LOCUS AF177663 3961 bp mRNA linear HUM 09-MAR-2000
DEFINITION Homo sapiens GTPase-activating protein 6 isoform 4 (ARHGAP6) mRNA,
alternatively spliced, complete cds.
ACCESSION AF177663
VERSION AF177663.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3961)
AUTHORS Prakash,S.K., Paylor,R., Jenna,S., Lamarche-Vane,N.,
Armstrong,D.L., Xu,B., Mancini,M.A. and Zoghbi,H.Y.
TITLE Functional analysis of ARHGAP6, a novel GTPase-activating protein
for RhoA
JOURNAL Hum. Mol. Genet. 9 (4), 477-488 (2000)
PUBMED 10699171
REFERENCE 2 (bases 1 to 3961)
AUTHORS Prakash,S.K.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-1999) Molecular and Human Genetics, Baylor
College of Medicine, 1 Baylor Plaza, Room T836, Houston, TX 77030,
USA
FEATURES Location/Qualifiers
source 1..3961
/db_xref="H-InvDB:HIT000072724"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.3"
gene 1..3961
/gene="ARHGAP6"
CDS 312..2627
/gene="ARHGAP6"
/note="alternatively spliced"
/codon_start=1
/product="GTPase-activating protein 6 isoform 4"
/protein_id="AAD53166.1"
/translation="MSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITI
PKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQ
KDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMS
VDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHL
EKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDP
LLTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNI
SKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMI
ENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRH
SSTDSNKASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSS
SKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPC
SLSQGNLSPNWPRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVA
GKAERPTARSEQYLTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYP
GPGKPAAAAAWIQGPPEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLG
DAGWLDWQRERWQIWELLSTDNPDALPETLV"
BASE COUNT 1157 a 955 c 931 g 918 t
ORIGIN
1 gcctgcctct gttctgaaag gacaggaact tctcaatgat ccgatgaaaa gattgcatat
61 ttttggtccc aagattcaca gtagcggagg tctctggcaa caaaaggtat cgtgggagtc
121 acagctatgc cagctgggcc atttctcaga cattcaatat gatctgccat ttcaggatgc
181 attttttacc aaaaaaataa tttttttaaa acagactcaa cttcctactg caagcttagt
241 tcagttagat tagagaggac agcaaagacg cggctgatta taatttatgg ggtgatttca
301 cctggaacag catgtcaggc cgcagtgtac ggctgaggtc agtccccatc cagagtctct
361 cagagctgga gagggcccgg ctgcaggaag tggcttttta tcagttgcaa caggactgtg
421 acctgagctg tcagatcacc attcccaaag atggacaaaa gagaaagaaa tctttaagaa
481 agaaactgga ttcactagga aaggagaaaa acaaagacaa agaattcatc ccacaggcat
541 ttggaatgcc cttatcccaa gtcattgcga atgacagggc ctataaactc aagcaggact
601 tgcagaggga cgagcagaaa gatgcatctg actttgtggc ttccctcctc ccatttggaa
661 ataaaagaca aaacaaagaa ctctcaagca gtaactcatc tctcagctca acctcagaaa
721 caccgaatga gtcaacgtcc ccaaacaccc cggaaccggc tcctcgggct aggaggaggg
781 gtgccatgtc agtggattct atcaccgatc ttgatgacaa tcagtctcga ctactagaag
841 ctttacaact ttccttgcct gctgaggctc aaagtaaaaa ggaaaaagcc agagataaga
901 aactcagtct gaatcctatt tacagacagg tccctaggct ggtggacagc tgctgtcagc
961 acctagaaaa acatggcctc cagacagtgg ggatattccg agttggaagc tcaaaaaaga
1021 gagtgagaca attacgtgag gaatttgacc gtgggattga tgtctctctg gaggaggagc
1081 acagtgttca tgatgtggca gccttgctga aagagttcct gagggacatg ccagaccccc
1141 ttctcaccag ggagctgtac acagctttca tcaacactct cttgttggag ccggaggaac
1201 agctgggcac cttgcagctc ctcatatacc ttctacctcc ctgcaactgc gacaccctcc
1261 accgcctgct acagttcctc tccatcgtgg ccaggcatgc cgatgacaac atcagcaaag
1321 atgggcaaga ggtcactggg aataaaatga catctctaaa cttagccacc atatttggac
1381 ccaacctgct gcacaagcag aagtcatcag acaaagaatt ctcagttcag agttcagccc
1441 gggctgagga gagcacggcc atcatcgctg ttgtgcaaaa gatgattgaa aattatgaag
1501 ccctgttcat ggttccccca gatctccaga acgaagtgct gatcagcctg ttagagaccg
1561 atcctgatgt cgtggactat ttactcagaa gaaaggcttc ccaatcatca agccctgaca
1621 tgctgcagtc ggaagtttcc ttttccgtgg gagggaggca ttcatctaca gactccaaca
1681 aggcctccag cggagacatc tccccttatg acaacaactc cccagtgctg tctgagcgct
1741 ccctgctggc tatgcaagag gacgcggccc cggggggctc ggagaagctt tacagagtgc
1801 cagggcagtt tatgctggtg ggccacttgt cgtcgtcaaa gtcaagggaa agttctcctg
1861 gaccaaggct tgggaaagat ctgtcagagg agcctttcga tatctgggga acttggcatt
1921 caacattaaa aagcggatcc aaagacccag gaatgacagg ttcctctgga gacatttttg
1981 aaagcagctc cctaagagcg gggccctgct ccctttctca agggaacctg tccccaaatt
2041 ggcctcggtg gcaggggagc cccgcagagc tggacagcga cacgcagggg gctcggagga
2101 ctcaggccgc agcccccgcg acggagggca gggcccaccc tgcggtgtcg cgcgcctgca
2161 gcacgcccca cgtccaggtg gcagggaaag ccgagcggcc cacggccagg tcggagcagt
2221 acttgaccct gagcggcgcc cacgacctca gcgagagtga gctggatgtg gccgggctgc
2281 agagccgggc cacacctcag tgccaaagac cccatgggag tgggagggat gacaagcggc
2341 ccccgcctcc atacccgggc ccagggaagc ccgcggcagc ggcagcctgg atccaggggc
2401 ccccggaagg cgtggagaca cccacggacc agggaggcca agcagccgag cgagagcagc
2461 aggtcacgca gaaaaaactg agcagcgcca actccctgcc agcgggcgag caggacagtc
2521 cgcgcctggg ggacgctggc tggctcgact ggcagagaga gcgctggcag atctgggagc
2581 tcctgtcgac cgacaacccc gatgccctgc ccgagacgct ggtctgagcc cgcacccagc
2641 cgagcccccc ctgccccgag ccccccgccc tccagcccag gggggaccgt gggtggtggc
2701 cactggcaca cttagtgttc ttctttcaca cttctcaaaa gtgacacaag agaaatccag
2761 ttcacctaca gaggtagagc actcacgccc ccgccattga gaataaggtt ccattgcgta
2821 gccagcctta ggaaaaacaa acagaaccca aaccagatgg caatgtccaa tctaaaaacg
2881 tccctcttgg ctctataata taagatacaa ctcttgcttg gtatagccta accgtattta
2941 tgtgtcttcg gttttgacta ttgtgtattc tgtaacagat tatgtataat catatatgat
3001 atattcacaa agagaaaaca aaaggaactt ttaaaaaaaa aatcacttca cttatattaa
3061 gcaatgagat atactaaaca atgagattct atagaatgtt ctagaatgtg cacaagcggg
3121 tttctgtgct tttgccatag ctttataact ggggataacc cttccttcga taccaaacac
3181 taacaagagg aagcagaata tgagaagcca tatttttaca taggagtcag atacaaaaag
3241 aaaaatcact gaatgctttt agatattgaa tacgttttca ggaaaatgct aaatctgata
3301 gattacgaaa tatattttta gaacttgttt agaaaggatt cagttaacca aacaagaaaa
3361 aggcagtgcc tcacaaagaa attaagaagt tgtccgtccc acgttacatc aaattcagtt
3421 ttatataggc catatataat atatatttat aatgtataat ttttatgtat ttttcaaaac
3481 tacaaactgg aatccaacta taaagtgttt aagaatctac acagaatatt caaattatag
3541 aacatgtttt ttccctttgc cccataatca gtatttgcca aattacatgc aattccttaa
3601 aaactaaatc acattggtaa aaggcctaca gctttgtact tacattgtgc caaaggctga
3661 ggaaatgttt tctttcgaat ttttatgtgt attgtaaaat gttctaccgt actttagtag
3721 tttgaagttt tcaagtgcat aactattttt gaccagcaga aggcgatacg cttcagtatt
3781 ttatgcaatt ttttttcact tcgaagggaa agtgtattat aaaaaaagat tttttttttt
3841 taaaacatgc tactcttaat tttcatgttg gtgatgaaat tcccagtggt gtttcttaag
3901 gttctatctt gtgccatgat gaataaaaag ttaagcaaaa aaaaaaaaaa aaaaaaaaaa
3961 a
//