LOCUS AF180681 9501 bp mRNA linear HUM 02-MAR-2000
DEFINITION Homo sapiens guanine nucleotide exchange factor (LARG) mRNA,
complete cds.
ACCESSION AF180681
VERSION AF180681.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9501)
AUTHORS Kourlas,P.J., Strout,M.P., Becknell,B., Veronese,M.L., Croce,C.M.,
Theil,K.S., Krahe,R., Ruutu,T., Knuutila,S., Bloomfield,C.D. and
Caligiuri,M.A.
TITLE Identification of a gene at 11q23 encoding a guanine nucleotide
exchange factor: evidence for its fusion with MLL in acute myeloid
leukemia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (5), 2145-2150 (2000)
PUBMED 10681437
REFERENCE 2 (bases 1 to 9501)
AUTHORS Kourlas,P.J., Strout,M.P., Becknell,B., Bloomfield,C.B. and
Caligiuri,M.A.
TITLE Direct Submission
JOURNAL Submitted (25-AUG-1999) Internal Medicine, Division of
Hematology-Oncology, The Ohio State University, 4th floor
Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
FEATURES Location/Qualifiers
source 1..9501
/db_xref="H-InvDB:HIT000072800"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
/tissue_type="prostate"
gene 1..9501
/gene="LARG"
CDS 8..4642
/gene="LARG"
/codon_start=1
/product="guanine nucleotide exchange factor"
/protein_id="AAF36817.1"
/translation="MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDF
DPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGA
AMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSE
VEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQE
RLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTL
TVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTD
TQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLHHV
VSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEK
RRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKD
RLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLE
HKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKA
RHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKE
NDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPF
RKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYT
ERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRN
ETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQD
AESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILN
YVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKV
NRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVR
QVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQ
STPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSE
VRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLKQL
LVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSG
EHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASS
LTLQPMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPS
SCADSQSQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS"
BASE COUNT 2816 a 1872 c 2078 g 2735 t
ORIGIN
1 ggccccaatg agtggcacac agtctactat caccgacagg tttcccctca aaaaacctat
61 aaggcatgga agtattttga accgagagtc accaacagat aagaagcaga aagttgagcg
121 cattgcatca catgattttg accccacaga tagctcctcc aagaagacaa agtctagttc
181 agaggagagt agatccgaga tatatggtct tgttcagcgt tgcgtaatca tccagaaaga
241 tgacaatgga tttgggctga cggtcagtgg agacaatcca gtcttcgtac agtctgtcaa
301 agaagatgga gcagccatgc gggctggagt acagacaggt gatcgaatca tcaaggtgaa
361 tggaactctg gtgactcatt caaatcatct ggaggtggtg aagctaatca aatctggttc
421 ctatgtagct ctcactgttc agggacgccc acctgggtcg ccccagattc cacttgccga
481 ctctgaagta gagccgtcag tcattggaca tatgtctccc atcatgacat ctcctcattc
541 acctggagca tctgggaata tggagagaat cactagtcct gtgctcatgg gggaggaaaa
601 caatgtggtt cataaccaga aagtagaaat tctgagaaaa atgttacaga aagaacagga
661 acggctacag ttattgcagg aagattacaa ccgaacacct gcccaaagat tgctaaaaga
721 gatccaagag gccaagaaac acattcctca gctgcaagag cagttatcca aagccacagg
781 ctctgctcag gatggagctg tagttacacc ctccagacct ttaggggaca ccctaacagt
841 cagtgaggca gaaacagatc ctggagatgt actgggcagg actgactgta gcagtggaga
901 tgcttctcgg cccagtagtg acaatgcaga tagtcccaag agtggcccaa aagagagaat
961 ttatctagag gaaaacccag agaaaagtga aacaattcag gacactgaca ctcaatcact
1021 tgtcggaagt ccctcaaccc gtatagcacc tcatattatt ggagcagaag atgatgattt
1081 tggtactgaa catgaacaga tcaatggaca gtgcagctgt ttccagagca ttgaattact
1141 aaaatctcgc ccggctcatt tggctgtttt cttacaccat gtagtttcac aatttgaccc
1201 tgcgactttg ctctgttatc tctattcaga cctgtataaa cataccaatt ccaaagaaac
1261 tcgtcgcatc ttccttgagt ttcatcagtt ctttctagat cgatcagcac acctgaaagt
1321 ttctgttcct gatgaaatgt ctgcagatct agaaaagaga agacctgagc tcattcctga
1381 ggatctgcat cgccactata tccaaactat gcaagaaaga gtccatccag aagttcaaag
1441 gcacttagaa gattttcggc agaaacgtag tatgggactg accttggctg aaagcgagct
1501 gactaaactt gatgcagagc gagacaagga ccgattgact ttggagaagg agcggacatg
1561 tgcagaacag attgttgcca aaattgaaga agtattgatg actgctcagg ctgtagagga
1621 agataagagc tccaccatgc agtatgttat tctcatgtat atgaagcatt tgggagtaaa
1681 agtgaaagag cctcgaaatt tggagcacaa acggggtcgg attggatttc ttcccaaaat
1741 caagcaaagt atgaagaaag ataaagaagg ggaagaaaaa gggaagcgaa gaggattccc
1801 cagcatcctg ggacccccac ggagaccaag ccgtcatgac aacagtgcaa ttggcagagc
1861 catggaacta cagaaggcgc gccaccctaa gcacttatcc acaccctcat ctgtgagtcc
1921 tgaacctcag gactctgcca agttgcgcca gagtgggtta gcaaatgaag gaacagacgc
1981 tggatacctg cctgccaatt ccatgtcttc tgtagcttca ggggcctctt tttcccagga
2041 aggagggaaa gagaatgata caggatcaaa gcaagttgga gaaacatcag cacctggaga
2101 caccttagat ggcacacctc gtactctcaa tactgtcttt gatttcccac cacctccatt
2161 agaccaagtg caggaggagg aatgtgaagt agaaagggtg actgaacatg ggacaccaaa
2221 gccctttcga aagtttgaca gtgtagcttt tggagaaagt caaagtgagg atgaacaatt
2281 tgaaaatgac ttagagacag acccacccaa ctggcagcag cttgttagtc gagaagtgtt
2341 actgggacta aaaccttgtg aaatcaaaag acaggaagtg attaatgaat tgttctacac
2401 tgaaagagct catgttcgaa cactgaaggt tcttgatcaa gtgttctatc agcgagtatc
2461 cagagaagga attctgtcac cctcagagct acggaaaatt ttttcaaact tggaagatat
2521 tcttcaactt catattggat tgaatgaaca aatgaaggct gttcgaaaga gaaatgagac
2581 ctctgttatc gatcagattg gggaagattt gctgacatgg ttcagcggac caggagagga
2641 gaaattgaaa catgctgctg ctaccttttg cagtaaccaa cctttcgccc tggaaatgat
2701 caaatctcgt cagaaaaagg attctcgatt tcagactttt gtgcaagatg ctgaaagtaa
2761 tccactgtgt cgtcgtcttc aactgaagga tattattccc actcaaatgc aaaggcttac
2821 taagtaccca cttctgttgg ataatattgc caaatacaca gaatggccaa cagaaaggga
2881 gaaggtgaag aaagctgcag atcactgtcg tcagatctta aattatgtaa atcaggctgt
2941 caaggaggca gaaaacaagc agcgcctaga agattatcag cgtcgccttg atacctccag
3001 cctgaagttg tcagagtacc caaatgttga agagctcagg aatttggatt taacaaaaag
3061 gaagatgatt catgaagggc cattggtttg gaaggtgaat agagataaaa ctattgattt
3121 atacacgttg ctgctggaag acattcttgt attgttacaa aagcaggatg atagactggt
3181 tttaaggtgt catagtaaga ttctggcatc tacagctgat agcaaacaca cgtttagccc
3241 tgtcattaag ttgagtacag tgttggttcg acaagtggca acagataaca aagctttatt
3301 cgtcatttcc atgtcagaca atggcgctca gatttatgaa ctggtggcac agacagtttc
3361 tgaaaagact gtctggcagg acctaatctg tcggatggct gcatcagtga aggagcaatc
3421 cacaaagcca attccattac cacagtcaac acctggcgaa ggagataatg atgaagaaga
3481 tccttcaaaa ttaaaagagg agcagcatgg catttcagtc actggtttgc agagtccaga
3541 cagagatttg ggattagaat ctaccttaat atcgtcaaaa cctcagtctc attcactgag
3601 tacctctggg aaatcagagg tacgtgatct gtttgtggct gagagacagt ttgcaaagga
3661 acaacataca gatgggacac taaaggaagt tggagaagat tatcaaatcg caatcccaga
3721 ttcacacctg cctgtctcag aagaacggtg ggcattggat gcactaagaa atttgggttt
3781 gttgaagcag ttgctggtgc aacagctagg tttgactgag aagagcgttc aggaagactg
3841 gcaacatttc ccaagataca gaacagcctc tcaggggccg cagacagaca gtgtcatcca
3901 gaactctgaa aatattaagg cctatcattc tggtgaagga catatgccct ttagaactgg
3961 aactggtgac attgcaactt gttacagtcc acggacttca actgaatctt ttgctccacg
4021 ggattcagtg ggactggcac cccaggatag ccaggcaagt aacattttag taatggacca
4081 catgattatg accccagaga tgcctaccat ggagccagaa gggggtcttg atgacagtgg
4141 agagcacttt tttgatgccc gtgaagcaca tagtgatgag aatccatcag aaggtgatgg
4201 agcagttaac aaggaagaga aggatgttaa tttacgcatc tcaggaaact atttgatcct
4261 tgatggctat gacccagtgc aggagagttc cacagatgag gaggttgctt cctcacttac
4321 cctgcagccc atgacaggca tccctgctgt ggaatccacc caccagcagc aacattctcc
4381 tcagaatact cactccgatg gggcaatttc accattcacc cccgaatttc tggtccagca
4441 gcgctgggga gctatggagt attcctgttt tgagatccag agtccctcct cttgtgcaga
4501 ttcacagagc cagatcatgg agtacattca taagatagag gctgaccttg aacacttaaa
4561 gaaggtggag gaaagttaca ccattctttg ccaaaggctg gctggatcag ccctcacaga
4621 caagcactca gataaaagtt agagccgcat gtcctggagg tgactgcagg ttgttggatt
4681 tggagtatcg gccgtgtctc accacatcct ggctccagtg tggatgcaga gagagtgtga
4741 cagaggatct gcctgtgaac cacctgggat tagtcaagtc ccaaggtgcc cagagtggga
4801 ctagttcttc acagtgtggc agctgcacta atctgtttgt gagggaatat ccattccctc
4861 actctactct cctcactatc ggaaattcat tttgattcag aataaaaacc aaatgtatag
4921 agctttgggt gtaggatatg aaattgtact tagatttaag aaaaagagaa aatcagatgt
4981 atttatttga cttcattccg tatttgaaag cacattttaa tttttatttg ccttgttttg
5041 ttttaattga gtagtgagag ttttagacct ttgtctttag tacacccaag gatcaactgc
5101 tcctgaagca aagaggtcag gatggagtat gcagaagttg ggtagagagg ttaagaagag
5161 gaggaagtga gacggggaag ggaggagcac cttgcttcac tatacagtat tccaagctct
5221 ctgctgtcca gtaggctgct tctctgaggg tcacctcaaa ggtatgctat gccgtgtggc
5281 tcttatgtgc ccaggtggtg tggtcagaga gtggatgggc ttcctcccgc cctgaggcaa
5341 gcacctcttc tctgtagctg ggatcaacca caattaatag gaatcctcaa catactaaat
5401 agcaggcact tgaaaatggg tgtgttttct tccattgtcg tcttttctat tgagggttgg
5461 gatttgggtg ggagaggaaa gcaaatttta ttttcttgac tataaatttg ttattcttgg
5521 tatcatttca tttttataat tatacattag acattggcac ttgtgtaaaa ctgtccctgc
5581 agattgagca ggaagtaaaa acaaatggaa atgcttcgga tagtggcagg ggtgggggtt
5641 gctaaggaaa gggtgggatg ggagtgggta aagagtttgg gaaggttatc taactgaatc
5701 actactgagt tgaatcatgg ctatcattag ccacaggtac tgctgattat aaggccagta
5761 aaattttagt acctggaggt ttgactctaa tttttgcact gatggtgcca aagggccctg
5821 agtcaaaagg atagccaagg gtggagtgga aaaagatatg gtgaaggcag aactgctcac
5881 accagctcca gaagcacgtc ctctgacttc actgccgcag ctctttccac acggggccgt
5941 gattgaccct aaaaattgca gaccagcaca tacactggac actgcaggca aggtgttggt
6001 aactgcctgc tctaggatga atagtagcgt tagcagcacc ctacagaggg taagtttcag
6061 aattgtaatt tgagaactcc ttcaattata ttgactttct ttggttttcc ttgtgcatta
6121 ggtatatatt ttttgaagta tttttgccaa ctaaaatgaa gtctgtaaat tctgttaata
6181 aacaaggagt tcatccgttg ctcacatctt tcattggtgc cctctgaact ctgtgggttg
6241 ctaggatgta attttaatgc ttccctgcag tccaaagatg attttttcac cacaaatggt
6301 aagggatgcc cacctacttt tataaacacc actgcaactt aacaagttta tttatctatg
6361 tccagatttc tgtttctgtc ctaaattgat ctgtgttttt aggtggatca acttggatct
6421 ttagacctca tctataaatt gaaattatat ttttagtcat aagccaagta caatctaact
6481 cagaatggga ttaaaaattt tagaagcaga agctaatata taaatgaagt ttgggatttg
6541 gaactttctg tatctcttag gaggaacaag taaaaaccaa atggttacat tgtgctgcta
6601 gaaataatgt cattctcaat taaaagggtt acacctgtag ccacttgaca ctaacaccat
6661 cgagggcaat taatcaggag aaaagtaaat ataaaaactt tgctcttaac gtcacacact
6721 acagggtaat tatgtaattc tctagcactc aattaagaag cttgtaggtt agcaaaattt
6781 cagtttctct agttcagcca gtgtcttgtc cttagtaatt atttgctttc cctgcagttc
6841 aatttctcct tggaactcta acaggactaa ctggaaaaat actttgacca tagctctagt
6901 acttccaaat aaattcatat ctagattttc aaacaaagcc ccaagatgaa gtctaattct
6961 gaaaatatct cacaattttt gaatgttctt tttatcttac cgacctaact tctcttttcc
7021 ctcccaactt ggcctcccac acgttccatt tcattttggc cattatagtc acatccgttt
7081 gactttggtt gtgacatctt cctttcagga tgatggaatt agatgcagtc tgtctttgag
7141 tgagactggt caccatcaga ggagtttttt ctaagtgacg tgactagaag ttgaaatcta
7201 cttccctgct aaagggcaca ggggtggtgt acaaagaaag ctaccttccc agagcaagca
7261 ggctgcattt tagctatgga agtgacctgc tgtgacactg tgctctcttc tgtgggctta
7321 atggttcctt tgctatgaag tggcaaatta catgtagagt gtctccttcc ttttcagaga
7381 acagttaatc aaggcaaatc agcaagcccc caaagtgctg taatttaaca tcatgattac
7441 caccttcgaa gctatatatt ttgcatactt taaaatcacc taacttggac tgcttgaatt
7501 acattggctt ttagaaccga aattgtaact atgtattgta tttcatggga ggtatatttt
7561 atgagctttt tggctttctt ttttcccaca gcaactgcca atgaaggatg aatccccttt
7621 ttaaaaagtt gttgttgttg ttgtttattt gattttgagt taggagggat aatagagaag
7681 tccatttaaa aattattttt agaagctaaa gaaagtaatt atgcttcctg tgaattgtct
7741 tttactggca tctttgtttt cctctttgat gttagtaaat ttggtgtaat acgtggggct
7801 tccatatttc aaagtggaag ctttcttctc tgaagtcgat atatggtttt gaattactag
7861 agctttggtc agtatttcct tccctatatg tcacagaggg caccactgag aactgcgtgc
7921 ataggacctc aaaatacaaa attagcaggg cctcacagtc agcttcctca tggctagttt
7981 ttccccctta tattacaatt tttgttttat aagtcatttt tttcctgata tttccaccac
8041 ttttcagagt catctacaaa atttttcttt cctcaagaaa agagttcctt ttgccttatt
8101 ccttatgcct tccccactgg tattgagggt tttgataata aattggtagg aaaaaaaagt
8161 acctcctaga aggaagcctt ccccaccatt tccaggtgcc aactgctaag cagatatatt
8221 ccaaaaatgg taactgtcat gtgcacactg ttggttattt ttaataagcc tcttcctact
8281 agaacatttt attttccttg ttcaccatac aatcatgtac tctttaacag aaattgcttt
8341 taaaaaatat ctggaactat ctttaaaaaa actttattaa taatcatgta tttttactga
8401 tcacattttg aaatgcctaa aagactttat tgttctaatt atccagatgt acctttgtaa
8461 aatagctctt ttatgaatta gctgataagg ctgtatgttt ctggaacaaa atattggtca
8521 tctaaaaact ttctgttttc tggggtctgg gaaaatagaa aataagattt caaatattaa
8581 ataagcttaa aggaaccaag catgtgactt ttactttgta ttctggttga tttgtcttgt
8641 ccaagttata ttagaaaagt tgaggagtcg aggagcctgt aattaatttt cctgtcagtg
8701 actgtcagac atcttcctgc ttattagagc atccctagca acaaggctaa accttcatga
8761 cagtgctggc aggtgggctt gccctagcat gtggggcagg tttgttgttt ttttaatagc
8821 tttattgaga tattcacata tcatataatt catccattta aagtgtataa tcagatgggt
8881 tttggtatat tattgatttt taattgtggt gaaatatata tataacaaaa tttgctattg
8941 taactatttt taagtataaa gttcagtgag gtaggccagc ttttatgacg cacctgaaga
9001 taactttggt tttaatccta ccctaaatga agcatatgcc tctatttttc ctgtccccag
9061 tgctgggctt cttcacatac caacatttct gtgcttttac caacagcatt ttagctcaga
9121 aggctcgctt actttgggca tttgctgtat tttggttttg aaatacttgt aatttgactt
9181 attcttggga taatatttta gttttcagtc attcaagggc acatttggct gacggagcta
9241 ataagcgtaa taaaatgctt agtagtttat accatctttt agttaaacat tttaaagatt
9301 aagactattc aaatgtactt tgcggaaatt aacctgtttg tatgcctggc tttgtttaca
9361 aacatatatc tatatctata tatatagata cagatacaga tacatatctg gtggaacaaa
9421 gaaatacctg taccattccc acttgctctt tgatagccac ctcctaggaa tggagacaat
9481 aaaactctgt atttgcatgt g
//