LOCUS AF177665 2267 bp mRNA linear HUM 09-MAR-2000
DEFINITION Homo sapiens rho GTPase-activating protein 6 isoform 5 (ARHGAP6)
mRNA, complete cds.
ACCESSION AF177665
VERSION AF177665.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2267)
AUTHORS Schaefer,L., Prakash,S. and Zoghbi,H.Y.
TITLE Cloning and characterization of a novel rho-type GTPase-activating
protein gene (ARHGAP6) from the critical region for microphthalmia
with linear skin defects
JOURNAL Genomics 46 (2), 268-277 (1997)
PUBMED 9417914
REFERENCE 2 (bases 1 to 2267)
AUTHORS Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
TITLE Functional analysis of ARHGAP6, a novel GTPase-activating protein
for RhoA
JOURNAL Hum. Mol. Genet. 9 (4), 477-488 (2000)
PUBMED 10699171
REFERENCE 3 (bases 1 to 2267)
AUTHORS Prakash,S.K.
TITLE Direct Submission
JOURNAL Submitted (15-AUG-1999) Molecular and Human Genetics, Baylor
College of Medicine, 1 Baylor Plaza, Room T836, Houston, TX 77030,
USA
FEATURES Location/Qualifiers
source 1..2267
/db_xref="H-InvDB:HIT000072725"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.3"
gene 1..2267
/gene="ARHGAP6"
CDS 118..1806
/gene="ARHGAP6"
/note="alternatively spliced"
/codon_start=1
/product="rho GTPase-activating protein 6 isoform 5"
/protein_id="AAD55087.1"
/translation="MSGRSVRLRSVPIQSLSELERARLQEVPFYQLQQDCDLSCQITI
PKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQ
KDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMS
VDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHL
EKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDP
LLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNI
SKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMI
ENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSS
SKSRESSPGPRLGKGNWSLASRRWPKQATLLLLHVAWCGALRTFSSSLPYLMFL"
BASE COUNT 622 a 589 c 539 g 517 t
ORIGIN
1 ttggagttgt atgatcttca gatcttaggc acaaaaccac cgatgaattc cgatacacat
61 cgtaactttg accccaccgc aacccttaga aatcagggtg atttcacctg gaacagcatg
121 tcaggccgca gtgtgcggct gaggtcagtc cccatccaga gtctctcaga gctggagagg
181 gcccggctgc aggaagtgcc tttttatcag ttgcaacagg actgtgacct gagctgtcag
241 atcaccattc ccaaagatgg acaaaagaga aagaaatctt taagaaagaa actggattca
301 ctaggaaagg agaaaaacaa agacaaagaa ttcatcccac aggcatttgg aatgccctta
361 tcccaagtca ttgcgaatga cagggcctat aaactcaagc aggacttgca gagggacgag
421 cagaaagatg catctgactt tgtggcttcc ctcctcccat ttggaaataa aagacaaaac
481 aaagaactct caagcagtaa ctcatctctc agctcaacct cagaaacacc gaatgagtca
541 acgtccccaa acaccccgga accggctcct cgggctagga ggaggggtgc catgtcagtg
601 gattctatca ccgatcttga tgacaatcag tctcgactac tagaagcttt acaactttcc
661 ttgcctgctg aggctcaaag taaaaaggaa aaagccagag ataagaaact cagtctgaat
721 cctatttaca gacaggtccc taggctggtg gacagctgct gtcagcacct agaaaaacat
781 ggcctccaga cagtggggat attccgagtt ggaagctcaa aaaagagagt gagacaatta
841 cgtgaggaat ttgaccgtgg gattgatgtc tctctggagg aggagcacag tgttcatgat
901 gtggcagcct tgctgaaaga gttcctgagg gacatgccag acccccttct caccagggag
961 ctgtacacag ctttcatcaa cactctcttg ttggagccgg aggaacagct gggcaccttg
1021 cagctcctca tataccttct acctccctgc aactgcgaca ccctccaccg cctgctacag
1081 ttcctctcca tcgtggccag gcatgccgat gacaacatca gcaaagatgg gcaagaggtc
1141 actgggaata aaatgacatc tctaaactta gccaccatat ttggacccaa cctgctgcac
1201 aagcagaagt catcagacaa agaattctca gttcagagtt cagcccgggc tgaggagagc
1261 acggccatca tcgctgttgt gcaaaagatg attgaaaatt atgaagccct gttcatggtt
1321 cccccagatc tccagaacga agtgctgatc agcctgttag agaccgatcc tgatgtcgtg
1381 gactatttac tcagaagaaa ggcttcccaa tcatcaagcc ctgacatgct gcagtcggaa
1441 gtttcctttt ccgtgggagg gaggcattca tctacagact ccaacaaggc ctccagcgga
1501 gacatctccc cttatgacaa caactcccca gtgctgtctg agcgctccct gctggctatg
1561 caagaggacg cggccccggg gggctcggag aagctttaca gagtgccagg gcagtttatg
1621 ctggtgggcc acttgtcgtc gtcaaagtca agggaaagtt ctcctggacc aaggcttggg
1681 aaaggtaact ggagcctggc cagcaggcgc tggccaaaac aagcgaccct cctcttgttg
1741 catgtggcat ggtgtggggc tcttcggacc ttctcttcgt ctctccctta tttgatgttt
1801 ctgtaattca acctgcattt accgagtacc tgctgaacgc ctactctagg aagaggaagg
1861 tatggcgagc ccagtcgttg gctgggaggg tccctgcagg ccacactcca agtctcagat
1921 atctgggaaa taaacgcatg cccagaggag ccactcctat tcccagctga ttctttttcc
1981 ctccagcatc ctaggaactt tatgtatact ggatttgggt tgcatatttg ctagtctgag
2041 gtgccaccca attactgctg ttacatttct aaagaaaaca agctgaacct actatatgta
2101 tgaagacaac cttccagaac caaatagtgt tagtatccaa tgacaagaga gcactatact
2161 gggagtcaca aacctgctct gccactttca acctgcagga tctccagtga gcgattgagc
2221 ttcccagagt cccatttcct cctgctgtga aaactcagaa tgataac
//