccaggttctg tctaggaagg tgcgtcctca
241 ccatgctgga tggtgtccta gtccaggagc accccctgag ctcctggcct agactccaaa
301 gggttgggta gatgagcaaa gactttacaa agaccttagg cgatatatgt ccaggagcac
361 ccaggaatta ctgggctacc actgcagact gcaggacaag ctccaagaac aggaaggaag
421 tcttgcagct gaagggaggc actccttggc ctccgcagcc gatcacatga aggtggtgcc
481 aagtctcctg ctctccgtcc tcctggcaca ggtgtggctg gtacccggct tggcccccag
541 tcctcagtcg ccagagaccc cagcccctca gaaccagacc agcagggtag tgcaggctcc
601 caaggaggaa gaggaagatg agcaggaggc cagcgaggag aaggccagtg aggaagagaa
661 agcctggctg atggccagca ggcagcagct tgccaaggag acttcaaact tcggattcag
721 cctgctgcga aagatctcca tgaggcacga tggcaacatg gtcttctctc catttggcat
781 gtccttggcc atgacaggct tgatgctggg ggccacaggg ccgactgaaa cccagatcaa
841 gagagggctc cacttgcagg ccctgaagcc caccaagccc gggctcctgc cttccctctt
901 taagggactc agagagaccc tctcccgcaa cctggaactg ggcctcacac aggggagttt
961 tgccttcatc cacaaggatt ttgatgtcaa agagactttc ttcaatttat ccaagaggta
1021 ttttgataca gagtgcgtgc ctatgaattt tcgcaatgcc tcacaggcca aaaggctcat
1081 gaatcattac attaacaaag agactcgggg gaaaattccc aaactgtttg atgagattaa
1141 tcctgaaacc aaattaattc ttgtggatta catcttgttc aaagggaaat ggttgacccc
1201 atttgaccct gtcttcaccg aagtcgacac tttccacctg gacaagtaca agaccattaa
1261 ggtgcccatg atgtacggtg caggcaagtt tgcctccacc tttgacaaga attttcgttg
1321 tcatgtcctc aaactgccct accaaggaaa tgccaccatg ctggtggtcc tcatggagaa
1381 aatgggtgac cacctcgccc ttgaagacta cctgaccaca gacttggtgg agacatggct
1441 cagaaacatg aaaaccagaa acatggaagt tttctttccg aagttcaagc tagatcagaa
1501 gtatgagatg catgagctgc ttaggcagat gggaatcaga agaatcttct caccctttgc
1561 tgaccttagt gaactctcag ctactggaag aaatctccaa gtatccaggg ttttacaaag
1621 aacagtgatt gaagttgatg aaaggggcac tgaggcagtg gcaggaatct tgtcagaaat
1681 tactgcttat tccatgcctc ctgtcatcaa agtggaccgg ccatttcatt tcatgatcta
1741 tgaagaaacc tctggaatgc ttctgtttct gggcagggtg gtgaatccga ctctcctata
1801 attcaggaca cgcataagca cttcgcgtgt agtagatgct gaatctgagg tatcaaacac
1861 acacaggata ccagcaatgg atggcagggg agagtgttcc ttttgttctt aactagttta
1921 gggtgttctc aaataaatac agtagtcccc acttatctga gggggataca ttcaaagacc
1981 cccagcagat gcctgaaacg gtggacagtg ctgaacctta tatatatttt ttcctacaca
2041 tacataccta tgataaagtt taatttataa attaggcaca gtaagagatt aacaataata
2101 acaacattaa gtaaaatgag ttacttgaat gcaagcactg caataccata acagtcaaac
2161 tgattataga gaaggctact aagtgactca tgggcgagga gcatagacag tgtggagaca
2221 ttgggcaagg ggagaattca catcctgggt gggacagagc aggacaatgc aagattccat
2281 cccactactc agaatggcat gctgcttaag acttttagat tgtttatttc tggaattttt
2341 catttaatgt ttttggacca tggttgacca tggttaactg agactgcaga aagcaaaacc
2401 atggataagg gaggactact acaaaagcat taaattgata catatttttt aaaaaaaaaa
2461 aaaaaa
//