LOCUS AF154502 1479 bp mRNA linear HUM 02-DEC-1999
DEFINITION Homo sapiens quiescent cell proline dipeptidase (QPP) mRNA,
complete cds.
ACCESSION AF154502
VERSION AF154502.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1479)
AUTHORS Underwood,R., Chiravuri,M., Lee,H., Schmitz,T., Kabcenell,A.K.,
Yardley,K. and Huber,B.T.
TITLE Sequence, purification, and cloning of an intracellular serine
protease, quiescent cell proline dipeptidase
JOURNAL J. Biol. Chem. 274 (48), 34053-34058 (1999)
PUBMED 10567372
REFERENCE 2 (bases 1 to 1479)
AUTHORS Underwood,R., Chiravuri,M., Yardley,K., Lee,H., Schmitz,T. and
Huber,B.T.
TITLE Direct Submission
JOURNAL Submitted (26-MAY-1999) Pathology, Tufts University School of
Medicine, 136 Harrison, Boston, MA 02111, USA
FEATURES Location/Qualifiers
source 1..1479
/db_xref="H-InvDB:HIT000071896"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1479
/gene="QPP"
CDS 1..1479
/gene="QPP"
/function="serine protease"
/codon_start=1
/product="quiescent cell proline dipeptidase"
/protein_id="AAF12747.1"
/translation="MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFN
FERFGNKTFPQRFLVSDRFWVRGEGPTFFYTGNEGDVWAFANNSGFVAELAAERGALL
VFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFG
GSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPY
PTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD
PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP
DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRAS
HPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL"
sig_peptide 1..60
/gene="QPP"
/note="leader sequence"
misc_feature 385..447
/gene="QPP"
/note="responsible for homodimerization of QPP; Region:
leucine zipper"
misc_feature 478..492
/gene="QPP"
/note="serine-type protease active site"
misc_feature 1252..1254
/gene="QPP"
/note="active site histidine residues"
misc_feature 1327..1332
/gene="QPP"
/note="active site aspartate residue"
BASE COUNT 241 a 506 c 482 g 250 t
ORIGIN
1 atgggctccg ctccctgggc cccggtcctg ctgctggcgc tcgggctgcg cggcctccag
61 gcgggggccc gcagggcccc ggaccccggc ttccaggagc gcttcttcca gcagcgtctg
121 gaccacttca acttcgagcg cttcggcaac aagaccttcc cccagcgctt cctggtgtcg
181 gacaggttct gggtccgggg cgaggggccc accttcttct acactgggaa cgagggcgac
241 gtgtgggcct tcgccaacaa ctcgggcttc gtcgcggagc tggcggccga gcggggggct
301 ctactggtct tcgcggagca ccgctactac gggaagtcgc tgccgttcgg tgcgcagtcc
361 acgcagcgcg ggcacacgga gctgctgacg gtggagcagg ccctggccga cttcgcagag
421 ctgctccgcg cgctacgacg cgacctcggg gcccaggatg cccccgccat cgccttcggt
481 ggaagttatg gggggatgct cagtgcctac ctgaggatga agtatcccca cctggtggcg
541 ggggcgctgg cggccagcgc gcccgttcta gctgtggcag gcctcggcga ctccaaccag
601 ttcttccggg acgtcacggc ggactttgag ggccagagtc ccaaatgcac ccagggtgtg
661 cgggaagcgt tccgacagat caaggacttg ttcctacagg gagcctacga cacggtccgc
721 tgggagttcg gcacctgcca gccgctgtca gacgagaagg acctgaccca gctcttcatg
781 ttcgcccgga atgccttcac cgtgctggcc atgatggact acccctaccc cactgacttc
841 ctgggtcccc tccctgccaa ccccgtcaag gtgggctgtg atcggctgct gagtgaggcc
901 cagaggatca cggggctgcg agcactggca gggctggtct acaacgcctc gggctccgag
961 cactgctacg acatctaccg gctctaccac agctgtgctg accccactgg ctgcggcacc
1021 ggccccgacg ccagggcctg ggactaccag gcctgcaccg agatcaacct gaccttcgcc
1081 agcaacaatg tgaccgatat gttcccggac ctgcccttca ctgacgagct ccgccagcgg
1141 tactgcctgg acacctgggg cgtgtggccc cggcccgact ggctgctgac cagcttctgg
1201 gggggtgatc tcagagccgc cagcaacatc atcttctcca acgggaacct ggacccctgg
1261 gcagggggcg ggattcggag gaacctgagt gcctcagtca tcgccgtcac catccagggg
1321 ggagcgcacc acctcgacct cagagcctcc cacccagaag atcctgcttc cgtggttgag
1381 gcgcggaagc tggaggccac catcatcggc gagtgggtaa aggcagccag gcgtgagcag
1441 cagccagctc tgcgtggggg gcccagactc agcctctga
//