LOCUS AF171939 3462 bp mRNA linear HUM 10-SEP-1999
DEFINITION Homo sapiens NUMB isoform 2 (NUMB) mRNA, complete cds.
ACCESSION AF171939
VERSION AF171939.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3462)
AUTHORS Verdi,J.M., Bashirullah,A., Goldhawk,D.E., Kubu,C.J., Jamali,M.,
Meakin,S.O. and Lipshitz,H.D.
TITLE Distinct human NUMB isoforms regulate differentiation vs.
proliferation in the neuronal lineage
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (18), 10472-10476 (1999)
PUBMED 10468633
REFERENCE 2 (bases 1 to 3462)
AUTHORS Verdi,J.M., Bashirullah,A., Kubu,C.J., MacDonald,J., Meakin,S.O.
and Lipshitz,H.D.
TITLE Direct Submission
JOURNAL Submitted (26-JUL-1999) Neurodegeneration, Robarts Research
Institute, 100 Perth Drive, London, ONT N6A5K8, Canada
FEATURES Location/Qualifiers
source 1..3462
/db_xref="H-InvDB:HIT000072407"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="uninduced NT2 neuronal precursor cells"
gene 1..3462
/gene="NUMB"
CDS 271..2082
/gene="NUMB"
/note="signaling adapter; phosphotyrosine binding protein;
potential notch regulator"
/codon_start=1
/product="NUMB isoform 2"
/protein_id="AAD54280.1"
/translation="MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYL
GHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKT
KDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGC
AFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKK
AETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGS
FRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQI
TNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTEWGQSSGAASPGLFQAGHRRTPSEA
DRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVV
PALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSL
VRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVD
PFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL"
polyA_site 2987
/gene="NUMB"
/note="alternative"
polyA_site 3441
/gene="NUMB"
BASE COUNT 982 a 808 c 773 g 899 t
ORIGIN
1 ggcacgaggg cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct
61 tccggggaag agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata
121 gattggaata ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac
181 tgaggcttgg tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc
241 aagattcaga gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga
301 aagaaggatg tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa
361 ggcgttcgca ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat
421 gaatcaagag gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tgaaaggaag
481 ttcttcaaag gcttctttgg aaaaactgga aagaaagcag ttaaagcagt tctgtgggtc
541 tcagcagatg gactcagagt tgtggatgaa aaaactaagg acctcatagt tgaccagacg
601 atagagaaag tttctttctg tgccccagac aggaactttg atagagcctt ttcttacata
661 tgccgtgatg gcaccactcg tcgctggatc tgtcactgct tcatggctgt caaggacaca
721 ggtgaaaggt tgagccatgc agtaggctgt gcttttgcag cctgtttaga gcgcaagcag
781 aagcgggaga aggaatgtgg agtgactgct acttttgatg ctagtcggac cacttttaca
841 agagaaggat cattccgtgt cacaacagcc actgaacaag cagaaagaga ggagatcatg
901 aaacaaatgc aagatgccaa gaaagctgaa acagataaga tagtcgttgg ttcatcagtt
961 gcccctggca acactgcccc atccccatcc tctcccacct ctcctacttc tgatgccacg
1021 acctctctgg agatgaacaa tcctcatgcc atcccacgcc ggcatgctcc aattgaacag
1081 cttgctcgcc aaggctcttt ccgaggtttt cctgctctta gccagaagat gtcacccttt
1141 aaacgccaac tatccctacg catcaatgag ttgccttcca ctatgcagag gaagactgat
1201 ttccccatta aaaatgcagt gccagaagta gaaggggagg cagagagcat cagctccctg
1261 tgctcacaga tcaccaatgc cttcagcaca cctgaggacc ccttctcatc tgctccgatg
1321 accaaaccag tgacagtggt ggcaccacaa tctcctacct tccaagggac cgagtggggt
1381 caatcttctg gtgctgcctc tccaggtctc ttccaggccg gtcatagacg tactccctct
1441 gaggccgacc gatggttaga agaggtgtct aagagcgtcc gggctcagca gccccaggcc
1501 tcagctgctc ctctgcagcc agttctccag cctcctccac ccactgccat ctcccagcca
1561 gcatcacctt tccaagggaa tgcattcctc acctctcagc ctgtgccagt gggtgtggtc
1621 ccagccctgc aaccagcctt tgtccctgcc cagtcctatc ctgtggccaa tggaatgccc
1681 tatccagccc ctaatgtgcc tgtggtgggc atcactccct cccagatggt ggccaacgta
1741 tttggcactg caggccaccc tcaggctgcc catccccatc agtcacccag cctggtcagg
1801 cagcagacat tccctcacta cgaggcaagc agtgctacca ccagtccctt ctttaagcct
1861 cctgctcagc acctcaacgg ttctgcagct ttcaatggtg tagatgatgg caggttggcc
1921 tcagcagaca ggcatacaga ggttcctaca ggcacctgcc cagtggatcc ttttgaagcc
1981 cagtgggctg cattagaaaa taagtccaag cagcgtacta atccctcccc taccaaccct
2041 ttctccagtg acttacagaa gacgtttgaa attgaacttt aagcaatcat tatggctatg
2101 tatcttgtcc ataccagaca gggagcaggg ggtagcggtc aaaggagcaa aacagacttt
2161 gtctcctgat tagtactctt ttcactaatc ccaaaggtcc caaggaacaa gtccaggccc
2221 agagtactgt gaggggtgat tttgaaagac atgggaaaaa gcattcctag agaaaagctg
2281 ccttgcaatt aggctaaaga agtcaaggaa atgttgcttt ctgtactccc tcttccctta
2341 cccccttaca aatctctggc aacagagagg caaagtatct gaacaagaat ctatattcca
2401 agcacattta ctgaaatgta aaacacaaca ggaagcaaag caatctccct ttgtttttca
2461 ggccattcac ctgcctcctg tcagtagtgg cctgtattag agatcaagaa gagtggtttg
2521 tgctcaggct ggggaacaga gaggcacgct atgctgccag aattcccagg agggcatatc
2581 agcaactgcc cagcagagct atattttggg ggagaagttg agcttccatt ttgagtaaca
2641 gaataaatat tatatatatc aaaagccaaa atctttattt ttatgcattt agaatatttt
2701 aaatagttct cagatattaa gaagttgtat gagttgtaag taatcttgcc aaaggtaaag
2761 gggctagttg taagaaattg tacataagat tgatttatca ttgatgccta ctgaaataaa
2821 aagaggaaag gctggaagct gcagacagga tccctagctt gttttctgtc agtcattcat
2881 tgtaagtagc acattgcaac aacaatcatg cttatgacca atacagtcac taggttgtag
2941 ttttttttaa ataaaggaaa agcagtattg tcctggtttt aaacctatga tggaattcta
3001 atgtcattat tttaatggaa tcaatcgaaa tatgctctat agagaatata tcttttatat
3061 attgctgcag tttccttatg ttaatccttt aacactaagg taacatgaca taatcatacc
3121 atagaaggga acacaggtta ccatattggt ttgtaatatg ggtcttggtg ggttttgttt
3181 tatcctttaa attttgttcc catgagtttt gtggggatgg ggattctggt tttattagct
3241 ttgtgtgtgt cctcttcccc caaaccccct tttggtgaga acatcccctt gacagttgca
3301 gcctcttgac ctcggataac aataagagag ctcatctcat ttttactttt gaacgttggc
3361 cttacaatca aatgtaagtt atatatattt gtactgatga aaatttataa tctgctttaa
3421 caaaataaat cttcatggta gaaaaaaaaa aaaaaaaaaa aa
//