LOCUS       AF171068                1252 bp    mRNA    linear   HUM 13-JUN-2001
DEFINITION  Homo sapiens two-pore domain potassium channel TREK-1 (TREK-1)
            mRNA, complete cds.
ACCESSION   AF171068
VERSION     AF171068.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Meadows,H.J., Benham,C.D., Cairns,W., Gloger,I., Jennings,C.,
            Medhurst,A.D., Murdock,P. and Chapman,C.G.
  TITLE     Cloning, localisation and functional expression of the human
            orthologue of the TREK-1 potassium channel
  JOURNAL   Pflugers Arch. 439 (6), 714-722 (2000)
   PUBMED   10784345
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Chapman,C.G., Gloger,I.S. and Meadows,H.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUL-1999) Biotechnology & Genetics, SmithKline
            Beecham Pharmaceuticals, New Frontiers Science Park (North), Third
            Avenue, Harlow, Essex CM19 5AW, UK
FEATURES             Location/Qualifiers
     source          1..1252
                     /db_xref="H-InvDB:HIT000072391"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
                     /tissue_type="brain"
                     /dev_stage="fetus"
     gene            1..1252
                     /gene="TREK-1"
                     /gene_synonym="KCNK2"
     CDS             15..1250
                     /gene="TREK-1"
                     /gene_synonym="KCNK2"
                     /codon_start=1
                     /product="two-pore domain potassium channel TREK-1"
                     /protein_id="AAF89743.1"
                     /translation="MAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKW
                     KTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDEL
                     IQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCI
                     IYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFG
                     CVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWF
                     WILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSV
                     EIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYL
                     NGLTPHCAGEEIAVIENIK"
BASE COUNT          335 a          282 c          303 g          332 t
ORIGIN      
        1 gtctctgaat aagaatggcg gcacctgact tgctggatcc taaatctgcc gctcagaact
       61 ccaaaccgag gctctcgttt tccacgaaac ccacagtgct tgcttcccgg gtggagagtg
      121 acacgaccat taatgttatg aaatggaaga cggtctccac gatattcctg gtggttgtcc
      181 tctatctgat catcggagcc accgtgttca aagcattgga gcagcctcat gagatttcac
      241 agaggaccac cattgtgatc cagaagcaaa cattcatatc ccaacattcc tgtgtcaatt
      301 cgacggagct ggatgaactc attcagcaaa tagtggcagc aataaatgca gggattatac
      361 cgttaggaaa cacctccaat caaatcagtc actgggattt gggaagttcc ttcttctttg
      421 ctggcactgt tattacaacc ataggatttg gaaacatctc accacgcaca gaaggcggca
      481 aaatattctg tatcatctat gccttactgg gaattcccct ctttggtttt ctcttggctg
      541 gagttggaga tcagctaggc accatatttg gaaaaggaat tgccaaagtg gaagatacgt
      601 ttattaagtg gaatgttagt cagaccaaga ttcgcatcat ctcaacaatc atatttatac
      661 tatttggctg tgtactcttt gtggctctgc ctgcgatcat attcaaacac atagaaggct
      721 ggagtgccct ggacgccatt tattttgtgg ttatcactct aacaactatt ggatttggtg
      781 actacgttgc aggtggatcc gatattgaat atctggactt ctataagcct gtcgtgtggt
      841 tctggatcct tgtagggctt gcttactttg ctgctgtcct gagcatgatt ggagattggc
      901 tccgagtgat atctaaaaag acaaaagaag aggtgggaga gttcagagca cacgctgctg
      961 agtggacagc caacgtcaca gccgaattca aagaaaccag gaggcgactg agtgtggaga
     1021 tttatgacaa gttccagcgg gccacctcca tcaagcggaa gctctcggca gaactggctg
     1081 gaaaccacaa tcaggagctg actccttgta ggaggaccct gtcagtgaac cacctgacca
     1141 gcgagaggga tgtcttgcct cccttactga agactgagag tatctatctg aatggtttga
     1201 cgccacactg tgctggtgaa gagattgctg tgattgagaa catcaaatag cc
//