LOCUS AF180682 4940 bp mRNA linear HUM 10-JAN-2000
DEFINITION Homo sapiens DNA (cytosine-5)-methyltransferase mRNA, complete cds.
ACCESSION AF180682
VERSION AF180682.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4940)
AUTHORS Li,L.C., Au,H., Chui,R. and Dahiya,R.
TITLE Human DNA methyltransferase (DNMT1) is alternatively spliced
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 4940)
AUTHORS Li,L.C., Au,H., Chui,R. and Dahiya,R.
TITLE Direct Submission
JOURNAL Submitted (25-AUG-1999) Urology, UCSF, 4150 Clement St., San
Francisco, CA 94121, USA
FEATURES Location/Qualifiers
source 1..4940
/db_xref="H-InvDB:HIT000072801"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="TSUPr1"
/tissue_type="prostate cancer"
CDS 752..4594
/note="DNMT1; alternatively spliced"
/codon_start=1
/product="DNA (cytosine-5)-methyltransferase"
/protein_id="AAF23609.1"
/translation="MARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQM
LTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGS
AKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYA
PIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHA
QFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKD
RGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKAC
KDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNK
NRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDS
SNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWA
MEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEM
RQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRV
NKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYS
MGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEI
KLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCN
ILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVS
FLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQ
TRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTIT
VRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAAR
MRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAG
KACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVL
HPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLA
KARESASAKIKEEEAAKD"
BASE COUNT 1279 a 1352 c 1378 g 931 t
ORIGIN
1 cgtccgcgtg gggggggtgt gtgcccgcct tgcgcatgcg tgttccctgg gcatggccgg
61 ctccgttcca tccttctgca cagggtatcg cctctctccg tttggtacat cccctcctcc
121 cccacgcccg gactggggtg gtagacgcgc ctccgctcat cgcccctccc aagtaactgg
181 gattagagct gaaccttcac ctagccccag gattacaagg aaaagcacca ggcaaaccac
241 catcacatct cattttgcaa agggccctgc caaacggaaa cctcaggaag agtctgaaag
301 agccaaatcg gatgagtcca tcaaggaaga agacaaagac caggatgaga agagacgtag
361 agttacatcc agagaacgag ttgctagacc gcttcctgca gaagaacctg aaagagcaaa
421 atcaggaacg cgcactgaaa aggaagaaga aagagatgaa aaagaagaaa agagactccg
481 aagtcaaacc aaagaaccaa cacccaaaca gaaactgaag gaggagccgg acagagaagc
541 cagggcaggc gtgcaggctg acgaggacga agatggagac gagaaagatg agaagaagca
601 cagaagtcaa cccaaagatc tagctgccaa acggaggccc gaagaaaaag aacctgaaaa
661 agtaaatcca cagatttctg atgaaaaaga cgaggatgaa aaggaggaga agagacgcaa
721 aacgaccccc aaagaaccaa cggagaaaaa aatggctcgc gccaaaacag tcatgaactc
781 caagacccac cctcccaagt gcattcagtg cgggcagtac ctggacgacc ctgacctcaa
841 atatgggcag cacccaccag acgcggtgga tgagccacag atgctgacaa atgagaagct
901 gtccatcttt gatgccaacg agtctggctt tgagagttat gaggcgcttc cccagcacaa
961 actgacctgc ttcagtgtgt actgtaagca cggtcacctg tgtcccatcg acaccggcct
1021 catcgagaag aatatcgaac tcttcttttc tggttcagca aaaccaatct atgatgatga
1081 cccgtctctt gaaggtggtg ttaatggcaa aaatcttggc cccataaatg aatggtggat
1141 cactggcttt gatggaggtg aaaaggccct catcggcttc agcacctcat ttgccgaata
1201 cattctgatg gatcccagtc ccgagtatgc gcccatattt gggctgatgc aggagaagat
1261 ctacatcagc aagattgtgg tggagttcct gcagagcaat tccgactcga cctatgagga
1321 cctgatcaac aagatcgaga ccacggttcc tccttctggc ctcaacttga accgcttcac
1381 agaggactcc ctcctgcgac acgcgcagtt tgtggtggag caggtggaga gttatgacga
1441 ggccggggac agtgatgagc agcccatctt cctgacgccc tgcatgcggg acctgatcaa
1501 gctggctggg gtcacgctgg gacagaggcg agcccaggcg aggcggcaga ccatcaggca
1561 ttctaccagg gagaaggaca ggggacccac gaaagccacc accaccaagc tggtctacca
1621 gatcttcgat actttcttcg cagagcaaat tgaaaaggat gacagagaag acaaggagaa
1681 cgcctttaag cgccggcgat gtggcgtctg tgaggtgtgt cagcagcctg agtgtgggaa
1741 atgtaaagcc tgcaaggaca tggttaaatt tggtggcagt ggacggagca agcaggcttg
1801 ccaagagcgg aggtgtccca atatggccat gaaggaggca gatgacgatg aggaagtcga
1861 tgataacatc ccagagatgc cgtcacccaa aaaaatgcac caggggaaga agaagaaaca
1921 gaacaagaat cgcatctctt gggtcggaga agccgtcaag actgatggga agaagagtta
1981 ctataagaag gtgtgcattg atgcggaaac cctggaagtg ggggactgtg tctctgttat
2041 tccagatgat tcctcaaaac cgctgtatct agcaagggtc acggcgctgt gggaggacag
2101 cagcaacggg cagatgtttc acgcccactg gttctgcgct gggacagaca cagtcctcgg
2161 ggccacgtcg gaccctctgg agctgttctt ggtggatgaa tgtgaggaca tgcagctttc
2221 atatatccac agcaaagtga aagtcatcta caaagccccc tccgaaaact gggccatgga
2281 gggaggcatg gatcccgagt ccctgctgga gggggacgac gggaagacct acttctacca
2341 gctgtggtat gatcaagact acgcgagatt cgagtcccct ccaaaaaccc agccaacaga
2401 ggacaacaag ttcaaattct gtgtgagctg tgcccgtctg gctgagatga ggcaaaaaga
2461 aatccccagg gtcctggagc agctcgagga cctggatagc cgggtcctct actactcagc
2521 caccaagaac ggcatcctgt accgagttgg tgatggtgtg tacctgcccc ctgaggcctt
2581 cacgttcaac atcaagctgt ccagtcccgt gaaacgccca cggaaggagc ccgtggatga
2641 ggacctgtac ccagagcact accggaaata ctccgactac atcaaaggca gcaacctgga
2701 tgcccctgag ccctaccgaa ttggccggat caaagagatc ttctgtccca agaagagcaa
2761 cggcaggccc aatgagactg acatcaaaat ccgggtcaac aagttctaca ggcctgagaa
2821 cacccacaag tccactccag cgagctacca cgcagacatc aacctgctct actggagcga
2881 cgaggaggcc gtggtggact tcaaggctgt gcagggccgc tgcaccgtgg agtatgggga
2941 ggacctgccc gagtgcgtcc aggtgtactc catgggcggc cccaaccgct tctacttcct
3001 cgaggcctat aatgcaaaga gcaaaagctt tgaagatcct cccaaccatg cccgtagccc
3061 tggaaacaaa gggaagggca agggaaaagg gaagggcaag cccaagtccc aagcctgtga
3121 gccgagcgag ccagagatag agatcaagct gcccaagctg cggaccctgg atgtgttttc
3181 tggctgcggg gggttgtcgg agggattcca ccaagcaggc atctctgaca cgctgtgggc
3241 catcgagatg tgggaccctg cggcccaggc gttccggctg aacaaccccg gctccacagt
3301 gttcacagag gactgcaaca tcctgctgaa gctggtcatg gctggggaga ccaccaactc
3361 ccgcggccag cggctgcccc agaagggaga cgtggagatg ctgtgcggcg ggccgccctg
3421 ccagggcttc agcggcatga accgcttcaa ttcgcgcacc tactccaagt tcaaaaactc
3481 tctggtggtt tccttcctca gctactgcga ctactaccgg ccccggttct tcctcctgga
3541 gaatgtcagg aactttgtct ccttcaagcg ctccatggtc ctgaagctca ccctccgctg
3601 cctggtccgc atgggctatc agtgcacctt cggcgtgctg caggccggtc agtacggcgt
3661 ggcccagact aggaggcggg ccatcatcct ggccgcggcc cctggagaga agctccctct
3721 gttcccggag ccactgcacg tgtttgctcc ccgggcctgc cagctgagcg tggtggtgga
3781 tgacaagaag tttgtgagca acataaccag gttgagctcg ggtcctttcc ggaccatcac
3841 ggtgcgagac acgatgtccg acctgccgga ggtgcggaat ggagcctcgg cactggagat
3901 ctcctacaac ggggagcctc agtcctggtt ccagaggcag ctccggggcg cacagtacca
3961 gcccatcctc agggaccaca tctgtaagga catgagtgca ttggtggctg cccgcatgcg
4021 gcacatcccc ttggccccag ggtcagactg gcgcgatctg cccaacatcg aggtgcggct
4081 ctcagacggc accatggcca ggaagctgcg gtatacccac catgacagga agaacggccg
4141 cagcagctct ggggccctcc gtggggtctg ctcctgcgtg gaagccggca aagcctgcga
4201 ccccgcagcc aggcagttca acaccctcat cccctggtgc ctgccccaca ccgggaaccg
4261 gcacaaccac tgggctggcc tctatggaag gctcgagtgg gacggcttct tcagcacaac
4321 cgtcaccaac cccgagccca tgggcaagca gggccgcgtg ctccacccag agcagcaccg
4381 tgtggtgagc gtgcgggagt gtgcccgctc ccagggcttc cctgacacct accggctctt
4441 cggcaacatc ctggacaagc accggcaggt gggcaatgcc gtgccaccgc ccctggccaa
4501 agccattggc ttggagatca agctttgtat gttggccaaa gcccgagaga gtgcctcagc
4561 taaaataaag gaggaggaag ctgctaagga ctagttctgc cctcccgtca cccctgtttc
4621 tggcaccagg aatccccaac atgcactgat gttgtgtttt taacatgtca atctgtccgt
4681 tcacatgtgt ggtacatggt gtttgtggcc ttggctgaca tgaagctgtt gtgtgaggtt
4741 cgcttatcaa ctaatgattt agtgatcaaa ttgtgcagta ctttgtgcat tctggatttt
4801 aaaagttttt tattatgcat tatatcaaat ctaccactgt atgagtggaa attaagactt
4861 tatgtagttt ttatatgttg taatatttct tcaaataaat ctctcctata aaccaaaaaa
4921 aaaaaaaaaa aaaaaaaaaa
//