LOCUS AF176813 5018 bp mRNA linear HUM 28-APR-2003
DEFINITION Homo sapiens soluble adenylyl cyclase mRNA, complete cds.
ACCESSION AF176813
VERSION AF176813.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5018)
AUTHORS Buck,J., Sinclair,M.L., Schapal,L., Cann,M.J. and Levin,L.R.
TITLE Cytosolic adenylyl cyclase defines a unique signaling molecule in
mammals
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (1), 79-84 (1999)
PUBMED 9874775
REFERENCE 2 (bases 1 to 5018)
AUTHORS Litvin,T.N., Kamenetsky,M., Zarifyan,A., Buck,J. and Levin,L.R.
TITLE Kinetic properties of 'soluble' adenylyl cyclase. Synergism between
calcium and bicarbonate
JOURNAL J. Biol. Chem. 278 (18), 15922-15926 (2003)
PUBMED 12609998
REFERENCE 3 (bases 1 to 5018)
AUTHORS Mattia,M., Buck,J. and Levin,L.R.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-1999) Pharmacology, Weill Cornell Medical
College, 1300 York Avenue, New York, NY 10021, USA
REFERENCE 4 (bases 1 to 5018)
AUTHORS Mattia,M., Buck,J. and Levin,L.R.
TITLE Direct Submission
JOURNAL Submitted (28-APR-2003) Pharmacology, Weill Cornell Medical
College, 1300 York Avenue, New York, NY 10021, USA
REMARK Sequence update by submitter
COMMENT On Apr 28, 2003 this sequence version replaced AF176813.1.
FEATURES Location/Qualifiers
source 1..5018
/db_xref="H-InvDB:HIT000072677"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q22"
CDS 186..5018
/EC_number="4.6.1.1"
/note="SAC"
/codon_start=1
/product="soluble adenylyl cyclase"
/protein_id="AAF65931.1"
/translation="MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLM
FVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALL
ALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDE
THSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFL
KPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQ
IDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINK
VFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVF
CGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVM
KGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYTMKKFLISNS
SQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMFMANVLG
LDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEI
LFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAA
ARAVIKNRNTTYIVVGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEEL
LKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTS
GVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKM
MIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLKPSEGMDHGEEEQLR
ELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEEDAHRCDHCRGRDF
IPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEI
REKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYF
LEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQ
IVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQ
LYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYH
HLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFF
YFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEW
DNFYKFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLK
NLENLVAQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCW
LNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
"
BASE COUNT 1456 a 1101 c 1111 g 1350 t
ORIGIN
1 gacagacatg gcgcttcagc tgtcttcaga ataatgtcac ccggcctcct ctcctgtctt
61 ctgcagtctt aaaagaccta gtccctaact gaggtctggc ttttcctcag ccctggatga
121 agtggagaag acctatttgg agactgcttc ctgtcaccat aaaatcctga acatttgtct
181 tgaacatgaa cactccaaaa gaagaattcc aggactggcc catagtcaga atagcagctc
241 atttaccaga cctcattgtc tatggacatt tctccccaga gcgacccttt atggattatt
301 ttgacggagt cctgatgttt gttgatattt caggttttac tgcaatgact gagaagttca
361 gcagtgccat gtacatggac agaggggctg agcagttggt ggagatcctc aactaccaca
421 taagtgcaat agtggagaaa gtgttgattt ttggaggaga catcctgaaa tttgcaggtg
481 atgcactgct agccctgtgg agggtggagc gaaagcagct gaaaaacatt atcacagtgg
541 taattaaatg tagcctggag atccatggat tgtttgagac ccaggagtgg gaagaaggcc
601 tagacatccg agtcaagata ggactggctg ctggccacat cagcatgttg gtctttggag
661 atgaaacaca cagccacttt ctggtgattg gtcaggcagt ggacgatgtg cgccttgccc
721 agaacatggc tcagatgaat gatgttattc tgtcaccaaa ctgctggcag ctctgtgacc
781 ggagcatgat tgaaattgag agtgttccag atcagagagc agttaaggtt aacttcttaa
841 aaccaccccc caattttaat tttgatgaat ttttcacaaa gtgtacgacc ttcatgcatt
901 attatccttc tggtgagcac aaaaacctcc tgaggcttgc atgcacgctg aagcctgatc
961 ctgaactgga gatgtcccta caaaagtatg tgatggaaag cattttgaag cagattgata
1021 acaaacagct tcagggctat ttatctgagc ttcgcccagt gacgattgtg tttgtgaacc
1081 tgatgtttga agaccaagac aaagcagaag agataggccc agccatccag gatgcctata
1141 tgcacatcac ttctgtcctg aagatcttcc aaggccaaat caataaagtc ttcatgtttg
1201 acaagggctg ctctttcctc tgtgtctttg gcttccctgg ggaaaaggta cctgacgagc
1261 tcactcatgc tctggaatgt gctatggata tatttgactt ctgctctcaa gtccacaaaa
1321 tccaaactgt atccatcggt gttgccagtg ggattgtctt ctgtgggatc gttggacaca
1381 ctgtgagaca cgagtacaca gtcattggtc aaaaagtcaa cttagctgcc aggatgatga
1441 tgtactaccc aggaattgtg acctgcgact ctgtcaccta caatgggagc aacctaccag
1501 cgtacttttt taaagagctt ccaaagaaag ttatgaaagg tgttgcagat tctggaccat
1561 tgtatcagta ttggggccgt actgagaaag tcatgtttgg tatggcgtgc ctcatctgca
1621 acagaaagga ggattaccct ttgctgggac gtaataaaga gatcaactac ttcatgtata
1681 ctatgaagaa atttttgata tctaacagca gccaagtctt aatgtatgag ggattaccag
1741 gatatggaaa aagccagata cttatgaaaa ttgagtacct ggcccaaggt aagaatcaca
1801 ggattattgc catttcattg aataagatca gcttccatca aactttctat accatccaga
1861 tgttcatggc caatgtccta ggcctagaca cttgtaaaca ttataaagaa cgacagacca
1921 accttcgaaa taaagtcatg acactgttgg atgaaaagtt ctactgtctt cttaatgaca
1981 ttttccatgt tcagttccct atttctcggg agatttccag gatgagcacc ttgaaaaagc
2041 aaaaacaatt ggaaatattg tttatgaaga tcttgaagct gatagtgaaa gaggaaagga
2101 ttatttttat cattgatgag gcccagtttg tggattcgac ctcctggaga tttatggaga
2161 agcttatccg gactcttcct atcttcatca ttatgtccct gtgtcccttc gttaacattc
2221 cctgtgcagc tgccagggcc gtaataaaga acaggaacac cacctacatt gtcgttggtg
2281 cagtacagcc taacgacatc tccaacaaga tctgtcttga cctcaatgtg agctgcatct
2341 ccaaagaact ggactcgtac ctgggggagg gaagctgtgg gattccattt tactgtgaag
2401 aattgcttaa aaacctggaa catcatgagg tactcgtttt ccaacaaacg gagtctgagg
2461 aaaagacaaa taggacctgg aataacctgt tcaagtattc cattaagcta acagagaagt
2521 taaacatggt tactctccat agtgataagg aaagtgaaga agtctgtcac ctcacaagtg
2581 gcgtcagact gaaaaacctg tcacctccaa cgtcattaaa agaaatctct ctgatccagc
2641 tggatagcat gagactttcc caccaaatgc tggtgagatg tgctgccatc attggcctga
2701 ccttcaccac tgagttgttg tttgagattc tcccctgttg gaatatgaag atgatgatca
2761 agaccctggc aaccctagtg gaatctaaca ttttttattg tttccggaat ggcaaggagc
2821 ttcaaaaggc cctgaaacag aatgatccct catttgaggt gcactatcgt tccttgtctc
2881 tgaagcccag tgaagggatg gatcacggtg aagaggaaca gcttcgtgaa ctggagaatg
2941 aggtgatcga gtgccacagg attcgattct gtaaccctat gatgcagaaa acagcctacg
3001 agctgtggct caaggaccag agaaaagcca tgcacttgaa atgtgcccgc tttttagaag
3061 aagatgccca cagatgtgac cactgccgag gcagggactt cattccctat catcacttca
3121 cagtgaatat tcggctcaac gctttagaca tggatgccat taaaaagatg gctatgtctc
3181 atggatttaa aactgaagaa aagcttatct tgtccaactc agagattcct gagacatctg
3241 cattttttcc tgaaaatcgc agtcctgaag aaataagaga aaagatcttg aatttctttg
3301 accacgtttt aacaaaaatg aagacatctg acgaagacat tatccctctg gaatcttgcc
3361 agtgtgaaga aatcctagag attgtcatct tgcctctggc ccaccatttt ctggctttgg
3421 gagaaaatga caaagcctta tattacttct tagaaattgc atctgcttat ctcatctttt
3481 gtgataacta catggcatac atgtatttga atgaaggaca gaagttgcta aaaactctca
3541 agaaggacaa atcttggagc cagacatttg agtctgccac cttttacagc ctcaaaggtg
3601 aggtctgttt caatatgggc cagatagtgc ttgccaagaa aatgctgagg aaggcactga
3661 agctcctcaa ccgaatcttt ccttacaact taatctcctt gtttctccat atccatgtcg
3721 agaaaaacag acactttcat tatgtgaatc ggcaggccca agagagccca cctccaggga
3781 agaagaggct ggcacaactt taccggcaaa ctgtctgcct ttccttgctg tggcgcatct
3841 atagctacag ttatcttttt cactgcaagt attatgccca cctggcagtt atgatgcaaa
3901 tgaatactgc actggaaact caaaattgtt tccagatcat taaggcttac ctagactatt
3961 cgctatacca ccacctggct ggctacaaag gtgtgtggtt caaatatgaa gtcatggcca
4021 tggagcacat cttcaacctc cccctgaaag gcgagggcat tgaaatcgtg gcatacgtgg
4081 ctgagacact ggtcttcaac aagctcataa tgggacacct ggatttggcc attgagttag
4141 gctcccgagc ccttcagatg tgggcactgc tccagaatcc caaccgacat tatcagtccc
4201 tctgcagact tagcagatgt ctccttctga acagcagata cccgcaattg atccaggtgc
4261 tggggcggct gtgggagctt tctgtaacac aggaacacat cttcagcaag gcatttttct
4321 attttgtctg cttggacatc ctgctttatt ctggttttgt ttatagaaca tttgaagaat
4381 gtttggaatt catacaccaa tacgaaaaca acagaatcct caagttccac agtggactcc
4441 tcctgggact ttattcctct gtagctatct ggtatgccag acttcaggaa tgggacaact
4501 tttacaaatt ttccaataga gctaaaaatc ttttgccaag aagaaccatg acacttactt
4561 actatgacgg aatatctagg tacatggagg ggcaagttct tcaccttcaa aaacaaatca
4621 aagaacagtc agagaatgcc caagccagtg gggaggagct actcaagaac ttggagaatc
4681 tggtggctca aaataccact ggccctgtct tttgcccaag gctctaccac ctgatggctt
4741 acgtctgtat attaatggga gatgggcaga aatgtggcct cttcctgaac acagccttgc
4801 ggctctctga aacacagggg aatatactgg agaaatgctg gctgaacatg aacaaagaat
4861 catggtactc aacctctgag ttaaaagaag accaatggct tcagacgatc ttgagtctcc
4921 catcatggga aaaaattgta gcaggcaggg taaacattca ggatcttcaa aaaaacaaat
4981 tcctgatgag agctaatacc gtggacaatc atttctaa
//