LOCUS AF168793 2074 bp mRNA linear HUM 18-OCT-1999
DEFINITION Homo sapiens peroxisomal carnitine octanoyltransferase mRNA,
complete cds.
ACCESSION AF168793
VERSION AF168793.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2074)
AUTHORS Ferdinandusse,S., Mulders,J., IJlst,L., Denis,S., Dacremont,G.,
Waterham,H.R. and Wanders,R.J.
TITLE Molecular cloning and expression of human carnitine
octanoyltransferase: evidence for its role in the peroxisomal
beta-oxidation of branched-chain fatty acids
JOURNAL Biochem. Biophys. Res. Commun. 263 (1), 213-218 (1999)
PUBMED 10486279
REFERENCE 2 (bases 1 to 2074)
AUTHORS Ferdinandusse,S., Mulders,J., Ijlst,L. and Wanders,R.J.A.
TITLE Direct Submission
JOURNAL Submitted (13-JUL-1999) Genetic Metabolic Diseases, Academic
Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
FEATURES Location/Qualifiers
source 1..2074
/db_xref="H-InvDB:HIT000072323"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="fibroblast"
/tissue_type="skin"
CDS 137..1975
/function="converts acyl-CoA + L-carnitine to
L-acyl-carnitine + CoA"
/note="COT; contains putative PTS-1 signal; involved in
peroxisomal fatty acid beta-oxidation"
/codon_start=1
/product="peroxisomal carnitine octanoyltransferase"
/protein_id="AAF03234.1"
/translation="MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFAN
QEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVN
FAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKLPVHKVGNTPLDMNQFR
MLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELL
RQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVY
SMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMI
MVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREAS
DLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHG
RTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLL
GLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFF
YHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAFHDMIQLMNSTHL"
BASE COUNT 622 a 389 c 469 g 594 t
ORIGIN
1 ggcgcgggcg gtgaggacgg acagtcaccg acttagtcca gttccctgtc atctcaaaac
61 aattgttgca gcaggctcct ggcagtctca agcagttcat cttcttggtg tactggtttc
121 ctattgtgat tttatcatgg aaaatcaatt ggctaaatca actgaagaac gaacatttca
181 gtaccaggat tctcttccat cactgcctgt tccttcactt gaagaatcat taaaaaaata
241 ccttgaatca gtgaaaccat ttgcaaatca agaagaatat aagaaaactg aagaaatagt
301 tcaaaaattt caaagtggga ttggagaaaa attgcaccag aaattgcttg aaagagcaaa
361 aggaaaaaga aattggctgg aagagtggtg gctgaatgtt gcctatctgg atgttcgtat
421 accatcacaa ttgaatgtca actttgcggg tcctgcagct cattttgaac actactggcc
481 tccaaaggaa gggactcaat tagaaagagg aagtataact ctttggcata acttgaacta
541 ctggcagcta ttaagaaaag aaaagttgcc tgttcataaa gttggaaata ctcctctaga
601 tatgaatcaa ttccgaatgc tattttctac ctgcaaggtt ccaggaatta ctagagactc
661 cattatgaat tattttagga ctgagagtga agggcgttcc ccaaaccaca ttgtagtgct
721 gtgtcgaggc cgagcttttg tctttgatgt aatacatgaa ggatgtttgg tcaccccgcc
781 agagcttctc agacaactga catatatcca caagaagtgc catagtgaac ctgatggacc
841 tgggattgca gcattaacta gtgaggagcg aactcgatgg gctaaggcac gagaatatct
901 gattggtctt gatccagaga acttggcttt gttagaaaaa attcagagta gtttactggt
961 atattccatg gaggatagca gtccacatgt aacaccagag gattattctg agattattgc
1021 agccatcctt attggagatc caacagtacg ctggggtgac aaatcctata acttgatttc
1081 cttttctaat ggagtatttg gctgtaattg tgatcatgct ccttttgatg caatgattat
1141 ggtgaacatc agttattatg tggatgagaa aatttttcag aatgaaggaa gatggaaggg
1201 ttcagagaag gtacgagata taccacttcc agaagagctc attttcattg tggatgagaa
1261 agttttaaat gacatcaacc aagctaaagc ccagtatctc agggaggcat ctgatctaca
1321 gattgcggct tatgccttta catcttttgg caaaaagcta accaagaaca agatgcttca
1381 cccggatacg tttattcagc ttgcacttca gctggcctat tacagacttc atggacaccc
1441 tggttgttgc tatgaaacag ctatgacaag acatttttat catggccgta cagagactat
1501 gcgatcatgc acagttgaag cagtgaggtg gtgccagtcc atgcaggatc cttctgtcaa
1561 tcttcgtgag cggcagcaaa agatgttaca agcttttgca aagcataata aaatgatgaa
1621 agattgttca gctggaaaag gatttgatcg tcacctttta ggtctcttac tcatagcaaa
1681 agaggaaggt cttcctgttc cagaactctt tacggaccca cttttttcca aaagcggagg
1741 aggtggaaat tttgttctct caacaagtct ggttggctat ttacgagtcc agggagtggt
1801 agttcccatg gtacacaatg gttatggatt tttctaccat atcagagatg acaggtttgt
1861 tgtggcctgt tcagcctgga aatcctgtcc cgagactgat gcggaaaagc tagttcagct
1921 gactttttgt gcttttcatg atatgataca gctgatgaac tctactcatc tttagagatg
1981 aatcatctat taagcactta ccaaaacata tcattaaact gagtgctggg agtgagttgg
2041 taatatgaga tgggaaggaa tgttgacttg ctaa
//