LOCUS AF172264 4083 bp mRNA linear HUM 25-OCT-1999
DEFINITION Homo sapiens Traf2 and NCK interacting kinase, splice variant 1
(TNIK) mRNA, complete cds.
ACCESSION AF172264
VERSION AF172264.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4083)
AUTHORS Fu,C.A., Shen,M., Huang,B.C., Lasaga,J., Payan,D.G. and Luo,Y.
TITLE TNIK, a novel member of the germinal center kinase family that
activates the c-Jun N-terminal kinase pathway and regulates the
cytoskeleton
JOURNAL J. Biol. Chem. 274 (43), 30729-30737 (1999)
PUBMED 10521462
REFERENCE 2 (bases 1 to 4083)
AUTHORS Fu,C.A., Shen,M., Huang,B.C.B., Lasaga,J., Payan,D.G. and Luo,Y.
TITLE Direct Submission
JOURNAL Submitted (27-JUL-1999) Rigel, Inc., 240 East Grand Avenue, South
San Francisco, CA 94403, USA
FEATURES Location/Qualifiers
source 1..4083
/db_xref="H-InvDB:HIT000072418"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..4083
/gene="TNIK"
CDS 1..4083
/gene="TNIK"
/codon_start=1
/product="Traf2 and NCK interacting kinase, splice variant
1"
/protein_id="AAF03782.1"
/translation="MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRH
VKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLW
LVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVL
LTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWS
LGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ
RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND
SGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQ
KRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQ
LEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ
EQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPP
RSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQE
ALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQP
SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKK
AIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVA
VSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKR
SGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKAS
FTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNI
RPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIH
YKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQR
LKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEG
VYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW"
BASE COUNT 1231 a 929 c 1088 g 835 t
ORIGIN
1 atggcgagcg actccccggc tcgaagcctg gatgaaatag atctctcggc tctgagggac
61 cctgcaggga tctttgaatt ggtggaactt gttggaaatg gaacatacgg gcaagtttat
121 aagggtcgtc atgtcaaaac gggccagctt gcagccatca aggttatgga tgtcacaggg
181 gatgaagagg aagaaatcaa acaagaaatt aacatgttga agaaatattc tcatcaccgg
241 aatattgcta catactatgg tgcttttatc aaaaagaacc caccaggcat ggatgaccaa
301 ctttggttgg tgatggagtt ttgtggtgct ggctctgtca ccgacctgat caagaacaca
361 aaaggtaaca cgttgaaaga ggagtggatt gcatacatct gcagggaaat cttacggggg
421 ctgagtcacc tgcaccagca taaagtgatt catcgagata ttaaagggca aaatgtcttg
481 ctgactgaaa atgcagaagt taaactagtg gactttggag tcagtgctca gcttgatcga
541 acagtgggca ggaggaatac tttcattgga actccctact ggatggcacc agaagttatt
601 gcctgtgatg aaaacccaga tgccacatat gatttcaaga gtgacttgtg gtctttgggt
661 atcaccgcca ttgaaatggc agaaggtgct ccccctctct gtgacatgca ccccatgaga
721 gctctcttcc tcatcccccg gaatccagcg cctcggctga agtctaagaa gtggtcaaaa
781 aaattccagt catttattga gagctgcttg gtaaagaatc acagccagcg accagcaaca
841 gaacaattga tgaagcatcc atttatacga gaccaaccta atgagcgaca ggtccgcatt
901 caactcaagg accatattga tagaacaaag aagaagcgag gagaaaaaga tgagacagag
961 tatgagtaca gtggaagtga ggaagaagag gaggagaatg actcaggaga gcccagctcc
1021 atcctgaatc tgccagggga gtcgacgctg cggagggact ttctgaggct gcagctggcc
1081 aacaaggagc gttctgaggc cctacggagg cagcagctgg agcagcagca gcgggagaat
1141 gaggagcaca agcggcagct gctggccgag cgtcagaagc gcatcgagga gcagaaagag
1201 cagaggcggc ggctggagga gcaacaaagg cgagagaagg agctgcggaa gcagcaggag
1261 agggagcagc gccggcacta tgaggagcag atgcgccggg aggaggagag gaggcgtgcg
1321 gagcatgaac aggaatacat caggcgacag ttagaggagg agcagagaca gttagagatc
1381 ttgcagcagc agctactgca tgaacaagct ctacttctgg aatataagcg caaacaattg
1441 gaagaacaga gacaagcaga aagactgcag aggcagctaa agcaagaaag agactactta
1501 gtttcccttc agcatcagcg gcaggagcag aggcctgtgg agaagaagcc actgtaccat
1561 tacaaagaag gaatgagtcc tagtgagaag ccagcatggg ccaaggaggt agaagaacgg
1621 tcaaggctca accggcaaag ttcccctgcc atgcctcaca aggttgccaa caggatatct
1681 gaccccaacc tgcccccaag gtcggagtcc ttcagcatta gtggagttca gcctgctcga
1741 acacccccca tgctcagacc agtcgatccc cagatcccac atctggtagc tgtaaaatcc
1801 cagggacctg ccttgaccgc ctcccagtca gtgcacgagc agcccacaaa gggcctctct
1861 gggtttcagg aggctctgaa cgtgacctcc caccgcgtgg agatgccacg ccagaactca
1921 gatcccacct cggaaaatcc tcctctcccc actcgcattg aaaagtttga ccgaagctct
1981 tggttacgac aggaagaaga cattccacca aaggtgcctc aaagaacaac ttctatatcc
2041 ccagcattag ccagaaagaa ttctcctggg aatggtagtg ctctgggacc cagactagga
2101 tctcaaccca tcagagcaag caaccctgat ctccggagaa ctgagcccat cttggagagc
2161 cccttgcaga ggaccagcag tggcagttcc tccagctcca gcacccctag ctcccagccc
2221 agctcccaag gaggctccca gcctggatca caagcaggat ccagtgaacg caccagagtt
2281 cgagccaaca gtaagtcaga aggatcacct gtgcttcccc atgagcctgc caaggtgaaa
2341 ccagaagaat ccagggacat tacccggccc agtcgaccag ctagctacaa aaaagctata
2401 gatgaggatc tgacggcatt agccaaagaa ctaagagaac tccggattga agaaacaaac
2461 cgcccaatga agaaggtgac tgattactcc tcctccagtg aggagtcaga aagtagcgag
2521 gaagaggagg aagatggaga gagcgagacc catgatggga cagtggctgt cagcgacata
2581 cccagactga taccaacagg agctccaggc agcaacgagc agtacaatgt gggaatggtg
2641 gggacgcatg ggctggagac ctctcatgcg gacagtttca gcggcagtat ttcaagagaa
2701 ggaaccttga tgattagaga gacgtctgga gagaagaagc gatctggcca cagtgacagc
2761 aatggctttg ctggccacat caacctccct gacctggtgc agcagagcca ttctccagct
2821 ggaaccccga ctgagggact ggggcgcgtc tcaacccatt cccaggagat ggactctggg
2881 actgaatatg gcatggggag cagcaccaaa gcctccttca ccccctttgt ggaccccaga
2941 gtataccaga cgtctcccac tgatgaagat gaagaggatg aggaatcatc agccgcagct
3001 ctgtttacta gcgaacttct taggcaagaa caggccaaac tcaatgaagc aagaaagatt
3061 tcggtggtaa atgtaaaccc aaccaacatt cggcctcata gcgacacacc agaaatcaga
3121 aaatacaaga aacgattcaa ctcagaaata ctttgtgcag ctctgtgggg tgtaaacctt
3181 ctggtgggga ctgaaaatgg cctgatgctt ttggaccgaa gtgggcaagg caaagtctat
3241 aatctgatca accggaggcg atttcagcag atggatgtgc tagagggact gaatgtcctt
3301 gtgacaattt caggaaagaa gaataagcta cgagtttact atctttcatg gttaagaaac
3361 agaatactac ataatgaccc agaagtagaa aagaaacaag gctggatcac tgttggggac
3421 ttggaaggct gtatacatta taaagttgtt aaatatgaaa ggatcaaatt tttggtgatt
3481 gccttaaaga atgctgtgga aatatatgct tgggctccta aaccgtatca taaattcatg
3541 gcatttaagt cttttgcaga tctccagcac aagcctctgc tagttgatct cacggtagaa
3601 gaaggtcaaa gattaaaggt tatttttggt tcacacactg gtttccatgt aattgatgtt
3661 gattcaggaa actcttatga tatctacata ccatctcata ttcagggcaa tatcactcct
3721 catgctattg tcatcttgcc taaaacagat ggaatggaaa tgcttgtttg ctatgaggat
3781 gagggggtgt atgtaaacac ctatggccgg ataactaagg atgtggtgct ccaatgggga
3841 gaaatgccca cgtctgtggc ctacattcat tccaatcaga taatgggctg gggcgagaaa
3901 gctattgaga tccggtcagt ggaaacagga catttggatg gagtatttat gcataagcga
3961 gctcaaaggt taaagtttct atgtgaaaga aatgataagg tattttttgc atccgtgcga
4021 tctggaggaa gtagccaagt gtttttcatg accctcaaca gaaattccat gatgaactgg
4081 taa
//