LOCUS AF171941 3429 bp mRNA linear HUM 10-SEP-1999
DEFINITION Homo sapiens NUMB isoform 4 (NUMB) mRNA, complete cds.
ACCESSION AF171941
VERSION AF171941.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3429)
AUTHORS Verdi,J.M., Bashirullah,A., Goldhawk,D.E., Kubu,C.J., Jamali,M.,
Meakin,S.O. and Lipshitz,H.D.
TITLE Distinct human NUMB isoforms regulate differentiation vs.
proliferation in the neuronal lineage
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (18), 10472-10476 (1999)
PUBMED 10468633
REFERENCE 2 (bases 1 to 3429)
AUTHORS Verdi,J.M., Bashirullah,A., Kubu,C.J., MacDonald,J., Meakin,S.O.
and Lipshitz,H.D.
TITLE Direct Submission
JOURNAL Submitted (26-JUL-1999) Neurodegeneration, Robarts Research
Institute, 100 Perth Drive, London, ONT N6A5K8, Canada
FEATURES Location/Qualifiers
source 1..3429
/db_xref="H-InvDB:HIT000072409"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="uninduced NT2 neuronal precursor cells"
gene 1..3429
/gene="NUMB"
CDS 271..2049
/gene="NUMB"
/note="signaling adapter; phosphotyrosine binding protein;
potential notch regulator"
/codon_start=1
/product="NUMB isoform 4"
/protein_id="AAD54282.1"
/translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
GHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEK
VSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQK
REKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSS
VAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKM
SPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPF
SSAPMTKPVTVVAPQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSV
RAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQ
SYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEA
SSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALEN
KSKQRTNPSPTNPFSSDLQKTFEIEL"
polyA_site 2954
/gene="NUMB"
/note="alternative"
polyA_site 3408
/gene="NUMB"
BASE COUNT 970 a 804 c 765 g 890 t
ORIGIN
1 ggcacgaggg cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct
61 tccggggaag agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata
121 gattggaata ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac
181 tgaggcttgg tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc
241 aagattcaga gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga
301 aagaaggatg tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa
361 ggcgttcgca ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat
421 gaatcaagag gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tactggaaag
481 aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa
541 actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg
601 aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt
661 cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct
721 tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact
781 tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact
841 gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca
901 gataagatag tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct
961 cccacctctc ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc
1021 ccacgccggc atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct
1081 gctcttagcc agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg
1141 ccttccacta tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa
1201 ggggaggcag agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct
1261 gaggacccct tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct
1321 cctaccttcc aagggaccga gtggggtcaa tcttctggtg ctgcctctcc aggtctcttc
1381 caggccggtc atagacgtac tccctctgag gccgaccgat ggttagaaga ggtgtctaag
1441 agcgtccggg ctcagcagcc ccaggcctca gctgctcctc tgcagccagt tctccagcct
1501 cctccaccca ctgccatctc ccagccagca tcacctttcc aagggaatgc attcctcacc
1561 tctcagcctg tgccagtggg tgtggtccca gccctgcaac cagcctttgt ccctgcccag
1621 tcctatcctg tggccaatgg aatgccctat ccagccccta atgtgcctgt ggtgggcatc
1681 actccctccc agatggtggc caacgtattt ggcactgcag gccaccctca ggctgcccat
1741 ccccatcagt cacccagcct ggtcaggcag cagacattcc ctcactacga ggcaagcagt
1801 gctaccacca gtcccttctt taagcctcct gctcagcacc tcaacggttc tgcagctttc
1861 aatggtgtag atgatggcag gttggcctca gcagacaggc atacagaggt tcctacaggc
1921 acctgcccag tggatccttt tgaagcccag tgggctgcat tagaaaataa gtccaagcag
1981 cgtactaatc cctcccctac caaccctttc tccagtgact tacagaagac gtttgaaatt
2041 gaactttaag caatcattat ggctatgtat cttgtccata ccagacaggg agcagggggt
2101 agcggtcaaa ggagcaaaac agactttgtc tcctgattag tactcttttc actaatccca
2161 aaggtcccaa ggaacaagtc caggcccaga gtactgtgag gggtgatttt gaaagacatg
2221 ggaaaaagca ttcctagaga aaagctgcct tgcaattagg ctaaagaagt caaggaaatg
2281 ttgctttctg tactccctct tcccttaccc ccttacaaat ctctggcaac agagaggcaa
2341 agtatctgaa caagaatcta tattccaagc acatttactg aaatgtaaaa cacaacagga
2401 agcaaagcaa tctccctttg tttttcaggc cattcacctg cctcctgtca gtagtggcct
2461 gtattagaga tcaagaagag tggtttgtgc tcaggctggg gaacagagag gcacgctatg
2521 ctgccagaat tcccaggagg gcatatcagc aactgcccag cagagctata ttttggggga
2581 gaagttgagc ttccattttg agtaacagaa taaatattat atatatcaaa agccaaaatc
2641 tttattttta tgcatttaga atattttaaa tagttctcag atattaagaa gttgtatgag
2701 ttgtaagtaa tcttgccaaa ggtaaagggg ctagttgtaa gaaattgtac ataagattga
2761 tttatcattg atgcctactg aaataaaaag aggaaaggct ggaagctgca gacaggatcc
2821 ctagcttgtt ttctgtcagt cattcattgt aagtagcaca ttgcaacaac aatcatgctt
2881 atgaccaata cagtcactag gttgtagttt tttttaaata aaggaaaagc agtattgtcc
2941 tggttttaaa cctatgatgg aattctaatg tcattatttt aatggaatca atcgaaatat
3001 gctctataga gaatatatct tttatatatt gctgcagttt ccttatgtta atcctttaac
3061 actaaggtaa catgacataa tcataccata gaagggaaca caggttacca tattggtttg
3121 taatatgggt cttggtgggt tttgttttat cctttaaatt ttgttcccat gagttttgtg
3181 gggatgggga ttctggtttt attagctttg tgtgtgtcct cttcccccaa accccctttt
3241 ggtgagaaca tccccttgac agttgcagcc tcttgacctc ggataacaat aagagagctc
3301 atctcatttt tacttttgaa cgttggcctt acaatcaaat gtaagttata tatatttgta
3361 ctgatgaaaa tttataatct gctttaacaa aataaatctt catggtagaa aaaaaaaaaa
3421 aaaaaaaaa
//