LOCUS AF178930 4485 bp mRNA linear HUM 13-FEB-2001
DEFINITION Homo sapiens NOD2 protein (NOD2) mRNA, complete cds.
ACCESSION AF178930
VERSION AF178930.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4485)
AUTHORS Ogura,Y., Inohara,N., Benito,A., Chen,F.F., Yamaoka,S. and Nunez,G.
TITLE Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes
and activates NF-kappaB
JOURNAL J. Biol. Chem. 276 (7), 4812-4818 (2001)
PUBMED 11087742
REFERENCE 2 (bases 1 to 4485)
AUTHORS Inohara,N., Ogura,Y. and Nunez,G.
TITLE Direct Submission
JOURNAL Submitted (19-AUG-1999) Department of Pathology, Comprehensive
Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA
FEATURES Location/Qualifiers
source 1..4485
/db_xref="H-InvDB:HIT000072744"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
gene 1..4485
/gene="NOD2"
CDS 106..3228
/gene="NOD2"
/note="contains two CARD domains and LRRs; novel member of
NOD protein family"
/codon_start=1
/product="NOD2 protein"
/protein_id="AAG33677.1"
/translation="MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVEL
LVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQK
LIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERG
FVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAAT
CKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATL
GLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCR
QLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRE
RHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQ
GIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPK
TTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFS
AQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPA
LLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLL
SREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFI
WLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLD
YNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLT
DGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDE
GAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGV
CSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDK
LGCRDTRLLL"
regulatory 4465..4470
/regulatory_class="polyA_signal_sequence"
/gene="NOD2"
polyA_site 4485
/gene="NOD2"
BASE COUNT 953 a 1264 c 1213 g 1055 t
ORIGIN
1 gtagacagat ccaggctcac cagtcctgtg ccactgggct tttggcgttc tgcacaaggc
61 ctacccgcag atgccatgcc tgctccccca gcctaatggg ctttgatggg ggaagagggt
121 ggttcagcct ctcacgatga ggaggaaaga gcaagtgtcc tcctcggaca ttctccgggt
181 tgtgaaatgt gctcgcagga ggcttttcag gcacagagga gccagctggt cgagctgctg
241 gtctcagggt ccctggaagg cttcgagagt gtcctggact ggctgctgtc ctgggaggtc
301 ctctcctggg aggactacga gggcttccac ctcctgggcc agcctctctc ccacttggcc
361 aggcgccttc tggacaccgt ctggaataag ggtacttggg cctgtcagaa gctcatcgcg
421 gctgcccaag aagcccaggc cgacagccag tcccccaagc tgcatggctg ctgggacccc
481 cactcgctcc acccagcccg agacctgcag agtcaccggc cagccattgt caggaggctc
541 cacagccatg tggagaacat gctggacctg gcatgggagc ggggtttcgt cagccagtat
601 gaatgtgatg aaatcaggtt gccgatcttc acaccgtccc agagggcaag aaggctgctt
661 gatcttgcca cggtgaaagc gaatggattg gctgccttcc ttctacaaca tgttcaggaa
721 ttaccagtcc cattggccct gcctttggaa gctgccacat gcaagaagta tatggccaag
781 ctgaggacca cggtgtctgc tcagtctcgc ttcctcagta cctatgatgg agcagagacg
841 ctctgcctgg aggacatata cacagagaat gtcctggagg tctgggcaga tgtgggcatg
901 gctggacccc cgcagaagag cccagccacc ctgggcctgg aggagctctt cagcacccct
961 ggccacctca atgacgatgc ggacactgtg ctggtggtgg gtgaggcggg cagtggcaag
1021 agcacgctcc tgcagcggct gcacttgctg tgggctgcag ggcaagactt ccaggaattt
1081 ctctttgtct tcccattcag ctgccggcag ctgcagtgca tggccaaacc actctctgtg
1141 cggactctac tctttgagca ctgctgttgg cctgatgttg gtcaagaaga catcttccag
1201 ttactccttg accaccctga ccgtgtcctg ttaacctttg atggctttga cgagttcaag
1261 ttcaggttca cggatcgtga acgccactgc tccccgaccg accccacctc tgtccagacc
1321 ctgctcttca accttctgca gggcaacctg ctgaagaatg cccgcaaggt ggtgaccagc
1381 cgtccggccg ctgtgtcggc gttcctcagg aagtacatcc gcaccgagtt caacctcaag
1441 ggcttctctg aacagggcat cgagctgtac ctgaggaagc gccatcatga gcccggggtg
1501 gcggaccgcc tcatccgcct gctccaagag acctcagccc tgcacggttt gtgccacctg
1561 cctgtcttct catggatggt gtccaaatgc caccaggaac tgttgctgca ggaggggggg
1621 tccccaaaga ccactacaga tatgtacctg ctgattctgc agcattttct gctgcatgcc
1681 acccccccag actcagcttc ccaaggtctg ggacccagtc ttcttcgggg ccgcctcccc
1741 accctcctgc acctgggcag actggctctg tggggcctgg gcatgtgctg ctacgtgttc
1801 tcagcccagc agctccaggc agcacaggtc agccctgatg acatttctct tggcttcctg
1861 gtgcgtgcca aaggtgtcgt gccagggagt acggcgcccc tggaattcct tcacatcact
1921 ttccagtgct tctttgccgc gttctacctg gcactcagtg ctgatgtgcc accagctttg
1981 ctcagacacc tcttcaattg tggcaggcca ggcaactcac caatggccag gctcctgccc
2041 acgatgtgca tccaggcctc ggagggaaag gacagcagcg tggcagcttt gctgcagaag
2101 gccgagccgc acaaccttca gatcacagca gccttcctgg cagggctgtt gtcccgggag
2161 cactggggcc tgctggctga gtgccagaca tctgagaagg ccctgctccg gcgccaggcc
2221 tgtgcccgct ggtgtctggc ccgcagcctc cgcaagcact tccactccat cccgccagct
2281 gcaccgggtg aggccaagag cgtgcatgcc atgcccgggt tcatctggct catccggagc
2341 ctgtacgaga tgcaggagga gcggctggct cggaaggctg cacgtggcct gaatgttggg
2401 cacctcaagt tgacattttg cagtgtgggc cccactgagt gtgctgccct ggcctttgtg
2461 ctgcagcacc tccggcggcc cgtggccctg cagctggact acaactctgt gggtgacatt
2521 ggcgtggagc agctgctgcc ttgccttggt gtctgcaagg ctctgtattt gcgcgataac
2581 aatatctcag accgaggcat ctgcaagctc attgaatgtg ctcttcactg cgagcaattg
2641 cagaagttag ctctattcaa caacaaattg actgacggct gtgcacactc catggctaag
2701 ctccttgcat gcaggcagaa cttcttggca ttgaggctgg ggaataacta catcactgcc
2761 gcgggagccc aagtgctggc cgaggggctc cgaggcaaca cctccttgca gttcctggga
2821 ttctggggca acagagtggg tgacgagggg gcccaggccc tggctgaagc cttgggtgat
2881 caccagagct tgaggtggct cagcctggtg gggaacaaca ttggcagtgt gggtgcccaa
2941 gccttggcac tgatgctggc aaagaacgtc atgctagaag aactctgcct ggaggagaac
3001 catctccagg atgaaggtgt atgttctctc gcagaaggac tgaagaaaaa ttcaagtttg
3061 aaaatcctga agttgtccaa taactgcatc acctacctag gggcagaagc cctcctgcag
3121 gcccttgaaa ggaatgacac catcctggaa gtctggctcc gagggaacac tttctctcta
3181 gaggaggttg acaagctcgg ctgcagggac accagactct tgctttgaag tctccgggag
3241 gatgttcgtc tcagtttgtt tgtgagcagg ctgtgagttt gggccccaga ggctgggtga
3301 catgtgttgg cagcctcttc aaaatgagcc ctgtcctgcc taaggctgaa cttgttttct
3361 gggaacacca taggtcacct ttattctggc agaggaggga gcatcagtgc cctccaggat
3421 agacttttcc caagcctact tttgccattg acttcttccc aagattcaat cccaggatgt
3481 acaaggacag cccctcctcc atagtatggg actggcctct gctgatcctc ccaggcttcc
3541 gtgtgggtca gtggggccca tggatgtgct tgttaactga gtgccttttg gtggagaggc
3601 ccggcctctc acaaaagacc ccttaccact gctctgatga agaggagtac acagaacaca
3661 taattcagga agcagctttc cccatgtctc gactcatcca tccaggccat tccccgtctc
3721 tggttcctcc cctcctcctg gactcctgca cacgctcctt cctctgaggc tgaaattcag
3781 aatattagtg acctcagctt tgatatttca cttacagcac ccccaaccct ggcacccagg
3841 gtgggaaggg ctacacctta gcctgccctc ctttccggtg tttaagacat ttttggaagg
3901 ggacacgtga cagccgtttg ttccccaaga cattctaggt ttgcaagaaa aatatgacca
3961 cactccagct gggatcacat gtggactttt atttccagtg aaatcagtta ctcttcagtt
4021 aagcctttgg aaacagctcg actttaaaaa gctccaaatg cagctttaaa aaattaatct
4081 gggccagaat ttcaaacggc ctcactaggc ttctggttga tgcctgtgaa ctgaactctg
4141 acaacagact tctgaaatag acccacaaga ggcagttcca tttcatttgt gccagaatgc
4201 tttaggatgt acagttatgg attgaaagtt tacaggaaaa aaaattaggc cgttccttca
4261 aagcaaatgt cttcctggat tattcaaaat gatgtatgtt gaagcctttg taaattgtca
4321 gatgctgtgc aaatgttatt attttaaaca ttatgatgtg tgaaaactgg ttaatattta
4381 taggtcactt tgttttactg tcttaagttt atactcttat agacaacatg gccgtgaact
4441 ttatgctgta aataatcaga ggggaataaa ctgttgagtc aaaac
//