LOCUS AF158180 10182 bp mRNA linear HUM 12-OCT-2004
DEFINITION Homo sapiens methyl CpG binding protein 2 (MECP2) mRNA, complete
cds.
ACCESSION AF158180
VERSION AF158180.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10182)
AUTHORS Reichwald,K., Thiesen,J., Wiehe,T., Weitzel,J., Poustka,W.A.,
Rosenthal,A., Platzer,M., Stratling,W.H. and Kioschis,P.
TITLE Comparative sequence analysis of the MECP2-locus in human and mouse
reveals new transcribed regions
JOURNAL Mamm. Genome 11 (3), 182-190 (2000)
PUBMED 10723722
REFERENCE 2 (bases 1 to 10182)
AUTHORS Reichwald,K. and Platzer,M.
TITLE Direct Submission
JOURNAL Submitted (10-JUN-1999) Genome Analysis, Institute of Molecular
Biology, Beutenbergstr. 11, Jena 07743, Germany
FEATURES Location/Qualifiers
source 1..10182
/db_xref="H-InvDB:HIT000072005"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq28"
/clone="PAC 671D9"
gene 1..10182
/gene="MECP2"
5'UTR 1..167
/gene="MECP2"
CDS 168..1628
/gene="MECP2"
/codon_start=1
/product="methyl CpG binding protein 2"
/protein_id="AAF33023.1"
/translation="MVAGMLGLREEKSEDQDLQGLKDKPLKFKKVKKDKKEEKEGKHE
PVQPSAHHSAEPAEAGKAETSEGSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPE
GWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVT
GRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTTRPKAATSEGVQVKRVLEKSPG
KLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVV
AAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGK
GLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPE
PESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVATAATAAEKY
KHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS"
3'UTR 1629..10182
/gene="MECP2"
regulatory 1731..1736
/regulatory_class="polyA_signal_sequence"
/gene="MECP2"
/note="alternative signal"
polyA_site 1755
/gene="MECP2"
/note="alternative site"
regulatory 10159..10163
/regulatory_class="polyA_signal_sequence"
/gene="MECP2"
regulatory 10175..10179
/regulatory_class="polyA_signal_sequence"
/gene="MECP2"
polyA_site 10182
/gene="MECP2"
BASE COUNT 2368 a 2742 c 2602 g 2470 t
ORIGIN
1 ccggaaaatg gccgccgccg ccgccgccgc gccgagcgga ggaggaggag gaggcgagga
61 ggagagactg ctccataaaa atacagactc accagttcct gctttgatgt gacatgtgac
121 tccccagaat acaccttgct tctgtagacc agctccaaca ggattccatg gtagctggga
181 tgttagggct cagggaagaa aagtcagaag accaggacct ccagggcctc aaggacaaac
241 ccctcaagtt taaaaaggtg aagaaagata agaaagaaga gaaagagggc aagcatgagc
301 ccgtgcagcc atcagcccac cactctgctg agcccgcaga ggcaggcaaa gcagagacat
361 cagaagggtc aggctccgcc ccggctgtgc cggaagcttc tgcctccccc aaacagcggc
421 gctccatcat ccgtgaccgg ggacccatgt atgatgaccc caccctgcct gaaggctgga
481 cacggaagct taagcaaagg aaatctggcc gctctgctgg gaagtatgat gtgtatttga
541 tcaatcccca gggaaaagcc tttcgctcta aagtggagtt gattgcgtac ttcgaaaagg
601 taggcgacac atccctggac cctaatgatt ttgacttcac ggtaactggg agagggagcc
661 cctcccggcg agagcagaaa ccacctaaga agcccaaatc tcccaaagct ccaggaactg
721 gcagaggccg gggacgcccc aaagggagcg gcaccacgag acccaaggcg gccacgtcag
781 agggtgtgca ggtgaaaagg gtcctggaga aaagtcctgg gaagctcctt gtcaagatgc
841 cttttcaaac ttcgccaggg ggcaaggctg aggggggtgg ggccaccaca tccacccagg
901 tcatggtgat caaacgcccc ggcaggaagc gaaaagctga ggccgaccct caggccattc
961 ccaagaaacg gggccgaaag ccggggagtg tggtggcagc cgctgccgcc gaggccaaaa
1021 agaaagccgt gaaggagtct tctatccgat ctgtgcagga gaccgtactc cccatcaaga
1081 agcgcaagac ccgggagacg gtcagcatcg aggtcaagga agtggtgaag cccctgctgg
1141 tgtccaccct cggtgagaag agcgggaaag gactgaagac ctgtaagagc cctgggcgga
1201 aaagcaagga gagcagcccc aaggggcgca gcagcagcgc ctcctcaccc cccaagaagg
1261 agcaccacca ccatcaccac cactcagagt ccccaaaggc ccccgtgcca ctgctcccac
1321 ccctgccccc acctccacct gagcccgaga gctccgagga ccccaccagc ccccctgagc
1381 cccaggactt gagcagcagc gtctgcaaag aggagaagat gcccagagga ggctcactgg
1441 agagcgacgg ctgccccaag gagccagcta agactcagcc cgcggttgcc accgccgcca
1501 cggccgcaga aaagtacaaa caccgagggg agggagagcg caaagacatt gtttcatcct
1561 ccatgccaag gccaaacaga gaggagcctg tggacagccg gacgcccgtg accgagagag
1621 ttagctgact ttacacggag cggattgcaa agcaaaccaa caagaataaa ggcagctgtt
1681 gtctcttctc cttatgggta gggctctgac aaagcttccc gattaactga aataaaaaat
1741 attttttttt ctttcagtaa acttagagtt tcgtggcttc agggtgggag tagttggagc
1801 attggggatg tttttcttac cgacaagcac agtcaggttg aagacctaac cagggccaga
1861 agtagctttg cacttttcta aactaggctc cttcaacaag gcttgctgca gatactactg
1921 accagacaag ctgttgacca ggcacctccc ctcccgccca aacctttccc ccatgtggtc
1981 gttagagaca gagcgacaga gcagttgaga ggacactccc gttttcggtg ccatcagtgc
2041 cccgtctaca gctcccccag ctccccccac ctcccccact cccaaccacg ttgggacagg
2101 gaggtgtgag gcaggagaga cagttggatt ctttagagaa gatggatatg accagtggct
2161 atggcctgtg cgatcccacc cgtggtggct caagtctggc cccacaccag ccccaatcca
2221 aaactggcaa ggacgcttca caggacagga aagtggcacc tgtctgctcc agctctggca
2281 tggctaggag gggggagtcc cttgaactac tgggtgtaga ctggcctgaa ccacaggaga
2341 ggatggccca gggtgaggtg gcatggtcca ttctcaaggg acgtcctcca acgggtggcg
2401 ctagaggcca tggaggcagt aggacaaggt gcaggcaggc tggcctgggg tcaggccggg
2461 cagagcacag cggggtgaga gggattccta atcactcaga gcagtctgtg acttagtgga
2521 caggggaggg ggcaaagggg gaggagaaga aaatgttctt ccagttactt tccaattctc
2581 ctttagggac agcttagaat tatttgcact attgagtctt catgttccca cttcaaaaca
2641 aacagatgct ctgagagcaa actggcttga attggtgaca tttagtccct caagccacca
2701 gatgtgacag tgttgagaac tacctggatt tgtatatata cctgcgcttg ttttaaagtg
2761 ggctcagcac atagggttcc cacgaagctc cgaaactcta agtgtttgct gcaattttat
2821 aaggacttcc tgattggttt ctcttctccc cttccatttc tgccttttgt tcatttcatc
2881 ctttcacttc tttcccttcc tccgtcctcc tccttcctag ttcatccctt ctcttccagg
2941 cagccgcggt gcccaaccac acttgtcggc tccagtcccc agaactctgc ctgccctttg
3001 tcctcctgct gccagtacca gccccaccct gttttgagcc ctgaggaggc cttgggctct
3061 gctgagtccg acctggcctg tctgtgaaga gcaagagagc agcaaggtct tgctctccta
3121 ggtagccccc tcttccctgg taagaaaaag caaaaggcat ttcccaccct gaacaacgag
3181 ccttttcacc cttctactct agagaagtgg actggaggag ctgggcccga tttggtagtt
3241 gaggaaagca cagaggcctc ctgtggcctg ccagtcatcg agtggcccaa caggggctcc
3301 atgccagccg accttgacct cactcagaag tccagagtct agcgtagtgc agcagggcag
3361 tagcggtacc aatgcagaac tcccaagacc cgagctggga ccagtacctg ggtccccagc
3421 ccttcctctg ctcccccttt tccctcggag ttcttcttga atggcaatgt tttgcttttg
3481 ctcgatgcag acagggggcc agaacaccac acatttcact gtctgtctgg tccatagctg
3541 tggtgtaggg gcttagaggc atgggcttgc tgtgggtttt taattgatca gttttcatgt
3601 gggatcccat ctttttaacc tctgttcagg aagtccttat ctagctgcat atcttcatca
3661 tattggtata tccttttctg tgtttacaga gatgtctctt atatctaaat ctgtccaact
3721 gagaagtacc ttatcaaagt agcaaatgag acagcagtct tatgcttcca gaaacaccca
3781 caggcatgtc ccatgtgagc tgctgccatg aactgtcaag tgtgtgttgt cttgtgtatt
3841 tcagttattg tccctggctt ccttactatg gtgtaatcat gaaggagtga aacatcatag
3901 aaactgtcta gcacttcctt gccagtcttt agtgatcagg aaccatagtt gacagttcca
3961 atcagtagct taagaaaaaa ccgtgtttgt ctcttctgga atggttagaa gtgagggagt
4021 ttgccccgtt ctgtttgtag agtctcatag ttggactttc tagcatatat gtgtccattt
4081 ccttatgctg taaaagcaag tcctgcaacc aaactcccat cagcccaatc cctgatccct
4141 gatcccttcc acctgctctg ctgatgaccc ccccagcttc acttctgact cttccccagg
4201 aagggaaggg gggtcagaag agagggtgag tcctccagaa ctcttcctcc aaggacagaa
4261 ggctcctgcc cccatagtgg cctcgaactc ctggcactac caaaggacac ttatccacga
4321 gagcgcagca tccgaccagg ttgtcactga gaagatgttt attttggtca gttgggtttt
4381 tatgtattat acttagtcaa atgtaatgtg gcttctggaa tcattgtcca gagctgcttc
4441 cccgtcacct gggcgtcatc tggtcctggt aagaggagtg cgtggcccac caggcccccc
4501 tgtcacccat gacagttcat tcagggccga tggggcagtc gtggttggga acacagcatt
4561 tcaagcgtca ctttatttca ttcgggcccc acctgcagct ccctcaaaga ggcagttgcc
4621 cagcctcttt cccttccagt ttattccaga gctgccagtg gggcctgagg ctccttaggg
4681 ttttctctct atttccccct ttcttcctca ttccctcgtc tttcccaaag gcatcacgag
4741 tcagtcgcct ttcagcaggc agccttggcg gtttatcgcc ctggcaggca ggggccctgc
4801 agctctcatg ctgcccctgc cttggggtca ggttgacagg aggttggagg gaaagcctta
4861 agctgcagga ttctcaccag ctgtgtccgg cccagttttg gggtgtgacc tcaatttcaa
4921 ttttgtctgt acttgaacat tatgaagatg ggggcctctt tcagtgaatt tgtgaacagc
4981 agaattgacc gacagctttc cagtacccat ggggctaggt cattaaggcc acatccacag
5041 tctcccccac ccttgttcca gttgttagtt actacctcct ctcctgacaa tactgtatgt
5101 cgtcgagctc cccccaggtc tacccctccc ggccctgcct gctggtgggc ttgtcatagc
5161 cagtgggatt gccggtcttg acagctcagt gagctggaga tacttggtca cagccaggcg
5221 ctagcacagc tcccttctgt tgatgctgta ttcccatatc aaaagacaca ggggacaccc
5281 agaaacgcca catcccccaa tccatcagtg ccaaactagc caacggcccc agcttctcag
5341 ctcgctggat ggcggaagct gctactcgtg agcgccagtg cgggtgcaga caatcttctg
5401 ttgggtggca tcattccagg cccgaagcat gaacagtgca cctgggacag ggagcagccc
5461 caaattgtca cctgcttctc tgcccagctt ttcattgctg tgacagtgat ggcgaaagag
5521 ggtaataacc agacacaaac tgccaagttg ggtggagaaa ggagtttctt tagctgacag
5581 aatctctgaa ttttaaatca cttagtaagc ggctcaagcc caggagggag cagagggata
5641 cgagcggagt cccctgcgcg ggaccatctg gaattggttt agcccaagtg gagcctgaca
5701 gccagaactc tgtgtccccc gtctaaccac agctcctttt ccagagcatt ccagtcaggc
5761 tctctgggct gactgggcca ggggaggtta caggtaccag ttctttaaga agatctttgg
5821 gcatatacat ttttagcctg tgtcattgcc ccaaatggat tcctgtttca agttcacacc
5881 tgcagattct aggacctgtg tcctagactt cagggagtca gctgtttcta gagttcctac
5941 catggagtgg gtctggagga cctgcccggt gggggggcag agccctgctc cctccgggtc
6001 ttcctactct tctctctgct ctgacgggat ttgttgattc tctccatttt ggtgtctttc
6061 tcttttagat attgtatcaa tctttagaaa aggcatagtc tacttgttat aaatcgttag
6121 gatactgcct cccccagggt ctaaaattac atattagagg ggaaaagctg aacactgaag
6181 tcagttctca acaatttaga aggaaaacct agaaaacatt tggcagaaaa ttacatttcg
6241 atgtttttga atgaatacga gcaagctttt acaacagtgc tgatctaaaa atacttagca
6301 cttggcctga gatgcctggt gagcattaca ggcaagggga atctggaggt agccgacctg
6361 aggacatggc ttctgaacct gtcttttggg agtggtatgg aaggtggagc gttcaccagt
6421 gacctggaag gcccagcacc accctccttc ccactcttct catcttgaca gagcctgccc
6481 cagcgctgac gtgtcaggaa aacacccagg gaactaggaa ggcacttctg cctgaggggc
6541 agcctgcctt gcccactcct gctctgctcg cctcggatca gctgagcctt ctgagctggc
6601 ctctcactgc ctccccaagg ccccctgcct gccctgtcag gaggcagaag gaagcaggtg
6661 tgagggcagt gcaaggaggg agcacaaccc ccagctcccg ctccgggctc cgacttgtgc
6721 acaggcagag cccagaccct ggaggaaatc ctacctttga attcaagaac atttggggaa
6781 tttggaaatc tctttgcccc caaaccccca ttctgtccta cctttaatca ggtcctgctc
6841 agcagtgaga gcagatgagg tgaaaaggcc aagaggtttg gctcctgccc actgatagcc
6901 cctctccccg cagtgtttgt gtgtcaagtg gcaaagctgt tcttcctggt gaccctgatt
6961 atatccagta acacatagac tgtgcgcata ggcctgcttt gtctcctcta tcctgggctt
7021 ttgttttgct ttttagtttt gcttttagtt tttctgtccc ttttatttaa cgcaccgact
7081 agacacacaa agcagttgaa tttttatata tatatctgta tattgcacaa ttataaactc
7141 attttgcttg tggctccaca cacacaaaaa aagacctgtt aaaattatac ctgttgctta
7201 attacaatat ttctgataac catagcatag gacaagggaa aataaaaaaa gaaaaaaaag
7261 aaaaaaaaac gacaaatctg tctgctggtc acttcttctg tccaagcaga ttcgtggtct
7321 tttcctcgct tctttcaagg gctttcctgt gccaggtgaa ggaggctcca ggcagcaccc
7381 aggttttgca ctcttgtttc tcccgtgctt gtgaaagagg tcccaaggtt ctgggtgcag
7441 gagcgctccc ttgacctgct gaagtccgga acgtagtcgg cacagcctgg tcgccttcca
7501 cctctgggag ctggagtcca ctggggtggc ctgactcccc cagtcccctt cccgtgacct
7561 ggtcagggtg agcccatgtg gagtcagcct cgcaggcctc cctgccagta gggtccgagt
7621 gtgtttcatc cttcccactc tgtcgagcct gggggctgga gcggagacgg gaggcctggc
7681 ctgtctcgga acctgtgagc tgcaccaggt agaacgccag ggaccccaga atcatgtgcg
7741 tcagtccaag gggtcccctc caggagtagt gaagactcca gaaatgtccc tttcttctcc
7801 cccatcctac gagtaattgc atttgctttt gtaattctta atgagcaata tctgctagag
7861 agtttagctg taacagttct ttttgatcat ctttttttaa taattagaaa caccaaaaaa
7921 atccagaaac ttgttcttcc aaagcagaga gcattataat caccagggcc aaaagcttcc
7981 ctccctgctg tcattgcttc ttctgaggcc tgaatccaaa agaaaaacag ccataggccc
8041 tttcagtggc cgggctaccc gtgagccctt cggaggacca gggctggggc agcctctggg
8101 cccacatccg gggccagctc cggcgtgtgt tcagtgttag cagtgggtca tgatgctctt
8161 tcccacccag cctgggatag gggcagagga ggcgaggagg ccgttgccgc tgatgtttgg
8221 ccgtgaacag gtgggtgtct gcgtgcgtcc acgtgcgtgt tttctgactg acatgaaatc
8281 gacgcccgag ttagcctcac ccggtgacct ctagccctgc ccggatggag cggggcccac
8341 ccggttcagt gtttctgggg agctggacag tggagtgcaa aaggcttgca gaacttgaag
8401 cctgctcctt cccttgctac cacggcctcc tttccgtttg atttgtcact gcttcaatca
8461 ataacagccg ctccagagtc agtagtcaat gaatatatga ccaaatatca ccaggactgt
8521 tactcaatgt gtgccgagcc cttgcccatg ctgggctccc gtgtatctgg acactgtaac
8581 gtgtgctgtg tttgctcccc ttccccttcc ttctttgccc tttacttgtc tttctggggt
8641 ttttctgttt gggtttggtt tggtttttat ttctcctttt gtgttccaaa catgaggttc
8701 tctctactgg tcctcttaac tgtggtgttg aggcttatat ttgtgtaatt tttggtgggt
8761 gaaaggaatt ttgctaagta aatctcttct gtgtttgaac tgaagtctgt attgtaacta
8821 tgtttaaagt aattgttcca gagacaaata tttctagaca ctttttcttt acaaacaaaa
8881 gcattcggag ggagggggat ggtgactgag atgagagggg agagctgaac agatgacccc
8941 tgcccagatc agccagaagc cacccaaagc agtggagccc aggagtccca ctccaagcca
9001 gcaagccgaa tagctgatgt gttgccactt tccaagtcac tgcaaaacca ggttttgttc
9061 cgcccagtgg attcttgttt tgcttcccct ccccccgaga ttattaccac catcccgtgc
9121 ttttaaggaa aggcaagatt gatgtttcct tgaggggagc caggagggga tgtgtgtgtg
9181 cagagctgaa gagctgggga gaatggggct gggcccaccc aagcaggagg ctgggacgct
9241 ctgctgtggg cacaggtcag gctaatgttg gcagatgcag ctcttcctgg acaggccagg
9301 tggtgggcat tctctctcca aggtgtgccc cgtgggcatt actgtttaag acacttccgt
9361 cacatcccac cccatcctcc agggctcaac actgtgacat ctctattccc caccctcccc
9421 ttcccagggc aataaaatga ccatggaggg ggcttgcact ctcttggctg tcacccgatc
9481 gccagcaaaa cttagatgtg agaaaacccc ttcccattcc atggcgaaaa catctcctta
9541 gaaaagccat taccctcatt aggcatggtt ttgggctccc aaaacacctg acagcccctc
9601 cctcctctga gaggcggaga gtgctgactg tagtgaccat tgcatgccgg gtgcagcatc
9661 tggaagagct aggcagggtg tctgccccct cctgagttga agtcatgctc ccctgtgcca
9721 gcccagaggc cgagagctat ggacagcatt gccagtaaca caggccaccc tgtgcagaag
9781 ggagctggct ccagcctgga aacctgtctg aggttgggag aggtgcactt ggggcacagg
9841 gagaggccgg gacacactta gctggagatg tctctaaaag ccctgtatcg tattcacctt
9901 cagtttttgt gttttgggac aattacttta gaaaataagt aggtcgtttt aaaaacaaaa
9961 attattgatt gcttttttgt agtgttcaga aaaaaggttc tttgtgtata gccaaatgac
10021 tgaaagcact gatatattta aaaacaaaag gcaatttatt aaggaaattt gtaccatttc
10081 agtaaacctg tctgaatgta cctgtatacg tttcaaaaac accccccccc cactgaatcc
10141 ctgtaaccta tttattatat aaagagtttg ccttataaat tt
//