LOCUS AF171940 3573 bp mRNA linear HUM 10-SEP-1999
DEFINITION Homo sapiens NUMB isoform 3 (NUMB) mRNA, complete cds.
ACCESSION AF171940
VERSION AF171940.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3573)
AUTHORS Verdi,J.M., Bashirullah,A., Goldhawk,D.E., Kubu,C.J., Jamali,M.,
Meakin,S.O. and Lipshitz,H.D.
TITLE Distinct human NUMB isoforms regulate differentiation vs.
proliferation in the neuronal lineage
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (18), 10472-10476 (1999)
PUBMED 10468633
REFERENCE 2 (bases 1 to 3573)
AUTHORS Verdi,J.M., Bashirullah,A., Kubu,C.J., MacDonald,J., Meakin,S.O.
and Lipshitz,H.D.
TITLE Direct Submission
JOURNAL Submitted (26-JUL-1999) Neurodegeneration, Robarts Research
Institute, 100 Perth Drive, London, ONT N6A5K8, Canada
FEATURES Location/Qualifiers
source 1..3573
/db_xref="H-InvDB:HIT000072408"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="uninduced NT2 neuronal precursor cells"
gene 1..3573
/gene="NUMB"
CDS 271..2193
/gene="NUMB"
/note="signaling adapter; phosphotyrosine binding protein;
potential notch regulator"
/codon_start=1
/product="NUMB isoform 3"
/protein_id="AAD54281.1"
/translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
GHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEK
VSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQK
REKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSS
VAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKM
SPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPF
SSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDA
ANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAA
PLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPY
PAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFK
PPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSP
TNPFSSDLQKTFEIEL"
polyA_site 3098
/gene="NUMB"
/note="alternative"
polyA_site 3552
/gene="NUMB"
BASE COUNT 1003 a 851 c 797 g 922 t
ORIGIN
1 ggcacgaggg cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct
61 tccggggaag agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata
121 gattggaata ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac
181 tgaggcttgg tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc
241 aagattcaga gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga
301 aagaaggatg tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa
361 ggcgttcgca ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat
421 gaatcaagag gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tactggaaag
481 aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa
541 actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg
601 aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt
661 cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct
721 tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact
781 tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact
841 gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca
901 gataagatag tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct
961 cccacctctc ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc
1021 ccacgccggc atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct
1081 gctcttagcc agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg
1141 ccttccacta tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa
1201 ggggaggcag agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct
1261 gaggacccct tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct
1321 cctaccttcc aagctaatgg cactgactca gccttccatg tgcttgctaa gccagcccat
1381 actgctctag cacccgtagc aatgcctgtg cgtgaaacca acccttgggc ccatgcccct
1441 gatgctgcta acaaggaaat tgcagccaca tgttcgggga ccgagtgggg tcaatcttct
1501 ggtgctgcct ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac
1561 cgatggttag aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct
1621 cctctgcagc cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct
1681 ttccaaggga atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg
1741 caaccagcct ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc
1801 cctaatgtgc ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact
1861 gcaggccacc ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca
1921 ttccctcact acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag
1981 cacctcaacg gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac
2041 aggcatacag aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct
2101 gcattagaaa ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt
2161 gacttacaga agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc
2221 cataccagac agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga
2281 ttagtactct tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg
2341 tgaggggtga ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat
2401 taggctaaag aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac
2461 aaatctctgg caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt
2521 actgaaatgt aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca
2581 cctgcctcct gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc
2641 tggggaacag agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc
2701 ccagcagagc tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata
2761 ttatatatat caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc
2821 tcagatatta agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt
2881 gtaagaaatt gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa
2941 ggctggaagc tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag
3001 cacattgcaa caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta
3061 aataaaggaa aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta
3121 ttttaatgga atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca
3181 gtttccttat gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg
3241 aacacaggtt accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta
3301 aattttgttc ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg
3361 tcctcttccc ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga
3421 cctcggataa caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc
3481 aaatgtaagt tatatatatt tgtactgatg aaaatttata atctgcttta acaaaataaa
3541 tcttcatggt agaaaaaaaa aaaaaaaaaa aaa
//