LOCUS AF163151 9944 bp DNA linear HUM 15-NOV-2000
DEFINITION Homo sapiens dentin sialophosphoprotein precursor (DSPP) gene,
complete cds.
ACCESSION AF163151
VERSION AF163151.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9944)
AUTHORS Gu,K., Chang,S., Ritchie,H.H., Clarkson,B.H. and Rutherford,R.B.
TITLE Molecular cloning of a human dentin sialophosphoprotein gene
JOURNAL Eur. J. Oral Sci. 108 (1), 35-42 (2000)
PUBMED 10706475
REFERENCE 2 (bases 1 to 9944)
AUTHORS Gu,K., Racenis,P., Clarkson,B.H. and Rutherford,R.B.
TITLE Cloning and functional analysis of cis-acting element regulating
the expression of human dentin sialophosphoprotein
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 9944)
AUTHORS Gu,K.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-1999) Cariology, Restorative Sciences and
Endodontics, University of Michigan School of Dentistry, 1011 N.
University Ave., Ann Arbor, MI 48109, USA
REFERENCE 4 (bases 1 to 9944)
AUTHORS Gu,K. and Rutherford,R.B.
TITLE Direct Submission
JOURNAL Submitted (09-MAR-2000) Cariology, Restorative Sciences and
Endodontics, University of Michigan School of Dentistry, 1011 N.
University Ave., Ann Arbor, MI 48109, USA
REMARK Sequence update by submitter
COMMENT On Nov 15, 2000 this sequence version replaced AF163151.1.
FEATURES Location/Qualifiers
source 1..9944
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
gene 1..9944
/gene="DSPP"
regulatory 1..1749
/regulatory_class="promoter"
/gene="DSPP"
mRNA join(1750..1841,4102..4180,5320..5403,5537..6523,
7000..9944)
/gene="DSPP"
/product="dentin sialophosphoprotein"
exon 1750..1841
/gene="DSPP"
/number=1
exon 4102..4180
/gene="DSPP"
/number=2
CDS join(4130..4180,5320..5403,5537..6523,7000..9639)
/gene="DSPP"
/codon_start=1
/product="dentin sialophosphoprotein precursor"
/protein_id="AAF42472.1"
/translation="MKIITYFCIWAVAWAIPVPQSKPLERHVEKSMNLHLLARSNVSV
QDELNASGTIKESGVLVHEGDRGRQENTQDGHKGEGNGSKWAEVGGKSFSTYSTLANE
EGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDK
NTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQIN
SKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNN
SKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPE
DNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEV
GKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGY
DSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSK
GAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDS
SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS
DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD
SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS
SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS
NSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDSSDSDSS
NRSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS
SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSGDSSNSSDSS
DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDS
SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSGSSDSSDSSDSSDSSDSSDSSDSS
DSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD
SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS
SDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD"
sig_peptide 4130..4174
/gene="DSPP"
mat_peptide join(4175..4180,5320..5403,5537..6523,7000..9636)
/gene="DSPP"
/product="dentin sialophosphoprotein"
mat_peptide join(4175..4180,5320..5403,5537..6523,7000..7263)
/gene="DSPP"
/product="dentin sialoprotein"
mat_peptide 7264..9636
/gene="DSPP"
/product="phosphophoryn"
misc_feature 7339..7347
/gene="DSPP"
/note="Region: cell binding domain"
exon 5320..5403
/gene="DSPP"
/number=3
exon 5537..6523
/gene="DSPP"
/number=4
exon 7000..9944
/gene="DSPP"
/number=5
regulatory 9731..9736
/regulatory_class="polyA_signal_sequence"
/gene="DSPP"
regulatory 9914..9919
/regulatory_class="polyA_signal_sequence"
/gene="DSPP"
BASE COUNT 3326 a 1761 c 2180 g 2677 t
ORIGIN
1 atgaggtcat tgtttcaaaa cttcttctct tcatatatgg ttatttagtg ctataatttc
61 atcctaaata actgctttag tgacatccca cagattttga tatgctatgc tttcattttc
121 agtcatccca tatattttga atttcccttt tggtttcttc tttcacccat tgactattta
181 tgagtgttcc acttagcctt aaaatacttg cggttttcca gaattctttt gttattgatt
241 tctgattgcc ttccattgtg gtcagtaaac ataatttgta cgacttgaat tcttttaaat
301 ttattgagat tcattttggg gctcagaata cgttctatct tggtaaatgg tgcaggtaca
361 cttgaaaaga atgtttattc ttctgttgtt ggatgaagtc gtctgtaaat gtcaattaga
421 tcaagttgga tgatacttct gtttaaaggt tgtatatcca ttatattttt ctttcaatta
481 ttaatagatg gctattgaaa tctctaacca taattcatgt taattcaaat taaggaaaag
541 aaaggcaggt ttagttcacc aacctccact gatgaatgtg tgtgtgggta agggtgtcac
601 tcccataagt gactcgagcc ttgttaaaag ttcttaggcc ctttaatctg cccaagtaaa
661 catgctatat gaataaaaac aaagcattca ctatgaaaac agcttcaagg caaatttcct
721 tcccattcaa ttcacttcct tttaacctta ctttttccct acatataaag ctttatttgt
781 atataaatac catatatttt tgtatatata gtttctggag ataccactgt tgcatagtga
841 tatagcatta gtggtcttat gtgtttcacc ttctttaata ttgtaacaca aaaattggca
901 tattcctgaa aattctaaac aagtatatag agaaagacgg tcaagttttt gaatgcatga
961 attgaagaaa tagtttaggg attacctgca ttatagtaca tctagggttc aagagaatgg
1021 tgcactcatg ttgcaaaact tgttagacat aaagtctagt tttctacttt gcattctgca
1081 gctaacacag ataattgaga gataatggac agctaaatct gttgtcttta tgcacctttg
1141 gacatcttgc tacttttgac attttcaatg tctgtttttg aaatgtagtt tgaatactca
1201 attgatagat ttttaagctt ttatgtcact gcttatttca gttaaatcag agagatttca
1261 ggggagttac tgtttataga ttgttaaaga tccctcaggc aacgtcaagg ctgctgcatg
1321 tggacagttt cttgaattat agcacagaaa ctttaatacc tacctcaaga atgatagggg
1381 tcttaaatag gcagtcatat ttactaaaga aacctagagt tttcttagat tgccaacctt
1441 ggtaagacaa gaaatgtcag ggtgacagag tttaagtggc tcttttcagg tatcttacac
1501 tgattctcta tatttaagat gtgaaacagc ctcataggag ctgtttaatt aagtgaaagt
1561 aagtctagtc cttttggaac cgaacggttc agtgagcaaa tacatatcac caagtgaagg
1621 aagtggggaa gttattatgt gcttcataga ctcgatgaca ctttataacc ccatatcagg
1681 gatcctaaac agtgattggt tgagaaaatt atcaaactga gtttaaattt cggcaagtac
1741 aaaattgtca tgcaaaagtc caggacagtg ggccactttc agtcttcaaa gagaaagata
1801 agaaattctg gattttcaaa atccttttga agccttttaa ggtaagatga aatatccttt
1861 ttactcagaa ccaactgatt catttagaaa gaactttgaa tttcaaagat gaagccagtt
1921 tgattttaag aagcgagtac cccttaatga ttagattgta tgcttccttt ttgacttgtc
1981 atattgatag tatgtataaa agataacgga cgattacgac ctaaggaaga gatagattgg
2041 gaagaagaaa gacctcgtac tgaaaaattg gccaactgag gtggaaattt gacaattaac
2101 tatctgggca ctttgattag ttttgataaa aaatgagata actcagattt caaaaatcca
2161 ccttgggctt tcaaacaagg cttcaattag gctttgcttt ttagtatttt attacttact
2221 attacttatt atttattgtc ccacatgaaa tgaaatttag caatcactaa tgatgccaaa
2281 tctaattgct aaatgaaatg aagctaaatc tcatttcatt agtaacaata aatgaaataa
2341 tctgatggag cttcacaaat tctgaagtct ttgtttcatg ctgaggtcac ctgggccatt
2401 tttattgtag tcttcgaagt cattcacctg ccttggaaac ggtgataacc atcatggaat
2461 tgttcaggag tggagctgaa agagagatgt agtggtcaga tttctgaact gtagctcaga
2521 aactggacac gtatcactct ggccttggct gcaggtacct ttccagtatg ctgaggctct
2581 tccaaatcac agtgcagacg ggccttctgc agagctatgt aatgattagg cttgggactg
2641 caaagtacag gataactgtg gcttagtaaa cagctggcct tcaacatctg tgccccagag
2701 ctctgcatga tacttgtcct ggtgtcacct cagcctcact tgaatctatg gcatttcaga
2761 aggagctcta gctgttcttg gctttctgtt gaacagctat aagaatgagc acttttttcc
2821 ctctcagtag ctctggaact gtgtcatctc tcctgtgaga aaacgccagt aattctcatg
2881 acagttgata ttcagtgaag ttttattata ttttcactac caccattaaa ttcaatcaaa
2941 gccattttat gacatgcagc attataatct atacatctgg tgggagttca tgaaatagga
3001 gtaaaactct cctttctatc attacttcaa gaaatccaac ttgcaatata aattaatttt
3061 tttactcaca cagattataa aatgtctatt ccaacttatc agaaacatgt tttagaccat
3121 ttctgaattt gaattctaac agggatgaag aatcatgatt ttagaagtcc cataaaataa
3181 ttgctatcat ttattcaaaa attgcaaagt gcctgaagca atgctagata ttgctgatag
3241 tcataaatat ttatcaacaa cattcagaaa acgttttttt ctgtgctttg cattggaata
3301 caataatcac caagacactc tcctgggcct caggagctta caggaaatca gggcaacaca
3361 taagtaacta ggcaatttta aacagtgcaa tgcgttacca gtgagacgtg caaacttcct
3421 tggtataaaa aggaaagaga taccaaatac cctttgaagt ggcgtcagag agggcgtctc
3481 agagataatt ctaccaaact tcaggataat cctgaggtgc aggtgttgtt attattccag
3541 gtggagggat aataaaccta cttaaatttc tcaagcttac acagcaagta gcaggggtaa
3601 catttgaacc caggtctctg aatacaaacc ccgtattctt tccactagcg taggctccct
3661 catgttagta atttctttct cttaaagtct ggtatagctc aattctatag atttggagta
3721 aggatgacaa gtgttttacc tttgaagcac aatttcagca gaattagtta gtacttgatt
3781 aaagctattc agaagagaaa tagatgtttt tacacccaag aattgcagaa gaacaaagtt
3841 acagctatgc cctttgtacc tattatggtg ttttccttca ttggcacagg cagaaaaaaa
3901 tctaggaagc tacattagtg ctgagcctgg tgatgtcccc ataaccacac caggtatgtt
3961 ctggaccatc gtatgtcttc tcgtgttaga tacatgcttc ttgtccagga aaagggcaaa
4021 tgcttacaca tcaaaataat atagtactat gattttccct ttactttata agtaattttg
4081 tgctgttcct tttttataca gccattgatt attattattc ctaaagaaaa tgaagataat
4141 tacatatttt tgcatttggg cagtagcatg ggccattcca gtaagtatgc ctttcttaga
4201 aaacctcttc actttgttat cttttttaac ctaacattaa tacaaaatgt agtgtgtgtg
4261 tgtgtgtgtg tgtgtgtgtg tgtgtgcatg tacatgtgtg tatatatgtg tgtgtgtata
4321 tatgtttcct taattttttt taacaggctg agtctaaaca tttagatttg cactaagggc
4381 tttatgtgat atctgtgagg tttcaacaaa accactccaa ttcatcgtct cattcctcta
4441 tagaaactca tatctcgtct gaaggattat tattatttaa aacatttatt cagattaatt
4501 tacacttaat gcccagaagt catggagact ttgtccatct ttgcttcata ctctgtgaat
4561 ttcattctaa tacgaacaaa gtctgtgctg tttaggaagt ttccaagaaa gaataataag
4621 aaaaagtaga ttttttttca acatatagga gactaatttt tcactcagag ttattattta
4681 tgtgctcact gtggaaaatt tggaatatat gacgaaaacc aataaaaaat tgagaaaatt
4741 caaccattta taattttact agccagccat catgtttaac attttcatat gctttcataa
4801 taccaaacat ttggtattta tgtagttgaa aatgttctca agtatttcaa atgtgctctt
4861 gcagagcaca gaagtatact agcgtaatac ttgattttgc ttctgtgcag gctctggtca
4921 cgcctcctgt tctcttaaga gttttcatca ggattacact tagagcgggt ttgtgctagt
4981 gcaagaggct ttttgtagag aaacaccaga ggtctatccc ctcgtctttc tacaagactc
5041 tttccttcta cagttgagat aagtgggctg atctaacacg tccataaaat tggtaatacc
5101 acagtgaaaa atatccatgt acccagttta aattctacac aagccctgta agaagccact
5161 tctcttttct atctgattag atcatacttt ggcctttgtg ttaaaccttt cttcttcatg
5221 gagggaagaa tatttgtgtg tgtgtgtgtg tgtgtgcacg ctcacacaca tattcacaaa
5281 taagaacctt ttcaatagcc agtattttct acttggcagg ttcctcaaag caaaccactg
5341 gagagacatg tcgaaaaatc catgaatttg catctcctag caagatcaaa tgtgtcagta
5401 caggtatagg atgtaatata tttcatttta tttcctattt ctgagttgct acattccatt
5461 aacttctcca agattgcaat ttgctttcct tcaagatcat tgacactcat aattgattga
5521 attgtttctt tttcaggatg agttaaatgc cagtggaacc atcaaagaaa gtggtgtcct
5581 ggtgcatgaa ggtgatagag gaaggcaaga gaatacccaa gatggtcaca agggagaagg
5641 gaatggctct aagtgggcag aagtaggagg gaagagtttt tctacatatt ccacattagc
5701 aaacgaagag gggaatattg agggctggaa tggggacaca ggaaaagcag aaacatatgg
5761 tcatgatgga atacatggga aagaagaaaa catcacagca aatggcatcc agggacaagt
5821 aagcatcatt gacaatgctg gagccacaaa cagaagcaac actaatggaa atactgataa
5881 gaatacccaa aatggggatg ttggcgatgc aggtcacaat gaggatgtcg ctgttgtcca
5941 agaagatgga cctcaagtag ctggaagcaa taacagtaca gacaatgagg atgaaataat
6001 tgagaattcc tgtagaaacg agggtaatac aagtgaaata acacctcaga tcaacagcaa
6061 gagaaatggg actaaggaag ctgaggtaac accaggcact ggagaagatg ctggcctgga
6121 taattccgat gggagtccta gtgggaatgg agcagatgag gatgaagacg agggttctgg
6181 tgatgatgaa gatgaagaag cagggaatgg aaaagacagt agtaataaca gcaagggcca
6241 ggagggccag gaccatggga aagaagatga tcatgatagt agcataggtc aaaattcgga
6301 tagtaaagaa tattatgacc ctgaaggcaa agaagatccc cataatgaag ttgatggaga
6361 caagacctcc aagagtgagg agaattctgc tggtattcca gaagacaatg gcagccaaag
6421 aatagaggac acccagaagc tcaaccatag agaaagcaaa cgcgtagaaa atagaatcac
6481 caaagaatca gagacacatg ctgttgggaa gagccaagat aaggttagtt tgtaaagctg
6541 atttctttca atggcagttt aaattcttcc cctccatcta ttgatgctag cacaaaaata
6601 aaccatgaca agcatccatg tatttttgta tccatattac ttgactattt aaggaaatct
6661 agagtcctta ctagacttcg agatagaaca actttaaaca tcttacattt ctgataactt
6721 agttataatt ctagaaaagt cttatgtgaa atcatggatc cccatgtaat tgtttacaaa
6781 agttcctact gggtaggaat gtggatgaat ttttaaggaa tctaagcacc aggatgcttt
6841 caattacaga ataaagcaca ttttcacaaa taactgtgaa gtactagaaa tgtaactcct
6901 atccctatgg caacttttcc cagttattct tcctcagatc aatgcaattt tgcagcaaat
6961 attcactagt taatcattct ttcctccatc cttccatagg gaatagaaat caagggtccc
7021 agcagtggca acagaaatat taccaaagaa gttgggaaag gcaacgaagg taaagaggat
7081 aaaggacaac atggaatgat cttgggcaaa ggcaatgtca agacacaagg agaggttgtc
7141 aacatagaag gacctggcca aaaatcagaa ccaggaaata aagttggaca cagcaataca
7201 ggtagtgaca gcaatagtga tggatatgac agttatgatt ttgatgataa gtccatgcaa
7261 ggagatgatc ccaatagcag tgatgaatct aatggcaatg atgatgctaa ttcagaaagt
7321 gacaataaca gcagtagccg aggagatgct tcttataact ctgatgaatc aaaagataat
7381 ggcaatggca gtgactcaaa aggagcagaa gatgatgaca gtgatagcac atcagacact
7441 aataatagtg acagtaatgg caatggtaac aatgggaatg atgacaatga caaatcagac
7501 agtggcaaag gtaaatcaga tagcagtgac agtgatagta gtgatagcag caatagcagt
7561 gatagtagtg acagcagtga cagtgacagc agtgatagca acagtagcag tgatagtgac
7621 agcagtgaca gtgacagcag tgatagcagt gacagtgata gtagtgatag cagcaatagc
7681 agtgacagta gtgacagcag tgatagcagt gacagtagtg atagtagtga cagcagtgac
7741 agcaagtcag acagcagcaa atcagagagc gacagcagtg atagtgacag taagtcagac
7801 agcagtgaca gcaacagcag tgacagtagt gacaacagtg atagcagcga cagcagcaat
7861 agcagtaaca gcagtgatag tagtgacagc agtgatagca gtgacagcag cagtagcagt
7921 gacagcagca gtagcagtga cagcagcaac agcagtgata gtagtgacag tagtgacagc
7981 agcaatagca gtgagagcag tgatagtagt gacagcagtg atagtgacag cagtgatagt
8041 agtgacagca gtaatagtaa cagcagcgat agtgacagca gcaacagcag cgatagcagt
8101 gacagcagtg atagcagtga cagcagcaac agcagtgaca gtagcgatag cagtgacagc
8161 agcaacagca gtgacagcag tgatagcagt gacagcagtg atagtagtga cagcagcaac
8221 agcagtgata gcaacgacag cagcaatagc agtgacagca gtgatagcag caacagcagt
8281 gatagcagca acagcagtga tagcagtgat agcagtgaca gcagtgatag cgacagcagc
8341 aatagcagtg acagcagtaa tagtagtgac agcagcgata gcagcaacag cagtgatagc
8401 agcgacagca gcgatagcag tgacagcagt gatagcgaca gcagcaatag aagtgacagt
8461 agtaatagta gtgacagcag cgatagcagt gacagcagca acagcagtga cagcagtgat
8521 agtagtgaca gcagtgacag caacgaaagc agcaatagca gtgacagcag tgatagcagc
8581 aacagcagtg atagtgacag cagtgatagc agcaacagca gtgacagcag tgatagcagc
8641 aacagcagtg atagcagtga aagcagtaat agtagtgaca acagcaatag cagtgacagc
8701 agcaacagca gtgacagcag tgatagcagt gacagcagta atagtagtga cagcagcaat
8761 agcggtgaca gcagcaacag cagtgacagc agtgatagca atagcagcga cagcagtgac
8821 agcagcaaca gcagcgatag cagtgacagc agtgatagca gtgacagcag tgacagcagt
8881 gatagcagca acagcagtga tagcagtgac agcagtgaca gcagtgatag cagtaatagt
8941 agtgacagca gcaacagcag tgacagcagc gatagcagtg acagcagcga tagcagtgac
9001 agcagtgaca gcagcaatag cagtgacagc agtgacagca gcgacagcag tgatagcagt
9061 gacagcagtg gcagcagcga cagcagtgat agcagtgaca gcagtgatag cagcgatagc
9121 agtgacagca gcgacagcag tgacagcagt gacagcagtg aaagcagcga cagcagcgat
9181 agcagcgaca gcagtgacag cagcgacagc agtgacagca gcgatagcag cgacagcagc
9241 gacagcagcg atagcagtga cagcagcaat agcagtgata gcagcgacag cagtgatagc
9301 agtgacagca gcgacagcag cgatagcagc gacagcagtg atagtagtga tagcagtgac
9361 agcagtgaca gcagcgacag cagtgacagc agcgacagca gtgacagcag cgacagcagt
9421 gacagcaatg aaagcagcga cagcagtgac agcagcgata gcagtgacag cagcaacagc
9481 agtgacagca gcgacagcag tgatagcagt gacagcacat ctgacagcaa tgatgagagt
9541 gacagccaga gcaagtctgg taacggtaac aacaatggaa gtgacagtga cagtgacagt
9601 gaaggcagtg acagtaacca ctcaaccagt gatgattaga acaaaagaaa aacccataag
9661 attccttttg tgaaaagttt ggtaatggga taggaaaaaa agatttccaa gaaagtaaag
9721 aaaggggaga aataaacata agacgtatgt aaacaaaaac aactggggga atcaaatcaa
9781 acagttggat tcagaaccaa gacctaactc ctgcagagac agactctgaa tgcatgacct
9841 ttggtacatg cctgttaata ttcatgttct gaaaatattt tgttaaaagt gtaaatctaa
9901 acataaaaga acaattaaaa tattctttaa tacttcacac agaa
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