LOCUS AF179680 8271 bp DNA linear HUM 15-AUG-2001
DEFINITION Homo sapiens apelin gene, complete cds.
ACCESSION AF179680
VERSION AF179680.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8271)
AUTHORS Lee,D.K., Cheng,R., Nguyen,T., Fan,T., Kariyawasam,A.P., Liu,Y.,
Osmond,D.H., George,S.R. and O'Dowd,B.F.
TITLE Characterization of apelin, the ligand for the APJ receptor
JOURNAL J. Neurochem. 74 (1), 34-41 (2000)
PUBMED 10617103
REFERENCE 2 (bases 1 to 8271)
AUTHORS Lee,D.K., Cheng,R., Nguyen,T., Fan,T., Kariyawasam,A.P., Liu,Y.,
Osmond,D.H., George,S.R. and O'Dowd,B.F.
TITLE Direct Submission
JOURNAL Submitted (23-AUG-1999) Pharmacology, University of Toronto, 8
Taddle Creek Rd. Rm. 4353, Toronto, Ontario M5S 1A8, Canada
FEATURES Location/Qualifiers
source 1..8271
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq25-q26.3"
mRNA join(1..225,5997..6168,6880..8271)
/product="apelin"
CDS join(159..225,5997..6163)
/codon_start=1
/product="apelin"
/protein_id="AAF25815.1"
/translation="MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQ
PRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF"
BASE COUNT 1770 a 2388 c 2350 g 1763 t
ORIGIN
1 agcggcgggg ctcagcgcgc acactcagcg gccggggagc ctcccgagct ctgcgcccgc
61 acgcgccagc cgcggctcgc gcctttcttg gcctccgggc gcccgacctc tcctcccccg
121 cgccggctcg ccggggccgc ggcggcccaa ggagcagcat gaatctgcgg ctctgcgtgc
181 aggcgctcct gctgctctgg ctctccttga ccgcggtgtg tggaggtgag tgcgcgccct
241 cccgctcgcc cgggctgcag ccggcgtgct cctttccctc cgccctattc gcactctccc
301 cgcctcccgg ggagcccggc gcgagccgtg cagtagcagc cacgcgccgg ccagcgccag
361 gcagcagatt gacagagcgc cccgagccat ggggcggctg gccacaagga ctgcttcttt
421 tgcggggctc aactcggcct ttggcatcac ctgcccgtca ccttgtccct cctaaccgtc
481 gctcgcagtc ccaggagctc aggaccacag gtgtgcgccg cgtgtcccac gccctgcacc
541 ccgcgtggta gaggtggagg cgggggacat gcccgctccc tcgtggatcg atggaaggaa
601 ctgaccagag tcgagtgggc tgggctccca tgttgaacgt cttctggtcc ctgaaggctg
661 ggagcctccc gccagtccag gggcgcggga aaccggggat gatgtgccaa catgcagacg
721 tgacacttgt tgcataggca ggagtgcgcg gagggggtgg cggcatggag cccagctgtt
781 gctcctttcg gcctgcatgt gtgagcagag gcagcctccc ccaggcaggg ccgggcccag
841 ccgggctggg ctggtcttct cctccctaac cccaaggtcc tggctggtct cctcccctgc
901 acaggatgcc ctccccatag cctccatccc acccccagag acttggttct cttacatcct
961 ggctccagcc ttcctttctg tcccaggcac ggacatgctt cactttagtc tccctgccgc
1021 taggcaccaa aggaggaagc acagcacctg acccgacccc tccctgcagc tcaggaaagg
1081 ggagtccttt tgccctcacc tgccaatact tggcactagt gcccatgtcc gcccctagcc
1141 tggtccccaa ccacgcccca gcagccccat cccaggctgc ctgtcctctg tgtcaatgtc
1201 tcctggggct gccagctccc acctccagct gccacagtcc tatgatctgg ctgtcattgc
1261 tgcctgcctg gcaccacaca aggggaaggc caagaccagg tggactaacg ccaggaccat
1321 ggctggagtc acagggaggt gggagcagaa agaaggagaa ggcagggcag tgagtttcct
1381 ggggcaaggg cacagggccc taagtggttc caaaccctcc agaacaggag gatggcatgc
1441 agcccaggag cctccgaggg gcccagccag ctctgcctgc ctctcatcgc aggccacctc
1501 ctttctctgc tcttgctttt tggccctgct gtggctctgg gaacactgcc tggcttctca
1561 gaaaggtgca gtggttgggg ctggcacctc ctgcctccag gtagctggcc ggtgatttct
1621 ctattcaaga cctgaacacg aagtgagcca ccaccacagt aagaagtggg taggcttttt
1681 ccacagaaac tcctgtcagg caggtaacag agggagcaaa agatacgaat gtaagatacg
1741 aatgatacac cataccagcc tatcctcagg gagcctacca tctggtgtca ttggcaaggc
1801 atgacacttg cacaatacca ccacaggcaa atagtccagg gtggtgcctt cagggaagaa
1861 gaagactggg tgcagagagt gttccagagg aaggtagggc tcctggatct gcacacttgg
1921 tgctcccccc agaggctgtg gggagacccc tggccaatag acaaccactc agaccctcct
1981 gggtcccagc cattgggaca gtactagcaa aggggagaga gctggtttca agggaaggga
2041 agtcagccag gatgcccgaa caccatgtgg ctggtccaga gcctgccact tcgtgcttta
2101 attcccccgt cttcattagg tcatctgtcc actgtgattt ggataaattc gttgccctca
2161 cattttgctc aagcctcgtg ctggaaactt tcagggctct cactgacttc tctactccct
2221 gacttctcct ggagccaagg aagggcatgt ccctggaagt ggccaccagc caagggtcca
2281 ggtacacatg tcctgctccc gctggctcct gtcctgggtt agaagcagga atcccagaac
2341 cactttgtcc ttggcccgga ctggcatgct gtccccagcc agagtcccca gtcaaagttc
2401 cagcctgaaa accacacttc ctcctctcca cagtctgtcc tgacttgaaa tgtccacccc
2461 cgacccctct ccacgctgcc tctcatcacc ccgctaccac cacgtacact cctccactgc
2521 ctcctgacct gggatacact ttgctcttgt gagtctgaga actcctggtc cagggccaag
2581 tgtccctcgg tctctgagca cccctctttt tccccttctc ctccccctcc gcaggcccag
2641 ctcaaagcct gcagtcacag tgggagtgtg aggagagcct actgtacccc tcctgctcag
2701 ggaagggcat ctctactcca tccccagtcc tcagcactaa gcacccgtgt aacctgagcc
2761 aggcctctcc tcgcaaagaa ctaaggcaag ggaagcagag ggccaccaga cagagcatga
2821 tgtatcccag ggcagcaaag ctggcactgg agacagcaca gggccctgga gaaggcgact
2881 gggatggggg gctgggcaga caaagagaca catgcaggac cacagagcag tggaggggca
2941 ttgccagcag ggtccccacc ggagcatacg tttgggcttt taaagtcatc acaagacagg
3001 ccagactgag agaggaaaaa caggtgcgtc attcctgatg agactggcat gttcctgaaa
3061 agtcgcaagt acctctttgt gcattggcag ggttggagtt cagatagcat gaaagtcaaa
3121 tcctgtcctc cccctgactg tggttctcag cgtggagatg ttgtagcttc gtggctgatg
3181 gcacttcagc aggcaatggc tccaatctct ctaggctcga gattgtttgg aggattgctc
3241 cagcctcctt ttacgtagca aatgagctgg aagaaaatat ttaagtgcat tagggctggc
3301 ctccatttct aaaggggaat tcttttttac agtcaagact tctgcagtga tgagaatcaa
3361 cagcctctaa tttgttcctt tggacagcat aaagccaggg tttcagatgt cagcttatct
3421 gatggtgagc cagactcaga atcaaaagta ggaaacaggt gggtgacggg ctcagagtgc
3481 gggaggagcc agcagatctc ggtgatgctg aggacaatga gtccccaacg caatgggagg
3541 gatgcaagaa gcctggggct gctctccagg gcccggctgg gggttcagtc agctcagagt
3601 ggttcttctc tgcagaccta gagtctagac atcttcctgg ccagagccac caaccctgct
3661 ccccatcctg acatatggcc tctagccctc cctttctgac tgccagacac tcacaatctg
3721 agcacctgga gatgatgccc tccccctcct ggcaccatgc ttctcttctc catgtctgcc
3781 accaccctga gctacaatgg cctgcaccac tgccccatcc cttctgcacc cccagcagtc
3841 gaaggtgcag aggtgagagc caagtgttga cttggttcac ttcacaaggc ccctaggtcc
3901 ttcccctgct ccttatcagc atcattcaga tccgccctca gtgatcaggg tgagccttgt
3961 ggggacccca gaactcaagg cagaggctga agcagctgca gtggggagct tagtgaaggt
4021 ctttccttcc tttccctctc cagccccagc cccctcacag atggcgccaa gagggtagct
4081 ctatgacagt cagacagaag cagccccctt gttccatcca tacttactgc tccaaagtgc
4141 taagataatt cttcttttaa ttctcatagg ttatgaattt aagggataag ttggcacgga
4201 agtgtggcta gttaaccaaa tgacccaagt caacagcggg gtcctcatgg gcctggcaat
4261 ttttcttggg gaaagaggga aggagggtgc aggcttggag aatatgtgtt tatgtgtgtg
4321 tgtgtggagg gggtgggtat gtctgggtgt gagtggggag aactgcaggc tcagaagcct
4381 gggggaagag ggccctaagg ccaaacccac ccacttttgg cccaagagga ggctgaacac
4441 ttggaaattg tgtgcaagca gaggaggact cacaaaaacc aaggagccaa ggaaggaaca
4501 gagcgtgggg atgttggagg cagaggcaga ggggaagggg gagctgccag gggtatgatt
4561 ggggtgtgag cagccaatgg gaggctctat ggaaactgtg agcaagtggt gggaattcct
4621 gggtagatgg caatggggct cgagggacag ggatctagat gcaggcaaat cagatggtgt
4681 gcagggggag agagactgtt attcattatc tctggcctca gatgctgtat ctgcacaggc
4741 ctgtactgga cattgcacaa gtaccctgcc tggctgcctc ttccccagca ccatctcatc
4801 tccacacact gcctgccacc accagccagg cttgtcttgg gggtggcagc tcagcttccc
4861 tgcatggact gcaggcttca cgagagtcgg cctgcatgcc ttttccctca ctgcacccaa
4921 ggataccctg caccacttgg attccattgt cagggctcag tctggtgtca ggaggcctct
4981 actctaagcc tcctgacaga tgtggacaga tgtaaagagg agccccagag tgcagaatag
5041 aagccagctg ggattgaaat ggaaggaatt tacatgagac acaggatgca gggtgtgatc
5101 tgggaatttc aggaggtagg gcattggtgg ggaggtacca actgcaacag cccacccccc
5161 tcctggtgca cagacatgct gctgaaggtg accattgttt catttattca ttctcaaata
5221 ttcatgcaat atttattggt ctctaaatct ggtctcaggt ctctaaatct ggtcacagca
5281 tgaggcaggc tgagtcagag acctctcccc cttaacccgc ctggcccagc cccatccact
5341 gggaggactt ggcgccctag agatgcctaa ccaccgatga gacacccagg ggcgagatat
5401 gagctcccta gtactcacaa gtgggtcatc ctgcatatca aaggatgtag gagtacaatg
5461 acgtgatgtt cgggatttgc tttaaaatac tgcagtcaag gaaaatagaa aagggataac
5521 taaagcatat gtgactccat ctggataact gttgaatctg ggtgatgggt ccatggcggt
5581 gggagggtca ttgtaatgtc atatgtctga aatgtttgaa gtgtaccagt tgcaggggtg
5641 ccgtggtgat tactgcctcc tgccccccag ccaagtacag gcgtgacaac ccaaagtgca
5701 caccccccaa tgacgttcca aagaaagaac ccacttgtgc ctgtcagaaa catgatataa
5761 ctgtcaaaag gacagaaagt cagctacatc aatggcaaga tgtgagtagt aggttccgtt
5821 tgtcccagga cagtgcagaa atggcaaatt ttccctcaat atgaaaaaaa gaaacaaaga
5881 aaatctatga gaagtgccac cacatggaca gaccacccct cccgcgggcc tgtggtctgc
5941 agcccctgcc cgtttccaac aaccttcctc actaacaggc tttctccttc ctgcagggtc
6001 cctgatgccg cttcccgatg ggaatgggct ggaagacggc aatgtccgcc acctggtgca
6061 gcccagaggg tcaaggaatg ggccagggcc ctggcaggga ggtcggagga aattccgccg
6121 ccagcggccc cgcctctccc ataagggacc catgcctttc tgaagcaggt acttgagcct
6181 ctgttcagtg gacagtgcta aagcggaggg agaaggacag cctagaagcc gggtgatcct
6241 gccgctcatc actggccaga cacatccatc aaacagtcct ggcgccacac tcacagaggc
6301 ttagagctgg caagagagct tatggggcag ctgtctagcc cctttatttt acagacgatc
6361 tcctcgtctg aggcctagag aggggcttga tacttggggc cagtctccct tccaccctgc
6421 tgcctggggt tggggaggct ggcctgctta gagatttcta gacatcctgg tggaccttaa
6481 tggctgggga ggggtgccca gggcaaacct acagatgtcc agtgtagatt gtcgccagag
6541 ttggggaagg aggcagagag ctctaggggc tctcaggcag agaacaagag gacagttgtg
6601 gctgtggttg cccggagctg tgagaaggag ggaagaacca aggtggcagc agagagagga
6661 gagctgaagc ctgccccttc cctggtctgc tggctgtccc actgcagtgg ggacaggcag
6721 gcaccaactc aggggccttg ggattgaggt ttgggctgag tggagtttgg gggaaagaga
6781 aggcggtctc ctctctcctc tcctttcctg gggagttcct ttggcctagg atatgtccat
6841 gacttctctc ttgtcatttt tgtctcctta ggactgaagg ggcccccaag tgcccacccc
6901 cggcggttat gtctcctcca tagattggtc tgcttctctg gaggcctcac gtccattcag
6961 ctctcacctc gcacctgctg tagccaccag tgggcccagc tcttctcacc tgcctgcttc
7021 ccccagtggc gtgctcctgg ctgtagtttg gatgattccc gttctctcac aagaatccgt
7081 ccagtccatc ttcctggccc ctccctggac tgactttgga gacctagccc cagaaagcct
7141 cccttcttct ccaggtcccc tccgccctag tccctgcctg tctcatctaa cgccccaaac
7201 cttcatttgg gccttccttc ctcatgtctg ccctgagcgc ggggtggaag tgctcccttc
7261 tgtgggctcc agcagatccc ttgttttcct gtcagttgga cccctcacct ggcctccagg
7321 gaagaatgca gagaaaagca aggagagact ctagttaaga ggtgctggct gcggggatcc
7381 agacagggca cattgggggc atggaagtgc cagggtggtt ttcaggagct ctggtgaagt
7441 gggtggagca tcagcgtttg ctcagttaag ggagaggtag agaggggccc gtgaagtcct
7501 ttgtcacttc tcttgcctta gtgtgcctcc caatactccc ttcttcctgc ccccacaccc
7561 catccccagc tagcccaagc tccaggtcag gaggggaggg tgctgggcct gacatggcta
7621 tataccctcc caggagtaaa agccaagcaa gaggttgttt ttgccaagaa tcacagaatg
7681 ttagagctga caggaccctt gaaggtcact tagccttctt aggcaaacgc ctgcaaaaca
7741 gaagcctgga gaggggagtg acctgctcag agtcattgca gagccgggat ggggaccagg
7801 tctcccatct cctactttat gacgccctct tccctcttga tgatgtcttt tcaaagcaaa
7861 tgaagtgcct tttcccgagg ctggggctgg gggtggctgg gaggggaagg gaagggagag
7921 gcaagctggc tgtgaactgt cctgttgtgg ggctggagct gctcccacct ccctgaccta
7981 cccctgctgc accattcccc cagctgggct ggaaggttcc ataactggcc agctgccccc
8041 ataactggca gcattcccag acccagggta ctctaatagg ggcggctcag gcactgagac
8101 taccgctcaa ccccagggtg gttttcagga gtccgaggta gccttcaatc actggactcc
8161 atggccttcc cttcgtgttg accggacctt ccttccaggg cttttccttt gggggaggcg
8221 gagaggggag aagaaggaag ggaagggcag aaggaaggag ggaagaaaag a
//