LOCUS AF162666 2749 bp mRNA linear HUM 19-OCT-1999
DEFINITION Homo sapiens tousled-like kinase 1 (TLK1) mRNA, complete cds.
ACCESSION AF162666
VERSION AF162666.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2749)
AUTHORS Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
TITLE Mammalian homologues of the plant Tousled gene code for
cell-cycle-regulated kinases with maximal activities linked to
ongoing DNA replication
JOURNAL EMBO J. 18 (20), 5691-5702 (1999)
PUBMED 10523312
REFERENCE 2 (bases 1 to 2749)
AUTHORS Sillje,H.H.W., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
TITLE Direct Submission
JOURNAL Submitted (24-JUN-1999) Molecular Biology, University of Geneva,
Quai Ernest-Ansermet 30, Geneva, CH 1211, Switzerland
FEATURES Location/Qualifiers
source 1..2749
/db_xref="H-InvDB:HIT000072200"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/tissue_type="placenta"
gene 1..2749
/gene="TLK1"
CDS 298..2454
/gene="TLK1"
/note="serine/threonine protein kinase"
/codon_start=1
/product="tousled-like kinase 1"
/protein_id="AAF03094.1"
/translation="MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKATTNNE
SSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYF
EYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLS
FKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKER
LNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQN
LVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPF
VRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINN
EDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIM
DDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRK
PFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN
DPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY"
BASE COUNT 896 a 561 c 606 g 686 t
ORIGIN
1 cggtttcctc ccccatcccc ttgactctcc cctcccagcc ctcgctctct cgctcgccct
61 cagcgcggcc cccgccatga cggaggcggg tgccggtgcc gttgccgccg ctgccgtcgc
121 agggggggag tcgggttccc agaaagtagc ttgatgagtg tccaaagtag cagtggaagt
181 ttggaggggc cgccatcttg gtcccagctc tccacgtctc caaccccggg ctcggcggcg
241 gcggccaggt ccctgctgaa tcacacgccg ccatccggga ggcccaggga aggtgcaatg
301 gatgagcttc atagtctgga tccaagaagg caagagttat tggaagctag atttactgga
361 gttgcaagtg ggagcactgg aagtacgggc agttgcagtg ttggtgctaa agccacaaca
421 aataacgaaa gctctaatca cagttttgga agcttgggat ctttaagtga caaagaatca
481 gagacaccgg agaagaaaca atcggaatca tccaggggaa gaaagagaaa agcagaaaac
541 cagaatgaaa gtagtcaggg aaaaagtatt gggggacgtg gccacaaaat tagcgactat
601 tttgaatacc agggtggaaa tggctcaagt ccagtaagag gcatacctcc tgcaatccgt
661 tctcctcaaa attcacattc acattccact ccttcctcat ctgttcgacc gaatagccct
721 tctcctactg cattagcatt tggggaccac cctattgtac aaccaaagca attatccttt
781 aaaattattc agactgatct cacaatgctg aaattagcag cattagaaag taataaaatc
841 caggacctgg aaaagaagga gggacgtata gatgatttgc tcagggctaa ctgtgatctc
901 agacggcaaa tagatgaaca acaaaaatta cttgaaaaat acaaagaacg attaaataag
961 tgcatatcaa tgagcaagaa acttcttatt gaaaagagta cacaagaaaa gctgtcaagc
1021 agagagaaga gtatgcaaga tcgattacgc ctcgggcact ttacaacagt tagacatggc
1081 gcttcattta ctgaacaatg gacagatggt tttgcatttc agaatcttgt gaagcaacaa
1141 gaatgggtga atcagcaaag ggaagatatt gaaaggcaaa ggaaacttct agccaaacgc
1201 aaacctccca cagctaataa ttctcaggca ccctctacca attctgaacc aaaacaaagg
1261 aaaaacaaag cagtcaatgg agcagagaat gatccctttg ttagaccaaa tttaccacaa
1321 ctgttgactt tggcagaata tcatgaacag gaagaaattt tcaaacttag actaggacat
1381 ctcaaaaagg aagaggcaga aatccaggca gaacttgaac gtttggaaag agtcagaaat
1441 cttcacatac gtgagctgaa aagaataaac aatgaagata attcacagtt caaagatcac
1501 ccaacattaa atgaaagata tttattactt catctgcttg gtagaggtgg ctttagtgaa
1561 gtgtataagg cttttgacct ttatgaacaa agatatgctg ctgtgaagat acatcagctt
1621 aataaaagct ggagagatga gaagaaagaa aactaccaca aacatgcctg cagagagtat
1681 agaatacaca aagaactgga tcaccccaga atagttaaac tctatgatta tttctccttg
1741 gatacagata cgttttgtac agtgttagaa tactgtgaag gcaatgactt ggatttctat
1801 ctgaagcaac acaagttaat gtcagagaaa gaagctcggt ctattgtaat gcagattgta
1861 aatgcactaa gatatctcaa tgagatcaaa ccccctatta tacattatga tcttaagcca
1921 ggaaacatcc tactggtaga tggaacagca tgtggtgaaa tcaaaatcac tgattttggt
1981 ctgtccaaga ttatggatga tgatagctat ggtgtagatg gaatggatct aacttcccag
2041 ggggcaggca cttactggta tttacctcct gagtgttttg tagttggaaa agagccacca
2101 aagatttcca acaaggttga tgtatggtcg gttggagtca tcttctttca gtgtctttat
2161 ggtagaaagc catttggtca caatcaatct caacaagaca ttcttcaaga aaatacaata
2221 ttaaaagcca cagaagtcca gttccctgta aaaccggttg taagcagtga agccaaggca
2281 tttataagac gctgtttggc atatcgaaaa gaagatcgat ttgatgtgca ccagctggca
2341 aatgacccat accttctccc acacatgaga agatcaaatt cttcaggaaa cctacacatg
2401 gctgggctga cagcatcccc tacaccccct tcttcaagca taattactta ctgactttcc
2461 tccaagattg gcatgatatc tttgaatttg cttccagatg cacacttaag tttgagagca
2521 tttgagtgtt tgttttcttt ttcttttttt tttttttttt ttttttacac aagacgtggt
2581 taaagaactg tttgtgactg aagttcctca tagtgtcatt ggtatgagag aggatcatgg
2641 acaatgaata aatgcacact tctgactata attttgagca gtgaaggaag gatgactgcc
2701 tgttacacag aaacaggaat accatgttaa gatagaggaa aaaaaaaaa
//