LOCUS AF179224 2081 bp mRNA linear HUM 08-JUN-2000
DEFINITION Homo sapiens transmembrane serine protease 3 (TMPRSS3) mRNA,
complete cds.
ACCESSION AF179224
VERSION AF179224.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2081)
AUTHORS Wallrapp,C., Hahnel,S., Muller-Pillasch,F., Burghardt,B.,
Iwamura,T., Ruthenburger,M., Lerch,M.M., Adler,G. and Gress,T.M.
TITLE A novel transmembrane serine protease (TMPRSS3) overexpressed in
pancreatic cancer
JOURNAL Cancer Res. 60 (10), 2602-2606 (2000)
PUBMED 10825129
REFERENCE 2 (bases 1 to 2081)
AUTHORS Wallrapp,C. and Gress,T.M.
TITLE Direct Submission
JOURNAL Submitted (20-AUG-1999) Internal Medicine I, University of Ulm,
Robert-Koch-Street 8, Ulm, Baden-Wuerttemberg 89081, Germany
FEATURES Location/Qualifiers
source 1..2081
/db_xref="H-InvDB:HIT000072758"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
/tissue_type="pancreatic carcinoma"
gene 1..2081
/gene="TMPRSS3"
CDS 215..1528
/gene="TMPRSS3"
/codon_start=1
/product="transmembrane serine protease 3"
/protein_id="AAF74526.1"
/translation="MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLA
SIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAV
AVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQ
DLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPW
QVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKI
IIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQ
NGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLM
YQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL"
misc_feature 215..307
/gene="TMPRSS3"
/note="Region: cytoplasmic domain"
misc_feature 308..373
/gene="TMPRSS3"
/note="Region: transmembrane domain"
misc_feature 374..1525
/gene="TMPRSS3"
/note="Region: extracellular domain"
misc_feature 602..604
/gene="TMPRSS3"
/note="glycosylation site"
misc_feature 746..748
/gene="TMPRSS3"
/note="glycosylation site"
misc_feature order(800..802,1142..1144)
/gene="TMPRSS3"
/note="disulfide bond"
misc_feature order(902..904,950..952)
/gene="TMPRSS3"
/note="disulfide bond"
misc_feature 947..949
/gene="TMPRSS3"
/note="active site"
misc_feature 1082..1084
/gene="TMPRSS3"
/note="active site"
misc_feature order(1280..1282,1328..1330)
/gene="TMPRSS3"
/note="disulfide bond"
misc_feature 1373..1375
/gene="TMPRSS3"
/note="active site"
BASE COUNT 484 a 597 c 576 g 424 t
ORIGIN
1 acacagagag aggcagcagc ttgctcagcg gacaaggatg ctgggcgtga gggaccaagg
61 cctgccctgc actcgggcct cctccagcca gtgctgacca gggacttctg acctgctggc
121 cagccaggac ctgtgtgggg aggccctcct gctgccttgg ggtgacaatc tcagctccag
181 gctacaggga gaccgggagg atcacagagc cagcatgtta caggatcctg acagtgatca
241 acctctgaac agcctcgatg tcaaacccct gcgcaaaccc cgtatcccca tggagacctt
301 cagaaaggtg gggatcccca tcatcatagc actactgagc ctggcgagta tcatcattgt
361 ggttgtcctc atcaaggtga ttctggataa atactacttc ctctgcgggc agcctctcca
421 cttcatcccg aggaagcagc tgtgtgacgg agagctggac tgtcccttgg gggaggacga
481 ggagcactgt gtcaagagct tccccgaagg gcctgcagtg gcagtccgcc tctccaagga
541 ccgatccaca ctgcaggtgc tggactcggc cacagggaac tggttctctg cctgtttcga
601 caacttcaca gaagctctcg ctgagacagc ctgtaggcag atgggctaca gcagcaaacc
661 cactttcaga gctgtggaga ttggcccaga ccaggatctg gatgttgttg aaatcacaga
721 aaacagccag gagcttcgca tgcggaactc aagtgggccc tgtctctcag gctccctggt
781 ctccctgcac tgtcttgcct gtgggaagag cctgaagacc ccccgtgtgg tgggtgggga
841 ggaggcctct gtggattctt ggccttggca ggtcagcatc cagtacgaca aacagcacgt
901 ctgtggaggg agcatcctgg acccccactg ggtcctcacg gcagcccact gcttcaggaa
961 acataccgat gtgttcaact ggaaggtgcg ggcaggctca gacaaactgg gcagcttccc
1021 atccctggct gtggccaaga tcatcatcat tgaattcaac cccatgtacc ccaaagacaa
1081 tgacatcgcc ctcatgaagc tgcagttccc actcactttc tcaggcacag tcaggcccat
1141 ctgtctgccc ttctttgatg aggagctcac tccagccacc ccactctgga tcattggatg
1201 gggctttacg aagcagaatg gagggaagat gtctgacata ctgctgcagg cgtcagtcca
1261 ggtcattgac agcacacggt gcaatgcaga cgatgcgtac cagggggaag tcaccgagaa
1321 gatgatgtgt gcaggcatcc cggaaggggg tgtggacacc tgccagggtg acagtggtgg
1381 gcccctgatg taccaatctg accagtggca tgtggtgggc atcgttagct ggggctatgg
1441 ctgcgggggc ccgagcaccc caggagtata caccaaggtc tcagcctatc tcaactggat
1501 ctacaatgtc tggaaggctg agctgtaatg ctgctgcccc tttgcagtgc tgggagccgc
1561 ttccttcctg ccctgcccac ctggggatcc cccaaagtca gacacagagc aagagtcccc
1621 ttgggtacac ccctctgccc acagcctcag catttcttgg agcagcaaag ggcctcaatt
1681 cctataagag accctcgcag cccagaggcg cccagaggaa gtcagcagcc ctagctcggc
1741 cacacttggt gctcccagca tcccagggag agacacagcc cactgaacaa ggtctcaggg
1801 gtattgctaa gccaagaagg aactttccca cactactgaa tggaagcagg ctgtcttgta
1861 aaagcccaga tcactgtggg ctggagagga gaaggaaagg gtctgcgcca gccctgtccg
1921 ttttcaccca tccccaagcc tactagagca agaaaccagt tgtaatataa aatgcactgc
1981 cctactgttg gtatgactac cgttacctac tgttgtcatt gttattacag ctatggccac
2041 tattattaaa gagctgtgta acatttctgg caaaaaaaaa a
//