LOCUS AF173994 7542 bp mRNA linear HUM 26-JUL-2002
DEFINITION Homo sapiens AF15q14 mRNA, complete cds.
ACCESSION AF173994
VERSION AF173994.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7542)
AUTHORS Kuefer,M.U., Chinwalla,V., Zeleznik-Le,N.J., Behm,F.G., Naeve,C.W.,
Rakestraw,K.M., Raimondi,S.C. and Morris,S.W.
TITLE Characterization of the MLL partner gene, AF15q14, involved in the
t(11;15)(q23;q14-15)
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7542)
AUTHORS Kuefer,M.U., Chinwalla,V., Zeleznik-Le,N.J., Behm,F.G., Naeve,C.W.,
Rakestraw,K.M., Raimondi,S.C. and Morris,S.W.
TITLE Direct Submission
JOURNAL Submitted (30-JUL-1999) Pediatrics, University of Ulm,
Prittwitzstr. 43, Ulm 89075, Germany
FEATURES Location/Qualifiers
source 1..7542
/db_xref="H-InvDB:HIT000072464"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q14"
/note="leukemic blasts from a de novo T-lineage ALL"
gene 1..7542
/gene="AF15q14"
/note="AF15q14 is fused to MLL in the
t(11;15)(q23;q14-q15); AF15q14 appears to be identical to
the human S6 A-8 mRNA expressed in chromosome 6-suppressed
melanoma cells deposited in Genbank Accession Number
U52052"
CDS 391..7419
/gene="AF15q14"
/codon_start=1
/product="AF15q14"
/protein_id="AAM45143.1"
/translation="MDGVSSEANEENDNIERPVRRRHSSILKPPRSPLQDHRGGNERV
QESNALRNKKNSRRVSFADTIKVFQTESHMKIVRKSEMEGCSAMVPSQLQLLPPGFKR
FSCLSLPETETGENLLLIQNKKLEDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRE
RKHANDQTVIFSDENQMDLTSSHTVMITKGLLDNPISEKSTKIDTTSFLANLKLHTED
SRMKKEVNFSVDQNTSSENKIDFNDFIKRLKTGKCSAFPDVPDKENFEIPIYSKEPNS
ASSTHQMHVSLKEDENNSNITRLFREKDDGMNFTQCHTANIQTLIPTSSETNSRESKG
NDITIYGNDFMDLTFNHTLQILPATGNFSEIENQTQNAMDVTTGYGTKASGNKTVFKS
KQNTAFQDLSINSADKIHITRSHIMGAETHIVSQTCNQDARILAMTPESIYSNPSIQG
CKTVFYSSCNDAMEMTKCLSNMREEKNLLKHDSNYAKMYCNPDAMSSLTEKTIYSGEE
NMDITKSHTVAIDNQIFKQDQSNVQIAAAPTPEKEMMLQNLMTTSEDGKMNVNCNSVP
HVSKERIQQSLSNPLSISLTDRKTELLSGENTDLTESHTSNLGSQVPLAAYNLAPEST
SESHSQSKSSSDECEEITKSRNEPFQRSDIIAKNSLTDTWNKDKDWVLKILPYLDKDS
PQSADCNQEIATSHNIVYCGGVLDKQITNRNTVSWEQSLFSTTKPLFSSGQFSMKNHD
TAISSHTVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMIICSEEEQNMDLTKSHTVVI
GFGPSELQELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPIEKSGVLKSNCIMDVLED
ESVQKPKFPKEKQNVKIWGRKSVGGPKIDKTIVFSEDDKNDMDITKSYTIEINHRPLL
EKRDCHLVPLAGTSETILYTCGQDDMEITRSHTTALECKTVSPDEITTRPMDKTVVFV
DNHVELEMTESHTVFIDYQEKERTDRPNFELSQRKSLGTPTVICTPTEESVFFPGNGE
SDRLVANDSQLTPLEEWSNNRGPVEVADNMELSKSATCKNIKDVQSPGFLNEPLSSKS
QRRKSLKLKNDKTIVFSENHKNDMDITQSCMVEIDNESALEDKEDFHLAGASKTILYS
CGQDDMEITRSHTTALECKTLLPNEIAIRPMDKTVLFTDNYSDLEVTDSHTVFIDCQA
TEKILEENPKFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVGNKIVLHTEQKQQLFAA
TNRTTNEIIKFHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNRDRRNVDFTSSHATA
VCGSSDNYSCLPNVISCTDNLEGSAMLLCDKDEEKANYCPVQNDLAYANDFASEYYLE
SEGQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHKDQDLIKDPRNLLANQTLVYSQDL
GEMTKLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPKKGQSSINKEEVILS
KAGNKSLNIIENSSAPICENKPKILNSEEWFAAACKKELKENIQTTNYNTALDFHSNS
DVTKQVIQTHVNAGEAPDPVITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLPPLPE
QLLELGNKAHNDMHIVQATEIHNINIISSNAKDSRDEENKKSHNGAETTSLPPKTVFK
DKVRRCSLGIFLPRLPNKRNCSVTGIDDLEQIPADTTDINHLETQPVSSKDSGIGSVA
GKLNLSPSQYINEENLPVYPDEINSSDSINIETEEKALIETYQKEISPYENKMGKTCN
SQKRTWVQEEEDIHKEKKIRKNEIKFSDTTQDREIFDHHTEEDIDKSANSVLIKNLSR
TPSSCSSSLDSIKADGTSLDFSTYRSSQMESQFLRDTICEESLREKLQDGRITIREFF
ILLQVHILIQKPRQSNLPGNFTVNTPPTPEDLMLSQYVYRPKIQIYREDCEARRQKIE
ELKLSASNQDKLLVDINKNLWEKMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTHQGK
VALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVEEW
DSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSL
SEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFLDKRYRKIVDVNFQSLLDEDQ
APPSSLLVHKLIFQYVEEKESWKKTCTTQHQLPKMLEEFSLVVHHCRLLGEEIEYLKR
WGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQ
DDIATILSKVPLENNYLKNVVKQIYQDLFQDCHFYH"
BASE COUNT 2687 a 1377 c 1522 g 1956 t
ORIGIN
1 aagcaatcga aagaagatgg ccgctcccac gattgtgggg gaggtctcca ccggggaggg
61 gcagaggaaa ttcggtcgaa aaagagataa agttgaagga aataaaattg gcacggagtc
121 tgggaaagta gtttccctaa aggagtctta gaaatagggt tggtctggaa cctaaggggc
181 ggagccgacg cgtagagccg ctttgcgcgt gcgcatcacc taggcggtta gatttgaata
241 cttcactgag gcgagccggg cgttgtgagc ggactgctag aggcggctgt ctgtttccgc
301 tctaaggaaa ctcagagcgt gtggacccca aacaagtctg cgcaaaattt gtcgaggagg
361 tttgccgcgg cagaaaagtt ttcttcaaaa atggatgggg tgtcttcaga ggctaatgaa
421 gaaaatgaca atatagagag acctgttaga agacggcatt cttcaatatt gaaaccccca
481 aggagtcctc ttcaggacca cagaggtggg aatgaaagag ttcaggaatc caatgctttg
541 agaaataaga aaaactctcg tcgagtcagc tttgcagata ctataaaggt attccagacg
601 gagtctcata tgaaaatagt gagaaagtca gaaatggaag gctgcagtgc aatggtgcca
661 tctcagctgc aacttctgcc tcctgggttt aagcgattct cctgcctcag cctcccagaa
721 acagaaacag gagaaaatct tcttttgata cagaataaga aattagaaga taattactgt
781 gaaattactg ggatgaacac attgctttct gctcccattc atacccagat gcaacagaag
841 gagttttcaa ttatagaaca tacccgtgaa aggaaacatg caaatgacca gacagtcatt
901 ttttcagatg aaaaccagat ggacctgaca tcaagtcaca ctgtaatgat taccaaaggc
961 cttttagata atcccataag tgaaaagtcc accaagatag ataccacatc atttctagct
1021 aatttaaagc ttcacaccga ggactcaaga atgaaaaaag aagtaaattt ttccgtggat
1081 caaaacactt cttcagaaaa taaaatagat ttcaatgact tcataaaaag attgaaaaca
1141 ggaaaatgta gtgcttttcc tgatgtgcct gataaagaaa attttgagat acctatttat
1201 tccaaggaac cgaacagtgc ctcttctaca catcaaatgc atgtatctct taaggaagat
1261 gaaaataaca gtaatattac taggctcttt agagaaaaag atgatgggat gaatttcacc
1321 cagtgtcata cagccaatat tcagacattg attcccacat ccagtgagac caactcacgg
1381 gaatctaaag gtaatgatat tacaatttat ggcaatgact ttatggactt gacatttaac
1441 cacactttgc agatcttacc tgcaacaggt aatttttctg aaatagaaaa tcaaactcag
1501 aatgccatgg atgtaacaac aggttatgga actaaagctt caggaaataa aacagttttt
1561 aagagtaaac aaaatactgc ttttcaagac ctttccataa actctgcaga caaaatacat
1621 attaccagaa gtcatattat gggggcagaa actcacatag tctcacagac ttgtaatcag
1681 gatgccagaa tattagccat gaccccagaa tctatatatt ctaatccatc tattcaaggt
1741 tgtaagactg ttttctattc tagttgtaat gatgccatgg aaatgaccaa atgtctctca
1801 aatatgagag aggagaaaaa tttgctaaag catgacagta attatgctaa aatgtattgc
1861 aatccagatg ctatgtcttc tctcacagag aaaactattt attccggaga ggagaacatg
1921 gacattacca agagtcatac agttgcaata gataatcaaa tttttaaaca agatcaatca
1981 aatgtgcaaa tagcagctgc accaacaccc gaaaaagaaa tgatgctcca aaatcttatg
2041 accacatcag aagatgggaa aatgaatgta aattgtaact cagttcctca tgtatctaag
2101 gaaagaatac agcagagcct gtcaaatcct ttgtctattt cattgactga tagaaagact
2161 gaactcttat caggtgaaaa tacggatttg actgaaagtc acacaagtaa cttaggaagt
2221 caggttcctc ttgcagctta taatctagca ccggagagta ccagtgaatc tcactctcag
2281 agcaaaagct cttcagatga atgtgaagaa attaccaaaa gtcgtaatga accatttcag
2341 cgatcagaca taatagccaa aaacagctta accgacacct ggaacaaaga caaagattgg
2401 gttttgaaga ttttgcccta ccttgataaa gattctcctc agtcagctga ttgtaatcag
2461 gagatagcaa caagccataa tatagtctac tgtggtggag ttcttgataa acaaataact
2521 aatagaaata cagtatcatg ggaacaatct ttgttttcta ccacaaagcc attattttca
2581 tcaggacagt tctctatgaa aaatcatgat actgctataa gtagtcatac agtgaaatct
2641 gtactaggcc agaattctaa actggctgag ccactgagga aaagtttaag caatcccaca
2701 cctgactatt gccatgacaa gatgattata tgttcagagg aagagcaaaa tatggatcta
2761 acaaagagcc acactgttgt cattggattt ggtccttctg aactacaaga acttggtaaa
2821 actaatttag aacacactac tggccagcta acaacaatga acagacagat agctgtaaaa
2881 gttgaaaaat gtggtaaaag tcccatagaa aaaagtggag tgcttaaatc taactgtatt
2941 atggatgtgt tagaggacga aagtgtacag aaacctaaat ttccaaagga aaagcaaaat
3001 gtcaaaattt ggggaaggaa aagtgttggt ggaccaaaaa ttgataagac gattgtattt
3061 tcagaagacg ataagaatga tatggatatc actaagagtt atacaataga aataaaccat
3121 agacctttat tagagaaacg tgattgtcat ttggtgccat tggcaggaac ttctgaaact
3181 attttatata catgtgggca ggatgacatg gagatcacta gaagtcacac aactgcctta
3241 gaatgtaaaa ctgtctcacc agatgaaata actactaggc ctatggacaa aactgtagtg
3301 tttgtagata atcatgttga actagaaatg acagagtccc atactgtttt cattgactac
3361 caagaaaagg aaagaacaga cagacctaac tttgaactat cccaaaggaa aagcctagga
3421 acaccaacag tgatatgtac tcctactgag gagagtgttt tctttccagg aaatggtgaa
3481 agtgaccgtc tagtagcaaa tgacagccag ctaacccctc tggaggaatg gtctaataat
3541 aggggccctg tagaggtagc tgataacatg gaattgtcta aatcagccac ttgcaaaaac
3601 atcaaagatg tacaaagtcc tggatttctg aatgaacctc tatcaagcaa aagtcagaga
3661 agaaaaagcc ttaagctaaa aaatgacaag accattgtat tttcagagaa tcataaaaat
3721 gatatggata ttacccagag ttgtatggtg gaaatagata acgaaagtgc cctggaggat
3781 aaagaggact tccatttggc aggggcttct aaaactattt tgtattcatg tgggcaggat
3841 gacatggaga tcactaggag tcacacaact gccttagaat gtaaaactct cctgccaaat
3901 gaaatagcta ttaggcccat ggacaaaacc gtattgttca cagataatta cagtgatctg
3961 gaagtcaccg attcccatac tgttttcatt gactgtcaag ccacagagaa aatacttgaa
4021 gaaaacccta aatttggaat aggaaaagga aaaaacttgg gtgtttcctt tcctaaggat
4081 aatagctgtg ttcaagaaat cgctgaaaaa caagcactgg ctgtaggaaa caaaatagtt
4141 cttcacaccg agcaaaagca acaactcttt gctgctacta atagaactac taatgaaatc
4201 atcaaatttc atagtgctgc tatggatgaa aaggtcatag ggaaagttgt agaccaggcc
4261 tgtacattgg aaaaagcgca agttgaaagc tgtcagttaa ataatagaga tagaagaaat
4321 gtggacttta caagtagtca tgcaactgct gtttgtggat ccagtgataa ttattcctgt
4381 ttaccaaatg ttatttcctg tactgataat ttggagggta gtgccatgct cttatgtgat
4441 aaagatgagg aaaaagccaa ttattgccca gtgcaaaatg atcttgctta tgcaaatgat
4501 tttgccagtg aatattactt ggaatctgag ggacagcctc tctctgctcc ttgtcctttg
4561 ttagagaagg aagaagttat tcaaaccagt accaaaggac agttagactg tgttataaca
4621 ctgcacaaag atcaagatct gattaaggat ccacgaaatc tattggctaa tcaaacttta
4681 gtatatagtc aagatctggg ggagatgact aaacttaatt caaagcgagt atcttttaag
4741 cttccaaagg atcaaatgaa agtctatgtt gatgacattt atgttattcc tcagcctcat
4801 ttctcaaccg accaacctcc attacctaaa aaaggacaga gtagtatcaa taaagaagaa
4861 gtaatactgt ctaaagctgg aaataagagt ttaaatatta tagaaaattc ctctgcaccc
4921 atatgtgaaa acaagcccaa aatactcaat agtgaggaat ggtttgctgc agcctgtaaa
4981 aaagaactga aggaaaatat tcaaacaact aactataata cagctctaga tttccacagt
5041 aactcagacg taactaagca agtcattcaa actcatgtca atgctggaga agcaccagat
5101 cctgtaatta catctaatgt tccatgtttt catagtatca aaccaaatct gaataatttg
5161 aatggaaaaa ctggagagtt tttagccttt caaactgttc atctaccacc ccttccagag
5221 caattacttg aattaggaaa taaggcacac aatgatatgc atatagtgca agctacagaa
5281 atacataata ttaacataat ctccagcaat gctaaagata gtagagatga ggaaaataaa
5341 aagtctcata atggagctga aaccacctct ctaccgccaa agacagtttt taaagataaa
5401 gtaaggagat gttctttggg aatctttttg cctagattgc ccaacaagag aaattgtagt
5461 gtcactggta ttgatgacct ggaacagatt ccagcagaca caactgatat aaatcactta
5521 gaaactcagc cggtctctag caaagattca ggcattggat ctgttgcagg taaactgaac
5581 ctaagtcctt ctcaatatat aaatgaggaa aatcttcctg tatatcctga tgagatcaat
5641 tcttcagact ctattaacat agaaactgag gaaaaggcct tgattgagac ataccaaaaa
5701 gagatttcac catatgaaaa taaaatggga aaaacttgca atagccaaaa aagaacgtgg
5761 gtacaagaag aagaagatat tcataaggag aaaaaaatca gaaaaaatga gattaagttt
5821 agtgatacga cacaagatcg ggagattttt gatcaccata ctgaagagga tatagataaa
5881 agtgctaaca gtgtattgat aaaaaacctg agcaggaccc catctagttg cagcagctct
5941 ctggattcaa tcaaggctga tgggacctct ctggacttca gcacttaccg cagtagtcaa
6001 atggaatcac agtttctcag agatactatt tgtgaagaga gcttgaggga gaaactccaa
6061 gatgggagaa taacaataag ggagttcttt atacttctcc aggtccacat cttgatacag
6121 aaaccccgac agagcaatct cccaggcaat tttactgtaa acacaccacc tactccagaa
6181 gacctgatgt taagtcaata tgtttaccga cccaagatac agatttatag agaagattgt
6241 gaggctcgtc gccaaaagat tgaagaatta aagctttctg catcgaacca agataagctg
6301 ttggttgata taaataagaa cctgtgggaa aaaatgagac actgctctga caaagagctg
6361 aaggcctttg gaatttatct taacaaaata aagtcatgtt ttaccaagat gactaaagtc
6421 ttcactcacc aaggaaaagt ggctctgtat ggcaagctgg tgcagtcagc tcagaatgag
6481 agggagaaac ttcaaataaa gatagatgag atggataaaa tacttaagaa gatcgataac
6541 tgcctcactg agatggaaac agaaactaag aatttggagg atgaagagaa aaacaatcct
6601 gtggaagaat gggattctga aatgagagct gcagaaaaag aattggaaca gctgaaaact
6661 gaagaagagg agcttcaaag aaatctctta gaactggagg tacaaaaaga gcagaccctt
6721 gctcaaatag actttatgca aaaacaaaga aatagaactg aagagctact ggatcagttg
6781 agcttgtctg agtgggatgt cgttgagtgg agtgatgatc aagctgtatt cacctttgtt
6841 tatgacacga tacaactcac catcaccttt gaagagtcag ttgttggttt ccctttcctg
6901 gacaagcgtt ataggaagat tgttgatgtc aattttcaat ctctgttaga tgaggatcaa
6961 gctcctcctt cctccctttt agttcataag cttattttcc agtacgttga agaaaaggaa
7021 tcctggaaga agacatgtac aacccagcat cagttaccca agatgcttga agaattctca
7081 ctggtagtgc accattgcag actccttgga gaggagattg agtatttaaa gagatgggga
7141 ccaaattata acctaatgaa catagatatt aataataatg aattgagact tttattctct
7201 agctccgcag catttgcaaa gtttgaaata actttgtttc tctcagccta ttatccatct
7261 gtaccattac cttccaccat tcagaatcac gttgggaaca ctagccaaga tgatattgct
7321 accattctat ctaaagtgcc actggagaac aactacctga agaatgtagt caagcaaatt
7381 taccaagatc tgtttcagga ctgccatttc taccactaga cccttggacc accattggaa
7441 caaccaagca gaatgtactt gatattattt cagggtccca ttgctgttca gcctttgttt
7501 ttacgtcatt acaagctgag taaaattcct tctgatgatg tt
//