LOCUS       AF172093                1485 bp    mRNA    linear   HUM 16-MAR-2000
DEFINITION  Homo sapiens 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH)
            mRNA, complete cds.
ACCESSION   AF172093
VERSION     AF172093.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Vaz,F.M., Fouchier,S.W., Ofman,R., Sommer,M. and Wanders,R.J.
  TITLE     Molecular and biochemical characterization of rat
            gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for
            the involvement of human aldehyde dehydrogenase 9 in carnitine
            biosynthesis
  JOURNAL   J. Biol. Chem. 275 (10), 7390-7394 (2000)
   PUBMED   10702312
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Vaz,F.M., Fouchier,S.W., Ofman,R., Sommer,M. and Wanders,R.J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JUL-1999) Laboratory for Genetic and Metabolic
            Diseases (FO-224), Clinical Chemistry and Pediatrics, Academic
            Medical Center, University of Amsterdam, P.O. Box 22700, Amsterdam
            1100 DE, The Netherlands
FEATURES             Location/Qualifiers
     source          1..1485
                     /db_xref="H-InvDB:HIT000072416"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22-q23"
                     /tissue_type="liver"
     gene            1..1485
                     /gene="TMABADH"
     CDS             1..1485
                     /gene="TMABADH"
                     /EC_number="1.2.1.47"
                     /function="mediates penultimate step in carnitine
                     biosynthesis"
                     /note="NAD+ dependent dehydrogenase"
                     /codon_start=1
                     /product="4-trimethylaminobutyraldehyde dehydrogenase"
                     /protein_id="AAF43600.1"
                     /translation="MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFT
                     CSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKS
                     IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF
                     QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQF
                     LCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA
                     LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRP
                     HLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEI
                     FGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV
                     SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF"
     misc_difference 55
                     /gene="TMABADH"
                     /note="compared to Homo sapiens aldehyde dehydrogenase 9
                     encoded by GenBank Accession Number U34252"
                     /replace=""
     misc_difference 58
                     /gene="TMABADH"
                     /note="compared to Homo sapiens aldehyde dehydrogenase 9
                     encoded by GenBank Accession Number U34252"
                     /replace=""
     misc_difference 75
                     /gene="TMABADH"
                     /note="compared to Homo sapiens aldehyde dehydrogenase 9
                     encoded by GenBank Accession Number U34252"
                     /replace=""
BASE COUNT          387 a          313 c          407 g          378 t
ORIGIN      
        1 atgagcactg gcaccttcgt cgtgtcgcag ccgctcaatt accgcggcgg ggcccgcgtg
       61 gagccggcgg acgcctccgg taccgagaaa gctttcgagc cagcaaccgg ccgagtgata
      121 gctactttca catgttcagg agaaaaggaa gtaaatttgg ctgttcaaaa tgcaaaggct
      181 gcttttaaaa tatggagtca aaaatctggc atggagcgtt gccgaatcct tttggaggct
      241 gccaggataa taagggaacg ggaggatgaa attgctacta tggagtgcat caacaatggc
      301 aagtccatct ttgaggcccg cttggacatt gacatttcct ggcagtgcct ggagtattat
      361 gcgggcttgg ctgcatccat ggctggtgaa cacatccagc tcccaggtgg atcgtttggt
      421 tataccagaa gagaaccact tggggtatgt gtgggaatag gagcatggaa ctaccccttt
      481 cagattgcct cttggaagtc ggctccagca ttagcctgtg gtaatgccat ggtctttaaa
      541 ccttctccct ttacacctgt ttctgcattg ctactggctg aaatctacag tgaggctggt
      601 gtacctcctg ggctcttcaa tgtggtgcag ggaggggctg ccacaggcca gtttctgtgt
      661 cagcatcccg atgtggccaa agtctccttc actggaagtg tgcccactgg catgaagatc
      721 atggagatgt cagctaaagg aatcaaacct gttaccttgg aacttggagg caaatctcca
      781 ctcatcatct tctcagactg tgatatgaac aatgctgtaa agggggcgct gatggccaac
      841 ttcctcacac aaggccaggt ttgctgtaat ggcacaagag tatttgtgca gaaagaaatt
      901 cttgataaat ttacagagga agtggtgaaa cagacccaaa ggattaaaat tggagatccc
      961 cttctggaag atacaaggat gggtccactc atcaaccgac cacacctgga gcgagtcctt
     1021 gggtttgtca aagtggcaaa ggagcagggt gctaaagtgt tatgtggtgg agatatatat
     1081 gtacctgaag atcccaaatt aaaggatgga tattacatga gaccttgtgt attaactaat
     1141 tgcagagacg acatgacctg tgtgaaggaa gagatctttg ggcctgttat gtccatttta
     1201 tcatttgaca ctgaagctga ggttctagaa agagccaatg ataccacttt tggactagca
     1261 gctggcgtct ttaccaggga catccaacgg gctcatagag tggtagctga gcttcaggct
     1321 gggacgtgct tcattaacaa ctataacgtc agcccagtgg agttgccctt tggtggatat
     1381 aagaagtcag gatttggcag agagaacggc cgtgtgacaa tcgaatatta ttcacagctg
     1441 aagactgtgt gtgtggagat gggtgatgtg gaatctgctt tttga
//